Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Role of Antioxidants in Maternal Diet during Pregnancy
Chronic diseases represent one of the major causes of death worldwide. It has been suggested that pregnancy-related conditions, such as gestational diabetes mellitus (GDM), maternal obesity (MO), and intra-uterine growth restriction (IUGR) induce an adverse intrauterine environment, increasing the offspring’s predisposition to chronic diseases later in life. There are several CD risks factors an individual can manage. Recent research suggested that the intrauterine environment, which is modulated by maternal behaviors and disease, severely influences the offspring’s CD development risk.
  • 296
  • 15 Nov 2023
Topic Review
Congenital Heart Diseases
Congenital heart diseases (CHDs) are structural or functional defects present at birth due to improper heart development. Current therapeutic approaches to treating severe CHDs are primarily palliative surgical interventions during the peri- or prenatal stages, when the heart has fully developed from faulty embryogenesis.
  • 125
  • 03 Nov 2023
Topic Review
Retrovirus-Derived RTL/SIRH Genes in Eutherian Developmental System
Eutherians have 11 retrotransposon Gag-like (RTL)/sushi-ichi retrotransposon homolog (SIRH) genes presumably derived from a certain retrovirus. Accumulating evidence indicates that the RTL/SIRH genes play a variety of roles in the mammalian developmental system, such as in the placenta, brain, and innate immune system, in a eutherian-specific manner. It has been shown that the functional role of Paternally Expressed 10 (PEG10) in placental formation is unique to the therian mammals, as are the eutherian-specific roles of PEG10 and PEG11/RTL1 in maintaining the fetal capillary network and the endocrine regulation of RTL7/SIRH7 (aka Leucine Zipper Down-Regulated in Cancer 1 (LDOCK1)) in the placenta. In the brain, PEG11/RTL1 is expressed in the corticospinal tract and hippocampal commissure, mammalian-specific structures, and in the corpus callosum, a eutherian-specific structure. Unexpectedly, at least three RTL/SIRH genes, RTL5/SIRH8, RTL6/SIRH3, and RTL9/SIRH10, play important roles in combating a variety of pathogens, namely viruses, bacteria, and fungi, respectively, suggesting that the innate immunity system of the brain in eutherians has been enhanced by the emergence of these new components. 
  • 162
  • 25 Oct 2023
Topic Review
Key Transcription Factors Involved in Cardiac Conduction System
The heart is composed of muscle cells called cardiomyocytes, including a specialized population named pacemaker cells that form the cardiac conduction system (CCS), which is responsible for generating the action potential dictating heart contractions. Failure of the CCS system leads to cardiac arrhythmias, which require complicated therapies and often the surgical implantation of electrical pacemakers. 
  • 154
  • 20 Oct 2023
Topic Review
Experimental Injury Models of Cardiac Regeneration
Cardiac regeneration is an ancestral trait in vertebrates, a general capacity that seems to be inversely correlated with evolutionary complexity across the animal kingdom. To better understand the biology of MI, as well as to develop different therapeutic strategies, in vitro, ex vivo and in vivo models have been developed. 
  • 158
  • 13 Oct 2023
Topic Review
Somatic Embryogenesis in Spinach
Conventional spinach breeding is limited by the very complex sex determination. However, these limitations could be circumvented in synergy with a biotechnological approach. Accordingly, tissue culture techniques allow rapid and efficient clonal propagation of selected valuable genotypes, and somatic embryogenesis has been recognized as a superior process for clonal propagation because somatic embryos resemble zygotic embryos and therefore can spontaneously develop into complete plants. 
  • 221
  • 08 Oct 2023
Topic Review
In Vitro Embryogenesis and Gastrulation Using Stem Cells
During early mammalian embryonic development, fertilized one-cell embryos develop into pre-implantation blastocysts and subsequently establish three germ layers through gastrulation during post-implantation development. Stem cells have emerged as a powerful tool to study embryogenesis and gastrulation without the need for eggs, allowing for the generation of embryo-like structures known as synthetic embryos or embryoids. These in vitro models closely resemble early embryos in terms of morphology and gene expression and provide a faithful recapitulation of early pre- and post-implantation embryonic development. Synthetic embryos can be generated through a combinatorial culture of three blastocyst-derived stem cell types, such as embryonic stem cells, trophoblast stem cells, and extraembryonic endoderm cells, or totipotent-like stem cells alone. 
  • 292
  • 26 Sep 2023
Topic Review
Duplicated Genes within Neural Crest Gene Regulatory Network
Neural crest cells (NCCs) are an embryonic cell type that are unique to vertebrates, which emerge from the neural plate border. During neurulation, NCCs migrate throughout the body to give rise to a diverse array of neural and non-neural cell types including cartilage, bone, smooth muscle, peripheral neurons, and melanocytes.
  • 134
  • 13 Sep 2023
Topic Review
The Impact of Hormesis upon Clinical Aging
Digital information technology is placing an increased cognitive load on our neurons. This enriched environment, provides ‘information-that-requires-action’, which acts through hormesis and activates the neuronal stress response. As a result, human neurons are under continual pressure to maintain themselves. Thus, repair resources must be allocated preferentially to the neuron, at the expense of the germline, through the bidirectional cross-talk between neuron vs germline. The result of this hormetic cognitive stress may be a reduction of age-related degeneration, which lasts indefinitely, with a corresponding reduction in reproduction.
  • 111
  • 11 Sep 2023
Topic Review
Desmosomes in Cell Fate Determination
Desmosomes play a vital role in providing structural integrity to tissues that experience significant mechanical tension, including the heart. Deficiencies in desmosomal proteins lead to the development of arrhythmogenic cardiomyopathy (AC). The limited availability of preventative measures in clinical settings underscores the pressing need to gain a comprehensive understanding of desmosomal proteins not only in cardiomyocytes but also in non-myocyte residents of the heart, as they actively contribute to the progression of cardiomyopathy.
  • 202
  • 31 Aug 2023
  • Page
  • of
  • 15
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Feedback