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Topic Review
Alpha-Thalassemia
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 and HBA2. Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood. Normal hemoglobin consists of two alpha chains and two beta chains; in alpha-thalassemia, there is a quantitative decrease in the amount of alpha chains, resulting in fewer normal hemoglobin molecules. Furthermore, alpha-thalassemia leads to the production of unstable beta globin molecules which cause increased red blood cell destruction. The degree of impairment is based on which clinical phenotype is present (how many genes are affected).
  • 527
  • 31 Oct 2022
Topic Review
AlphaFold Predictions in Viral Research
AlphaFold, a modern deep-learning algorithm, enables the prediction of protein structure to a high level of accuracy. It has been applied in numerous studies in various areas of biology and medicine. Viruses are biological entities infecting eukaryotic and procaryotic organisms. They can pose a danger for humans and economically significant animals and plants, but they can also be useful for biological control, suppressing populations of pests and pathogens. AlphaFold can be used for studies of molecular mechanisms of viral infection to facilitate several activities, including drug design.
  • 406
  • 10 May 2023
Topic Review
Alphaviruses in Immunotherapy and Anticancer Therapy
Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of recombinant particles, naked or nanoparticle-encapsulated RNA or plasmid-based DNA replicons.
  • 386
  • 19 Oct 2022
Topic Review
Alpheus (Genus)
Alpheus is a genus of snapping shrimp of the family Alpheidae. This genus contains in excess of 250 species, making this the most species-rich genus of shrimp. Like other snapping shrimp, the claws of Alpheus are asymmetrical, with one of the claws enlarged for making a popping noise. Some species in the genus enter into symbiotic relationships with gobiid fishes.It's also the noisiest of all sea creatures and can immobilize small fish with its high pitched frequency.
  • 386
  • 09 Oct 2022
Topic Review
Alpheus (Shrimp)
Alpheus is a genus of snapping shrimp of the family Alpheidae. This genus contains in excess of 291 species, making this the most species-rich genus of shrimp. Like other snapping shrimp, the claws of Alpheus are asymmetrical, with one of the claws enlarged for making a popping noise. Some species in the genus enter into symbiotic relationships with gobiid fishes, and others associate with sea anemones. It's also the noisiest of all sea creatures and can immobilize small fish with its high pitched frequency.
  • 406
  • 30 Nov 2022
Topic Review
Alport Syndrome
Alport syndrome is a genetic condition characterized by kidney disease, hearing loss, and eye abnormalities.
  • 531
  • 24 Dec 2020
Topic Review
ALS-Specific GWAS Challenges
Amyotrophic Lateral Sclerosis (ALS) is the most common late-onset motor neuron disorder, but our current knowledge of the molecular mechanisms and pathways underlying this disease remains elusive. Genome-Wide Association Studies (GWAS) aim to identify Single Nucleotide Polymorphisms (SNPs) and other types of genetic variation that are more frequent in patients than in people without the disease, using a variety of statistical tests. Despite the rapid recent technological advances and great efforts in the GWAS field that have led to the genomic profiling of large ALS cohorts, the identified associations have been able to explain only a very small fraction of the ALS heritability and aetiology. Here, we outline ALS-Specific GWAS Challenges, explaining the limitations of traditional GWAS analyses, considering known features of the ALS genetic architecture and hypotheses about ALS pathology (e.g., multilocus interactions, rare variations with low effect size). Future advances in the genomic and machine learning fields may bring about a better understanding of ALS genetic architecture and enable improved personalized approaches to this and other devastating and complex diseases.
  • 715
  • 01 Dec 2021
Topic Review
ALS2 Gene
ALS2, alsin Rho guanine nucleotide exchange factor. The ALS2 gene provides instructions for making a protein called alsin.
  • 389
  • 24 Dec 2020
Topic Review
ALS2-Related Motor Neuron Diseases
Mutations of the ALS2 gene, which encodes for the protein Alsin, are linked to three recessive motor neuron diseases characterized by early onset. Alsin is an intriguing protein characterized by several structured domains with distinct functions. 
  • 460
  • 20 Jan 2022
Topic Review
Alsophila Dealbata
Alsophila dealbata, synonym Cyathea dealbata, commonly known as the silver fern or silver tree-fern, or as ponga /ˈpɒŋə/ or punga /ˈpʌŋə/ (from Māori kaponga or ponga), is a species of medium-sized tree fern, endemic to New Zealand. The fern is usually recognisable by the silver-white colour of the under-surface of mature fronds. It is a symbol commonly associated with the country both overseas and by New Zealanders themselves.
  • 867
  • 02 Nov 2022
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