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Khattar, S.;  Khan, S.A.;  Zaidi, S.A.A.;  Darvishikolour, M.;  Farooq, U.;  Naseef, P.P.;  Kurunian, M.S.;  Khan, M.Z.;  Shamim, A.;  Khan, M.M.U.; et al. Resveratrol from Dietary Supplement to a Drug Candidate. Encyclopedia. Available online: https://encyclopedia.pub/entry/26541 (accessed on 17 November 2024).
Khattar S,  Khan SA,  Zaidi SAA,  Darvishikolour M,  Farooq U,  Naseef PP, et al. Resveratrol from Dietary Supplement to a Drug Candidate. Encyclopedia. Available at: https://encyclopedia.pub/entry/26541. Accessed November 17, 2024.
Khattar, Shivani, Sauban Ahmed Khan, Syed Amir Azam Zaidi, Mahdi Darvishikolour, Uzma Farooq, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kurunian, Mohammed Zaafar Khan, Athar Shamim, Mohd Masih Uzzaman Khan, et al. "Resveratrol from Dietary Supplement to a Drug Candidate" Encyclopedia, https://encyclopedia.pub/entry/26541 (accessed November 17, 2024).
Khattar, S.,  Khan, S.A.,  Zaidi, S.A.A.,  Darvishikolour, M.,  Farooq, U.,  Naseef, P.P.,  Kurunian, M.S.,  Khan, M.Z.,  Shamim, A.,  Khan, M.M.U.,  Iqbal, Z., & Mirza, M.A. (2022, August 26). Resveratrol from Dietary Supplement to a Drug Candidate. In Encyclopedia. https://encyclopedia.pub/entry/26541
Khattar, Shivani, et al. "Resveratrol from Dietary Supplement to a Drug Candidate." Encyclopedia. Web. 26 August, 2022.
Resveratrol from Dietary Supplement to a Drug Candidate
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This entry is adapted from the peer-reviewed paper 10.3390/ph15080957

Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be treated by the therapeutic effect of RVT since it has antioxidant, anti-cancer activity and anti-inflammatory activities. It also has a major role in diabetes, arthritis, cardiac disorder and platelet aggregation etc. The major requirements are establishments regarding safety, efficacy profile and physicochemical characterization. 

antioxidants resveratrol anti-aging

1. Introduction

Resveratrol (3, 4′, 5-trihydroxystilbene) is a stilbenoid class of compound and works as phytoalexin (i.e., a substance that is produced by plant tissues in response to contact with a parasite and specifically inhibits the growth of that parasite) [1]. Because of its intriguing pharmacological potential, it has recently gained a lot of study attention. Early studies have illustrated the presence of substantial amounts of Resveratrol (RVT) in wounded, infected, and UV-treated leaves [2]. It is primarily found in grapes, peanuts, and berries. In the 1940s, RVT was discovered in the white hellebore plant. It is also found in processed plant products; its presence in red wine (concentrations of 0.1–14.3 mg/L) has been proposed as a possible explanation for the “French paradox,” the observation of an unusually low rate of heart disease among Southern French people who drink a lot of red wine, despite a high saturated fat diet [3][4]. SIRT1, one of the mammalian versions of the sirtuin family of proteins, is activated by RVT [5], deacetylates histones and non-histone proteins, such as transcription factors [6]. Metabolism, stress resistance, cell survival, cellular senescence, inflammation-immune function, endothelial functions, and circadian rhythms are all affected by the SIRT1-regulated pathway [5]. Since RVT has been demonstrated to activate SIRT1, it is expected to help people with disorders such as improper metabolic regulation, inflammation, and cell cycle abnormalities. RVT’s usage as a nutraceutical and a therapeutic agent for a variety of disorders has been extensively investigated in preclinical trials as a natural molecule. Moreover, clinical trials are been conducted globally so as to establish its therapeutic efficacy for treatment of different diseases. A detailed description of it is mentioned in subsequent subtopics.
Because of the substantial dangers associated with standard cancer therapies, such as surgery and chemotherapy, its usage is of particular interest to cancer patients [7]. The intricacies of cancer cell signalling networks make it difficult for targeted inhibitors that target only one network to be effective. RVT, on the other hand, has been found to have chemo-preventive and chemotherapeutic effects on tumours in vitro and in vivo by targeting various pathways, making it a promising anticancer drug [8]. RVT has an effect on carcinogenesis at all three stages: initiation, promotion, and progression. Additionally, RVT has been demonstrated to directly trigger the apoptotic pathway via a variety of methods [9][10]. For example it has an effect on the nuclear factor κB (NF-B) signalling system, which governs inflammation, immunological response to infection, and cellular response to stimuli [11]. Furthermore, it has also been demonstrated that it blocks the IGF-1R/Akt/Wnt pathways and activates p53, influencing cell development and carcinogenesis [12]. Moreover, it can also block the PI3K/Akt pathway, which regulates cell differentiation, development, and proliferation, and other factors [13]. Several studies have been conducted to investigate the various methods by which RVT operates the PI3K/Akt pathway.
Considering its diverse potentials, an attempt has been made to advocate the development of RVT as a drug molecule. Although there are several dietary supplement products available in the global market, a thorough investigation in terms of clinical safety and efficacy may pave the way for a new therapeutic molecule.
Since resveratrol is a well-known antioxidant and has been utilised as a nutraceutical for many years, it possesses a range of therapeutic properties. As some of its clinical trials are completed, it could therefore be regarded as a promising drug candidate to be used in the treatment of certain diseases.

2. Occurrence/Sources

Dark grape extracts (Vitis vinifera) and giant knot weed (Polygonnum cuspidatum, a perennial shrub) are the richest natural sources of RVT (Table 1). It is also abundant in labrusca and muscadine grapes. Additionally, it is also found in plants such as eucalyptus, spruce, and lily, as well as in foods such as mulberries, peanuts, blueberries, strawberries, hops, and their derivatives [14][15]. It may also be found in the vines, roots, seeds, and stalks, but the skin has the highest concentration, with 50–100 g per gm [16]. RVT is a phytoalexin, which is a kind of antibiotic molecule generated by plants as part of their defense against diseases. For example, in reaction to an invading fungus, RVT is produced from p-coumaroyl CoA and malonyl CoA [1][17]. As fungal infections are more prevalent in cooler areas, grapes produced in cooler climates have a higher quantity of RVT [18]. Table 2 shows the total RVT concentration of several wines and foods. Similarly, Figure 1 shows the occurrence of RVT in different sources.
Pharmaceuticals 15 00957 g001 550
Figure 1. shows the occurrence of RVT in different sources.
Table 1. List of biological sources of resveratrol and their concentration.
S. No Biological Source Specified Parts Concentration of Resveratrol References
1 Peanut
Arachis hypogaea
Family: Fabaceae		 Raw Peanut Kernels 0.02 to 0.31 μg/g [19][20]
Peanut leaves, 2.05-μg/g fresh weight
Peanut roots, 1.19-μg/g
Peanut sprouts, 11.7 to 25.7 μg/g
Peanut butter 0.577 to 0.753 μg/g
2 Grapes
Vitis vinifera.
Family: Vitaceae		 Skins of grape berries 24.06 μg/g [19][20][21][22]
Red wines 0.352–1.99 μg/mL
fruit 3.66 × 10−2 (g kg−1)
3 Ampelopsis cantoniensis
Family: Vitaceae		 stem 1.04 × 10−2 (g kg−1)  
4 Japanese Knotweed
Itadori plant
(Polygonum cuspidatum. Sieb et Zucc)
Family: Polygonaceae		 Stem 497 µg/g [19]
root 523-μg/g [20]
5 White hellebore
(Veratrum grandiflorum O. Loes)
Family: Melanthiaceae		 roots Not notified [23]
6 Blueberries
Vaccinium corymbosum
Family: Ericaceae		 - 140.0 ± 29.9 pmol/g (or 0.00014 ± 0.00003 μmol/g), [20]
7 Bilberries
Vacciniu mmyrtillus. L.
Family: Ericaceae		 - 71.0 ± 15.0 pmol/g (or 0.000071 ± 0.000015 μmol/g) [20]
8 Pistachio Nut
Pistaciavera
Family: Anacardiaceae		 seeds 0.09–1.67 μg/g [20]
9 Paeonia suffruticosaAndr. var. papaveracea (Andr.) Kerner   8.7 × 10−1 g kg−1 [21]
10 Reynoutria japonica Houtt
Polygonaceae		 roots 4.209 × 10−1 g kg−1 [21]
Table 2. List of Resveratrol sources with its concentration.
Source Concentration References
Wine 0.32–15.35 µg/g [24]
Peanut butter 0.02–0.98 µg/g [25]
Peanut 0.01–0.07 µg/g [26]
Green peanuts 0.19–0.72 µg/g [24]
Polygonum cuspidatum 296–377 µg/g [16]
Green grapes 0.02–0.32 µg/g [27]
Black graps 0.95–1.88 µg/g [24]
Risins 0.0005–0.003 µg/g [28]
Grape juice-black Traces-0.09 µg/g [29]
Grape juice-green Traces-0.01 µg/g [30]
White wines (Spanish) 0.05–1.80 mg/L [31]
Rose wine (Spanish) 0.43–3.52 mg/L [32]
Red wine (Spanish) 1.92–12.59 mg/L [33]
Red wine (global) 1.98–7.13 mg/L [34]
Red grape juice (Spanish) 1.14–8.69 mg/lL [35]

3. Commercial Products of Resveratrol

Data pertaining to marketed products have been collected from the National Institute of Health, dietary supplement label database and other websites. These items include either RVT or a combination of RVT. These items have a great variation of doses, such as 20 mg per serving to 1400 mg. It indicates a better safety profile of the molecule.

4. Clinical Trials on Resveratrol Based Products

RVT has also been studied clinically, such as assessment of the effect of RVT on cognitive and cerebral blood flow in the United Kingdom. In Canada, an analysis on the effect of antioxidants on cardio vascular risk was assessed. Furthermore, in Brazil the RVT was examined for its effectiveness in the management of pain due to endometriosis. Moreover, in Taiwan the effect of RVT on complications in patients with haemodialysis was investigated. Additionally, RVT with or without Piperine to enhance the plasma level of RVT was also assessed (USA). Meanwhile, in Singapore, a phase-1 trial is being conducted to analyse the effect of RVT in patients with Type-2 Diabetes (RED). The impact of RVT on brain function and structure was also studied. Moreover, in Italy, RVT’s anti-inflammatory and antioxidants effects on healthy adults were examined. In Tamil Nadu (India), RVT was evaluated as a potent supplement for patient with Type-2 Diabetes Mellitus. Likewise, a similar study was conducted in Maharashtra (India) to confirm whether the addition of RVT is beneficial and safe for patient with diabetes, dyslipidemia and hypertension (who are already on standard therapy). In Karnataka (India), the effect of nutritional supplementation of RVT on patients with advanced cancers and undergoing chemotherapy was evaluated. A similar trial was conducted in Maharashtra (India), to study the effects of nutritional supplementation of extremely active RVT (XAR) in healthy human individuals. In Maharashtra, effect of RVT and copper in reducing toxic side-effects of chemotherapy in patients with advanced mouth cancer was analysed. A similar trial was held in Maharashtra (India), to study the effect of RVT-copper in reducing oral mucositis in patients receiving concurrent chemo radiotherapy for locally advanced oropharyngeal cancer. Additionally, a similar trial was performed in Maharashtra (India) to assess the effect of the addition of RVT with chemotherapeutic agents in patients with gastric cancer. Likewise, the effect of RVT-copper on treating COVID-19 pneumonia was analysed in Maharashtra (India). Additionally, a study to assess the effect of oral RVT and copper combination on life span of glioblastoma patients undergoing surgery was conducted in Maharashtra (India). In Australia, RVT as an option for the treatment of Friedreich ataxia was assessed. A study of dietary RVT on glucose and lipid metabolism disorder is being conducted in China. In Australia, the effect of RVT on circulatory function of obese people with elevated blood pressure was examined. Another trial on similar lines was conducted in Australia where the sustained effect of RVT on circulatory functions in obese adults were assessed. Additionally, the role of RVT in the prevention of colorectal polyps was also investigated in Australia. Moreover, the effect of RVT’s supplementation on gut hormone secretion, gastric emptying and blood glucose responses to meals in patients with type-2 diabetes was assessed in Australia. Meanwhile, another study on RVT supplementation on cerebrovascular function, mood and cognitive performance in type-2 diabetes mellitus (T2DM) was completed in Australia. Another clinical trial was executed in Australia to establish whether RVT can enhance mood, physical function and cerebrovascular function and counteract cognitive decline in post-menopausal women. In Germany, the bioavailability of three different RVT products was evaluated in healthy individuals. Likewise, a similar study was also conducted in Germany, to examine the bioavailability and metabolism of RVT as a constituent of berries in humans. Furthermore, a biokinetic study on the impact of formulation on RVT bioavailability was also performed in Germany. More details about clinical trials are mentioned in Table 3.
Table 3. List of global clinical trials on Resveratrol. 
S. No. CT Number Title of the Study Status/Phase Condition Sample Size Sponsor Location/Country
1. NCT01010009 The Cognitive and Cerebral Blood Flow Effects of Resveratrol Completed
PHASE: Not Applicable		 Cognitive and Cerebral Blood Flow Effects of Resveratrol 24 participants North Umbria University North Umbria University
Newcastle upon Tyne, United Kingdom
2. NCT01964846 Effect of Antioxidant Intake on Cardiovascular Risk Completed
PHASE: Not Applicable		 Effect of Resveratrol and Curcumin on Inflammation 22 participants Laval University
Atrium Innovations		 Institute on Nutrition and Functional Foods (INAF), Laval University
Québec City, Quebec, Canada
3. NCT02475564 Resveratrol for Pain Due to Endometriosis (ResvEndo) Completed
Phase 4		 Endometriosis 44 participants Hospital de Clinicas de Porto Alegre HCPA
Porto Alegre, RS, Brazil
4. NCT03446625 Resveratrol as a Preventive Treatment of OHSS (RES-OHSS) Completed
Phase 3		 Infertility 70 participants IVI Madrid Ivi Madrid
Madrid, Spain
5. NCT03352895 The Effects of Resveratrol on the Complications of Patients With Hemodialysis Completed
PHASE: Not Applicable		 Chronic Kidney Disease 36 participants Dalin Tzu Chi General Hospital Dalin Tzu Chi Hospital
Chiayi City, Taiwan
6. NCT01324089 Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol Completed
Phase: Not Applicable		 Focus of the Study: Normal Volunteers 24 participants University of Wisconsin, Madison
National Institutes of Health (NIH)
National Cancer Institute (NCI)		 University of Wisconsin
Madison, Wisconsin, United States
7. NCT01677611 Effects of Resveratrol in Patients With Type 2 Diabetes (RED) Completed
Phase 1		 Type 2 Diabetes 10 participants Khoo Teck Puat Hospital
National Medical Research Council (NMRC), Singapore		 Alexandra Health, Khoo Teck Puat Hospital
Singapore, Singapore
8. NCT02433925 Resveratrol’s Effects on Inflammation and Oxidative Stress in Chronic Kidney Disease Completed
Phase 3		 Chronic Renal Insufficiency 20 participants Universidade Federal Fluminense No Contacts or Locations Provided
9. NCT02621554 Impact of Resveratrol on Brain Function and Structure Completed
Phase: Not Applicable		 Healthy 60 participants Max Planck Institute for Human Cognitive and Brain Sciences
University of Leipzig
Evolva SA		 Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences
Leipzig, Germany
10. NCT01492114 Anti-inflammatory and Antioxidant Effects of Resveratrol on Healthy Adults Completed
Phase 3		 Chronic Subclinic Inflammation
Redox Status		 40 participants University of Turin, Italy Simona Bo
Turin, Italy
11. CTRI/2011/05/001731 Evaluation of Resveratrol as a Dietary Supplement in Type 2 Diabetes Mellitus Applicable only for Completed/Terminated trials
Phase 4		 Type 2 Diabetes Mellitus 60 participants Dr MJ Nanjan
JSS College of Pharmacy, (Off Campus of JSS University, Mysore) Post Box 20, Rocklands, Ootacamund-643001 The Nilgiris, Tamilnadu
Research institution		 Outpatient Department of Government headquarter hospital, Ootacamund, Tamil Nadu
12. CTRI/2017/04/008384 A study to check whether addition of Resveratrol is beneficial and safe in patients with Diabetes, Dyslipidemia and Hypertension (who are already on standard therapy) Phase 4
Completion date missing		 Dyslipidemia, Diabetes and hypertension 180 participants Rakesh Ojha
Dept of Pharmacology, Uka Tarsadia University, Gopal Vidyanagar, Bardoli Mahuva Road,, Tarsadi, Bardoli, Surat, Pin code: 394350		 Department of Medicine, Vikas Hospital,
Maharashtra
13. CTRI/2017/04/008376 To study the effects of nutritional supplementation of resveratrol on fatigue and quality of life in patients with advanced cancers undergoing chemotherapy. Applicable only for Completed/Terminated trials
N/A		 Patients diagnosed with advanced cancers undergoing non-biological, second-line chemotherapy. 40 participants Dr Vijay Agarwal
HCG Towers, No. 8, P. Kalinga Rao Road, Sampangi Ram Nagar, Bangalore-560027		 HealthCare Global Specialty Hospital,
Karnataka
14. CTRI/2017/09/009694 To study the effects of nutritional supplementation of extremely active resveratrol (XAR) in healthy human individuals. Applicable only for Completed/Terminated trials
N/A		 Healthy human volunteers not suffering from any disease 100 participants Epigeneres Biotech Pvt Ltd.
A-206, Dalamal Towers, Free Press Journal Marg, Nariman Point, Mumbai-400021		 National facility for Biopharmaceutical,
Maharashtra
15. CTRI/2018/03/012459 A study to assess the effect of Resveratrol and Copper in reducing toxic side-effects of chemotherapy in patients with advanced mouth cancer. Applicable only for Completed/Terminated trials
N/A		 Operable stage IV squamous cell carcinoma of buccal mucosa patients planned for surgery who have not received any prior treatment. 25 participants TMC Research Administrative Council
Department of Atomic Energy, Government of India; Tata Memorial Centre; Parel. Mumbai. India. PIN:400011
Government funding agency		 Tata Memorial Hospital, Maharashtra
16. CTRI/2019/06/019500 To study the effect of Resveratrol-Copper in reducing oral mucositis in patients receiving concurrent chemo-radiotherapy for locally advanced oropharyngeal cancer. Applicable only for Completed/Terminated trials
Phase 2		 Malignant neoplasm of oropharynx, unspecified 102 participants Tata Memorial Hospital
Dr. E Borges Road, Parel, Mumbai, Maharashtra 400012
Research institution and hospital		 Tata Memorial Hospital, Mumbai, Maharashtra
17. CTRI/2019/07/020289 Addition of resveratrol copper with chemotherapy in gastric cancer patients Applicable only for Completed/Terminated trials
Phase 2		 Malignant neoplasm of stomach, unspecified 42 participants Tata Memorial Hospital
Dr Ernest Borges Marg Parel Mumbai
Research institution and hospital		 Tata Memorial Hospital, Maharashtra
18. CTRI/2020/06/026256 Resveratrol and copper for the treatment of COVID-19 pnuemonia. Applicable only for Completed/Terminated trials
N/A		 Coronavirus as the cause of diseases classified elsewhere 230 participants TopiwalaNational Medical College and BYL Nair charitable Hospital
Dr Anandrao Nair Marg, Mumbai Central, Mumbai, Maharashtra 400008
Government Medical college		 T.N.M.C and B.Y.L.Nair Hospital, Maharashtra
19. CTRI/2020/09/027794 Role of Copper in addition to whole brain radiotherapy in brain metastases in lung cancer Applicable only for Completed/Terminated trials
Phase 2		 Malignant neoplasm of unspecifiedpart of bronchus or lung 120 participants Jai Prakash Agarwal
Room No 1131, Homi Bhabha Block, Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai		 Tata Memorial Hospital, Maharashtra
20. CTRI/2020/10/028476 Study to assess the effect of oral resveratrol and copper combination on life span of glioblastoma patients undergoing surgery. Applicable only for Completed/Terminated trials
Phase 1/ Phase 2		 Other specified disorders of brain 66 participants Tata Memorial Centre TMC
Tata Memorial Hospital Dr E Borges Road Parel Mumbai
Research institution and hospital		 Tata Memorial Hospital, Maharashtra
21 NCT01339884 A Study of Resveratrol as Treatment for Friedreich Ataxia Completed
Phase 1
Phase 2		 Friedreich Ataxia 27 participants Murdoch Children’s Research Institute
Friedreich’s Ataxia Research Alliance		 Monash Medical Centre, Southern Health
Clayton, Melbourne, Victoria, Australia
22. ChiCTR2100043997 A dose-response study of dietary resveratrol on glucose and lipid metabolism disorder Recruiting glucose and lipid metabolism disorder 40 participants Department of Nutrition, School of Public Health, Sun Yat-Sen University Huanghuagang Street Community Health Service Center, Yuexiu District, Guangzhou City, China
23. ACTRN12609000023257 Acute effects of resveratrol on circulatory function in obese people with elevated blood pressure. Completed
Phase
Not Applicable		 Endothelial vasodilator function
Blood pressure response to exercise		 20 participants Professor Peter Howe
Nutritional Physiology Research Centre
University of South Australia, PO Box 2471
Adelaide, South Australia, 5001
Australia		 Nutritional Physiology Research Centre
University of South Australia, PO Box 2471
Adelaide, South Australia, 5001
24. ACTRN12611000060943 Sustained effects of resveratrol on circulatory function in obese adults Completed
Phase
Not Applicable		 Endothelial vasodilator function
Cognitive function		 30 participants Professor Peter Howe
Nutritional Physiology Research Centre,
University of South Australia
PO Box 2471
Adelaide, 5001
Australia

Dr Narelle Berry
University of South Australia
PO Box 2471
Adelaide, 5001
Australia		 Clinical Nutrition Research Centre
University of Newcastle
School of Biomedical Sciences & Pharmacy
Callaghan NSW 2308
Australia
25. ACTRN12611000560998 Resveratrol in the prevention of colorectal polyps Completed
Phase
Not Applicable		 high risk/familial risk of colorectal cancer 128 participants Melbourne Health
Royal Melbourne Hospital City Campus, Grattan St, Parkville. Vic 3050
Australia

Australian Wine Research Insititute
PO Box 197, Glen Osmond SA 5064
Australia		 Level 3 Centre,
Department of Colorectal Medicine & Genetics
Royal Melbourne Hosptial
Parkville, VIC, 3050
Australia
26. ACTRN12611001288910 The effect of resveratrol in red wine on cognitive function in older adults: Preliminary study Completed
Phase
Phase 1/Phase 2		 Cognitive function in older adults
Absorption rates of resveratrol		 2 participants Swinburne University of Technology
PO Box 218
Hawthorn VIC 3122
Australia		 H24, Po Box 218 Hawthorn, Vic, 3122
Australia
27. ACTRN12613000717752 The effect of resveratrol supplementation on gut hormone secretion, gastric emptying, and blood glucose responses to meals in patients with type 2 diabetes Completed
Phase
Phase 2		 type 2 diabetes mellitus 15 participants Royal Adelaide Hospital
North Terrace Adelaide South Australia 5000
Australia		 Discipline of Medicine Royal Adelaide Hospital North Terrace Adelaide SA 5000
Australia
28. ACTRN12615000291583 Assisting post-menopausal women towards healthy aging-can resveratrol enhance mood, physical function and cerebrovascular function and counteract cognitive decline? Completed
Phase
Phase 3		 Menopause
Cognitive function		 80 participants University of Newcastle
University Drive
Callaghan NSW 2308
Australia		 Clinical Nutrition Research Centre
School of Biomedical Sciences & Pharmacy
Medical Sciences Building, MS 514
University of Newcastle
University Drive
Callaghan NSW 2308
Australia
29. DRKS00021683 Bioavailability of three different Resveratrol products in healthy subjects—a randomized, double-blind three-way cross-over study complete
Phase: N/A		 Resveratrol Bioavailability 15 participants Wacker Chemie AG
Ms. Rachela Mohr
Hanns-Seidel-Platz 4
81737 München
Germany		 Biotesys GmbH, Esslingen am Neckar
30. DRKS00004311 Biokinetic studies on the impact of formulation on resveratrol bioavailability complete
Phase: N/A		 metabolism of resveratrol in healthy volunteers 12 participants Max Rubner-Institut
Haid-und-Neu-Str. 9
76131 Karlsruhe
Germany		 Max Rubner-Institut, Karlsruhe
31. DRKS00008788 Investigation on the bioavailability and metabolism of resveratrol an ingredient of berries in humans complete
Phase: N/A		 healthy volunteers 100 participants Max Rubner-InstitutBundesforschungsinstitut für Ernährung und Lebensmittel
Haid-und-Neu-Str.9
76131 Karlsruhe
Germany		 Max Rubner-Institut; Bundesforschungsinstitut für Ernährung und Lebensmittel, Karlsruhe

5. Recent Patent on Resveratrol

The medicinal advantages and other beneficial features of RVT have drawn the attention of numerous researchers to investigate and develop some intellectual property in the form of patents; some of them are included in Table 4.
Table 4. List of Patent on Resveratrol Globally.
S. No. Patent Publication Number Country Title of the Patent Details of the Invention
1. US20160215306A1 USA Method for Producing Modified Resveratrol This Invention Generates Glycosylated and Methylated Resveratrol in a Genetically Modified Cell, Through Two Methods, Bioconversion And In Vitro.
2. CN108815116 China Resveratrol Ointment Capable of Curing Pathological Scars, Preparation Method and Application The Invention Reveals Resveratrol Ointment Which Is Capable of Curing Pathological Scars, A Preparation Method and Application.
3. EP2007366 Europe Animal Product Enrichment Using Resveratrol Combining Resveratrol with a Bioavailability Promoter to Make a Bioavailable Resveratrol is one of the methods and systems disclosed herein.
4. US11103465B2 USA Trans-Resveratrol Topical Medication for The Treatment of Pain and Method of Manufacture Thereof A Topical Pain Medication and Method of Their Manufacture. In one Embodiment, The Medication Includes: (1) Enriched Resveratrol Having a Trans Concentration of Resveratrol More Than That of Naturally Occurring Trans-Resveratrol
(2) At Least One Inactive Ingredient Configured to Mix with The Resveratrol to Form the Topical Medication.
5. CN108354915 China Medicine For Treating Cervical Cancer by Formula of Combined Resveratrol and Sodium Pyruvate, And Preparation Method The Invention Reveals a Medicine for Treating Cervical Cancer by A Formula of Combined Resveratrol and Sodium Pyruvate.
6. CN109602702 China Resveratrol Nanoparticles with Brain Targeting Function and Preparation Process Thereof. A Resveratrol Nanoparticle Has Brain Targeting Function.
According To Preparation Provided by The Invention, The Lactoferrin Modified Resveratrol Nanoparticles, Which Enhances the Brain-Targeting and Has an Anti-Ad Effect.
7. CN108042515 China Application of Resveratrol in Preparation of Estrogen Level Adjusting Medicines and Pharmaceutic Preparation of Resveratrol The Invention Discloses Application of Resveratrol in Preparation of Estrogen Level Adjusting Medicines and A Pharmaceutic Preparation of The Resveratrol.
8. CN110339170 China Resveratrol Nanocomposite Powder and Preparation Method Thereof The Invention Discloses Resveratrol Nanocomposite Powder and A Preparation Method.
9. CN103550161 China Resveratrol Loaded Polyurethane Micro-Nano Particle and Preparation Method Thereof The Invention Relates to Resveratrol Loaded Polyurethane Micro-Nano Particles and A Preparation Method Thereof.
10. CN107951870 China Medicinal Composition Containing Resveratrol and Being Capable of Inhibiting Drug-Resisting Staphylococcus Aureus The Invention Belongs to The Field of Pharmacy, And Relates to Compound 3, 4′,5-Trihydroxy-Diphenyl (Resveratrol) And Applications of The Compound 3, 4′,5-Trihydroxy-Diphenyl (Resveratrol) In Preparing Sensitivity Enhancing Medicines of Methicillin-Resistant Staphylococcus Aureus Capable of Resisting Fluoroquinolones.
11. CN102276667 China High-Efficiency Anti-Liver Cancer Resveratrol Prodrug and Synthetic Method Thereof The Invention Discloses High-Efficiency Anti-Liver Cancer Resveratrol Prodrug and Synthetic Method Thereof.
12. CN107213142 China Application Of Oxidized Resveratrol and Combined Oxidized Resveratrol and Antibiotic in Preparation of Anti-Fungal-Infection Product The Invention Relates to Application of Oxidized Resveratrol and Combined Oxidized Resveratrol and Antibiotic in The Preparation of An Anti-Fungal-Infection Product, Belonging to The Technical Field of Medicines.
13. CN106176772 China Health care food containing resveratrol and preparing method of health-care food The Invention Relates to A Health-Care Food Containing Resveratrol and A Preparing Method of The Health-Care Food.
14. CN101371827 China Resveratrol Composition for Delaying Age The Invention Relates to An Anti-Aging Combination of Resveratrol. The Technical Proposal of The Invention Is That the Anti-Aging Combination Consists of Resveratrol and Quercetin, And the Compatibility Proportion Is 40–350 mg Of Resveratrol And 8–200 mg Of Quercetin.
15. CN107281107 China Polyethylene Glycol Modified Resveratrol Magnetic Nanoliposomes and Preparation Method Thereof The Invention Discloses Polyethylene Glycol Modified Resveratrol Magnetic Nanoliposomes Covered with Ferro Ferric Oxide.
16. CN110041173 China Novel Resveratrol as well as Derivative Synthesis Method and Application Thereof The Invention Belongs to The Technical Field of Organic Synthesis and Discloses Novel Resveratrol as Well as A Derivative Synthesis Method and Application Thereof.
17. CN111423444 China Resveratrol-Temozolomide Eutectic Crystal and Preparation Method and Application Thereof The Invention Aims to Provide Resveratrol-Temozolomide Eutectic Crystal, that can improve the Solubility of Medicine, Improve the Stability and Improve the Bioavailability, and Also Provides a Preparation Method and Application of The Resveratrol-Temozolomide Eutectic Crystal.
18. WO2006000603 Spain Use Of Trans-Resveratrol as Therapeutic Agent for the Treatment of Male Infertility and/or Subfertility in Mammals The Invention Relates to The Use of Trans-Resveratrol as A Therapeutic Agent for The Treatment of Male Infertility and/or Subfertility in Mammals.
19. EP1076556 Europe Administration Of Resveratrol to Prevent or Treat Restenosis Following Coronary Intervention A Method for Preventing or Treating Restenosis and For Preventing the Recurrence or Progression of Coronary Heart Disease Is Provided.
20. JP2016088858 Japan Resveratrol Derivative that Generates Hydrogen and Exhibits Keratin Producing Action and Method for Producing the Derivative To provide a Resveratrol Derivative that Generates Hydrogen and Exhibits Keratin Producing Action, which is Useful as A Cosmetic, Food Preparation, Medicine, And, Especially When used in Cosmetic, Expected to Improve Degradation of Sebum, Moisture Holding Power of Skin, And Resilience of Skin.
21. EP3082780 Europe Combination of Bezafibrate and of Resveratrol or Resveratrol Derivatives for Treatment and Prevention of diseases involving a Mitochondrial energy dysfunction The Present Invention Relates to the combined use of bezafibrate and of Resveratrol and its derivatives for the treatment of diseases involving mitochondrial energy dysfunction, and also to a pharmaceutical kit comprising both Bezafibrate and Resveratrol and its derivatives.
22. ES2685094T3 Spain Cosmetics composition containing Resveratrol Resveratrol, A Component of a Variety of Common Edible Plants, Including Peanuts and Red Grapes, Is A Phytoestrogen.
23. CN101579291 China Resveratrol Phospholipid Composite Nano-Emulsion and Preparation Method and Application Thereof The Invention discloses Resveratrol Phospholipid composite Nano-Emulsion and preparation method and application Thereof.
24. EP1138323 Europe Resveratrol For the Treatment of Exfoliative Eczema, Acne or Psoriasis The Use of Resveratrol (3,4′,5-Trihydroxy-Trans-Stilbene) and Derivatives Thereof, for the Preparation of Medicaments for the Treatment of Exfoliative Eczema, Acne and Psoriasis, Topical Pharmaceutical Formulations Containing Resveratrol or Derivatives Thereof in Combination with Other active principles.
25. CN102000045 China Application Of Resveratrol in Preparing Medicament for Preventing and Treating Radiation Induced Depigmentation Skin Disease The Invention Discloses Application of Resveratrol in Preparing a Medicament for Preventing and Treating Radiation Induced Depigmentation Skin Disease.
26. KR1020080012483 South korea Transgenic Rice Containing Resveratrol Having Medicinal Effects on Cancer, Hyperlipidemia and Thrombosis Rice Containing Resveratrol Having Anticancer, Anti-Hyperlipidemia and Antithrombic Effects in Rice by Using a Gene Encoding Resveratrol, so that the Rice is useful for Production of Various Processed Products including Food, Cosmetics, Drink and Fodder.
27. WO2015126129 Korea Resveratrol Multimer Having Selective Inhibitory Activity for Hepatitis C Virus Genome Replication, and Use Thereof Invention Concerns Resveratrol Multimer with Selective Inhibitory Activity for Hepatitis C Virus Genome Replication and Its Use, And More Particularly a Pharmaceutical Composition for Preventing or Treating Hepatitis C, Containing the Same.
28. CN110812360 China Application Of Resveratrol and Combination of Resveratrol and Ketoconazole in Preparation of Medicaments for Resisting Fungal Infection Diseases The Invention Discloses an Application of Resveratrol and Combination of Resveratrol and Ketoconazole in Preparation of Medicaments for Resisting Fungal Infection Diseases.
29. EP2249806 Europe Resveratrol Formulations Resveratrol Can Be Used in Large Quantity to Treat or Inhibit the Onset of Many Diseases that Are Related to The Aging Process. the Present Invention Provides Concentrated Liquid Formulations of Resveratrol, typically having a Resveratrol Concentration of at least 10% By Weight.
30. WO2011097691 Brazil Composition containing resveratrol and its Derivatives Thereof and Plant Oil, Process for Producing Said Composition, Nutraceutical and/or Pharmaceutical Product, and Method for Enhancing the Potential of Resveratrol Chemical has been developed to produce substances that have anti-inflammatory, antiviral, cardiovascular, neuroprotective and cancer-preventive properties
31. US6572882B1 USA Compositions based on resveratrol Cancer Chemo preventive Activity of Resveratrol, a Natural Product Derived from Grapes
32. US6414037B1 USA Pharmaceutical formulations of resveratrol and methods of use thereof Historical context, evaluation of the transformation assay, and evolution and optimization of the transformation assay methodology in C3H10T1/2 C18 mouse embryo fibroblasts.
33. US10780056 USA Resveratrol delivery system The potential of resveratrol as a treatment for neurodegenerative and other diseases must be thoroughly investigated.
34. US8642660 USA The influential patent that’s driving anti-aging research It could one day lead to treatment for parkinson’s and alzheimer’s slow down aging or even extended life expectancy.

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Shivani Khattar
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Sauban Ahmed Khan
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Syed Amir Azam Zaidi
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Mahdi Darvishikolour
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Uzma Farooq
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Punnoth Poonkuzhi Naseef
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Mohamed Saheer Kurunian
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Mohammed Zaafar Khan
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Athar Shamim
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Mohd Masih Uzzaman Khan
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Zeenat Iqbal
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Mohd. Aamir Mirza
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Update Date: 29 Aug 2022
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