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Topic Review
Tumor Invasion and Metastasis
Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality. Metastasis occurs via a series of integrated processes involving tumor cells and the tumor microenvironment. The innate immune components of the microenvironment have been shown to engage with tumor cells and not only regulate their proliferation and survival, but also modulate the surrounding environment to enable cancer progression. 
  • 1.8K
  • 01 Dec 2021
Topic Review
Surface-Functionalized Nanoparticles for Bio-Application
Surface functionalization of nanoparticles applies to the use of covalent and non-covalent bonds—such as hydrogen bonds, electrostatic force, and the van der Waals interactions—to integrate diverse organic and inorganic molecules at the nanoscale. Typically, multiple linker molecules are used to form covalent bonds between ligands and the surfaces of nanoparticles (NPs).
  • 1.7K
  • 20 Apr 2022
Topic Review
Dextran
Dextran is an exopolysaccharide (EPS) synthesized by lactic acid bacteria (LAB) or their enzymes in the presence of sucrose. Dextran is composed of a linear chain of d-glucoses linked by α-(1→6) bonds, with possible branches of d-glucoses linked by α-(1→4), α-(1→3), or α-(1→2) bonds, which can be low (<40 kDa) or high molecular weight (>40 kDa). The characteristics of dextran in terms of molecular weight and branches depend on the producing strain, so there is a great variety in its properties. Dextran has commercial interest because its solubility, viscosity, and thermal and rheological properties allow it to be used in food, pharmaceutical, and research areas. 
  • 1.7K
  • 07 Jul 2021
Topic Review
Azaphilone Pigments
Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones pigments with structural diversity and advantages over vegetal-derived colored natural products such agile and simple cultivation in the lab, acceptance of low-cost substrates, speed yield improvement, and ease of downstream processing. Modern genetic engineering allows industrial production, providing pigments with higher thermostability, water-solubility, and promising bioactivities combined with ecological functions.
  • 1.6K
  • 29 Jul 2021
Topic Review
Cyanidin-3-Glucoside
Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic acid, which enhance C3G bioavailability and contribute to both mucosal barrier and microbiota.
  • 1.6K
  • 02 Aug 2021
Topic Review
Wild Edible Plants in India
Despite significant evidence base on quantifying ecosystem services, the role of biodiversity in supporting such services in diversified landscapes, and how indigenous communities exploit, utilize and manage plant resources in a biocultural regime, remains understudied.  A sum total of 172 WEPs comprising 60 vegetables, 70 fruits, seeds and nuts, 23 underground tubers and 19 mushrooms were collected, consumed, and surplus were marketed by the communities. On average, the number of wild edibles collected annually by households were in the following quantities: 40–240 kg leafy vegetables, 125–386 kg flowers, 120–250 kg fruits, 12–125 kg legumes, 24–120 kg tubers, 5–35 kg mushrooms. Among ethnic groups, the Baiga primitive community utilized 70–90% followed by Gonds (58–81%), Kols (52–78%), Oraons (43–79%), and other communities (38–68%) in different zones. WEPs have contributed to 5–24% (Rs 3559- 12,710) of household income, which was highest in the core zone and lowest in the transition zone. It was observed that WEPs were complemented the diets rather than being a substitute for staple foods. They supplied only 3.7–8.3% of energy and 1.1–4.9% protein requirements; however, they significantly supplemented ascorbic acid, thiamine, calcium, and iron by 38.1–73%, 13.7–35.4%, 17.2–29.1%, 2.6–13.5%, respectively. Significantly higher quantities of nutrients were supplemented in the core zone compared to other zones. WEPs were currently underutilized (less intake) especially in buffer and transition zones, complementing the staple foods and partially supplementing the essential macro- and micro-nutrients. However, these have the potential to fulfill the dietary needs and ensure balanced nutrition, if consumed in recommended portions and sizes.
  • 1.5K
  • 14 Jan 2022
Topic Review
Chloroplasts in Plant Stress Responses
The chloroplast has a central position in oxygenic photosynthesis and primary metabolism. In addition to these functions, the chloroplast has recently emerged as a pivotal regulator of plant responses to abiotic and biotic stress conditions. Chloroplasts have their own independent genomes and gene-expression machinery and synthesize phytohormones and a diverse range of secondary metabolites, a significant portion of which contribute the plant response to adverse conditions.
  • 1.5K
  • 05 Jan 2022
Topic Review
Prosopis Plant
Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/postpartum pains, callouses, conjunctivitis, diabetes, diarrhea, expectorant, fever, flu, lactation, liver infection, malaria, otitis, pains, pediculosis, rheumatism, scabies, skin inflammations, spasm, stomach ache, bladder and pancreas stone removal. Flour, syrup, and beverages from Prosopis pods have also been potentially used for foods and food supplement formulation in many regions of the world. In addition, various in vitro and in vivo studies have revealed interesting antiplasmodial, antipyretic, anti-inflammatory, antimicrobial, anticancer, antidiabetic and wound healing effects. The phytochemical composition of Prosopis plants, namely their content of C-glycosyl flavones (such as schaftoside, isoschaftoside, vicenin II, vitexin and isovitexin) has been increasingly correlated with the observed biological effects. 
  • 1.4K
  • 22 Jul 2021
Topic Review
Infrared Spectroscopy in Biological Studies
Infrared (IR) radiation is electromagnetic radiation with wavenumbers ranges of 12,500–10 cm−1. The IR region in the electromagnetic spectrum can be subdivided into three spectral regions, namely near-IR (NIR, 12,500–4000 cm−1), mid-IR (MIR, 4,000–400 cm−1), and far-IR (FIR, 400–10 cm−1). Accumulating evidence has shown that IR radiation has been widely investigated for biological studies and effects. The interaction between IR radiation and biomolecules enables to study the specific molecular vibrations of the sample constituents. IR spectroscopy, specifically MIR, has been used to investigate large numbers of biological samples such as cells, tissues, organ, and biofluids, providing qualitative and quantitative information that could be used for detection and classification. Notably, FTIR spectroscopy is considered a promising tool to study and analyze biological samples using MIR radiation. 
  • 1.4K
  • 09 Jan 2023
Topic Review
Awns
Awns are extending structures from lemmas in grasses and are very active in photosynthesis, contributing directly to the filling of the developing grain. Barley (Hordeum vulgare L.) awns are highly diverse in shape and length and are known to be controlled by multiple awn-related genes. The genetic effects of these genes on awn diversity and development in barley are multiplexed and include complementary effect, cumulative effect, duplicate effect, recessive epistasis, dominant epistasis, and inhibiting effect, each giving a unique modified Mendelian ratio of segregation. The complexity of gene interactions contributes to the awn diversity in barley. Excessive gene interactions create a challenging task for genetic mapping and specific strategies have to be developed for mapping genes with specific interactive effects. Awn gene interactions can occur at different levels of gene expression, from the transcription factor-mediated gene transcription to the regulation of enzymes and metabolic pathways. A better understanding of gene interactions will greatly facilitate deciphering the genetic mechanisms underlying barley awn diversity and development. 
  • 1.4K
  • 07 May 2021
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