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Topic Review
Bacteria on 2-keto-L-gulonic Acid Production
Vitamin C, a water-soluble vitamin with strong reducing power, cannot be synthesized by the human body and participates in a variety of important biochemical reactions. Vitamin C is widely used in the pharmaceutical, food, health care, beverage, cosmetics, and feed industries, with a huge market demand. The classical two-step fermentation method is the mainstream technology for vitamin C production. D-sorbitol is transformed into L-sorbose by Gluconobacter oxydans in the first step of fermentation; then, L-sorbose is transformed into 2-keto-L-gulonic acid (2-KGA) by a coculture system composed of Ketogulonicigenium vulgare and associated bacteria; and finally, 2-KGA is transformed into vitamin C through chemical transformation.
  • 1.5K
  • 06 Dec 2023
Topic Review
Computed Tomography Reconstruction
Computed tomography (CT) is a vital medical imaging technology that revolutionizes healthcare by providing high-resolution images of internal body structures, making it an essential tool in fields like radiology, oncology, and surgery. CT imaging uses X-ray technology to scan a patient. During the CT imaging process, the patient is positioned on a motorized examination table that passes through a CT scanner. The scanner emits narrow X-ray beams, which are measured by detectors on the opposite side of the patient. The data collected are X-ray projections or profiles. 
  • 1.5K
  • 13 Dec 2023
Topic Review
Adsorption Techniques for Lead Removal
The long-term sustainability of the global water supply, with a paramount emphasis on cleanliness and safety, stands as a formidable challenge in modern era. In response to this pressing issue, adsorption techniques have emerged as pivotal and widely recognized solutions for the removal of hazardous pollutants, with a particular emphasis on lead adsorption from wastewater.
  • 1.5K
  • 08 Dec 2023
Topic Review
Stabilization of Rice Bran
One of the major problems in food science is meeting the demand of the world’s growing population, despite environmental limitations such as climate change, water scarcity, land degradation, marine pollution, and desertification. Preventing food from going to waste and utilizing nutritive by-products as food rather than feed are easy and powerful strategies for overcoming this problem. Rice is an important staple food crop for more than half of the world’s population and substantial quantities of rice bran emerge as the main by-product of rice grain milling. Usually, rice bran is used as animal feed or discarded as waste. Although it is highly nutritious and comprises many bioactive compounds with considerable health benefits, the rapid deterioration of bran limits the exploitation of the full potential of rice bran. Hydrolytic rancidity is the main obstacle to using rice bran as food, and the enzyme inactivation process, which is termed stabilization, is the only way to prevent it.
  • 1.5K
  • 24 May 2023
Topic Review
Development of SARS-CoV-2 Variants
A novel coronavirus (SARS-CoV-2) emerged towards the end of 2019 that caused a severe respiratory disease in humans called COVID-19. It led to a pandemic with a high rate of morbidity and mortality that is ongoing and threatening humankind. Most of the mutations occurring in SARS-CoV-2 are synonymous or deleterious, but a few of them produce improved viral functions. The first known mutation associated with higher transmissibility, D614G, was detected in early 2020. Since then, the virus has evolved; new mutations have occurred, and many variants have been described. Depending on the genes affected and the location of the mutations, they could provide altered infectivity, transmissibility, or immune escape. To date, mutations that cause variations in the SARS-CoV-2 spike protein have been among the most studied because of the protein’s role in the initial virus–cell contact and because it is the most variable region in the virus genome. Some concerning mutations associated with an impact on viral fitness have been described in the Spike protein, such as D614G, N501Y, E484K, K417N/T, L452R, and P681R, among others. To understand the impact of the infectivity and antigenicity of the virus, the mutation landscape of SARS-CoV-2 has been under constant global scrutiny. The virus variants are defined according to their origin, their genetic profile (some characteristic mutations prevalent in the lineage), and the severity of the disease they produce, which determines the level of concern. If they increase fitness, new variants can outcompete others in the population. The Alpha variant was more transmissible than previous versions and quickly spread globally. The Beta and Gamma variants accumulated mutations that partially escape the immune defenses and affect the effectiveness of vaccines. Nowadays, the Delta variant, identified around March 2021, has spread and displaced the other variants, becoming the most concerning of all lineages that have emerged. The Delta variant has a particular genetic profile, bearing unique mutations, such as T478K in the spike protein and M203R in the nucleocapsid. This entry summarizes the current knowledge of the different mutations that have appeared in SARS-CoV-2, mainly on the spike protein. It analyzes their impact on the protein function and, subsequently, on the level of concern of different variants and their importance in the ongoing pandemic. 
  • 1.5K
  • 28 Dec 2021
Topic Review
Mindfulness-Based Interventions for Undergraduate Nursing Students
Undergraduate (UG) nursing students are vulnerable to stress throughout their education, known to result in burnout, with high attrition rates of up to 33%. There is a growing body of evidence to suggest that mindfulness-based interventions are effective for the management of anxiety, depression and wellbeing, thereby reducing stress in healthcare provider populations. 
  • 1.5K
  • 18 Nov 2021
Topic Review
Gangliosides in Vascular
Vascular diseases, such as myocardial infarction and cerebral infarction, are most commonly caused by atherosclerosis, one of the leading causes of death worldwide. Several types of cells, such as vascular (endothelial cell), vascular-associated (smooth muscle cell and fibroblast) and inflammatory cells, are involved in plaque formation, plaque rupture and thrombus formation, which result in atherosclerosis. Gangliosides, a group of glycosphingolipids, are expressed on the surface of vascular, vascular-associated and inflammatory cells, where they play functional roles. Here we introduce gangliosides expressed on those cells and their relevance to vascular diseases.
  • 1.5K
  • 23 Oct 2020
Topic Review
Protofibrils in Alzheimer’s Disease
Worldwide, Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and is characterized by unique pathological hallmarks in the brain, including plaques composed of amyloid β-protein (Aβ) and neurofibrillary tangles of tau protein. Genetic studies, biochemical data, and animal models have suggested that Aβ is responsible for the pathogenesis of AD (i.e., the amyloid hypothesis). Indeed, Aβ molecules tend to aggregate, forming oligomers, protofibrils, and mature fibrils. However, while these Aβ species form amyloid plaques of the type implicated in AD neurodegeneration, recent clinical trials designed to reduce the production of Aβ and/or the plaque burden have not demonstrated clinical efficacy. In addition, recent studies using synthetic Aβ peptides, cell culture models, Arctic transgenic mice, and human samples of AD brain tissues have suggested that the pre-fibrillar forms of Aβ, particularly Aβ protofibrils, may be the most critical species, compared with extracellular fibrillar forms. We recently reported that protofibrils of Aβ1-42 disturbed membrane integrity by inducing reactive oxygen species generation and lipid peroxidation, resulting in decreased membrane fluidity, intracellular calcium dysregulation, depolarization, and synaptic toxicity. Therefore, the therapeutic reduction of protofibrils may prevent the progression of AD by ameliorating neuronal damage and cognitive dysfunction through multiple mechanisms.
  • 1.5K
  • 21 Apr 2021
Topic Review
Gut Microbiota in the Elderly
Gut microbiota is involved in the maintenance of physiological homeostasis, thus the alteration of its composition and functionality, called dysbiosis, has been associated with many pathologies, and could also be linked with the progressive degenerative process in aging. Specific gut microbiota taxa could be associated to the development of inflammation underlying aging, but also it has been identified some beneficial profiles related to a healthy status in the elderly. Thus, gut microbiota emerges as a therapeutic target with a double impact in the elderly, counteracting both aging itself and associated diseases. 
  • 1.5K
  • 12 Jan 2021
Topic Review
Sulforaphane
Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs.
  • 1.5K
  • 02 Jul 2021
Topic Review
Application of Campylobacter jejuni Phages
Campylobacter jejuni is a zoonotic bacterial pathogen found in abundance, e.g., in raw poultry. C. jejuni is part of the avian gut microbiome, causing no harm to birds. When birds are slaughtered, the bacterium is released from the intestines and contaminates the meat. Cross-contaminated foods processed in parallel to the meat cause diarrhea in humans and in rare cases may cause post-infectious complications like arthritis and paralysis of peripheral nerves. Illnesses caused by C. jejuni have been on the rise in both developed and developing countries. At the same time, C. jejuni has acquired resistance to important antibiotics, which further complicates therapeutic approaches. To decrease the Campylobacter load on chicken carcasses, chemical or thermal treatment can be used. However, this may change the taste or affect the appearance of chicken meat. 
  • 1.5K
  • 15 Dec 2021
Topic Review
Tetranychus urticae in Northern Africa
In North Africa, Tetranychus urticae Koch, 1836 represents one of the most destructive generalists among mite herbivores. Unfortunately, it is a source of important annual casualties in crop production. It is a phytophagous mite that can feed on hundreds of host plants and produces significant damage. The control of Tetranychus urticae in North Africa has been principally based on acaricide sprays. However, new alternative methods have shown effective results, such as artificial ultraviolet-B, natural enemies, and the introduction of new genetic methods.
  • 1.5K
  • 30 Mar 2022
Topic Review
England School Census
The School Census is a statutory data collection for all maintained (state-funded) schools in England . This includes nursery, primary, secondary, middle-deemed primary, middle-deemed secondary, local authority maintained special and non-maintained special schools, academies including free schools, studio schools and university technical colleges and city technology colleges. Service children's education schools also participate on a voluntary basis. Schools that are entirely privately funded are not included. It is a statutory obligation for schools to complete the census and schools must ask parents for information, tell parents and pupils where data are optional, and tell them what it will be used for before submitting it to Local Authorities or Department for Education. There is no obligation for parents or children to provide all of the data. The census dataset contains approximately eight million records per year and includes variables on the pupil's personal data, including name, home postcode, gender, age, ethnicity, special educational needs, free school meals eligibility, as well as educational history and attainment results. The census also sends sensitive data to the Department for Education, such as absence, exclusions and their reasons, indicators of armed forces or linked to indicators of children in care. The data collected on children from age 2-19, three times a year, creates a "lifetime school record" of characteristics, testing and tracking, to form a single longitudinal record over time. This single central view of a child's personal confidential data and their educational achievement, behaviours and personal characteristics, is core to the National Pupil Database, a linked database controlled by the Department for Education. The data collected for each individual pupil is listed in the National Pupil Database User Guide. Data is retained indefinitely and in December 2015, the National Pupil Database contained 19,807,973 individual pupil records on a named basis. It is "one of the richest education datasets in the world" according to the National Pupil Database (NPD) User Guide. Controversy surrounds the school census expansion in 2016 to collect nationality data, first reported on in June, 2016, in Schools Week.
  • 1.5K
  • 23 Nov 2022
Topic Review
Nokia N73
The Nokia N73 is a smartphone announced by Nokia on 25 April 2006, as part of the Nseries and started shipping on 24 July. The N73 succeeded the N70 and packed in numerous multimedia features. It features a 3.2 megapixel autofocus camera, a front camera, a then-large 2.4 inch display, and stereo speakers, all in a relatively slim and pocketable size and form. It runs on Symbian v9.1 (S60 3rd Edition). It became one of the top selling Nseries devices during 2006 and 2007, and its high popularity helped Nokia's sales of 'multimedia' phones grow 28% year-on-year in Q3 2007 (according to Nokia the other top selling from the line were the N70 and N95).
  • 1.5K
  • 01 Dec 2022
Topic Review
Corporate Governance in Investment Efficiency, Financial Information Disclosure
Corporate governance minimizes the conflicting interests between internal and external stakeholders and shareholders. The corporate governance structure affects the quality of accounting disclosure and information quality assessment and guides analysts to accurately forecast future performance. There is no consensus definition for corporate governance, but its ultimate goal is to achieve accountability, transparency, justice, fairness, and respect for the rights of all stakeholders. Corporate governance is not related to the primary operations of a company. Still, it is related to leading the company, monitoring the activities of the CEO, and assessing the accountability power of the company’s executives to stakeholders. A proper corporate governance system can help companies gain investors’ trust and encourage investment.
  • 1.5K
  • 13 Dec 2022
Topic Review
Mechanisms of Pain Modulation
A review of the pathophysiology of pain and its treatment, from a surgical point of view has been published (Sola RG, Pulido P. Neurosurgical Traatment of Pain. Brain Sci. 2022, 12(11), 1584; https://doi.org/10.3390/brainsci12111584) There are pain syndromes of difficult medical control.In these cases, surgical treatment may be an excellent alternative. The bases on which the different surgical approaches are based are described. The attached table shows a very schematic view of the neurosurgical treatment of pain.      
  • 1.5K
  • 22 Jan 2023
Topic Review
Three-Dimensional Point Cloud Semantic Segmentation for Cultural Heritage
In the cultural heritage field, point clouds, as important raw data of geomatics, are not only three-dimensional (3D) spatial presentations of 3D objects but they also have the potential to gradually advance towards an intelligent data structure with scene understanding, autonomous cognition, and a decision-making ability. The approach of point cloud semantic segmentation as a preliminary stage can help to realize this advancement.
  • 1.5K
  • 09 Mar 2023
Topic Review
Therapeutic Approach of Thermogenic Nutraceuticals to Obesity
Current evidence, both on animal and human models, indicates that several diet components may have beneficial effects on obesity by affecting brown adipose tissue (BAT) and energy metabolism, including polyunsaturated fatty acids, capsaicin and capsinoids, catechins, curcumin, resveratrol and berberine, oleuropein, anthocyanins, quercetin, gingerol, shogaol, 6-paradol, thiacremonone, cinnamaldehyde and menthol. 
  • 1.5K
  • 25 May 2023
Topic Review
Geologic Background of Sixtymile Gold District, Yukon, Canada
The Sixtymile gold district, Yukon, Canada has been mined for placer gold since the late 19th century. 
  • 1.5K
  • 14 Apr 2022
Topic Review
Hyperoncotic Human Albumin Solution in Traumatic Brain Injury
Fluid resuscitation with human albumin solution (HAS) corrects low serum albumin levels and aids in preserving euvolemia in non-brain-injured intensive care units and in perioperative patients. Ischemia, hypotension, hypoxia, and energy dysfunction are important determinants of the outcomes following a severe traumatic brain injury (TBI). Cerebral edema and increased intracranial pressure (ICP) are frequently observed after TBI, leading to cerebral ischemia.
  • 1.5K
  • 17 May 2022
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