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Topic Review
Bisphenol A
Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as a protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few decades, studies exploring the mechanism of BPA activity revealed a direct link between BPA induced oxidative stress and disease pathogenesis. Antioxidants, reducing agents that prevent cellular oxidation reactions, can protect BPA toxicity. Although the important role of antioxidants in minimizing BPA stress has been demonstrated in many studies, a clear consensus on the associated mechanisms is needed, as well as the directives on their efficacy and safety. Herein, considering the distinct biochemical properties of BPA and antioxidants, we provide a framework for understanding how antioxidants alleviate BPA‐associated stress. We summarize the current knowledge on the biological function of enzymatic and non‐enzymatic antioxidants, and discuss their practical potential as BPA‐detoxifying agents.
  • 1.2K
  • 26 Oct 2020
Topic Review
Australian Tropical Medicinal Plants
Australian tropical plants have been a rich source of food (bush food) and medicine to the first Australians (Aboriginal people), who are believed to have lived for more than 50,000 years. Plants such as spreading sneezeweed (Centipeda minima), goat’s foot (Ipomoea pes-caprae), and hop bush (Dodonaea viscosa and D. polyandra) are a few popular Aboriginal medicinal plants.
  • 714
  • 01 Jul 2022
Topic Review
Anti-Haemonchus Contortus Vaccines Development
Haemonchosis/barber’s pole disease is a socio-economically important disease caused by one of the most pathogenic nematode parasite of ruminants called Haemonchus contortus. The control practices through anthelmintics, and resistance to these drugs demands for an effective, safe and durable vaccine against H. contortus.  During host-parasite relationship, parasites excrete and secrete large number of molecules into the host, which perform adversative immune-regulatory functions upon bindings to host immune cells. Various potential vaccine antigens have been tested by different ways and strategies applied in animal models, and significant progress has been made in the development of vaccines against H. contortus.
  • 735
  • 28 Oct 2020
Topic Review
Aetiology and Pathogenesis of Vitiligo
Vitiligo is an acquired, chronic condition characterised by depigmentation of the epidermis or by destruction/loss of melanin. Skin cells (melanocytes) are responsible for producing melanin, the substance that gives pigmentation to the skin. Although there is no specific ethnic group, gender, or skin type that is more prone to vitiligo than others, it can affect anyone. Even though vitiligo is typically thought of as a cosmetic disorder, its effects on the physical and psychosocial health of sufferers cannot be ignored.
  • 244
  • 09 Jun 2023
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