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Topic Review
Surgical Coaptation Techniques in Peripheral Nerve Injuries
Peripheral nerve injuries requiring surgical repair affect over 100,000 individuals in the US annually. Three accepted methods of peripheral repair include end-to-end, end-to-side, and side-to-side neurorrhaphy, each with its own set of indications.
  • 1.4K
  • 23 Feb 2023
Topic Review
Modified Generalized Feistel Network Block Cipher
With the advent of the Internet-of-Things (IoT) technologies, millions of low-resource devices are constantly used at the network’s edge. As a result, the large amount of private and sensitive data generated by these devices must be securely transported, stored, and processed, posing a challenge because these resource-constrained IoT devices cannot meet the criteria of conventional encryption ciphers. Feistel networks are further divided into two types: classical Feistel networks and generalized Feistel networks (GFN). While classical Feistel ciphers divide a message into two sub-blocks, GFN divides a message into k sub-blocks for some k > 2 called the partition number.
  • 1.4K
  • 30 Oct 2023
Topic Review
Biosynthesis of Aurones
Natural products are a boundless source for the development of pharmaceutical agents against a wide range of human diseases. Accordingly, naturally occurring aurones possess various biological benefits, such as anticancer, antioxidant, antimicrobial, antidiabetic, anti-inflammatory, antiviral and neuroprotective effects. In addition, various studies have revealed that aurones are potential templates for the regulation of diabetes mellitus and its associated complications. Likewise, certain aurones and their analogues have been found to be remarkable kinase inhibitors of DARK2, PPAR-γ, PTPM1, AGE, α-amylase and α-glucosidase, which represents a promising approach for the treatment of chronic metabolic disorders such as diabetes. 
  • 1.4K
  • 01 Nov 2023
Topic Review
Perceived Collective Family Efficacy Scale
The Perceived Collective Family Efficacy Scale is a tool utilized to assess the effectiveness of a family as a functioning system. The scale has a single-factor structure with good validity and reliability.
  • 1.4K
  • 13 Oct 2023
Topic Review
Gut and Intratumoral Microbiomes in Tumor Metastasis
Cancer cell dissemination involves invasion, migration, resistance to stressors in the circulation, extravasation, colonization, and other functions responsible for macroscopic metastases. By enhancing invasiveness, motility, and intravasation, the epithelial-to-mesenchymal transition (EMT) process promotes the generation of circulating tumor cells and their collective migration. Preclinical and clinical studies have documented intensive crosstalk between the gut microbiome, host organism, and immune system. According to the findings, polymorphic microbes might play diverse roles in tumorigenesis, cancer progression, and therapy response. Microbial imbalances and changes in the levels of bacterial metabolites and toxins promote cancer progression via EMT and angiogenesis. In contrast, a favorable microbial composition, together with microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), can attenuate the processes of tumor initiation, disease progression, and the formation of distant metastases.
  • 1.4K
  • 15 Apr 2024
Topic Review
Amino-Acid Metabolism in Apicomplexan Parasites
The review covers the current knowledge on the presence of amino acid biosynthesis and uptake within the Apicomplexa phylum, focusing on human-infecting pathogens: Toxoplasma gondii and Plasmodium falciparum. Given the complex multi-host lifecycle of these pathogens, we hypothesize that amino acids are made, rather than acquired, depending on the host niche. We summarize the stage-specificities of the biosynthesis enzymes, the role of amini acid transporters and the relevance of amino acids for parasite pathogenesis in vivo.
  • 1.4K
  • 12 Feb 2021
Topic Review
Hyper-Progressive Disease
Antibody-mediated disruption of the programmed cell death protein 1 (PD-1) pathway has brought much success to the fight against cancer. Nevertheless, a significant proportion of patients respond poorly to anti-PD-1 treatment. Cases of accelerated and more aggressive forms of cancer following therapy have also been reported. Termed hyper-progressive disease (HPD), this phenomenon often results in fatality, thus requires urgent attention. Among possible causes of HPD, regulatory T-cells (Tregs) are of suspect due to their high expression of PD-1, which modulates Treg activity. Tregs are a subset of CD4+ T-cells that play a non-redundant role in the prevention of autoimmunity and is functionally dependent on the X chromosome-linked transcription factor FoxP3. In cancer, CD4+FoxP3+ Tregs migrate to tumors to suppress anti-tumor immune responses, allowing cancer cells to persist.
  • 1.4K
  • 22 Apr 2022
Topic Review
Extracellular Hsp60, Hsp70 and Hsp90
The role of three members of the Chaperone Systems (CS)—heat shock protein (Hsp)60, Hsp70, and Hsp90—in Immune Systems (IS) modulation and neuroinflammation. These three chaperones occur intra- and extracellularly, with the latter being the most likely involved in neuroinflammation because they can interact with the IS.
  • 1.4K
  • 13 Apr 2021
Topic Review
Chronic Rhinosinusitis and Alzheimer’s Disease
Among millions of sufferers of chronic rhinosinusitis (CRS), the challenge is not only constantly coping with CRS-related symptoms, such as congested nose, sinus pain, and headaches, but also various complications, such as attention difficulties and possible depression. These complications suggest that neural activity in the central nervous system may be altered in those patients, leading to unexpected conditions, such as neurodegeneration in elderly patients. 
  • 1.4K
  • 26 Oct 2021
Topic Review
Direct Rock Art Dating in China
This paper summarizes the scientific study of rock art in China, focusing on the direct dating of rock art. It pays particular attention to the recent work of the International Centre for Rock Art Dating (ICRAD) at Hebei Normal University and explains the problems of the uranium-thorium analysis of reprecipitated calcium-carbonate skins related to rock art.
  • 1.4K
  • 01 Dec 2021
Topic Review
Natural Products against Oxidative Stress in Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central nervous system (CNS) characterized by immune cell infiltration, demyelination and axonal injury. Oxidative stress-induced inflammatory response, especially the destructive effect of immune cell-derived free radicals on neurons and oligodendrocytes, is crucial in the onset and progression of MS. Therefore, targeting oxidative stress-related processes may be a promising preventive and therapeutic strategy for MS. Animal models, especially rodent models, can be used to explore the in vivo molecular mechanisms of MS considering their similarity to the pathological processes and clinical signs of MS in humans and the significant oxidative damage observed within their CNS. Consequently, these models have been used widely in pre-clinical studies of oxidative stress in MS. To date, many natural products have been shown to exert antioxidant effects to attenuate the CNS damage in animal models of MS.
  • 1.4K
  • 23 Aug 2022
Topic Review
Nickel Allergy
Nickel allergy or nickel allergic contact dermatitis (Ni-ACD) is a form of allergic contact dermatitis (ACD) caused by exposure to the chemical element nickel. It typically causes a rash that is red and itchy and that may be bumpy or scaly. The main treatment is avoiding contact with nickel-releasing metals, such as wearing inexpensive jewelry.
  • 1.4K
  • 28 Apr 2023
Topic Review
Classification of Various Ligands
Enantioselective gold catalysis has flourished due to its distinct performance. In particular, a series of valuable chiral ligands have been identified, including aryl phosphine ligands bearing the proximal chiral sulfinamide motif, phosphoramidite and phosphonite ligands, phosphine ligands comprising the ferrocene scaffold, bifunctional phosphine ligands, biphosphine ligands, chiral counterion-based ligands derived from chiral phosphoric acids and chiral carbene ligands for gold(I) catalysis, along with unique ligand frameworks for cyclometalated gold(III) catalysis. 
  • 1.4K
  • 25 Sep 2023
Topic Review
Cross-Laminated Timber in Finland
Although cross-laminated timber (CLT) construction, driven by only a few domestic manufacturers, is relatively new in Finland, sustainability concerns may increase interest in renewable materials, and therefore, CLT may be more accepted in the Finnish construction market. Additionally, active communication about successful projects and new applications can open new avenues for CLT to gain popularity in the Finnish construction market.
  • 1.4K
  • 28 Dec 2023
Topic Review
MIMO Radars
This entry reports a thorough overview on the last developments concerning the vital sign detection and the human localization employing the multiple-input-multiple-output (MIMO) technology. The wireless motion and vital sign detection represents an outstanding research area aimed at monitoring the health conditions of human subjects and at detecting their presence in different environments with minimal concern. MIMO radars exhibit several interesting advantages over conventional single-input-single-output architectures mainly related to their angle detection capabilities and enhanced signal-to-noise ratio. This paper describes the main features and details the operating principles of MIMO technology. Thereafter, it summarizes the state-of-the-art of the available solutions with the purpose of fueling the research activities on this hot topic.
  • 1.4K
  • 17 Sep 2020
Topic Review
Yuan-Harel-Lupski Syndrome
Yuan-Harel-Lupski (YUHAL) syndrome is a rare neurological condition that has a combination of features of two other disorders, Potocki-Lupski syndrome and type 1A Charcot-Marie-Tooth disease.  
  • 1.4K
  • 24 Dec 2020
Topic Review
Molecular Hydrogen Neuroprotection in Post-Ischemic Brain Injury
Molecular hydrogen has gained the attention of both preclinical and clinical researchers. The death of pyramidal neurons in especially the CA1 area of the hippocampus, increased permeability of the blood-brain barrier, neuroinflammation, amyloid accumulation, tau protein dysfunction, brain atrophy, cognitive deficits and dementia are considered an integral part of the phenomena occurring during brain neurodegeneration after ischemia.
  • 1.4K
  • 01 Jul 2022
Topic Review
Effects of Food Additives on Gut Microbiota
The gut microbiota has been confirmed as an important part in human health, and is even take as an ‘organ’. The interaction between the gut microbiota and host intestinal environment plays a key role in digestion, metabolism, immunity, inflammation, and diseases. The dietary component is a major factor that affects the composition and function of gut microbiota. Food additives have been widely used to improve the color, taste, aroma, texture, and nutritional quality of processed food. The increasing variety and quantity of processed food in diets lead to increased frequency and dose of food additives exposure, especially artificial food additives, which has become a concern of consumers. There are studies focusing on the impact of food additives on the gut microbiota, as long-term exposure to food additives could induce changes in the microbes, and the gut microbiota is related to human health and disease. 
  • 1.4K
  • 28 Jan 2023
Topic Review
Tungsten Inert Gas Welding Process of Dissimilar Metals
Special attention is required when joining two materials with distinct chemical, physical and thermal properties in order to make the joint bond robust and rigid. Welded samples employing ER-309L filler wires had a microstructure consisting of a delta ferrite network in an austenite matrix. The tensile strength experimental results revealed that welding current, followed by GFR, was a highly influential parameter on tensile strength. Weld metals had higher hardness and flexural strength than stainless steel and carbon steel base metals. 
  • 1.4K
  • 15 Jul 2022
Topic Review
Microglia as Therapeutic Target for Radiation-Induced Brain Injury
Radiation-induced brain injury (RIBI) after radiotherapy has become an increasingly important factor affecting the prognosis of patients with head and neck tumor. With the delivery of high doses of radiation to brain tissue, microglia rapidly transit to a pro-inflammatory phenotype, upregulate phagocytic machinery, and reduce the release of neurotrophic factors. 
  • 1.4K
  • 12 Aug 2022
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