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Topic Review
American Marten
The American Marten (Martes americana), a charismatic and agile member of the mustelid family, is native to the forests of North America. Renowned for its sleek fur, arboreal prowess, and elusive nature, the American Marten plays a significant ecological role in the diverse ecosystems it inhabits.
  • 252
  • 04 Feb 2024
Topic Review
Bay Cat
The Bay Cat (Catopuma badia), a mysterious and elusive felid species native to the dense forests of Southeast Asia, remains one of the least studied and understood wild cats. Known for its striking reddish-brown fur and secretive behavior, the Bay Cat captivates researchers and conservationists alike as they strive to unravel the mysteries surrounding this enigmatic feline species.
  • 303
  • 04 Feb 2024
Topic Review
scATAC-seq in Plants
The Single-cell Assay for Transposase-Accessible Chromatin with high throughput sequencing (scATAC-seq) has gained increasing popularity in recent years, allowing for chromatin accessibility to be deciphered and gene regulatory networks (GRNs) to be inferred at single-cell resolution. This cutting-edge technology now enables the genome-wide profiling of chromatin accessibility at the cellular level and the capturing of cell-type-specific cis-regulatory elements (CREs) that are masked by cellular heterogeneity in bulk assays. Additionally, it can also facilitate the identification of rare and new cell types based on differences in chromatin accessibility and charting of cellular developmental trajectories within lineage-related cell clusters. Due to technical challenges and limitations, the data generated from scATAC-seq exhibits unique features, often characterized by high sparsity and noise, even within the same cell type. To address these challenges, various bioinformatic tools have been developed. Furthermore, the application of scATAC-seq in plant science is still in its infancy, with most research focusing on root tissues and model plant species.
  • 110
  • 04 Feb 2024
Topic Review
Mountain Weasel
The Mountain Weasel (Mustela altaica), a sleek and agile carnivore, inhabits the high-altitude regions of Asia, showcasing remarkable adaptations to life in mountainous terrains. Known for its elusive nature and diverse range of habitats, the Mountain Weasel plays a vital role in alpine ecosystems, preying on small mammals and contributing to the delicate balance of these high-altitude environments.
  • 349
  • 04 Feb 2024
Topic Review
American Black Bear
The American black bear (Ursus americanus) stands as an iconic and widely distributed bear species native to North America. Known for its adaptable nature and diverse habitats, this bear species exhibits a range of coat colors, including black, brown, cinnamon, and even blonde. With a complex social structure and omnivorous diet, the American black bear plays a vital ecological role in the diverse ecosystems it inhabits.
  • 252
  • 04 Feb 2024
Topic Review
Japanese Badger
The Japanese Badger (Meles anakuma), native to Japan, is a fascinating and elusive mustelid species that holds a distinctive place in the country's diverse wildlife. Recognized for its unique physical characteristics and behavior, this badger species is a nocturnal and solitary creature with a keen sense of smell, contributing to its foraging prowess in a variety of habitats. The Japanese Badger's role in Japanese folklore and its interactions with the ecosystem make it a subject of interest for both researchers and enthusiasts exploring the rich fauna of Japan.
  • 345
  • 04 Feb 2024
Topic Review
Southern Spotted Skunk
The Southern Spotted Skunk (Spilogale angustifrons) is a small and elusive carnivore known for its distinctive coat pattern featuring conspicuous spots and stripes. Inhabiting various regions of the southern United States and parts of Central America, this species exhibits remarkable adaptability to diverse habitats, ranging from woodlands and grasslands to urban areas. Despite its diminutive size, the Southern Spotted Skunk plays a significant role in local ecosystems, displaying nocturnal behavior and an omnivorous diet.
  • 205
  • 04 Feb 2024
Topic Review
Angolan Genet
The Angolan Genet (Genetta angolensis), indigenous to the southwestern regions of Africa, is a captivating small carnivore that belongs to the Genet family. Recognized for its distinctive coat pattern and slender physique, this elusive species navigates a range of habitats, from woodlands to savannas, showcasing its adaptability in diverse ecosystems. With its nocturnal habits and agile climbing skills, the Angolan Genet remains a subject of interest for researchers and wildlife enthusiasts exploring the rich biodiversity of the African continent.
  • 233
  • 04 Feb 2024
Topic Review
Bush Dog
The Bush Dog (Speothos venaticus) emerges as a captivating and elusive canid species, residing in the dense and remote habitats of Central and South America. Recognized for its unique appearance and social behaviors, the Bush Dog stands out as a small yet highly specialized predator within the intricate tapestry of neotropical ecosystems. This elusive canid's cryptic lifestyle and distinctive pack dynamics make it a subject of intrigue for wildlife enthusiasts and researchers alike.
  • 360
  • 04 Feb 2024
Topic Review
Mass Spectrometry Investigation of ATP-Binding Cassette Proteins
Drug resistance remains one of the main causes of poor outcome in cancer therapy. It is also becoming evident that drug resistance to both chemotherapy and to antibiotics is driven by more than one mechanism. So far, there are at least eight recognized mechanisms behind such resistance. In normal tissues, ATP-binding cassette (ABC)  transporters protect the cells from the toxic effects of xenobiotics, whereas in tumor cells, they reduce the intracellular concentrations of anticancer drugs, which ultimately leads to the emergence of multidrug resistance (MDR). A deeper understanding of the structures and the biology of these proteins is central to current efforts to circumvent resistance to both chemotherapy, targeted therapy, and antibiotics. 
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  • 04 Feb 2024
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