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Topic Review
Targeting Signalling Pathways in Chronic Wound Healing
Chronic wounds fail to achieve complete closure and are an economic burden to healthcare systems due to the limited treatment options and constant medical attention. Chronic wounds are characterised by dysregulated signalling pathways.
  • 121
  • 04 Jan 2024
Topic Review
Sampling of Non-Electrochemical Sweat Sensors
Sweat, commonly referred to as the ultrafiltrate of blood plasma, is an essential physiological fluid in the human body. It contains a wide range of metabolites, electrolytes, and other biologically significant markers that are closely linked to human health. Compared to other bodily fluids, such as blood, sweat offers distinct advantages in terms of ease of collection and non-invasive detection. 
  • 247
  • 04 Jan 2024
Topic Review
Matrix Vesicles and Media Vesicles
Mineralization-competent cells, including hypertrophic chondrocytes, mature osteoblasts, and osteogenic-differentiated smooth muscle cells secrete media extracellular vesicles (media vesicles) and extracellular vesicles bound to the extracellular matrix (matrix vesicles). Media vesicles are purified directly from the extracellular medium. On the other hand, matrix vesicles are purified after discarding the extracellular medium and subjecting the cells embedded in the extracellular matrix or bone or cartilage tissues to an enzymatic treatment. 
  • 223
  • 04 Jan 2024
Topic Review
Powdery Mildew Resistance in Cannabis
Powdery mildew (PM) is one of the most common Cannabis sativa diseases. In spite of this, very few documented studies have characterized the resistance genes involved in PM defense mechanisms, or sources of natural genetic resistance in cannabis.
  • 205
  • 04 Jan 2024
Topic Review
Small Molecules to Enhance Gene Therapy
In the rapidly evolving landscape of genetic engineering, the advent of CRISPR-Cas technologies has catalyzed a paradigm shift, empowering scientists to manipulate the genetic code with unprecedented accuracy and efficiency. Despite the remarkable capabilities inherent to CRISPR-Cas systems, recent advancements have witnessed the integration of small molecules to augment their functionality, introducing new dimensions to the precision and versatility of gene editing applications. 
  • 128
  • 03 Jan 2024
Topic Review
Nano-Agrochemicals
Nano-agrochemicals (NACs) are nanomaterials and formulations specifically designed and controlled at the nanoscale. They can be defined as agricultural formulations in the form of nanopesticides (NPCs) which have unique properties (high aspect ratio) due to elements ranging in nanometer size (up to 100 nm). They have the potential to revolutionize agriculture through the promotion of efficient and ecofriendly NPCs with properties such as target specificity, the ability to control usage, and high surface area which allow the targeted delivery of nutrients and protection of crop yields. NACs, or nanotechnology-based agrochemicals, have gained considerable attention in recent years due to extensive research and development efforts. These cutting-edge products harness the special qualities of NPs to improve the effectiveness, safety, and ecofriendliness of conventional agrochemicals. This technology has emerged as a valuable tool in the agricultural sector, offering novel and efficient solutions for conventional agricultural methods and practices. Some of these include NPCs, among other NACs, which have the capacity to revolutionize agriculture by enhancing sustainability and efficiency. These NPCs, ranging in size from 1 to 200 nm, serve as a vehicle to transport agrochemical ingredients (AcI). With unique properties, they outperform conventional pesticides by 31.5% in managing crop pathogens, weeds, and insects. These unique properties include enhanced water solubility, improved bioavailability, and increased protection of agrochemicals from environmental degradation. Thus, NPCs address the drawbacks of conventional pesticides such as limited availability, susceptibility to degradation from light, and the negative effects of organic solvent pollution.
  • 606
  • 03 Jan 2024
Topic Review
Combination Immunotherapiess for Renal cell carcinoma
Renal cell carcinoma (RCC) constitutes a considerable burden on public health, with an estimated 81,800 new diagnoses and 14,890 mortality cases predicted for 2023 in the United States alone. Over the recent years, the incidence of RCC has exhibited a consistent upward trend. Among the various subtypes, clear cell renal cell carcinoma (ccRCC) predominates, accounting for approximately 70–80% of RCC cases, with the majority originating from the proximal convoluted tubule. Conversely, the non-clear cell renal cell carcinomas (nccRCCs), encompassing entities such as papillary, chromophobe, translocation, and medullary RCC, as well as collecting duct carcinoma, comprise 20–30% of RCC and harbor distinct histopathological and molecular characteristics.
  • 124
  • 03 Jan 2024
Topic Review
Fermented Vegetables
Fermentation is a traditional method used to preserve vegetables. Many regions worldwide have a tradition of consuming fermented vegetables. Numerous fermented vegetables exist according to the raw materials, formula, and fermentation technologies used. Typical fermented vegetables include sauerkraut, paocai, zhacai, and kimchi. The primary constituents for producing fermented vegetables are cruciferous vegetables, such as cabbage, kale, mustard green, or radish. Other prevalent vegetables include chili pepper, lotus root, carrot, ginger, cucumber, eggplant, beetroot, garlic, olive, papaya, and chayote. There are variations in the production procedures used for different fermented vegetables. 
  • 287
  • 03 Jan 2024
Topic Review
A Challenging Story of Schizophrenia and Glutathione
Schizophrenia (SZ) is a devastating mental illness with a complex and heterogeneous clinical state. Oxidative stress, and in particular glutathione (GSH) dysregulation, has been demonstrated to play a crucial role in SZ pathophysiology. In fact, glutathione is a leading actor of oxidative-stress-mediated damage in SZ and appears to reflect the heterogeneity of the disease.
  • 207
  • 03 Jan 2024
Topic Review
State-of the-Art Constraint-Based Modeling of Microbial Metabolism
Methanotrophy is the ability of an organism to capture and utilize the greenhouse gas, methane, as a source of energy-rich carbon. Over the years, significant progress has been made in understanding of mechanisms for methane utilization, mostly in bacterial systems, including the key metabolic pathways, regulation and the impact of various factors (iron, copper, calcium, lanthanum, and tungsten) on cell growth and methane bioconversion. The implementation of -omics approaches provided vast amount of heterogeneous data that require the adaptation or development of computational tools for a system-wide interrogative analysis of methanotrophy. The genome-scale mathematical modeling of its metabolism has been envisioned as one of the most productive strategies for the integration of muti-scale data to better understand methane metabolism and enable its biotechnological implementation. 
  • 246
  • 03 Jan 2024
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