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Topic Review
Excipients to Inhibit Efflux Transporters
Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration. Efflux transporters in the gastrointestinal tract mainly include P-gp, MRPs and BCRP.
  • 799
  • 17 Jun 2022
Topic Review
Dietary Nitrate and the Maintenance of Oral Health
Nitrate (NO3) is the oxidative product of nitric oxide (NO) and nitrite (NO2). As soil content, NO3 is an essential substrate for all plant growth and provides, among other things, the nitrogen required for the synthesis of nitrogenous amino acids. It is taken up by the plant roots and originates either from the microbial decomposition of organic waste or from the activity of certain soil bacteria utilizing atmospheric nitrogen for the synthesis of ammonia, nitrite and nitrate. Since available nitrate is the limiting factor for plant growth, it is deliberately added to the soil in agricultural crop production in the form of nitrate-containing fertilizers. Although the role of the oral microbiota as a key element in the alternative formation of NO2 and NO from nitrate-rich foods has been known for many years, it is surprisingly only in recent years that the therapeutic and preventive prospects of a nitrate-rich diet have attracted the interest of dental researchers.
  • 607
  • 10 Jun 2022
Topic Review
Reducing Antifungal Resistance in Dentistry with Phytotherapy
Microorganisms of fungal origin currently show resistance to the different antifungals of conventional use, which is undoubtedly altering the oral health of human beings, but there are new therapeutic possibilities such as the active principles of various natural species. In this situation, a therapeutic option of great validity could be the use of various active components that are found in different vegetable species, which is an alternative that might decrease both the side effects that are present when using conventional drugs and the resistance to different medicines
  • 526
  • 09 Jun 2022
Topic Review
Osteoimmunology in Periodontitis
Periodontitis is one of the most common oral diseases resulting in gingival inflammation and tooth loss. Growing evidence indicates that it results from dysbiosis of the oral microbiome, which interferes with the host immune system, leading to bone destruction. Immune cells activate periodontal ligament cells to express the receptor activator of nuclear factor kappa-B (NF-κB) ligand (RANKL) and promote osteoclast activity. Osteocytes have active roles in periodontitis progression in the bone matrix. Local proteins are involved in bone regeneration through functional immunological plasticity.
  • 680
  • 02 Jun 2022
Topic Review
Overview of COVID-19-Associated Mucormycosis
Immune-compromised diseases lead to a majority of opportunistic conditions such as oral fungal infections, also known as oral mycosis. Often, the impairment of host resistance leads to the initiation of pathogenic conditions in the oral cavity, and progression through local colonization. The use of immunosuppressive drugs and immunodeficiency upon viral infection, especially in COVID-19 patients, has led to a significant increase in the frequency of oral mycosis globally. 
  • 476
  • 27 May 2022
Topic Review
Management of COVID-19-Associated Mucormycosis
The outbreak of coronavirus disease (COVID-19), which comes with several comorbidities, was declared a pandemic in early 2020 by World Health Organization (WHO). Glucocorticoids that are used in severe cases of COVID-19 as therapeutic measures may lead to opportunistic fungal infections in such patients. Mucormycosis is one of these infections and mostly occurs in immune-compromised patients such as those who undergo transplant surgeries. 
  • 687
  • 26 May 2022
Topic Review
Current Trends in Skeletal Borderline Patients
Skeletal balance, functional occlusion, and facial harmony are common goals in orthodontics and orthognathic surgery. However, the boundary line for the decision between orthodontic and surgical treatment remains very controversial in adult borderline patients. Up to 10% of orthodontically treated patients are borderline and may have been treated either way (both with camouflage and orthognathic surgery). It is suggested that orthodontic camouflage of skeletal malocclusions would have acceptable results if there were an average or short facial pattern, mild anteroposterior jaw discrepancy, dental crowding lower than 4–6 mm, normal soft tissue features (nose, lips, chin), and no transverse skeletal problems. Poor results would be expected with the following: a long vertical facial pattern, moderate or severe antero-posterior jaw discrepancy, dental crowding greater than 4–6 mm, exaggerated facial features, and a transverse skeletal discrepancy.
  • 601
  • 23 May 2022
Topic Review
Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin
Neohesperidin, hesperidin and hesperetin are citrus flavonoids from the flavanones subclass that have anti-inflammatory and antioxidant potential. Neohesperidin, in the form of neohesperidin dihydrochalcone (NHDC), also has dietary properties as a sweetener. 
  • 760
  • 23 May 2022
Topic Review
Regenerative Materials in Furcations of Patients with Periodontitis
Periodontitis is a chronic, multi-factorial inflammatory disease, caused by an inflammatory reaction by the host to a dysbiotic subgingival microflora, which can be modified by genetic and lifestyle factors, and it results in the loss of tooth-supporting apparatus, the connective tissue attachment and alveolar bone. Worldwide, periodontitis affects about 20–50% of the global population. Regeneration of lost tissues around the teeth remains a clinical challenge, especially in furcation defects of molar teeth. This research will give an overview of the outcomes of the use of different regenerative materials in the treatment of class II furcation defects in patients with periodontitis. 
  • 371
  • 19 May 2022
Topic Review
Endodontic Regenerative Procedures in Necrotic Adult Teeth
Regenerative endodontic procedures (from now on REPs) have been defined as ‘biologically based procedures that intend to physiologically replace damaged tooth structures, including dentine and root, as well as cells of the pulp–dentin complex’. REPs were first exclusively developed for the treatment of immature teeth, with the purpose of achieving a complete root development. Nevertheless, these procedures can also restore tooth vitality and pulp functions thanks to the pulp tissue regeneration. Thus, sensibility, immunity, healing, and restorative properties of dental pulp would also be recovered, in turn reducing the chances of reinfection. For that reason, the feasibility of this treatment in mature teeth should be further studied, as until now, conservative treatment for irreversible necrosis or pulpitis has been limited to conventional endodontic therapy. 
  • 422
  • 16 May 2022
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