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Topic Review
Sleep Health Promotion Interventions
Sleep health promotion is the public health field that is concerned with improving sleep health in primarily healthy populations. Good sleep health is characterized by subjective satisfaction, appropriate timing, adequate duration, high efficiency, and sustained alertness during waking hours (Buysse,2014). As in the last decade evidence has been mounting that good sleep is crucial for health, sleep health promotion is receiving increasing attention in public health. In this contribution, an overview is provided of the sleep health promotion interventions that have been described in reviews. 
  • 1.2K
  • 31 May 2021
Topic Review
Equine Endometrium Morphology
Mares are seasonal polyestric. The morphology of the healthy equine endometrium is influenced by the season of the year, the stage of the endometrial cycle, as well as the presence of endometrial diseases. The latter have an impact on the wellbeing of individual mares and can also inflict major financial losses for the horse breeding industry. The microscopic examination of an endometrial biopsy is an important diagnostic tool, since it can also detect subclinical diseases. This review provides an overview about morphological and molecular features of the healthy and diseased equine endometrium. It reviews the diagnostic findings of inflammatory and degenerative endometrial disease of mares, as well as the current state of knowledge regarding their cellular and molecular pathogenesis. It further shows that the comparative evaluation of morphological features and molecular characteristics of the healthy and diseased equine endometrium is an important prerequisite for the identification of disease-associated molecular markers, which in turn will facilitate the development of diagnostic and predictive biomarkers, as well as novel prophylactic and therapeutic options. Although currently numerous molecular data are already available, future studies are required to establish their translation into clinical practice.
  • 1.2K
  • 01 Nov 2020
Topic Review
Risk of Trigonelline in Coffee and Coffee By-Products
Trigonelline is a bioactive pyridine alkaloid that occurs naturally in high concentrations in coffee (up to 7.2 g/kg) and coffee by-products (up to 62.6 g/kg) such as coffee leaves, flowers, cherry husks or pulp, parchment, silver skin, and spent grounds. In the past, coffee by-products were mostly considered waste and discarded. However, the use of coffee by-products as food has attracted interest because of their economic and nutritional value and the environmental benefits of sustainable resource use. Their authorization as so-called novel foods in the European Union may lead to increased oral exposure of the general population to trigonelline. 
  • 1.2K
  • 21 Apr 2023
Topic Review
Metal Oxide Nanoparticles for Food Packaging
Metal oxide nanoparticles have a higher surface area due to their smaller size, which makes them useful in various applications such as biosensors, bio-nanotechnology, and nanomedicine. These nanoparticles have many atoms on their surfaces, making them highly reactive.  There is a huge demand for packaging materials that can keep food fresher for extended periods of time. The incorporation of nanoscale fillers in the polymer matrix would assists in the alleviation of packaging material challenges while also improving functional qualities.
  • 1.2K
  • 20 Jun 2022
Topic Review
Biobeneficiation of PGMs
Conventional beneficiation of the Platinum Group of Metals (PGMs) relies on the use of inorganic chemicals. With the depreciation of high grade deposits, these conventional processes are becoming less economically viable. Furthermore, the use of chemicals has serious negative impacts on the environment. To address the challenges of conventional PGM beneficiation, biobeneficiation has been proposed. Bio-beneficiation is the concentration of mineral species by employing microorganisms that interact with either the gangue or the valuable mineral species. Bio-beneficiation can also be described as the use of microorganisms to interact with minerals to subsequently induce processes such as magnetic separation, flotation, and flocculation.
  • 1.2K
  • 19 Jan 2022
Topic Review
Genetics of Primary Aldosteronism
Primary aldosteronism (PA) is the most common form of secondary hypertension, with a prevalence of 5–10% among patients with hypertension. PA is mainly classified into two subtypes: aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism. Recent developments in genetic analysis have facilitated the discovery of mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, CACNA1H, CLCN2, and CTNNB1 in sporadic or familial forms of PA in the last decade. These findings have greatly advanced our understanding of the mechanism of excess aldosterone synthesis, particularly in APA. Most of the causative genes encode ion channels or pumps, and their mutations lead to depolarization of the cell membrane due to impairment of ion transport. Depolarization activates voltage-gated Ca2+ channels and intracellular calcium signaling and promotes the transcription of aldosterone synthase, resulting in overproduction of aldosterone. 
  • 1.2K
  • 07 May 2021
Topic Review
Probiotics in Obesity and IBD
The Firmicutes/Bacteroidetes (F/B) ratio is widely accepted to have an important influence in maintaining normal intestinal homeostasis. Increased or decreased F/B ratio is regarded as dysbiosis, whereby the former is usually observed with obesity, and the latter with inflammatory bowel disease (IBD). Probiotics as live microorganisms can confer health benefits to the host when administered in adequate amounts. There is considerable evidence of their nutritional and immunosuppressive properties including reports that elucidate the association of probiotics with the F/B ratio, obesity, and IBD. Orally administered probiotics can contribute to the restoration of dysbiotic microbiota and to the prevention of obesity or IBD. However, as the effects of different probiotics on the F/B ratio differ, selecting the appropriate species or mixture is crucial.
  • 1.2K
  • 19 Nov 2020
Topic Review
Application of Bioactive Compounds in the Food Industry
The fruit production and processing sectors produce tremendous amounts of by-products and waste that cause significant economic losses and an undesirable impact on the environment. The effective utilization of these fruit wastes can help to reduce the carbon footprint and greenhouse gas emissions, thereby achieving sustainable development goals. These by-products contain a variety of bioactive compounds, such as dietary fiber, flavonoids, phenolic compounds, antioxidants, polysaccharides, and several other health-promoting nutrients and phytochemicals. These bioactive compounds can be extracted and used as value-added products in different industrial applications. The bioactive components extracted can be used in developing nutraceutical products, functional foods, or food additives.
  • 1.2K
  • 18 May 2023
Topic Review
Ubiquitin-Proteasome System
Kidney transplantation is the preferred treatment for end-stage kidney disease (ESKD). Compared to maintenance dialysis, kidney transplantation results in improved patient survival and quality of life. Kidneys from living donors perform best; however, many patients with ESKD depend on kidneys from deceased donors. After procurement, donor kidneys are placed in a cold-storage solution until a suitable recipient is located. Sadly, prolonged cold storage times are associated with inferior transplant outcomes; therefore, in most situations when considering donor kidneys, long cold-storage times are avoided. The identification of novel mechanisms of cold-storage-related renal damage will lead to the development of new therapeutic strategies for preserving donor kidneys; to date, these mechanisms remain poorly understood. In this review, we discuss the importance of mitochondrial function, protein homeostasis, and renal recovery during stress from cold storage plus transplantation. Additionally, we discuss novel targets for therapeutic intervention.
  • 1.2K
  • 09 Nov 2020
Topic Review
Oral Cavity during Viral and Bacterial Infections
Several viral diseases often affect the oral cavity; for example, human immunodeficiency virus (HIV) infection may initially present with oral lesions, human papillomavirus (HPV) infection often increases the risk of developing oral squamous cell carcinoma, and oral damage has been documented during hepatitis B and C virus infections
  • 1.2K
  • 13 Oct 2022
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