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Topic Review
Institutional Racism
Institutional racism refers to the systemic discrimination and bias embedded within social institutions, such as government agencies, educational systems, and corporations, that perpetuate racial inequalities. Unlike individual acts of racism, institutional racism operates at a structural level, resulting in unequal access to resources, opportunities, and social privileges based on race. It manifests through policies, practices, and norms that disadvantage certain racial or ethnic groups while advantaging others, contributing to disparities in areas such as employment, education, healthcare, and criminal justice.
  • 1.6K
  • 02 Feb 2024
Topic Review
Scleroderma
Vitamin D status has been linked to immune system and autoimmune disorders; in fact, low levels of vitamin D are common in many autoimmune disorders. The aims of our study were to assess the prevalence of vitamin D insufficiency and the possible correlation with clinical parameters in systemic sclerosis (SSc). We recruited 40 patients (38 female and two male) with scleroderma and 40 healthy controls matched for age and gender. Demographic and clinical parameters were recorded and the 25-hydroxivitamin D3 serum levels were measured. Serum 25-hydroxivitamin D3 levels were significantly lower in patients with systemic sclerosis than in the control group. The prevalence of 25-hydroxivitamin D3 insufficiency was 50% in the patients and 22.5% in the control group. A statistically significant association was observed between the insufficiency of 25-hydroxivitamin D3 and skin involvement (p = 0.02) and echocardiography systolic pulmonary artery pressure >35 mmHg (p = 0.02). Our data show that the systemic sclerosis group has significantly lower serum 25-hydroxivitamin D3 concentrations compared to the control group; skin involvement and pulmonary hypertension are associated with vitamin D3 insufficiency.
  • 1.6K
  • 01 Nov 2020
Topic Review
1D MPC and Thin-Film Analysis
The development of magnetic photonic crystals (MPC) has been a rapidly evolving research area since the late 1990s. Magneto-optic (MO) materials and the techniques for their characterization have also continually undergone functional and property-related improvements. MPC Optimization is a feature-rich Windows software application designed to enable researchers to analyse the optical and magneto-optical spectral properties of multilayers containing gyrotropic constituents. A set of computational approaches, and a custom software package have been described, designed to enable the design and optimization of 1D magnetic photonic crystals in terms of the achievable combinations of Faraday rotation, transmission, and reflection spectra. 
  • 1.6K
  • 25 Aug 2021
Topic Review
Lewy Body Dementia Mice Model
Lewy bodies are pathological characteristics of Lewy body dementia (LBD) and are composed of α-synuclein (α-Syn), which is mostly degraded via the ubiquitin–proteasome system. More importantly, 26S proteasomal activity decreases in the brain of LBD patients. 
  • 1.6K
  • 22 Sep 2021
Topic Review
Near-Surface Wind
Near-surface wind is one of the most important meteorological parameters. Near-surface wind grid products are an important part of live analysis products . Reliable near-surface wind products have an important role in the monitoring, prediction, and study of wind disasters. The evaluation of near-surface wind products can provide the direction for improving the data quality for Hainan, provide basic support for fine-grid forecasting and meteorological services, and help to reduce the losses that are caused by wind disasters.
  • 1.6K
  • 09 Jul 2021
Topic Review Peer Reviewed
Data Quality—Concepts and Problems
Data Quality is, in essence, understood as the degree to which the data of interest satisfies the requirements, is free of flaws, and is suited for the intended purpose. Data Quality is usually measured utilizing several criteria, which may differ in terms of assigned importance, depending on, e.g., the data at hand, stakeholders, or the intended use.
  • 1.6K
  • 14 Apr 2022
Topic Review
Microfluidic Systems and Breast Cancer Metastasis
Microfluidic devices are useful tools in studying biological phenomena involving fluid flow, thin tissue culture, and cell mobility; each of these aspects make microfluidic techniques attractive for studying human breast cancer, which is the most commonly occurring cancer in women and the second most common cancer overall worldwide.
  • 1.6K
  • 15 Feb 2022
Topic Review
Polymeric Composite of Magnetite Iron Oxide Nanoparticles
Iron oxide nanoparticles (IONPs) and superparamagnetic iron oxide nanoparticles (SPIONs) are magnetics nanoparticles (MNPs) that have received extensive attention because of their physicochemical and magnetic properties and their ease of combination with organic or inorganic compounds. Commonly, MNPs act as a reinforcing material for the polymer matrix. 
  • 1.6K
  • 01 Mar 2022
Topic Review
Catalyst Supports for Renewable Diesel Production
High energy demand from the market due to the rapid increment of the human population worldwide has urged society to explore alternatives to replace non-renewable energy. Renewable diesel produced from biomass could be the next potential energy source for its high stability, long-term storage, and comparable performance with diesel fuels. In producing renewable diesel, the application of catalyst is essential, and the catalyst support is synthesized with the catalyst to enhance the reaction rate and catalytic properties. The application of the supported catalyst in increasing the selectivity and yield of renewable diesel is significant, in which the catalytic properties depend on the interaction between catalyst and catalyst support. The supported catalyst as a favorable substance to assist in enhancing renewable diesel yield could lead to a sustainable and greener future for the biofuel industry in Malaysia.
  • 1.6K
  • 29 Apr 2022
Topic Review
Resveratrol from Dietary Supplement to a Drug Candidate
Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be treated by the therapeutic effect of RVT since it has antioxidant, anti-cancer activity and anti-inflammatory activities. It also has a major role in diabetes, arthritis, cardiac disorder and platelet aggregation etc. The major requirements are establishments regarding safety, efficacy profile and physicochemical characterization. 
  • 1.6K
  • 29 Aug 2022
Topic Review
Itza’ Language
Itza' (also known as Itza or Itzaj) is a critically endangered Mayan language spoken by the Itza people near Lake Peten Itza in north-central Guatemala. The language has only 25 fluent speakers and 60 nonfluent speakers. Itza' was the language of administration across much of the Yucatán Peninsula prior to 1697, when the Itza people controlled the last significant Mayan nation in Mesoamerica. During this time, the Itza people resettled their ancestral home in the Petén Basin. The subjugation of the Itza capital by the Spanish forced the Itza people to flee or live amongst the Spaniards, such as in San Jose, Guatemala, where the only modern speakers of the language live. The modern Itza people are the last of the Lowland Maya to be able to directly trace their heritage back to the pre-Columbian era. The Itza' language reflects this history in its nomenclature for the natural world: Itza' words referring to agriculture and agricultural practices remain unchanged since first being recorded. Additionally, Itza' possesses a rich vocabulary for crops and animals that encodes specific information about different varietals and individuals of the species.
  • 1.6K
  • 03 Nov 2022
Topic Review
Chromatin-Remodeling in Cancer Cells
ATP-dependent chromatin-remodeling complexes can reorganize and remodel chromatin and thereby act as important regulator in various cellular processes. Based on considerable studies over the past two decades, it has been confirmed that the abnormal function of chromatin remodeling plays a pivotal role in genome reprogramming for oncogenesis in cancer development and/or resistance to cancer therapy.
  • 1.6K
  • 11 Nov 2022
Topic Review
Biomass Fly Ash-Based Geopolymers
The production of conventional cement involves high energy consumption and the release of substantial amounts of carbon dioxide (CO2), exacerbating climate change. Additionally, the extraction of raw materials, such as limestone and clay, leads to habitat destruction and biodiversity loss. Geopolymer technology offers a promising alternative to conventional cement by utilizing industrial byproducts and significantly reducing carbon emissions.
  • 1.6K
  • 10 Aug 2023
Topic Review
Fruit and Vegetable Harvesting Robots
Intelligent agriculture imposes higher requirements on the recognition and localization of fruit and vegetable picking robots. Due to its unique visual information and relatively low hardware cost, machine vision is widely applied in the recognition and localization of fruit and vegetable picking robots.  Visual sensors are used to acquire image information and the three-dimensional positioning of targets. Machine vision algorithms are used for target recognition. Common algorithms include image segmentation, object detection, and three-dimensional reconstruction. Image segmentation algorithms can segment target objects in complex scenes, object detection algorithms can timely detect target objects and other interferences in images, while three-dimensional reconstruction algorithms can convert the two-dimensional image information obtained by the camera into three-dimensional spatial information of the target.
  • 1.6K
  • 26 Sep 2023
Topic Review
Fortification
Large-scale food fortification is an effective, sustainable, and scalable intervention to address vitamin and mineral deficiencies, however, pressing gaps exist globally around ensuring the quality of fortified foods. This paper summarizes the global challenges and gaps faced in monitoring the quality of fortified foods, the guidance produced in response to these challenges, where we are today in terms of effective implementation, and what approaches and opportunities may be usefully applied to enhance the quality of fortified foods moving forward.
  • 1.6K
  • 14 Jan 2021
Topic Review
γ-Hydroxybutyric Acid
γ-Hydroxybutyric acid (GHB) is an endogenous short chain fatty acid that acts as a neurotransmitter and neuromodulator in the mammalian brain. It has often been illegally abused or misused due to its strong anesthetic effect, particularly in drug-facilitated crimes worldwide. However, proving its ingestion is not straightforward because of the difficulty in distinguishing between endogenous and exogenous GHB, as well as its rapid metabolism. Metabolomics and metabolism studies have recently been used to identify potential biomarkers of GHB exposure. 
  • 1.6K
  • 04 Mar 2021
Topic Review
Asteraceae Paradox
Excessive pollen harvesting by bees can compromise the reproductive success of plants. Plants have therefore evolved different morphological structures and floral cues to narrow the spectrum of pollen feeding visitors. Among “filtering” mechanisms, the chemical and mechanical protection of pollen might shape bee-flower interactions and restrict pollen exploitation to a specific suite of visitors such as observed in Asteraceae. Asteraceae pollen is indeed only occasionally exploited by generalist bee species but plentifully foraged by specialist ones (i.e., Asteraceae paradox). During our bioassays, we observed that micro-colonies of generalist bumblebee (Bombus terrestris L.) feeding on Taraxacum pollen (Asteraceae) reduced their pollen collection and offspring production. Bees also experienced physiological effects of possible defenses in the form of digestive damage. Overall, our results suggest the existence of an effective chemical defense in Asteraceae pollen, while the hypothesis of a mechanical defense appeared more unlikely. Pre- and post-ingestive effects of such chemical defenses (i.e., nutrient deficit or presence of toxic compounds), as well as their role in the shaping of bee-flower interactions, are discussed. Our results strongly suggest that pollen chemical traits may act as drivers of plant selection by bees and partly explain why Asteraceae pollen is rare in generalist bee diets.
  • 1.6K
  • 02 Nov 2020
Topic Review
Sonodynamic Therapy
Sonodynamic therapy is an effective treatment for eliminating tumor cells by irradiating sonosentitizer in a patient’s body with higher penetration ultrasound and inducing the free radicals. Titanium dioxide has attracted the most attention due to its properties among many nanosensitizers. Hence, in this study, carbon doped titanium dioxide, one of inorganic materials, is applied to avoid the foregoing, and furthermore, carbon doped titanium dioxide is used to generate ROS under ultrasound irradiation to eliminate tumor cells. Spherical carbon doped titanium dioxide nanoparticles are synthesized by the sol-gel process. The forming of C-Ti-O bond may also induce defects in lattice which would be beneficial for the phenomenon of sonoluminescence to improve the e ectiveness of sonodynamic therapy. By dint of DCFDA, WST-1, LDH and the Live/Dead test, carbon doped titanium dioxide nanoparticles are shown to be a biocompatible material which may induce ROS radicals to suppress the proliferation of 4T1 breast cancer cells under ultrasound treatment. From in vivo study, carbon doped titanium dioxide nanoparticles activated by ultrasound may inhibit the growth of the 4T1 tumor, and it showed a significant di erence between sonodynamic therapy (SDT) and the other groups on the seventh day of the treatment.
  • 1.6K
  • 13 Apr 2021
Topic Review
Vitamin D arrests cell cycling
Vitamin D is a steroid hormone crucial for bone mineral metabolism. In addition, vitamin D has pleiotropic actions in the body, including anti-cancer actions. These anti-cancer properties observed within in vitro studies frequently report the reduction of cell proliferation by direct alteration of cell cycle regulators which induce cell cycle arrest. The most recurrent reported mode of cell cycle arrest by vitamin D is at the G1/G0 phase of the cell cycle. This arrest is mediated by p21 and p27 upregulation, which results in suppression of cyclin D and E activity which leads to G1/G0 arrest. In addition, vitamin D treatments within in vitro cell lines have observed a reduced C-MYC expression and increased retinoblastoma protein levels that also result in G1/G0 arrest.
  • 1.6K
  • 16 Dec 2020
Topic Review
Immune Mediated Diseases
Immune-mediated diseases (IMDs) are complex pathologies that are strongly influenced by environmental and genetic factors. Associations between genetic loci and susceptibility to these diseases have been widely studied, and hundreds of risk variants have emerged during the last two decades, with researchers observing a shared genetic pattern among them.
  • 1.6K
  • 22 Dec 2020
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