Encyclopedia
Scholarly Community
Encyclopedia
Entry
Video
Image
Journal
Book
News
About
Entry
Entry
Video
Image
Log in/Sign up
Submit
Entry
Video
Image
Subject:
All Disciplines
Arts & Humanities
Biology & Life Sciences
Business & Economics
Chemistry & Materials Science
Computer Science & Mathematics
Engineering
Environmental & Earth Sciences
Medicine & Pharmacology
Physical Sciences
Public Health & Healthcare
Social Sciences
Sort:
Hottest
Latest
Alphabetical (A-Z)
Alphabetical (Z-A)
Type:
All
Topic Review
Biography
Topic Review
Age-Related Changes of Gene Expression
An individual’s gene expression profile changes throughout their life. This change in gene expression is shaped by differences in physiological needs and functions between the younger and older organism. Despite intensive studies, the aging process is not fully understood, and several genes involved in this process may remain to be identified. In this study authors compared the expression profiles of two-day-old female adult Drosophila flies with 45-day-old flies. They identified 1184 genes with pronounced differences in expression level between young and old age groups, including 232 genes with unknown functions. Authors characterized the subcellular localization of twelve of them and discovered that knockdown of some of them affects the lifespan of flies.
380
23 Dec 2021
Topic Review
Age-Related Hearing Loss
Age-related hearing impairment, also referred to as presbycusis, is the most common sensory impairment seen in the elderly. As our cochlea, the peripheral organ of hearing, ages, we tend to experience a decline in hearing and are at greater risk of cochlear sensory-neural cell degeneration and exacerbated age-related hearing impairments (e.g., gradual hearing loss, deterioration in speech comprehension, difficulty in the localization sound sources, and ringing sensations in the ears). Here, we outline recent research into major causal factors of age-related hearing loss including both extrinsic (e.g. noise and ototoxic medication), and intrinsic factors (e.g. genetic predisposition, epigenetic factors and aging).
892
23 Oct 2020
Topic Review
Age-Related Lysosomal Dysfunctions
Aging is a process associated with the detriment of normal physiological functions, which leads to the manifestation of diverse diseases such as cardiovascular and neurodegenerative diseases, joint degenerative diseases, and metabolic diseases such as diabetes, among others. Lysosomes are heterogeneous organelles enclosed by a lipid bilayer and filled with hydrolytic enzymes. The lysosomes are traditionally described as the subcellular structures where the degradation of other organelles and macromolecules takes place, a fundamental process for maintaining cellular proteostasis. There are several degradation processes in which the lysosomes are involved. If the substrate reaching the lysosomes comes from the extracellular environment, the degradation process is called endocytosis. If the material to be digested comes from the cell itself, the process is classified as autophagy. The lysosomes are also involved in plasma membrane repair through a mechanism called lysosomal exocytosis. During aging, damage in cellular organelles disbalances the cellular homeostatic processes. Lysosomal dysfunction is emerging as an important factor that could regulate the production of inflammatory molecules, metabolic cellular state, or mitochondrial function. Thus, lysosomal alkalinization, amino acid storage, iron disturbances and lipofuscin accummulation are characteristic features of the lysosome during aging.
736
30 Jul 2022
Topic Review
Ageing and Inflammation in Periodontium
Periodontitis is a ubiquitous chronic inflammatory disease characterized by the gradual destruction of the periodontal ligament and alveolar bone, leading to periodontal pocket formation and gingival recession. Ageing is a primary risk factor for the development of periodontitis, exacerbating alveolar bone loss and leading to tooth loss in the geriatric population.
172
24 Nov 2023
Topic Review
Ageritin from Pioppino Mushroom
Ageritin is a specific ribonuclease, extracted from the edible mushroom Cyclocybe aegerita (synonym Agrocybe aegerita), which cleaves a single phosphodiester bond located within the universally conserved alpha-sarcin loop (SRL) of 23–28S rRNAs.This toxin is the prototype of ribotoxin-like protein family present in edible mushroom and possesses antifungal/antiviral activities and selective cytotoxicity against tumor cells with potential use in biotechnological applications (as bio-insecticides or antitumor agents).
749
14 Apr 2021
Topic Review
Aggression in Dogs
Aggression as a behavior is not always desirable, often ends in abandonment and/or euthanasia. However, it is possible to prevent the occurrence of unwanted aggression in domestic dogs. Aggression is not a fully understood phenomenon. To aim to generalize the dogs’ behavior and understand their behavioral needs, ethograms have been developed. Communication of any kind, including aggression, is a natural part of a dog’s ethogram. An ethogram is a species-specific list of natural behavior. Dog ethograms include affiliate, agonistic, defensive, sedative, sexual, demonstrative, warning, stressful, playful, grooming, exploratory, related to hunting, or related to the reduction of stress.
868
11 Mar 2022
Topic Review
Aging and Bone Marrow
The aging of bone marrow (BM) remains a very imperative and alluring subject, with an ever-increasing interest among fellow scientists. A considerable amount of progress has been made in this field with the established ‘hallmarks of aging’ and continued efforts to investigate the age-related changes observed within the BM. Inflammaging is considered as a low-grade state of inflammation associated with aging, and whilst the possible mechanisms by which aging occurs are now largely understood, the processes leading to the underlying changes within aged BM remain elusive. The ability to identify these changes and detect such alterations at the genetic level are key to broadening the knowledgebase of aging BM. Next-generation sequencing (NGS) is an important molecular-level application presenting the ability to not only determine genomic base changes but provide transcriptional profiling (RNA-seq), as well as a high-throughput analysis of DNA–protein interactions (ChIP-seq). Utilising NGS to explore the genetic alterations occurring over the aging process within alterative cell types facilitates the comprehension of the molecular and cellular changes influencing the dynamics of aging BM.
527
15 Nov 2021
Topic Review
Aging and Its Molecular Mechanism
Aging is a continuous process over time that is mainly related to natural alterations in mechanical–biological processes. This phenomenon is due to several factors, including the time and energy of biological processes. Aging can be attributed to biological factors such as oxidative stress, cell longevity, and stem cell senescence.
2.9K
22 Apr 2022
Topic Review
Aging and Muscle Oxygen Utilization
The cardiovascular and skeletal muscle systems are intrinsically interconnected, sharing the goal of delivering oxygen to metabolically active tissue. Deficiencies within those systems that affect oxygen delivery to working tissues are a hallmark of advancing age. Oxygen delivery and utilization are reflected as muscle oxygen saturation (SmO2) and are assessed using near-infrared resonance spectroscopy (NIRS). SmO2 has been observed to be reduced by ~38% at rest, ~24% during submaximal exercise, and ~59% during maximal exercise with aging (>65 y).
318
19 Oct 2022
Topic Review
Aging and Nicotinamide Adenine Dinucleotide Deficiency
Under normal physiological conditions, nicotinamide adenine dinucleotide (NAD+) consumption is matched by its synthesis primarily via the salvage pathway catalyzed by nicotinamide phosphoribosyltransferase (NAMPT). However, aging and muscular contraction enhance NAD+ utilization, whereas NAD+ replenishment is limited by cellular sources of NAD+ precursors and/or enzyme expression.
375
18 Apr 2022
Page
of
1746
Featured Entry Collections
>>
Featured Books
>>
Encyclopedia of Social Sciences
Chief Editor:
Michael McAleer
Encyclopedia of COVID-19
Chief Editor:
Stephen Bustin
Encyclopedia of Fungi
Chief Editor:
Luis V. Lopez-Llorca
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Chief Editor:
Sandro Serpa
Entry
Video
Image
Journal
Book
News
About
Log in/Sign up
New Entry
New Video
New Images
About
Terms and Conditions
Privacy Policy
Advisory Board
Contact
Partner
Video Production Service
Feedback
Top
Feedback
×
Help Center
Browse our user manual, common Q&A, author guidelines, etc.
Rate your experience
Let us know your experience and what we could improve.
Report an error
Is something wrong? Please let us know!
Other feedback
Other feedback you would like to report.
×
Did you find what you were looking for?
Love
Like
Neutral
Dislike
Hate
0
/500
Email
Do you agree to share your valuable feedback publicly on
Encyclopedia
’s homepage?
Yes, I agree. Encyclopedia can post it.
No, I do not agree. I would not like to post my testimonial.
Webpage
Upload a screenshot
(Max file size 2MB)
Submit
Back
Close
×