Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
CD19-CAR-T Cells
CD19-targeted chimeric antigen receptor (CAR) T (CD19-CAR-T) cell therapy usually causes B cell aplasia because of “on-target off-tumor” toxicity. The aim of the study was to assess the concept that the introduction of an inhibitory CAR (iCAR) into CAR-T cells could alleviate the side effect of CD19-CAR-T cell therapy. The results showed that CD19-CAR-T cells with a novel KIR/PD-1-based inhibitory CAR (iKP-19-CAR-T) exhibited more naïve, less exhausted phenotypes and preserved a higher proportion of central memory T cells (TCM). Furthermore, iKP-19-CAR-T cells exerted the similar level of cytotoxicity on CD19+HLA-C1- Burkitt’s lymphoma cells compared to CD19-CAR-T cells while sparing CD19+HLA-C1+ healthy human B cells both in vitro and in the xenograft model. Our data demonstrates that the KIR/PD-1-based inhibitory CAR can be a promising strategy to avoid B cell aplasia caused by CD19-CAR-T cell therapy.  
  • 1.7K
  • 26 Oct 2020
Topic Review
Chromothripsis
Chromothripsis has been defined as complex patterns of alternating genes copy number changes (normal, gain or loss) along the length of a chromosome or chromosome segment (International System for Human Cytogenomic Nomenclature 2020). The phenomenon of chromothripsis was discovered in 2011 and changed the concept of genome variability, mechanisms of oncogenic transformation, and hereditary diseases.
  • 1.7K
  • 27 May 2021
Topic Review
Land Use Transitions
Land use transition refers to the changes in land use morphologies, including dominant morphology and recessive morphology, of a certain region over a certain period of time driven by socio-economic change and innovation, and it usually corresponds to the transformation of the socio-economic development stage. The dominant morphology refers to the land use structure with features such as the quantity and spatial pattern of land use types. While the recessive morphology includes the land use features in the aspects of quality, property rights, management mode, input, output and function.
  • 1.7K
  • 17 Sep 2021
Topic Review
Crop Domestication
In agriculture, domestication is the process of a selection of the best trait with increased adaptation or acclimatization of the plant. Driven by human activities, the domestication of plants has dramatically changed the development of the ecological condition. Domestication is the outcome of both phenotypic and genomics changes of a species conferred with classical plant breeding. Gradually, a wild plant changed to an elite high yielding cultivar. Domestication of orphan or underutilized crop plants using recently developed frontier technologies such as genome editing based on current and emerging knowledge generated by genomics and postgenomics approaches are thought to be one of the promising ways for the improvement of the smart crop for the future smart agriculture
  • 1.7K
  • 22 Dec 2020
Topic Review
Personal Protective Equipment for Dentists
Severe Acute Respiratory-Syndrome-CoronaVirus-2 ( SARS-CoV-2) and all infectious agents can determine serious risk for systemic diseases. In literature there are some models of safety protocols in dentistry. All the personal protective equipment (PPE) actually on the market and their indications are reported and compared before and after COVID-19 onset, focusing on the correct safety procedures for each dental practice. 
  • 1.7K
  • 06 Nov 2020
Topic Review
Seaweed-Associated Bacteria
Seaweeds are broadly distributed and represent an important source of secondary metabolites (e.g., halogenated compounds, polyphenols) eliciting various pharmacological activities and playing a relevant ecological role in the anti-epibiosis. Importantly, host (as known as basibiont such as algae)–microbe (as known as epibiont such as bacteria) interaction (as known as halobiont) is a driving force for coevolution in the marine environment. 
  • 1.7K
  • 25 Dec 2020
Topic Review
Natural compounds for wood protection
Natural compounds for wood protection against fungi - all natural substances (or their mixtures) of plant or animal origin with proven antifungal activity and possibility to be applied into wood structure or on its surface to protect wood against wood decaying fungi, blue stain and mold, e.g. essential oils, tannins, wood extractives, alkaloids, propolis or chitosan.
  • 1.7K
  • 02 May 2021
Topic Review
Bacteroidetes
The phylum "Bacteroidetes" is composed of three large classes of Gram-negative, nonsporeforming, anaerobic or aerobic, and rod-shaped bacteria that are widely distributed in the environment, including in soil, sediments, and sea water, as well as in the guts and on the skin of animals. Although some Bacteroides spp. can be opportunistic pathogens, many "Bacteroidetes" are symbiotic species highly adjusted to the gastrointestinal tract. Bacteroides are highly abundant in intestines, reaching up to 1011 cells g−1 of intestinal material. They perform metabolic conversions that are essential for the host, such as degradation of proteins or complex sugar polymers. "Bacteroidetes" colonize the gastrointestinal tract already in infants, as non-digestible oligosaccharides in mother milk support the growth of both Bacteroides and Bifidobacterium spp. Bacteroides spp. are selectively recognized by the immune system of the host through specific interactions.
  • 1.7K
  • 02 Nov 2022
Topic Review
Apis mellifera
The current knowledge about viruses of the Western honey bee, Apis mellifera.
  • 1.7K
  • 02 Nov 2020
Topic Review
CNN in Leaf Disease Classification
Crop production can be greatly reduced due to various diseases, which seriously endangers food security. Thus, detecting plant diseases accurately is necessary and urgent. Traditional classification methods, such as naked-eye observation and laboratory tests, have many limitations, such as being time consuming and subjective. Currently, deep learning (DL) methods, especially those based on convolutional neural network (CNN), have gained widespread application in plant disease classification. They have solved or partially solved the problems of traditional classification methods and represent state-of-the-art technology in this field.
  • 1.7K
  • 12 Aug 2021
  • Page
  • of
  • 1746
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Video Production Service
Feedback