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Topic Review
Concurrent Disorder
Concurrent disorder refers to a diverse set of combinations of substance use disorders and mental disorders simultaneously in need of treatment. Concurrent disorders are underdiagnosed, undertreated, and more complex to manage, practicing the best recommendations can support better outcomes. The purpose of this work is to systematically assess the quality of the current concurrent disorders’ clinical recommendation management guidelines. Literature searches were performed by two independent authors in electronic databases, web, and gray literature. The inclusion criteria were English language clinical management guidelines for adult concurrent disorders between 2000 and 2020. The initial search resulted in 8841 hits. A total of 24 guidelines were identified and assessed with the standardized guidelines assessment tool: AGREE II (Appraisal of Guidelines for Research and Evaluation). Most guidelines had acceptable standards, however, only the NICE guidelines had all detailed information on all AGREE II Domains. Guidelines generally supported combinations of treatments for individual disorders with a very small evidence base for concurrent disorders, and they provided little recommendation for further structuring of the field, such as level of complexity or staging, or evaluating dierent models of treatment integration.
  • 1.6K
  • 01 Sep 2020
Topic Review
CeRNA Networks in Neurodegenerative Diseases
Protein aggregation is classically considered the main cause of neuronal death in neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration of RNA metabolism is a key factor in the etiopathogenesis of these complex disorders. Non-coding RNAs are the major contributor to the human transcriptome and are particularly abundant in the central nervous system, where they have been proposed to be involved in the onset and development of NDDs. Interestingly, some ncRNAs (such as lncRNAs, circRNAs and pseudogenes) share a common functionality in their ability to regulate gene expression by modulating miRNAs in a phenomenon known as the competing endogenous RNA mechanism. Moreover, ncRNAs are found in body fluids where their presence and concentration could serve as potential non-invasive biomarkers of NDDs.
  • 1.6K
  • 17 Feb 2021
Topic Review
Algae-Derived Compounds against PM-induced Diseases
Air pollution has recently become a subject of increasing concern in many parts of the world. The World Health Organization (WHO) estimated that nearly 4.2 million early deaths are due to exposure to fine particles in polluted air, which causes multiple respiratory diseases. As a natural product, algae can be an alternative treatment due to potential biofunctional properties and advantages.
  • 1.6K
  • 07 Jun 2021
Topic Review
Cathepsin K
Cathepsin K is a papain-like cysteine protease with high matrix-degrading activity. Among several cathepsins, cathepsin K is the most potent mammalian collagenase, mainly expressed by osteoclasts. This review summarizes most of the recent findings of cathepsin K expression, highlighting its role in renal tumors for diagnostic purposes and as a potential molecular target. Indeed, cathepsin K is a recognized diagnostic tool for the identification of TFE3/TFEB-rearranged renal cell carcinoma, TFEB-amplified renal cell carcinoma, and pure epithelioid PEComa/epithelioid angiomyolipoma. More recently, its expression has been observed in a subgroup of eosinophilic renal neoplasms molecularly characterized by TSC/mTOR gene mutations. Interestingly, both TSC mutations or TFE3 rearrangement have been reported in pure epithelioid PEComa/epithelioid angiomyolipoma. Cathepsin K seems to be a downstream marker of TFE3/TFEB rearrangement, TFEB amplification, and mTOR pathway activation. Given the established role of mTOR inhibitors as a pharmacological option in renal cancers, cathepsin K could be of use as a predictive marker of therapy response and as a potential target. In the future, uropathologists may implement the use of cathepsin K to establish a diagnosis among renal tumors with clear cells, papillary architecture, and oncocytic features. 
  • 1.6K
  • 07 Jun 2021
Topic Review
Essential Oil from Cistus ladanifer L.
In Oulmes (Middle Atlas, Morocco), the local population uses C. ladanifer traditionally to treat various diseases and health issues due to its antioxidant, gastric, anti-inflammatory, antitumor, antimicrobial, and antiviral properties. This plant is usually harvested in May in this area (flowering time). The leaves of all Cistus species secrete essential oils. Essential oils from different species of medicinal plants have been documented to possess antimicrobial propriety with strong activity against Gram-negative and Gram-positive bacteria and also fungi.
  • 1.6K
  • 25 Oct 2021
Topic Review
Microfluidic Systems and Breast Cancer Metastasis
Microfluidic devices are useful tools in studying biological phenomena involving fluid flow, thin tissue culture, and cell mobility; each of these aspects make microfluidic techniques attractive for studying human breast cancer, which is the most commonly occurring cancer in women and the second most common cancer overall worldwide.
  • 1.6K
  • 15 Feb 2022
Topic Review
Catalyst Supports for Renewable Diesel Production
High energy demand from the market due to the rapid increment of the human population worldwide has urged society to explore alternatives to replace non-renewable energy. Renewable diesel produced from biomass could be the next potential energy source for its high stability, long-term storage, and comparable performance with diesel fuels. In producing renewable diesel, the application of catalyst is essential, and the catalyst support is synthesized with the catalyst to enhance the reaction rate and catalytic properties. The application of the supported catalyst in increasing the selectivity and yield of renewable diesel is significant, in which the catalytic properties depend on the interaction between catalyst and catalyst support. The supported catalyst as a favorable substance to assist in enhancing renewable diesel yield could lead to a sustainable and greener future for the biofuel industry in Malaysia.
  • 1.6K
  • 29 Apr 2022
Topic Review
JAMM Deubiquitinating Enzymes in Disease
Deubiquitinating enzymes (DUBs) are a group of proteases that are important for maintaining cell homeostasis by regulating the balance between ubiquitination and deubiquitination. As the only known metalloproteinase family of DUBs, JAB1/MPN/Mov34 metalloenzymes (JAMMs) are specifically associated with tumorigenesis and immunological and inflammatory diseases at multiple levels. The far smaller numbers and distinct catalytic mechanism of JAMMs render them attractive drug targets. Several JAMM inhibitors have been successfully developed and have shown promising therapeutic efficacy. 
  • 1.6K
  • 22 Jul 2022
Topic Review
Role of Short-Chain Fatty Acids in COPD
Chronic obstructive pulmonary disease (COPD) is a widespread socially significant disease. The development of COPD involves the innate immune system. The regulation of the innate lung immune system is related to the gut microbiota. This connection is due to the production by gut microorganisms of short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. Nutritional disturbances and changes in the structure of the intestinal microbiota lead to a decrease in SCFAs production and their effect on pulmonary immunity. The presence of a metabolic and immune axis linking the lungs and gut plays an important role in the pathogenesis of COPD. 
  • 1.6K
  • 27 Jul 2022
Topic Review
Itza’ Language
Itza' (also known as Itza or Itzaj) is a critically endangered Mayan language spoken by the Itza people near Lake Peten Itza in north-central Guatemala. The language has only 25 fluent speakers and 60 nonfluent speakers. Itza' was the language of administration across much of the Yucatán Peninsula prior to 1697, when the Itza people controlled the last significant Mayan nation in Mesoamerica. During this time, the Itza people resettled their ancestral home in the Petén Basin. The subjugation of the Itza capital by the Spanish forced the Itza people to flee or live amongst the Spaniards, such as in San Jose, Guatemala, where the only modern speakers of the language live. The modern Itza people are the last of the Lowland Maya to be able to directly trace their heritage back to the pre-Columbian era. The Itza' language reflects this history in its nomenclature for the natural world: Itza' words referring to agriculture and agricultural practices remain unchanged since first being recorded. Additionally, Itza' possesses a rich vocabulary for crops and animals that encodes specific information about different varietals and individuals of the species.
  • 1.6K
  • 03 Nov 2022
Topic Review
Enchroma
EnChroma lenses are glasses designed to improve and modify some aspects of color vision deficiency for color blind people. The glasses were invented by Dr. Donald McPherson in 2002. Wearing the glasses results in subtle differences when color blind people look longer and more carefully.
  • 1.6K
  • 17 Nov 2022
Topic Review
Synergies between Shallow Geothermal Energy and DHC Networks
According to the EU Directive 2018/2001, “geothermal energy” means strictly “energy stored in the form of heat beneath the surface of solid earth”. Shallow geothermal energy (SGE) is a specific case where the temperature of the resources is generally under 30 °C (also known as “very-low enthalpy geothermal energy”). The heat exchange with surface-water bodies (sea, lakes, or rivers), ambient air, and sewage water is considered as “ambient energy” in the same document.
  • 1.6K
  • 09 Jan 2023
Topic Review
Last-Mile Drone Delivery
Sustainable green products and services garner more attention from companies and enterprises that aim to succeed and grow in highly competitive markets by imposing less harms on the environment and ecosystems. Last-mile delivery from local distribution centers to customers plays an essential role in the retail business. Retail companies are leaning towards implementing green, efficient transportation methods, such as drones, in their last-mile delivery operations to conserve ecosystems.
  • 1.6K
  • 06 Feb 2023
Topic Review
Bioplastics
Bioplastics are one of the possible alternative solutions to the polymers of petrochemical origins. Bioplastics have several advantages over traditional plastics in terms of low carbon footprint, energy efficiency, biodegradability and versatility.
  • 1.6K
  • 27 Feb 2023
Topic Review
Outer Membrane Porins in Gram-Negative Bacteria
Gram-negative bacteria depend on their cell membranes for survival and environmental adaptation. They contain two membranes, one of which is the outer membrane (OM), which is home to several different outer membrane proteins (Omps). One class of important Omps is porins, which mediate the inflow of nutrients and several antimicrobial drugs. The microorganism’s sensitivity to antibiotics, which are predominantly targeted at internal sites, is greatly influenced by the permeability characteristics of porins.
  • 1.6K
  • 14 Jul 2023
Topic Review
The IGF1 Signaling Pathway
Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in multiple aspects of growth, development and metabolism. The biological actions of IGF1 are mediated by the IGF1 receptor (IGF1R), a cell-surface protein that is evolutionarily related to the insulin receptor (InsR).
  • 1.6K
  • 12 Oct 2023
Topic Review
Restoration of Soils and Groundwater Contaminated by Explosives
Soil pollution resulting from explosives represents a critical environmental challenge. While physical methods like excavation and disposal are effective, their applicability is constrained by cost and logistical challenges for large contaminated areas. Chemical methods, such as oxidation and reduction, focus on transforming explosives into less toxic byproducts. Biological remediation utilizing plants and microorganisms emerges as a cost-effective and sustainable alternative. 
  • 1.6K
  • 31 Jan 2024
Topic Review
Institutional Racism
Institutional racism refers to the systemic discrimination and bias embedded within social institutions, such as government agencies, educational systems, and corporations, that perpetuate racial inequalities. Unlike individual acts of racism, institutional racism operates at a structural level, resulting in unequal access to resources, opportunities, and social privileges based on race. It manifests through policies, practices, and norms that disadvantage certain racial or ethnic groups while advantaging others, contributing to disparities in areas such as employment, education, healthcare, and criminal justice.
  • 1.6K
  • 02 Feb 2024
Topic Review
Major Mechanisms of Kaempferol in Management of Cancer
Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show significant anti-inflammatory, anticancer and antioxidant properties. Kaempferol (Kmp) is a well-studied compound and exhibits remarkable anticancer and antioxidant potential. Kmp can regulate various cancer-related processes and activities such as cell cycle, oxidative stress, apoptosis, proliferation, metastasis, and angiogenesis.
  • 1.6K
  • 28 Dec 2022
Topic Review
Scleroderma
Vitamin D status has been linked to immune system and autoimmune disorders; in fact, low levels of vitamin D are common in many autoimmune disorders. The aims of our study were to assess the prevalence of vitamin D insufficiency and the possible correlation with clinical parameters in systemic sclerosis (SSc). We recruited 40 patients (38 female and two male) with scleroderma and 40 healthy controls matched for age and gender. Demographic and clinical parameters were recorded and the 25-hydroxivitamin D3 serum levels were measured. Serum 25-hydroxivitamin D3 levels were significantly lower in patients with systemic sclerosis than in the control group. The prevalence of 25-hydroxivitamin D3 insufficiency was 50% in the patients and 22.5% in the control group. A statistically significant association was observed between the insufficiency of 25-hydroxivitamin D3 and skin involvement (p = 0.02) and echocardiography systolic pulmonary artery pressure >35 mmHg (p = 0.02). Our data show that the systemic sclerosis group has significantly lower serum 25-hydroxivitamin D3 concentrations compared to the control group; skin involvement and pulmonary hypertension are associated with vitamin D3 insufficiency.
  • 1.6K
  • 01 Nov 2020
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