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Topic Review
Quiescent Cancer Cells
Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis.
  • 1.2K
  • 23 Mar 2021
Topic Review
Obesity as A Cause of Cancer
Obesity is defined as the accumulation of an excessive amount of body fat. The correlation of obesity with increased cancer incidence and death has been well established. 
  • 1.2K
  • 03 Nov 2022
Topic Review
Agro-Industrial Food Waste for Production of Industrial Enzymes
The grave environmental, social, and economic concerns over the unprecedented exploitation of non-renewable energy resources have drawn the attention of policy makers and research organizations towards the sustainable use of agro-industrial food and crop wastes. Enzymes are versatile biocatalysts with immense potential to transform the food industry and lignocellulosic biorefineries. Microbial enzymes offer cleaner and greener solutions to produce fine chemicals and compounds. The production of industrially important enzymes from abundantly present agro-industrial food waste offers economic solutions for the commercial production of value-added chemicals. The recent developments in biocatalytic systems are designed to either increase the catalytic capability of the commercial enzymes or create new enzymes with distinctive properties. The limitations of low catalytic efficiency and enzyme denaturation in ambient conditions can be mitigated by employing diverse and inexpensive immobilization carriers, such as agro-food based materials, biopolymers, and nanomaterials. Moreover, revolutionary protein engineering tools help in designing and constructing tailored enzymes with improved substrate specificity, catalytic activity, stability, and reaction product inhibition. This review discusses the recent developments in the production of essential industrial enzymes from agro-industrial food trash and the application of low-cost immobilization and enzyme engineering approaches for sustainable development.
  • 1.2K
  • 21 Nov 2022
Topic Review Peer Reviewed
Asymptomatic Patients and Immune Subjects
An asymptomatic patient is someone who contracts a disease but shows no symptoms. An immune subject is a person who is free from virus infection. Both of these categories of people experience the limitations of government imposed by a pandemic situation, with one important difference. Probably only the first subjects contribute, in spite of themselves, to the spread of the disease and to the contagion of the people most susceptible to the virus. This implies that their detection is essential to limit infections. Therefore, knowing the characteristics of these people and those immune to the virus can be extremely useful in mitigating the effects of the disease and/or defeating it.
  • 1.2K
  • 13 Apr 2022
Topic Review
Extended-Spectrum β-Lactamases
The rise of antimicrobial resistance, particularly from extended-spectrum β-lactamase producing Enterobacteriaceae (ESBL-E), poses a significant global health challenge as it frequently causes the failure of empirical antibiotic therapy, leading to morbidity and mortality. The E. coli- and K. pneumoniae-derived CTX-M genotype is one of the major types of ESBL. Mobile genetic elements (MGEs) are involved in spreading ESBL genes among the bacterial population. Due to the rapidly evolving nature of ESBL-E, there is a lack of specific standard examination methods. Carbapenem has been considered the drug of first choice against ESBL-E. 
  • 1.2K
  • 07 Dec 2023
Topic Review
Machine Learning for Crop Disease
Crop diseases constitute a serious issue in agriculture, affecting both quality and quantity of agriculture production. Disease control has been a research object in many scientific and technologic domains. Technological advances in sensors, data storage, computing resources and artificial intelligence have shown enormous potential to control diseases effectively. A growing body of literature recognizes the importance of using data from different types of sensors and machine learning approaches to build models for detection, prediction, analysis, assessment, etc. However, the increasing number and diversity of research studies requires a literature review for further developments and contributions in this area. 
  • 1.2K
  • 24 Nov 2021
Topic Review
Mushroom Biotechnology
A mushroom is the fruit body of a fungus. There are 44,000 known species in the fungi kingdom, but not all of them produce mushrooms. Fungi lack chlorophyll and are heterotrophic organisms that break down organic matter in various ways. Mushrooms have always been an important source of food, with high nutritional value and medicinal attributes. With the use of biotechnological applications, mushrooms have gained further attention as a source of healthy food and bioenergy. Mushroom biotechnology is defined as the science in which mushrooms are included in processes like bioconversion, biorefining, bioremediation, and biodegradation.
  • 1.2K
  • 25 Jul 2023
Topic Review
Illicium verum Hook f. (Star Anise)
Illicium verum Hook f. (star anise) is considered an important species in Traditional Chinese Medicine and is also used in contemporary medicine in East Asian countries. It occurs in natural habitats in southeastern parts of China and Vietnam, and is cultivated in various regions in China. The raw materials—Anisi stellati fructus and Anisi stellati aetheroleum obtained from this species exhibit expectorant and spasmolytic activities. The European Pharmacopoeia (4th edition) indicates that these raw materials have been used in allopathy since 2002. The biological activities of the above-mentioned raw materials are determined by the presence of valuable secondary metabolites such as monoterpenoids, sesquiterpenoids, phenylpropanoids, and flavonoids. Recent pharmacological studies on fruit extracts and the essential oil of this species have confirmed their antibacterial, antifungal, anti-inflammatory, and antioxidant activities and thus their medicinal and cosmetic value.
  • 1.2K
  • 28 Jan 2022
Topic Review
Alpha-Emitting Radionuclides in Wild Mushrooms
Alpha-emitting radioisotopes are the most radiotoxic nuclides among all radionuclides. Especially medium- and long-living isotopes that enter the body, are hazardous metals of the greatest importance from the human life point of view. This review focuses on the most common natural and anthropogenic origin alpha-emitting radionuclides in wild mushrooms around the world. Mushrooms are considered as suitable bioindicators of environmental pollution with some metallic elements, for the reason they bioaccumulate a range of mineral ionic constituents including radioactive elements at different levels. Various species have different retain capacities of individual radionuclides. In turn, wild edible mushrooms are food products, mostly consumed regionally and also traded at an international scale. Mushrooms under pollution events situation might cause a risk to consumers due to exposure to highly radiotoxic decay particles produced by alpha emitters.
  • 1.2K
  • 20 Nov 2020
Topic Review
NLRP3 Inflammasome in Neurodegenerative
Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate inflammation activation in the innate immune system in response to pathogens and to host self-derived molecules. The NLRP3 belongs to the subfamily of NLRP which activates caspase 1, thus causing the production of proinflammatory cytokines (interleukin 1β and interleukin 18) and pyroptosis. This inflammasome is involved in multiple neurodegenerative and metabolic disorders including Alzheimer’s disease, multiple sclerosis, type 2 diabetes mellitus, and gout. 
  • 1.2K
  • 25 May 2022
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