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Topic Review
Sickle Cell Retinopathy
This work provides a complete review on sickle cell retinopathy (SCR), the most representative ophtalmologic complication of sickle cell disease (SCD), a hemoglobinopathy affecting both adults and children. It extensively relates the classification, epidemiology, clinical manifestations, risk factors, diagnosis, prevention and therapeutic options for SCR. It also highlights the need of a multidisciplinary theranostic approach.
  • 1.4K
  • 14 Dec 2020
Topic Review
Breast-Conserving Surgery
Breast-conserving surgery’s main goal is to fully remove the tumor with clear margins, while avoiding resection of healthy breast tissue in order to achieve better cosmetic results. 
  • 1.4K
  • 22 Feb 2021
Topic Review
MTOR Signaling
The identification of mammalian TOR (mTOR; later renamed mechanistic target of rapamycin) soon followed, revealing that TOR/mTOR, a serine/threonine protein kinase, is a conserved protein kinase from yeast to man
  • 1.4K
  • 31 May 2021
Topic Review
Drought/Salt Tolerance in Wheat
Drought and salinity are major constraints to agriculture. Here, we present an overview of the global situation and the consequences of drought and salt stress connected to climatic changes. 
  • 1.4K
  • 23 Jun 2021
Topic Review
Climate Change and Fisheries Regulation
Climate change and its effect on marine environment, especially ocean warming, acidification and sea level rise, impacts fisheries in different ways. However, fisheries and climate change are regulated by different international management mechanisms, which makes the current fisheries management system face challenges.
  • 1.4K
  • 03 Sep 2021
Topic Review
Calculating Nonlinear Hyperbolic Evolution Equations
Benchmark calculations of high-precision numerical scheme for nonlinear hyperbolic evolution equations are demonstrated. The scheme is based on the Fourier spectral method for spatial discretization and the implicit Runge-Kutta method for time discretization.
  • 1.4K
  • 19 Jul 2022
Topic Review
Effects of Waterborne Cadmium Exposure on Zebrafish intestine
Cadmium (Cd) is an extremely toxic heavy metal released in the environment due to a plethora of anthropic processes. Here focused on the effects of two sublethal cadmium concentrations on cells of the gastrointestinal surface epithelium with particular attention to changes in the distribution of glycan residues and the morphological features of the intestine. To evaluate the defense response of the mucosa, the expression of metallothionein was investigated. Data demonstrate that cadmium modifies the presence and/or distribution of glycans in the brush border and cytoplasm of enterocytes and in the goblet cells cytoplasm. Results suggest a significant interference of cadmium, in dose and site-dependent manner, with mucosal efficiency. This effect could be a direct health risk for the organism exposed to the contamination and indirectly a risk for the trophic chain.
  • 1.4K
  • 08 Mar 2022
Topic Review
Electrospun Nanofibers for Skin Tissue Engineering
Surface modification of electrospun products has been an attractive method for increasing multifunctionality and biocompatibility properties. 
  • 1.4K
  • 29 Mar 2022
Topic Review
Black Fungi on Stone-Built Heritage
Black Fungi are one of the main group of microorganisms responsible for the biodeterioration of stone cultural heritage artifacts. The term “black fungi” refers to a very huge group of dematiaceous fungi, unrelated phylogenetically, which have in common the presence of melanin in the cell wall that confers an olive brown appearance to the colony. Another common characteristic is the ability to withstand hostile environments such as scarcity of nutrients, high solar irradiation, scarcity of water, high osmolarity, and low pH.
  • 1.4K
  • 05 May 2022
Topic Review
Biodiesel as Renewable Biofuel in Current Diesel Engines
Many countries are immersed in several strategies to reduce the carbon dioxide (CO2) emissions of internal combustion engines. One option is the substitution of these engines by electric and/or hydrogen engines. However, apart from the strategic and logistical difficulties associated with this change, the application of electric or hydrogen engines in heavy transport, e.g., trucks, shipping, and aircrafts, also presents technological difficulties in the short-medium term. In addition, the replacement of the current car fleet will take decades. This is why the use of biofuels is presented as the only viable alternative to diminishing CO2 emissions in the very near future. Nowadays, it is assumed that vegetable oils will be the main raw material for replacing fossil fuels in diesel engines.
  • 1.4K
  • 13 May 2022
Topic Review
Atmospheric Sciences
Atmospheric sciences are the study of the Earth's atmosphere, its processes, the effects other systems have on the atmosphere, and the effects of the atmosphere on these other systems. Meteorology includes atmospheric chemistry and atmospheric physics with a major focus on weather forecasting. Climatology is the study of atmospheric changes (both long and short-term) that define average climates and their change over time, due to both natural and anthropogenic climate variability. Aeronomy is the study of the upper layers of the atmosphere, where dissociation and ionization are important. Atmospheric science has been extended to the field of planetary science and the study of the atmospheres of the planets of the solar system. Experimental instruments used in atmospheric sciences include satellites, rocketsondes, radiosondes, weather balloons, and lasers. The term aerology (from Greek ἀήρ, aēr, "air"; and -λογία, -logia) is sometimes used as an alternative term for the study of Earth's atmosphere. Early pioneers in the field include Léon Teisserenc de Bort and Richard Assmann.
  • 1.4K
  • 04 Nov 2022
Topic Review
Retrospective Memory
Retrospective memory is the memory of people, words, and events encountered or experienced in the past. It includes all other types of memory including episodic, semantic and procedural. It can be either implicit or explicit. In contrast, prospective memory involves remembering something or remembering to do something after a delay, such as buying groceries on the way home from work. However, it is very closely linked to retrospective memory, since certain aspects of retrospective memory are required for prospective memory.
  • 1.4K
  • 06 Dec 2022
Topic Review
Gut-Microbiota-Derived Metabolites and Inflammatory Bowel Disease
Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is characterized as a chronic and recurrent inflammatory disease whose pathogenesis is still elusive. The gut microbiota exerts important and diverse effects on host physiology through maintaining immune balance and generating health-benefiting metabolites. Many studies have demonstrated that IBD is associated with disturbances in the composition and function of the gut microbiota. Both the abundance and diversity of gut microbiota are dramatically decreased in IBD patients. Furthermore, some particular classes of microbiota-derived metabolites, principally short-chain fatty acids, tryptophan, and its metabolites, and bile acids have also been implicated in the pathogenesis of IBD.
  • 1.4K
  • 15 Dec 2022
Topic Review
Graph Databases
NoSQL databases were created with the primary goal of addressing the shortcomings in the efficiency of relational databases, and can be of four types: document, column, key-value, and graph databases. Graph databases are designed with a different way of representing and storing data, where data is defined as a collection of nodes and edges. Graph databases can store data and relationships efficiently, and have a flexible and easy to understand data schema. 
  • 1.4K
  • 01 Jun 2023
Topic Review
Storage of Cultural Heritage Objects
The storage of cultural heritage objects typically falls to the responsibility of cultural heritage institutions, or individuals. The proper storage of these objects can help to ensure a longer lifespan for the object with minimal damage or degradation. With so many different types of artifacts, materials, and combinations of materials, keepers of these artifacts often have considerable knowledge of the best practices in storing these objects to preserve their original state.
  • 1.4K
  • 07 Nov 2022
Topic Review
Chromatoid Bodies in the Regulation of Spermatogenesis
The CB is a membrane-less perinuclear organelle present in male germ cells which serve as storehouse for mRNAs transported by RNA binding and transport proteins like GRTH/DDX25. It also serves as a processing center of mRNAs awaiting translation during later stages of spermatogenesis. These CBs are involved in diverse pathways like RNA transport, decay, surveillance and regulate the stability of mRNAs to secure the correct timing of protein expression at different stages of spermiogenesis.
  • 1.4K
  • 11 Mar 2022
Topic Review
Exosome-Mediated Immunosuppression in Tumor Microenvironments
Exosomes are membranous structures secreted by nearly all cell types. As critical messengers for intercellular communication, exosomes deliver bioactive cargoes to recipient cells and are involved in multiple physiopathological processes, including immunoregulation. This pioneering research revealed that cancer cells release programmed death-ligand 1-positive exosomes into the circulation to counter antitumor immunity systemically via T cells. Tumor cell-derived exosomes (TDEs) also play an immunosuppressive role in other immunocytes, including dendritic cells (DCs), macrophages, natural killer (NK) cells, and myeloid-derived suppressor cells (MDSCs). Moreover, exosomes secreted by nontumor cells in the tumor microenvironments (TMEs) also exert immunosuppressive effects.
  • 1.4K
  • 29 Jun 2022
Topic Review
Mitigation Strategies for Heat Stress on Dairy Buffalo
Increases in temperature and the greater incidence of extreme events are the consequences of the climate change that is taking place on planet Earth. High temperatures create severe discomfort to animal farms as they are unable to efficiently dissipate their body heat, and for this, they implement mechanisms to reduce the production of endogenous heat (reducing feed intake and production). In tropical and subtropical countries, where buffalo breeding is more widespread, there are strong negative consequences of heat stress (HS) on the production and quality of milk, reproduction, and health. The increase in ambient temperature is also affecting temperate countries in which buffalo farms are starting to highlight problems due to HS. 
  • 1.4K
  • 19 Apr 2023
Topic Review
Microglia Purinoceptor P2Y6
The purinergic receptor P2Y6 is expressed in immune cells, including microglia that are implicated in neurological disorders. Its ligand, UDP, is a signaling molecule that can serve as a "find‐me" signal when released in significant quantities by damaged/dying cells. Binding of UDP by P2Y6R leads to the activation of different biochemical pathways, depending on the disease context and the pathological environment. Generally, P2Y6R stimulates phagocytosis. However, whether or not phagocytosis coincides with cell activation or secretion of pro-inflammatory cytokines, needs further investigations.  The current review aims to discuss various functions of P2Y6R in some CNS disorders. We present evidence that P2Y6R may have a detrimental or beneficial role in the nervous system, in the context of neurological pathologies, such as ischemic stroke, Alzheimer's disease, Parkinson's disease, radiation-induced brain injury, neuropathic pain.
  • 1.4K
  • 27 Oct 2020
Topic Review
NAFLD and Cardiovascular Diseases
Overwhelming evidence suggests an association of cardiovascular disease (CVD) with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanisms remain largely speculative.
  • 1.4K
  • 09 Feb 2021
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