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Topic Review
Biological Nitrogen Fixation
In agroecosystems, nitrogen is one of the major nutrients limiting plant growth. To meet the increased nitrogen demand in agriculture, synthetic fertilizers have been used extensively in the latter part of the twentieth century, which have led to environmental challenges such as nitrate pollution. Biological nitrogen fixation (BNF) in plants is an essential mechanism for sustainable agricultural production and healthy ecosystem functioning. BNF by legumes and associative, endosymbiotic, and endophytic nitrogen fixation in non-legumes play major roles in reducing the use of synthetic nitrogen fertilizer in agriculture, increased plant nutrient content, and soil health reclamation. 
  • 1.5K
  • 24 Nov 2021
Topic Review
Extracellular Vesicles Mediated Regulation
Small noncoding RNAs (sRNA) appear to play a key role in extracellular vesicle (EV)-mediated information transfer. Within the vesicular envelope, RNAs are well protected from degradation and can be shuttled between individuals from one and the same species and beyond. Various communication routes have been discovered such as mother-infant-interaction via breast milk, diverse host-pathogen-relations, and dietary uptake of food derived EVs, proving that EV-mediated inter-kingdom regulation is more than a random event.
  • 1.5K
  • 23 Oct 2020
Topic Review
Transplacental Gene Delivery
Transplacental gene delivery (TPGD) is a technique for delivering nucleic acids to fetal tissues via tail-vein injections in pregnant mice. After transplacental transport, administered nucleic acids enter fetal circulation and are distributed among fetal tissues. In 1995, TPGD was established by Tsukamoto et al., and its mechanisms, and potential applications have been further characterized since. In 2019, Nakamura et al. demonstrated that intravenous injection of plasmid DNA containing genome editing component (CRISPR/Cas9 system) produced indels in fetal myocardial cells. In the future, this unique technique will allow manipulation of fetal cell functions in basic studies of fetal gene therapy.
  • 1.5K
  • 31 Jul 2020
Topic Review
Oligodendrocyte (OL) Differentiation and Differentiation
Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the central nervous system. OL myelination is critical to the vertebrate central nervous system (CNS) function. It supports not only the myelinating cell in the CNS but also provides metabolic and trophic support to the myelinated axon. The myelin sheath is essential insulation surrounding axons for conduction in the nervous system. Hypermyelination or hypomyelination interferes with saltatory nerve conduction, causing neurological disabilities.
  • 1.5K
  • 18 May 2022
Topic Review
Bioactive Flavonoids from Citrus Fruits
Citrus species are one of the world’s popular fruit crops, cultivated all over the world for their economic and nutritional values. Citrus, like other fruits and vegetables, are an important source of several antioxidant molecules (polyphenols, ascorbic acid, and carotenoids) that can inhibit the harmful effects of free radicals on the human body; due to their functional values and health-promoting properties, Citrus species are considered valuable fruits not only in agri-food industry, but also in pharmaceutical industry. Flavonoids are among the major constituents of polyphenols found in different parts of Citrus fruits (skin, peels, seed, pulp membrane, and juice). Flavonoids have different biological properties (antiviral, antifungal, and antibacterial activities). Several studies have also shown the health-related properties of Citrus flavonoids, especially antioxidant, anticancer, anti-inflammation, anti-aging, and cardiovascular protection activities.
  • 1.5K
  • 29 Mar 2022
Topic Review
King Cherry
King cherry (Cerasus × nudiflora, 왕벚 wangbeoj, 왕벚나무 wangbeojnamu or 왕벚꽃 wangbeojkkoch) is a Korean native cherry tree originated from Jeju Island. It is a distinct species from Japanese native Yoshino cherry. King cherry is a rare plant and listed as an endangered species. As of April 2017, 194 King cherry trees were growing around Mt. Halla in Jeju Island. According to Gen-ichi Koidzumi, King cherry is erroneously believed to be discovered by a French missionary Emile Taquet although what he discovered was a different species. There have been disputes over the origin of king cherry and Yoshino cherry. In 2007, a study conducted on the comparison of king cherry and Yoshino cherry concluded that these trees were categorized as distinct species. However, South Korean media assert that King cherry is the same species as Yoshino cherry. In Korea most of the places for cherry blossom festivals, including Yeouido and Jinhae, are still planted with Japanese Yoshino cherry trees.
  • 1.5K
  • 01 Nov 2022
Topic Review
PYHIN Proteins
Pyrin and hematopoietic interferon-inducible nuclear (HIN) domain (PYHIN) proteins have originally emerged as sensors of exogenous DNA and stimulators of the innate immune response. Recent studies, however, indicate that nuclear PYHIN protein family members restrict viral replication by silencing gene expression, in a sensing-independent fashion. Not surprisingly, viruses evolved diverse ways to overcome such cellular defences.
  • 1.5K
  • 14 Jan 2021
Topic Review
Palm Oil Background
Palm oil plantations cover millions of hectares worldwide, which encompass a significant portion of global trade. Palm oil trees, or Arecaceae, are a genus of stemless, tree-like monocot plants that thrive in the tropics and are extremely valuable to humans and the ecosystem. The African oil palm, or Elaeis guineensis, is the most prominent palm species native to West Africa, cultivated for its oil-rich fruit as a semiwild food source for over 7000 years. The tree produces a profusion of fruit bunches yearly with each containing between 1000 and 3000 fruits.
  • 1.5K
  • 14 Jul 2022
Topic Review
Microalgae Impact on Oral Health
Microalgae and cyanobacteria could represent a potential natural alternative to antibiotic, antiviral, or antimycotic therapies, as well as a good supplement for the prevention and co-adjuvant treatment of different oral diseases.
  • 1.5K
  • 24 Nov 2020
Topic Review
5-(Hydroxymethyl)-2-furfural (HMF)
5-(Hydroxymethyl)-2-furfural (HMF), represents a wide class of heterocycles and is formed as an intermediary product of the Maillard reaction or formed by carbohydrate dehydration in an acid medium. HMF also can be generated in significantly amounts at low temperatures during long periods of storage. The formation of HMF is affected by the concentration and type of sugar, acid, minerals, pH as well as amino acids.
  • 1.5K
  • 16 Nov 2021
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