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Topic Review
Forest Reproductive Material Quality
More than two billion hectares worldwide offer opportunities for restoration. The need to accelerate reforestation programmes is caused by global climate change and human impacts. There is no consensus in the scientific community as to what goals to pursue in the implementation of programs and what methods to use to achieve the goals. Confusing terminology in the field of world reforestation, conflicting research makes it necessary to establish the basic quality criteria. The impact of the quality of forest reproductive material on reforestation cannot be underestimated. Definition of forest reproduction material (FRM) quality should be project specific, because seed and seedling quality attributes targeted and desirable for one site, could be unsuitable for others. Seed size and germinability have the strongest effect on plant performance, both in nursery and on the field. Root collar diameter is the single most useful seedling morphological attribute. The most important quality attributes of seed and seedling can be improved by simple techniques and practices. In a long term, the genetic aspect of FRM quality have a decisive role and any restoration program should be based on proper seed source to site matching, with maintaining the wide genetic diversity. In any restoration program, imperative should be the use of FRM with targeted quality attributes: physical, morphological, physiological, and genetic. Meeting demands for huge quantities of FRM, should not be at the cost of quality.
  • 1.4K
  • 29 Oct 2020
Topic Review
MicroRNA Processing by Dicer
MicroRNAs (miRNAs) are small non-coding RNAs that are about 22 nucleotides in length. They regulate gene expression post-transcriptionally with the effector protein complex, containing Argonaute or trinucleotide repeat containing 6 (TNRC6) proteins, and target mRNAs in a sequence-dependent manner, causing the translational repression and destabilization of the target mRNAs. Both Drosha and Dicer, members of the RNase III family proteins, are essential components in the canonical miRNA biogenesis pathway. miRNA is transcribed into primary-miRNA (pri-miRNA) from genomic DNA. Drosha then cleaves the flanking regions of pri-miRNA into precursor-miRNA (pre-miRNA), while Dicer cleaves the loop region of the pre-miRNA to form a miRNA duplex. In this report, we summarized and discussed the current reports in which double-stranded RNA binding proteins (dsRBPs), such as TAR RNA binding protein (TRBP) or the adenosine deaminase acting on RNA (ADAR), modulate the processing of miRNA by Dicer in various manners. 
  • 1.4K
  • 01 Oct 2021
Topic Review
Milk Bioactive Compounds
The milk fat fraction is a rich source of nutrients and bioactive factors. This fraction is composed of milk fat globules (MFGs) surrounded by the milk fat globule membrane (MFGM). In this review we revise the literature that deals two minor topics that characterize the milk fat fraction. The first topic is the MFGM proteome, which has several bioactive properties and shows similarities and variations among species and phases of lactation. The second topic is the content of essential nutrients among MFGs and MFGM, named minerals and lipophilic vitamins, in order to assess the nutrifunctional role of the milk fat fraction. 
  • 1.4K
  • 29 Apr 2021
Topic Review
Biological Roles and Applications of Aconitic Acid
Aconitic acid (propene-1,2,3-tricarboxylic acid) is the most prevalent 6-carbon organic acid that accumulates in sugarcane and sweet sorghum. As a top value-added chemical, aconitic acid may function as a chemical precursor or intermediate for high-value downstream industrial and biological applications. These downstream applications include use as a bio-based plasticizer, cross-linker, and the formation of valuable and multi-functional polyesters that have also been used in tissue engineering. Aconitic acid also plays various biological roles within cells as an intermediate in the tricarboxylic acid cycle (TCA) and in conferring unique survival advantages to some plants as an antifeedant, antifungal, and means of storing fixed pools of carbon. Aconitic acid has also been reported as a fermentation inhibitor, anti-inflammatory, and a potential nematicide. 
  • 1.4K
  • 16 Mar 2022
Topic Review
Sleeping Beauty Transposon System
Sleeping Beauty (SB) is a transposon system that has been widely used as a genetic engineering tool. Central to the development of any transposon as a research tool is the ability to integrate a foreign piece of DNA into the cellular genome. Driven by the need for efficient transposon-based gene vector systems, extensive studies have largely elucidated the molecular actors and actions taking place during SB transposition. Close transposon relatives and other recombination enzymes, including retroviral integrases, have served as useful models to infer functional information relevant to SB. Recently obtained structural data on the SB transposase enable a direct insight into the workings of this enzyme. These efforts cumulatively allowed the development of novel variants of SB that offer advanced possibilities for genetic engineering due to their hyperactivity, integration deficiency, or targeting capacity. However, many aspects of the process of transposition remain poorly understood and require further investigation. We anticipate that continued investigations into the structure–function relationships of SB transposition will enable the development of new generations of transposition-based vector systems, thereby facilitating the use of SB in preclinical studies and clinical trials.
  • 1.4K
  • 27 Jan 2021
Topic Review
Sal
Scientific name: Shorea robusta Gaertn. f. Family: Dipterocarpaceae Centre of origin: Southern Asia Common name: Sal, Sakwa, Sakhua,Shal, Borsal, Sagua, Sakhu
  • 1.4K
  • 08 Feb 2022
Topic Review
Childhood Asthma
Asthma is a complex and multifactorial respiratory disease with a high prevalence in the pediatric population. Variation in treatment response to asthma therapies has been described among patients, and difficult-to-treat asthma carries both high healthcare and socioeconomic burden to the patients and society. Omic studies can be used to discover the molecular mechanisms underlying asthma susceptibility and treatment response, contributing to a better knowledge and definition of asthma pathogenesis and therefore, to the development of precision medicine. This entry aims to summarize the recent findings of omic studies of treatment response in childhood asthma. Between 2018-2019 a total of 13 omic studies has been performed involving genomics, epigenomics, transcriptomics, metabolomics, and the microbiome. These have been focused on the response to three common asthma medications: short-acting beta agonists, inhaled corticosteroids, and leukotriene receptor antagonists. Novel associations of different biomarkers with asthma treatment response have been described. However, stronger evidence and more consistent results are required to implement these molecular biomarkers into clinical practice by establishing the most appropriate therapy for each patient.
  • 1.4K
  • 29 Oct 2020
Topic Review
Smart Electro-Clothing Systems
This entry presents an overview of the smart electro-clothing systems (SeCSs) targeted at health monitoring, sports benefits, fitness tracking, and social activities. Technical features of the available SeCSs, covering both textile and electronic components, are thoroughly discussed and their applications in the industry and research purposes are highlighted. In addition, it also presents the developments in the associated areas of wearable sensor systems and textile-based dry sensors. As became evident during the literature research, such a review on SeCSs covering all relevant issues has not been presented before. This entry will be particularly helpful for new generation researchers who are and will be investigating the design, development, function, and comforts of the sensor integrated clothing materials.
  • 1.4K
  • 01 Nov 2020
Topic Review
Streptavidin
Streptavidin /ˌstrɛpˈtævɪdɪn/ is a 52.8 kDa protein purified from the bacterium Streptomyces avidinii. Streptavidin homo-tetramers have an extraordinarily high affinity for biotin (also known as vitamin B7 or vitamin H). With a dissociation constant (Kd) on the order of ≈10−14 mol/L, the binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. Streptavidin is used extensively in molecular biology and bionanotechnology due to the streptavidin-biotin complex's resistance to organic solvents, denaturants (e.g. guanidinium chloride), detergents (e.g. SDS, Triton), proteolytic enzymes, and extremes of temperature and pH.
  • 1.4K
  • 25 Oct 2022
Topic Review
The B-cell Activating Factor/A Proliferation-Inducing Ligand System
It cannot present MZ B-cell populations without discussing the B-cell Activating Factor/A Proliferation-Inducing Ligand System (BAFF/APRIL) system. Without a doubt, one of the most important molecules for the survival and differentiation of B-cells is BAFF. BAFF, also known as B lymphocyte stimulator (BLyS), is part of the tumor necrosis factor (TNF) family and is encoded by the TNFSF13B gene.
  • 1.4K
  • 18 Apr 2022
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