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Topic Review
Calcium and Glutathione
Extracellular glutathione (GSH) and oxidized glutathione (GSSG) can modulate the function of the extracellular calcium sensing receptor (CaSR). The CaSR has a binding pocket in the extracellular domain of CaSR large enough to bind either GSH or GSSG, as well as the derivatives L-cysteine glutathione disulfide (CySSG) and the compound cysteinyl glutathione (CysGSH). CySSG occurs naturally in the circulation and may be the preferred ligand for modulation of CaSR.
  • 1.5K
  • 21 Jan 2022
Topic Review
A Development Strategy of a Low-Density Territory
Montesinho Natural Park is one of the largest Portuguese natural protected areas, presenting good biodiversity and a cultural heritage with a strong connection to the territory and its people. It constitutes a low-density territory, characterized by a human and social landscape based on community practices, such as joint aid and the community use of goods and means of agricultural production, which have contributed to the construction of the “transmontana” identity and to the richness of the habitats. The promotion of the sustainable development of this low-density rural region demands the understanding of its specificities and an appropriate approach to grasp its challenges and develop effective management tools, allowing to preserve and exploit the region’s potential from various perspectives. 
  • 1.5K
  • 25 Apr 2022
Topic Review
Osteopontin in Heart Failure
The matricellular protein osteopontin modulates cell–matrix interactions during tissue injury and healing. A complex multidomain structure of osteopontin enables it not only to bind diverse cell receptors but also to interact with various partners, including other extracellular matrix proteins, cytokines, and growth factors. Numerous studies have implicated osteopontin in the development and progression of myocardial remodeling in diverse cardiac diseases. Osteopontin influences myocardial remodeling by regulating extracellular matrix production, the activity of matrix metalloproteinases and various growth factors, inflammatory cell recruitment, myofibroblast differentiation, cardiomyocyte apoptosis, and myocardial vascularization. The exploitation of osteopontin loss- and gain-of-function approaches in rodent models provided an opportunity for assessment of the cell- and disease-specific contribution of osteopontin to myocardial remodeling.
  • 1.5K
  • 26 Aug 2022
Topic Review
Yin Style Baguazhang
Yin Style Baguazhang is a style of Baguazhang.
  • 1.5K
  • 01 Nov 2022
Topic Review
Derailleur Gears
Derailleur gears are a variable-ratio transmission system commonly used on bicycles, consisting of a chain, multiple sprockets of different sizes, and a mechanism to move the chain from one sprocket to another. Although referred to as gears in the bike world, these bicycle gears are technically sprockets since they drive or are driven by a chain, and are not driven by one another. Modern front and rear derailleurs typically consist of a moveable chain-guide that is operated remotely by a Bowden cable attached to a shifter mounted on the down tube, handlebar stem, or handlebar. When a rider operates the lever while pedalling, the change in cable tension moves the chain-guide from side to side, "derailing" the chain onto different sprockets. For more information about the choice of particular gear ratios and sprocket sizes, see Bicycle gearing.
  • 1.5K
  • 16 Nov 2022
Topic Review
TiO2 Photocatalysis
Catalysis on TiO2 nanomaterials in the presence of H2O and oxygen plays a crucial role in the advancement of many different fields, such as clean energy technologies, catalysis, disinfection, and bioimplants. Photocatalysis on TiO2 nanomaterials is well-established and has advanced in the last decades in terms of the understanding of its underlying principles and improvement of its efficiency. 
  • 1.5K
  • 17 Jul 2023
Topic Review
Ant Colony Optimization
Ant colony optimization (ACO) is a well-known class of swarm intelligence algorithms suitable for solving many NP-hard problems. An important component of such algorithms is a record of pheromone trails that reflect colonies’ experiences with previously constructed solutions of the problem instance that is being solved. By using pheromones, the algorithm builds a probabilistic model that is exploited for constructing new and, hopefully, better solutions.
  • 1.5K
  • 25 Jul 2023
Topic Review
Digital Twin Technology in Data Center Simulations
Mining activities often deem mine sites as temporary, leading to their eventual reclamation, rehabilitation, or abandonment. The abandoned mine sites can be reimagined as strategic assets, thus providing economic benefits while adhering to critical data center infrastructure standards.
  • 1.5K
  • 05 Dec 2023
Topic Review
Green Food Development in China
China feeds approximately 22% of the global population with only 7% of the global arable land because of its surprising success in intensive agriculture. This outstanding achievement is partially overshadowed by agriculture-related large-scale environmental pollution across the nation. To ensure nutrition security and environmental sustainability, China proposed the Green Food Strategy in the 1990s and set up a specialized management agency, the China Green Food Development Center, with a monitoring network for policy and standard creation, brand authorization, and product inspection.
  • 1.5K
  • 24 Dec 2020
Topic Review
Benign Prostatic Hyperplasia
The apoptosis machinery is a promising target against benign prostatic hyperplasia (BPH). Inhibitors of apoptosis proteins (IAPs) modulate apoptosis by direct inhibition of caspases. Serenoa Repens (SeR) may be combined with other natural compounds such as Lycopene (Ly) and Selenium (Se) to maximize its therapeutic activity in BPH. We investigated the effects of SeR, Se and Ly, alone or in association, on the expression of four IAPs, cIAP-1, cIAP-2, NAIP and survivin in rats with experimental testosterone-dependent BPH. Moreover, caspase-3, interleukin-6 (IL-6) and prostate specific membrane antigen (PSMA) have been evaluated. Rats were administered, daily, with testosterone propionate (3 mg/kg/sc) or its vehicle for 14 days. Testosterone injected animals (BPH) were randomized to receive vehicle, SeR (25 mg/kg/sc), Se (3 mg/kg/sc), Ly (1 mg/kg/sc) or the SeR-Se-Ly association for 14 days. Animals were sacrificed and prostate removed for analysis. BPH animals treated with vehicle showed unchanged expression of cIAP-1 and cIAP-2 and increased expression of NAIP, survivin, caspase-3, IL-6 and PSMA levels when compared with sham animals. Immunofluorescence studies confirmed the enhanced expression of NAIP and survivin with a characteristic pattern of cellular localization. SeR-Se-Ly association showed the highest efficacy in reawakening apoptosis; additionally, this therapeutic cocktail significantly reduced IL-6 and PSMA levels. The administration of SeR, Se and Ly significantly blunted prostate overweight and growth; moreover, the SeR-Se-Ly association was most effective in reducing prostate enlargement and growth by 43.3% in treated animals. The results indicate that IAPs may represent interesting targets for drug therapy of BPH.
  • 1.5K
  • 01 Nov 2020
Topic Review
Gigantea in Flower Development
ANTEA (GI) is a gene involved in multiple biological functions, which have been analysed and are partially conserved in a series of mono- and dicotyledonous plant species. The identified biological functions include control over the circadian rhythm, light signalling, cold tolerance, hormone signalling and photoperiodic flowering. The latter function is a central role of GI, as it involves a multitude of pathways, both dependent and independent of the gene CONSTANS(CO), as well as on the basis of interaction with miRNA. The complexity of the gene function of GI increases due to the existence of paralogs showing changes in genome structure as well as incidences of sub- and neofunctionalization. We present an updated report of the biological function of GI, integrating late insights into its role in floral initiation, flower development and volatile flower production.
  • 1.5K
  • 02 Nov 2020
Topic Review
Normal-Pressure Hydrocephalus
Normal-pressure hydrocephalus (NPH) is a neurological disease characterized by enlarged cerebral ventricles and clinical features of gait disturbance, urinary incontinence, and cognitive decline.
  • 1.5K
  • 23 Mar 2021
Topic Review
Reproductive Management of Farm Animals
Reproductive efficiency of farm animals has central consequences on productivity and profitability of livestock farming systems. Optimal reproductive management is based on applying different strategies, including biological, hormonal, nutritional strategies, as well as reproductive disease control.
  • 1.5K
  • 13 Jul 2021
Topic Review
Fetal Liver and Gestational Diabetes
Gestational diabetes mellitus (GDM) is a relatively common pregnancy pathological condition that was recently defined by the American Diabetes Association (ADA) as hyperglycemia, with no obvious cause, first appearing or discovered during the pregnancy’s second or third trimester. It was suggested to include in this definition the preexisting, nonidentified cases of type 2 diabetes mellitus (“overt diabetes”) and type 1 diabetes mellitus, but these are detected very early after the onset of the pregnancy. However, GDM develops later during the pregnancy and is usually detected between week 24 and week 28 of gestation.
  • 1.5K
  • 10 Aug 2021
Topic Review
Smart and Sustainable Cities (SSC)
The concept of SC, which was launched about 20 years ago, significantly influenced the city managers and paved the way for the transformation of cities to achieve their sustainability. More than 40 definitions and 30 conceptual models were proposed to clarify the term “smart city” that differ from each other due to the different perspectives and approaches developed for its modeling and design. Many SC definitions emphasize the use of ICT to effectively combine resources to make the city more interconnected, smart and viable, while some other sustainability oriented definitions focus on combining soft infrastructure (i.e., people, knowledge, communities, business processes, etc.) and the hard infrastructure (i.e., ICTs, buildings, city facilities, etc.) to provide a viable, efficient and sustainable city. In the latter case, the term SSC is often used instead of the term SC. Reference considers a smart (sustainable) city as an innovative city that exploits ICTs and other means, with the purpose of improving the quality of life, the efficiency of urban services and operation and competitiveness, while ensuring the needs of present and future generations regarding economic, social and environmental aspects. The improvement of the quality of life and the economy, the development of efficient urban infrastructure, ensuring social inclusion, sustainable management and conservation of natural resources and ensuring good governance are the main goals of SC. According to the conceptual model of, the SC ecosystem consists of six dimensions, which are: (i) smart economy, (ii) smart governance, (iii) smart environment, (iv) smart people, (v) smart mobility and (vi) smart living.
  • 1.5K
  • 23 Aug 2021
Topic Review
Circum-Saharan Prehistory through the Lens of mtDNA Diversity
African history has been significantly influenced by the Sahara, which has represented a barrier for migrations of all living beings, including humans. Major exceptions were the gene flow events that took place between North African and sub-Saharan populations during the so-called African Humid Periods, especially in the Early Holocene (11.5 to 5.5 thousand years ago), and more recently in connection with trans-Saharan commercial routes. The research indicates that maternal gene flow must have been important in this circum-Saharan space, not only within North Africa and the Sahel/Savannah belt but also between these two regions.
  • 1.5K
  • 25 Mar 2022
Topic Review
Business Incubators, Accelerators, and Performance of Technology-Based Ventures
Considering the turbulence existent in the entrepreneurial process of creation, survival, the management of new technology based ventures, and the increasingly important role played by both business incubators (BI) and business accelerators (BA), there is a need to better understand the portfolio of services supplied by this type of support structures and the needs of the companies that demand for a set of diversified services, which are not easily represented and typified in the reference literature.
  • 1.5K
  • 01 Apr 2022
Topic Review
Vascularization and Cancer Biology
Vascularization is another hallmark of cancer, whereby cancer cells promote the formation of blood vessels to deliver nutrients for fast-growing solid tumors. The most well-known process of vascularization is angiogenesis. In normal cells and tissues, the angiogenesis is a controlled process that is turned on or off depending on the needs of the cells; however, in cancerous cells and tumors, the angiogenesis process is continuous and there is a dysregulation of pro- and antiangiogenesis factors . This continuous activation of angiogenesis allows the cancer cells to form blood vessels to obtain sufficient nutrients for continuous growth and proliferation. There are other ways tumors can achieve vascularization, such as vascular co-option, intussusceptive microvascular growth and vasculogenic mimicry.
  • 1.5K
  • 22 Apr 2022
Topic Review
Social Media Addiction during COVID-19
In the early stages of the coronavirus disease 2019 (COVID-19) pandemic, national lockdowns and stay-at-home orders were implemented by many countries to curb the rate of infection. An extended stay-at-home period can frustrate people’s need for relatedness, with many turning to social media to interact with others in the outside world. However, social media use may be maladaptive due to its associations with social media addiction and psychosocial problems.
  • 1.5K
  • 24 Apr 2022
Topic Review
Degradation Mechanism of Autophagy-Related Proteins
In all eukaryotes, autophagy is the main pathway for nutrient recycling, which encapsulates parts of the cytoplasm and organelles in double-membrane vesicles, and then fuses with lysosomes/vacuoles to degrade them. Autophagy is a highly dynamic and relatively complex process influenced by multiple factors. Under normal growth conditions, it is maintained at basal levels. However, when plants are subjected to biotic and abiotic stresses, such as pathogens, drought, waterlogging, nutrient deficiencies, etc., autophagy is activated to help cells to survive under stress conditions. The regulation of autophagy is mainly reflected in hormones, second messengers, post-transcriptional regulation, and protein post-translational modification. 
  • 1.5K
  • 08 Jul 2022
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