Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Balancing Immune System to Treat Rheumatoid Arthritis
Rheumatoid arthritis (RA) and other autoimmune inflammatory diseases are examples of imbalances within the immune system (disrupted homeostasis) that arise from the effects of an accumulation of environmental and habitual insults over a lifetime, combined with genetic predispositions. The Ligand Epitope Antigen Presentation System (LEAPS) therapies are capable of inhibiting ongoing disease progression in animal models. Whereas DMARDs ablate or inhibit specific proinflammatory cytokines or cells and JAK inhibitors (jakinibs) inhibit the receptor activation cascade for expression of proinflammatory cytokines, the LEAPS therapeutic vaccines specifically modulate the ongoing antigen-specific, disease-driving, proinflammatory T memory cell responses. This decreases disease presentation and changes the cytokine conversation to decrease the expression of inflammatory cytokines while increasing the expression of regulatory cytokines. 
  • 1.7K
  • 09 May 2022
Topic Review
Yarrowia lipolytica
After having drawn some industrialists’ attention as early as the 1950s, the non-conventional oleaginous yeast Yarrowia lipolytica has been recognized since several decades, as a powerful host for heterologous protein expression, secretion and surface display. The development of sequencing and genetic engineering tools, combined with an increasing knowledge of its metabolism, have then facilitated the complex engineering of the metabolic pathways of this yeast for various applications. Since nearly two decades, numerous laboratories throughout the world have chosen Y. lipolytica as a chassis for designing microbial cell factories. White biotechnology applications of this yeast include notably single cell oil production, whole cell bioconversion and upgrading of industrial wastes. 
  • 1.7K
  • 19 Jul 2021
Topic Review
Japanese River Otter
The Japanese river otter (Japanese: ニホンカワウソ(日本川獺 ー, Hepburn: Nihon-kawauso) (Lutra lutra whiteleyi) is an extinct variety of otter formerly widespread in Japan. Dating back to the 1880s, it was even seen in Tokyo. The population suddenly shrank in the 1930s, and the mammal nearly vanished. Since then, it has only been spotted several times, in 1964 in the Seto Inland Sea, and in the Uwa Sea in 1972 and 1973. The last official sighting was in the southern part of Kōchi Prefecture in 1979, when it was photographed in the mouth of the Shinjo River in Susaki. It was subsequently classified as a "Critically Endangered" species on the Japanese Red List. On August 28, 2012, the Japanese river otter was officially declared extinct by the Ministry of the Environment. It is the official animal symbol of Ehime Prefecture. In February 2017, a wild otter was caught on camera on Tsushima Island, Nagasaki Prefecture. However, it is not known whether the observed otter was a Japanese river otter.
  • 1.7K
  • 18 Oct 2022
Topic Review
Antimicrobial Blue Light
Blue light primarily exhibits antimicrobial activity through the activation of endogenous photosensitizers, which leads to the formation of reactive oxygen species that attack components of bacterial cells, such as cell wall, cell membrane and genome. Current data show that blue light is innocuous on the skin, but may inflict photo-damage to the eyes. While complete resistance to blue light has not been reported, isolated evidence suggests that bacterial tolerance to blue light may occur over time, especially through gene mutations, although at a slower rate than antibiotic resistance. Future studies can aim at characterizing the amount and type of intracellular photosensitizers across bacterial species and at assessing the oxygen-independent mechanism of blue light.
  • 1.7K
  • 11 Jan 2021
Topic Review
Coypu
The coypu (from spa coipú, from arn koypu; Myocastor coypus), also known as the nutria, is a large, herbivorous, semiaquatic rodent. Classified for a long time as the only member of the family Myocastoridae, Myocastor is now included within Echimyidae, the family of the spiny rats. The coypu lives in burrows alongside stretches of water, and feeds on river plant stems. Originally native to subtropical and temperate South America, it has since been introduced to North America, Europe, Asia, and Africa, primarily by fur farmers. Although it is still hunted and trapped for its fur in some regions, its destructive burrowing and feeding habits often bring it into conflict with humans, and it is considered an invasive species.
  • 1.7K
  • 04 Nov 2022
Topic Review
RNA-Targeting CRISPR–Cas Systems
Many CRISPR–Cas systems have been used as a backbone for the development of potent research tools, with Cas9 being the most widespread. While most of the utilized systems are DNA-targeting, recently more and more attention is being gained by those that target RNA. Their ability to specifically recognize a given RNA sequence in an easily programmable way makes them ideal candidates for developing new research tools. 
  • 1.7K
  • 23 Dec 2020
Topic Review
GADD45A
The growth arrest and DNA damage-inducible 45 alpha (GADD45A) gene encodes a 165 aa protein localized in the nucleus, whose level is highest in the G1 phase of the cell cycle, with a substantial reduction in S. The involvement of GADD45A in the cell cycle regulation and interaction with other proteins underline its function in the cellular DNA damage response and maintaining genomic stability, which, in turn, determines its high potential in cancer transformation. The protective role of GADD45A in DNA damage-induced tumorigenesis is the main biological function of this protein, but exact mechanism of it is not known. Emerging evidence suggests that GADD45A may be important in breast cancer and several molecular pathways were reported to underline this importance, including Ras, mitogen-activated protein kinase 8 (MAPK8), JNK (c-Jun N-terminal kinase) and p38. GADD45A may play a tumor-suppressor role by induction of senescence and apoptosis in cancer cells. However, it was also shown that GADD45A may promote tumorigenesis via the GSK3 β (glycogen synthase kinase 3 beta)/β-catenin signaling. Therefore, GADD45A may function as either a tumor promotor or suppressor, depending on the kind of oncogenic stress, and these two functions are mediated by different signaling pathways.
  • 1.7K
  • 01 Nov 2020
Topic Review
Glossitis Areata Exfoliativa
Geographic tongue, also known by several other terms, is a condition of the mucous membrane of the tongue, usually on the dorsal surface. It is a common condition, affecting approximately 2–3% of the general population. It is characterized by areas of smooth, red depapillation (loss of lingual papillae) which migrate over time. The name comes from the map-like appearance of the tongue, with the patches resembling the islands of an archipelago. The cause is unknown, but the condition is entirely benign (importantly, it does not represent oral cancer), and there is no curative treatment. Uncommonly, geographic tongue may cause a burning sensation on the tongue, for which various treatments have been described with little formal evidence of efficacy.
  • 1.7K
  • 24 Oct 2022
Topic Review
TNF
TNF is a gene that plays an essential role in the body, it affects both immune response and inflammation. The gene encodes a protein called tumour necrosis factor alpha (TNFα) [1].
  • 1.7K
  • 05 Nov 2020
Topic Review
Enzymatic Antioxidant
Plant enzymes are superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), glutathione peroxidase (GPX), glutathione reductase (GR), glutathione S-transferases (GST), ascorbate peroxidase (APX), monodehydroascorbate reductase (MDHAR), and dehydroascorbate reductase (DHAR), which work as part of the antioxidant defence system. These enzymes together form a complex set of mechanisms to minimise, buffer, and scavenge the reactive oxygen species (ROS) efficiently. 
  • 1.7K
  • 24 Jun 2021
  • Page
  • of
  • 1814
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Video Production Service
Feedback