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Topic Review
Epithelial
Respiratory diseases are frequently characterised by epithelial injury, airway inflammation, de-fective tissue repair, and airway remodelling. This may occur in a subacute or chronic context, such as asthma and chronic obstructive pulmonary disease, or occur acutely as in pathogen challenge or acute respiratory distress syndrome (ARDS). Despite the frequent challenge of lung homeostasis, not all pulmonary insults lead to disease. Traditionally thought of as a quiescent organ, emerging evidence highlights that the lung has significant capacity to respond to injury by repairing and replacing damaged cells. This occurs with the appropriate and timely resolution of inflammation and concurrent initiation of tissue repair programmes. Airway epithelial cells are key effectors in lung homeostasis and host defence; continual exposure to pathogens, toxins, and particulate matter challenge homeostasis, requiring robust defence and repair mechanisms. As such, the epithelium is critically involved in the return to homeostasis, orchestrating the resolution of inflammation and initiating tissue repair. 
  • 1.1K
  • 04 Mar 2021
Topic Review
Lactic Acid Bacteria against Mycotoxins
Mycotoxins (aflatoxin, ochratoxin, patulin, zearalenone, fumonisins, trichothecenes) are a large group of chemically diverse, non-protein, low-molecular secondary metabolites produced by molds. They constitute a global threat to human food and health. The generally regarded as safe (GRAS) status and long history as essential ingredients of fermented foods and probiotics make Lactic Acid Bacteria (LAB) a major biological tool against various food-related toxins. Numerous studies have shown LAB to be effective against all major mycotoxins.
  • 1.1K
  • 17 May 2022
Topic Review
Circular Bacterial Chromosome
A circular bacterial chromosome is a bacterial chromosome in the form of a molecule of circular DNA. Unlike the linear DNA of most eukaryotes, typical bacterial chromosomes are circular. Most bacterial chromosomes contain a circular DNA molecule – there are no free ends to the DNA. Free ends would otherwise create significant challenges to cells with respect to DNA replication and stability. Cells that do contain chromosomes with DNA ends, or telomeres (most eukaryotes), have acquired elaborate mechanisms to overcome these challenges. However, a circular chromosome can provide other challenges for cells. After replication, the two progeny circular chromosomes can sometimes remain interlinked or tangled, and they must be resolved so that each cell inherits one complete copy of the chromosome during cell division.
  • 1.1K
  • 25 Nov 2022
Topic Review
Distribution of Sulfate-Reducing Bacteria in the Environment
Sulfate-reducing bacteria (SRB) are a heterogeneous group of anaerobic microorganisms that play an important role in producing hydrogen sulfide not only in the natural environment, but also in the gastrointestinal tract and oral cavity of animals and humans.
  • 1.1K
  • 25 Oct 2021
Topic Review
Epigenetic Changes and Stress-Related Disorders
Stress is defined as a state of threatened or perceived as threatened homeostasis. Emerging evidence suggests that life-stress experiences can alter the epigenetic landscape and impact the function of genes involved in the regulation of stress response. More importantly, epigenetic changes induced by stressors persist over time, leading to increased susceptibility for a number of stress-related disorders.
  • 1.1K
  • 12 Jun 2021
Topic Review
Bacterial Cellulose and Extracellular Matrixes Hydrogels
Application of biomaterials is one of the most innovative treatments for heart regeneration, involving the use of hydrogels from decellularized extracellular matrix, and their association with nanomaterials, such as alginate, chitosan, hyaluronic acid and gelatin. A promising material is bacterial cellulose hydrogel, due to its nanostructure and morphology being similar to collagen. Cellulose provides support and immobilization of cells, which can result in better cell adhesion, growth and proliferation, making it a safe and innovative material for cardiovascular repair.
  • 1.1K
  • 23 May 2022
Biography
Frances E. Allen
Frances Elizabeth "Fran" Allen (born August 4, 1932) is an American computer scientist and pioneer in the field of optimizing compilers.[1][2][3] Allen was the first female IBM Fellow and in 2006 became the first woman to win the Turing Award.[4] Her achievements include seminal work in compilers, program optimization, and parallelization.[5] Since 2002, she has been a Fellow Emerita from IBM.[6
  • 1.1K
  • 24 Nov 2022
Topic Review
Sarcoidosis
Sarcoidosis is a multisystem granulomatous disease with nonspecific clinical manifestations that commonly a ects the pulmonary system and other organs including the eyes, skin, liver, spleen, and lymph nodes. Sarcoidosis usually presents with persistent dry cough, eye and skin manifestations, weight loss, fatigue, night sweats, and erythema nodosum.
  • 1.1K
  • 28 Oct 2020
Topic Review
Neural Crest Cells
The neural crest shows an astonishing multipotency, generating multiple neural derivatives, but also pigment cells, skeletogenic and other cell types. Here w consider how these multipotent cells may give rise to all those diverse cell-types.  
  • 1.1K
  • 27 Dec 2021
Topic Review
Sex differences in umbilical cord
Biological differences between sexes should be considered in all stages of research, but there is still a lack of stratification by sex despite primary cultured cells retain memory of the sex and of the donor. The sex of donors in biological research must be known because variations in cells and cellular components can be used as end points, biomarkers and/or targets of pharmacological studies. This selective review focuses on the current findings regarding sex differences observed in the umbilical cord, a widely used source of research samples, both in the blood and in the circulating cells, as well as in the different cellular models obtainable from it. Moreover, an overview on sex differences in fetal programming is reported. As it emerges that the sex variable is still often forgotten in experimental models, we suggest that should be mandatory to adopt a sex oriented research, because only awareness of these issues can lead to innovative research.
  • 1.1K
  • 27 Jan 2021
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