Topic Review
Vitamin Supplements and Chronic Alcohol Consumption
Alcoholic drinks are extensively consumed worldwide. Drinking alcohol has negative and positive consequences. The health consequences of alcohol intake vary depending on the amount and pattern of consumption.
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  • 24 Mar 2022
Topic Review
Activity of Kalanchoe pinnata in Cancer
Kalanchoe pinnata (Lam) Pers. (syn. Bryophyllum pinnatum Lam.), belonging to the genus Kalanchoe, is a succulent plant cultivated in gardens, which can be found as a herb or shrub. The bioactive ingredients in Kalanchoe pinnata, a succulent herb with ethnomedical applications for several diseases, including cancer, and reveal its anticancer mechanisms through a molecular approach.
  • 2.6K
  • 17 Oct 2022
Topic Review
Point-Of-Care or Point-Of-Need Diagnostic Tests
In the recent years, the progress of international trade and travel has led to an increased risk of emerging infections. Around 75 percent of the pathogens causing these infections are of animal origin. Point-of-care tests (POCT) and point-of-need tests (PONT) have been established in order to directly provide accurate and rapid diagnostics at field level, the patient bed-side or at the site of outbreaks. These assays can help physicians and decision makers to take the right action without delay. Typically, POCT and PONT rely on genomic identification of pathogens or track their immunological fingerprint. Recently, protocols for metagenomic diagnostics in the field have been developed.
  • 2.6K
  • 20 Apr 2021
Topic Review
Tissues to Implant Abutments
This entry is based on the fact that physical or biomechanical phenomena can cause biologic results. Implant-abutment connection structures determine the stability of soft tissue attachment to abutments. The bone responses to the strain that the stress is converted to, not the stress itself. Some implant-abutment materials and connection designs prevent the marginal bone loss by converting the stress to the strain stimulating bone apposition properly. These biomechanical interpretation of soft tissue seal and bone stimulation should be understood for the clinical long-term success of dental implants.
  • 2.6K
  • 27 Oct 2020
Topic Review
Polyphenolic-Food and Longevity
Aging and, particularly, the onset of age-related diseases are associated with tissue dysfunction and macromolecular damage, some of which can be attributed to accumulation of oxidative damage. Recently, growing interest has emerged on the beneficial effects of plant-based diets for the prevention of chronic diseases including obesity, diabetes, and cardiovascular disease. Several studies collectively suggests that the intake of polyphenols and their major food sources may exert beneficial effects on improving insulin resistance and related diabetes risk factors, such as inflammation and oxidative stress. They are the most abundant antioxidants in the diet, and their intake has been associated with a reduced aging in humans. Polyphenolic intake has been shown to be effective at ameliorating several age-related phenotypes, including oxidative stress, inflammation, impaired proteostasis, and cellular senescence, both in vitro and in vivo.
  • 2.6K
  • 06 May 2022
Topic Review
Hypertensive Nephropathy
Hypertension is one of the most common risk factors for developing chronic cardiovascular diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes damage and activation of mesangial cells (MCs), eliciting the production of large amounts of vasoactive and proinflammatory agents. Accordingly, the activation of AT1 receptors by the vasoactive molecule angiotensin II (AngII) contributes to the pathogenesis of renal damage, which is mediated mostly by the dysfunction of intracellular Ca2+ ([Ca2+]i) signaling. Similarly, inflammation entails complex processes, where [Ca2+]i also play crucial roles. Deregulation of this second messenger increases cell damage and promotes fibrosis, reduces renal blood flow, and impairs the glomerular filtration barrier. In vertebrates, [Ca2+]i signaling depends, in part, on the activity of two families of large-pore channels: hemichannels and pannexons. Interestingly, the opening of these channels depends on [Ca2+]i signaling. 
  • 2.6K
  • 23 Dec 2022
Topic Review
Dewi Sri
Dewi Sri or Shridevi (Javanese: ꦢꦺꦮꦶꦱꦿꦶ), Dewi Sri) (Sundanese: Nyai Pohaci Sanghyang Asri) is the Javanese, Sundanese, and Balinese Hindu Goddess of rice and fertility, still widely worshiped on the islands of Java, Bali and Lombok, Indonesia. The cult of the rice goddess has its origin in the prehistoric domestication, development and propagation of rice cultivation in Asia, possibly brought by Austroasiatic or Austronesian population that finally migrated and settled in the archipelago. Similar but slightly different rice spirits mythologies are widespread among Indonesian ethnicities and also neighboring countries. The mythology of Dewi Sri is native to Java and Sunda and Hinduism in the archipelago since early as the first century. She was equated with the Hindu goddess Shri Lakshmi, and often regarded as an incarnation or one of her manifestations. The goddess is also associated with wealth and prosperity.
  • 2.5K
  • 11 Oct 2022
Topic Review
Seed Priming
Seed nano-priming is an efficient process that can change seed metabolism and signaling pathways, affecting not only germination and seedling establishment but also the entire plant lifecycle.
  • 2.5K
  • 13 Jan 2022
Topic Review
Potato Virus Y
Potato virus Y origin, emergence and evolution.
  • 2.5K
  • 21 Dec 2020
Topic Review
Sinhapura
Sinhapura (Sanskrit, "Lion City"; IAST: Siṃhapura) was the capital of the legendary Indian king Sinhabahu. It has been mentioned in the Buddhist legends about Prince Vijaya. The name is also transliterated as Sihapura or Singhapura. The location of Sinhapura is disputed with some scholars claiming the city was located in eastern India and others claiming it was located in present-day Malaysia or Thailand. The city is linked to the origin of the Sinhalese people and Sinhalese Buddhist mythology.
  • 2.5K
  • 27 Oct 2022
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