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Topic Review
Glass–Ceramics
Owing to their combinations of unique properties of sintered ceramics and the distinctive characteristics of glasses, glass-ceramics have attracted great interest from both academia and industry worldwide since their accidental discovery in 1953.
  • 6.7K
  • 27 Oct 2020
Topic Review
Smart Waste Management and Classification Systems
Waste management requires necessary processes and activities to dominate from its inception to demolition. Waste comes in solid, liquid, or gaseous form, and every type of waste demands a different method of classification, disposal, and management. Waste management deals with every waste category, including household, organic, industrial, municipal, biomedical, organic, biological, and radioactive waste. Any unnecessary substance or substance with no use is called “waste”. Waste management involves the collection of the waste and its transport and disposal to appropriate locations. In the European Union (EUROPA), 423 million tons or 56% of domestic waste was recycled in 2016. Reports reflect the need for proper household waste management for the recycling process. Most of the Earth’s population will emigrate from rural to urban areas in the coming years. Therefore, bigger cities will require a highly sustainable infrastructure and smart waste management system to fulfill the fundamental needs of its citizens and provide them with a good service for the future.
  • 6.7K
  • 06 Sep 2022
Topic Review
The Fibrosis-4 (FIB-4) Index
The fibrosis-4 (FIB-4) index is the first triaging tool for excluding advanced fibrosis because of its accuracy, simplicity, and cheapness, especially for general physicians or endocrinologists, although the FIB-4 index has several drawbacks. Accumulating evidence has suggested that vibration-controlled transient elastography (VCTE) and the enhanced liver fibrosis (ELF) test may become useful as the second step after triaging by the FIB-4 index. The leading cause of mortality in MAFLD is cardiovascular disease (CVD), extrahepatic malignancy, and liver-related diseases. MAFLD often complicates chronic kidney disease (CKD), resulting in increased simultaneous liver kidney transplantation. The FIB-4 index could be a predictor of not only liver-related mortality and incident hepatocellular carcinoma, but also prevalent and incident CKD, CVD, and extrahepatic malignancy.
  • 6.7K
  • 25 May 2021
Topic Review
Muesli
Muesli (/ˈmjuːzli/ MEWZ-lee; Template:Lang-gsw Template:IPA-gsw, non-Swiss Standard German: Müsli [ˈmyːsli] (listen)) is a cold oatmeal dish based on rolled oats and ingredients like grains, nuts, seeds and fresh or dried fruits. This mix may be combined with one or more liquids like milk, almond milk, other plant milks, yogurt, or fruit juice and left for a time to soften the oats before being consumed. Developed around 1900 by Swiss physician Maximilian Bircher-Benner for patients in his hospital, it is now eaten as a standard breakfast dish, and also in Switzerland as a supper called Birchermüesli complet: muesli with Café complet (milk coffee, accompanied with bread, butter, and jam. (Butterbrot)).
  • 6.7K
  • 15 Nov 2022
Topic Review
Nanotechnology in Warfare
Nanotechnology in Warfare is a branch of nano-science in which molecular systems are designed, produced and created to fit a nano-scale (1-100nm). The application of such technology, specifically in the area of warfare and defence, has paved the way for future research in the context of weaponisation. Nanotechnology unites a variety of scientific fields including material science, chemistry, physics, biology and engineering. Advancements in this area, have led to categorised development of such nano-weapons with classifications varying from; small robotic machines, hyper-reactive explosives, and electromagnetic super-materials. With this technological growth, has emerged implications of associated risks and repercussions, as well as regulation to combat these effects. These impacts give rise to issues concerning global security, safety of society, and the environment. Legislation may need to be constantly monitored to keep up with the dynamic growth and development of nano-science, due to the potential benefits or dangers of its use. Anticipation of such impacts through regulation, would 'prevent irreversible damages' of implementing defence related nanotechnology in warfare.
  • 6.7K
  • 02 Nov 2022
Topic Review
Tirukkuṛaḷ
The Tirukkural (திருக்குறள், literally Sacred Verses), or shortly the Kural, is a classic Tamil language text consisting of 1,330 short couplets of seven words each, or Kurals. The text is divided into three books, each with aphoristic teachings on virtue (aram, dharma), wealth (porul, artha) and love (inbam, kama). Considered one of the greatest works on ethics and morality, it is known for its universality and secular nature. Its authorship is traditionally attributed to Valluvar, also known in full as Thiruvalluvar. The text has been dated variously from 300 BCE to 5th century CE. The traditional accounts describe it as the last work of the third Sangam, but linguistic analysis suggests a later date of 450 to 500 CE and that it was composed after the Sangam period. The Kural is traditionally praised with epithets and alternate titles such as "the Tamil Veda" and "the divine book." It emphasizes non-violence and moral vegetarianism as virtues for an individual.[a] In addition, it highlights truthfulness, self-restraint, gratitude, hospitality, kindness, goodness of wife, duty, giving, and so forth, besides covering a wide range of social and political topics such as king, ministers, taxes, justice, forts, war, greatness of army and soldier's honor, death sentence for the wicked, agriculture, education, abstinence from alcohol and intoxicants. It also includes chapters on friendship, love, sexual union, and domestic life. The Kural has been widely admired by scholars and influential leaders across the ethical, social, political, economical, religious, philosophical, and spiritual spheres over its history. These include Ilango Adigal, Kambar, Leo Tolstoy, Mahatma Gandhi, Albert Schweitzer, Constantius Joseph Beschi, Karl Graul, George Uglow Pope, Alexander Piatigorsky, and Yu Hsi. The text has been translated into at least 40 Indian and non-Indian languages. The Kural is considered a masterpiece and one of the most important texts of the Tamil Literature. The Tamil people and the government of Tamil Nadu have long celebrated and upheld the text with reverence.
  • 6.7K
  • 10 Oct 2022
Topic Review
Pet Husbandry
Pet husbandry is the practices applied in day-to-day care of animal companions, which can greatly impact animal welfare. Pet husbandry include: (1) origin of pets; (2) number and type of pets in the household; (3) diet type and feeding practices; (4) living environment and daily activities; (5) preventive treatment for parasites and vaccination; (6) regular veterinary check-ups and access to health care; and (7) compliance with legal requirements and identification.
  • 6.7K
  • 29 Oct 2020
Topic Review
Burnside-Butler Syndrome Genotype-Phenotype Associations
The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most common cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing. Clinical findings in Burnside-Butler syndrome include developmental and motor delays, congenital abnormalities, learning and behavioral problems, and abnormal brain findings. To better define symptom presentation, we performed comprehensive cognitive and behavioral testing, collected medical and family histories, and conducted clinical genetic evaluations. The 15q11.2 BP1-BP2 region includes the TUBGCP5, CYFIP1, NIPA1, and NIPA2 genes. To determine if additional genomic variation outside of the 15q11.2 region influences expression of symptoms in Burnside-Butler syndrome, whole-exome sequencing was performed on the parents and affected children for the first time in five families with at least one parent and child with the 15q1l.2 BP1-BP2 deletion. In total, there were 453 genes with possibly damaging variants identified across all of the affected children. Of these, 99 genes had exclusively de novo variants and 107 had variants inherited exclusively from the parent without the deletion. There were three genes (APBB1, GOLGA2, and MEOX1) with de novo variants that encode proteins evidenced to interact with CYFIP1. In addition, one other gene of interest (FAT3) had variants inherited from the parent without the deletion and encoded a protein interacting with CYFIP1. The affected individuals commonly displayed a neurodevelopmental phenotype including ASD, speech delay, abnormal reflexes, and coordination issues along with craniofacial findings and orthopedic-related connective tissue problems. Of the 453 genes with variants, 35 were associated with ASD. On average, each affected child had variants in 6 distinct ASD-associated genes (x¯ = 6.33, sd = 3.01). In addition, 32 genes with variants were included on clinical testing panels from Clinical Laboratory Improvement Amendments (CLIA) approved and accredited commercial laboratories reflecting other observed phenotypes. Notably, the dataset analyzed in this study was small and reported results will require validation in larger samples as well as functional follow-up. Regardless, we anticipate that results from our study will inform future research into the genetic factors influencing diverse symptoms in patients with Burnside-Butler syndrome, an emerging disorder with a neurodevelopmental behavioral phenotype.
  • 6.7K
  • 25 Mar 2021
Topic Review
Sea Urchin
Sea urchins (/ˈɜːrtʃɪnz/) are spiny, globular echinoderms in the class Echinoidea. About 950 species of sea urchin live on the seabed of every ocean and inhabit every depth zone — from the intertidal seashore down to 5,000 metres (16,000 ft; 2,700 fathoms). The spherical, hard shells (tests) of sea urchins are round and spiny, ranging in diameter from 3 to 10 cm (1 to 4 in). Sea urchins move slowly, crawling with tube feet, and also propel themselves with their spines. Although algae are the primary diet, sea urchins also eat slow-moving (sessile) animals. In the food chain, the predators who eat sea urchins are the sea otter and the starfish, the wolf eel, the triggerfish, and human beings. Adult sea urchins have fivefold symmetry, but their pluteus larvae feature bilateral (mirror) symmetry, indicating that the sea urchin belongs to the Bilateria group of animal phyla, which also comprises the chordates and the arthropods, the annelids and the molluscs, and are found in every ocean and in every climate, from the tropics to the polar regions, and inhabit marine benthic (sea bed) habitats, from rocky shores to hadal zone depths. The fossil record of the Echinoids dates from the Ordovician period, some 450 million years ago; the closest echinoderm relatives of the sea urchin are the sea cucumbers (Holothuroidea); both are deuterostomes, a clade that includes the chordates. The animals have been studied since the 19th century as model organisms in developmental biology, as their embryos were easy to observe; this has continued with studies of their genomes because of their unusual fivefold symmetry and relationship to chordates. Species such as the slate pencil urchin are popular in aquariums, where they are useful for controlling algae. Fossil urchins have been used as protective amulets.
  • 6.7K
  • 19 Oct 2022
Topic Review
Context Collapse
Context collapse refers to the phenomenon in digital communication where distinct social spheres or contexts intersect, leading to challenges in managing audience expectations, privacy boundaries, and self-presentation. It occurs when content intended for one audience becomes visible to multiple, potentially disparate audiences, blurring the boundaries between personal, professional, and social identities online. Context collapse often raises concerns about privacy, authenticity, and social repercussions in digital environments.
  • 6.7K
  • 08 Feb 2024
Topic Review Peer Reviewed
Teachers’ Professional Digital Competence
Teachers’ professional digital competence (PDC) refers to digital competence specific to the teaching profession. PDC serves a dual purpose: it encompasses a range of instrumental, professional, ethical, critical, and epistemic dimensions related to, on the one hand, teaching with digital tools and resources and, on the other hand, teaching pupils about digital technologies, digital skills, digital cultural expression, and broader digital and critical competences relevant to study, work, and everyday life. Teachers’ PDC is a dynamic concept that evolves in step with societal development and technological advancement.
  • 6.7K
  • 17 Sep 2025
Topic Review
Lipid-Based Nanoparticles
COVID-19 vaccines have been developed with unprecedented speed which would not have been possible without decades of fundamental research on delivery nanotechnology. Lipid-based nanoparticles have played a pivotal role in the successes of COVID-19 vaccines and many other nanomedicines, such as Doxil® and Onpattro®, and have therefore been considered as the frontrunner in nanoscale drug delivery systems. In this review, we aim to highlight the progress in the development of these lipid nanoparticles for various applications, ranging from cancer nanomedicines to COVID-19 vaccines. The lipid-based nanoparticles discussed in this review are liposomes, niosomes, transfersomes, solid lipid nanoparticles, and nanostructured lipid carriers. We particularly focus on the innovations that have obtained regulatory approval or that are in clinical trials. We also discuss the physicochemical properties required for specific applications, highlight the differences in requirements for the delivery of different cargos, and introduce current challenges that need further development. This review serves as a useful guideline for designing new lipid nanoparticles for both preventative and therapeutic vaccines including immunotherapies.
  • 6.7K
  • 19 May 2021
Topic Review
Cathode Ray Tube
The cathode ray tube (CRT) is a vacuum tube that contains one or more electron guns and a phosphorescent screen, and is used to display images. It modulates, accelerates, and deflects electron beam(s) onto the screen to create the images. The images may represent electrical waveforms (oscilloscope), pictures (television, computer monitor), radar targets, or other phenomena. CRTs have also been used as memory devices, in which case the visible light emitted from the fluorescent material (if any) is not intended to have significant meaning to a visual observer (though the visible pattern on the tube face may cryptically represent the stored data). In television sets and computer monitors, the entire front area of the tube is scanned repetitively and systematically in a fixed pattern called a raster. An image is produced by controlling the intensity of each of the three electron beams, one for each additive primary color (red, green, and blue) with a video signal as a reference. In all modern CRT monitors and televisions, the beams are bent by magnetic deflection, a varying magnetic field generated by coils and driven by electronic circuits around the neck of the tube, although electrostatic deflection is commonly used in oscilloscopes, a type of electronic test instrument. A CRT is constructed from a glass envelope which is large, deep (i.e., long from front screen face to rear end), fairly heavy, and relatively fragile. The interior of a CRT is evacuated to approximately 0.01 pascals (9.9×10−8 atm) to 133 nanopascals (1.31×10−12 atm), evacuation being necessary to facilitate the free flight of electrons from the gun(s) to the tube's face. The fact that it is evacuated makes handling an intact CRT potentially dangerous due to the risk of breaking the tube and causing a violent implosion that can hurl shards of glass at great velocity. As a matter of safety, the face is typically made of thick lead glass so as to be highly shatter-resistant and to block most X-ray emissions, particularly if the CRT is used in a consumer product. Since the late 2000s, CRTs have been largely superseded by newer "flat panel" display technologies such as LCD, plasma display, and especially OLED displays, which in the case of LCD and OLED displays have lower manufacturing costs and power consumption, as well as significantly less weight and bulk. Flat panel displays can also be made in very large sizes; whereas 38 to 40 in (97 to 102 cm) was about the largest size of a CRT television, flat panels are available in 60 in (150 cm) and larger sizes.
  • 6.7K
  • 02 Dec 2022
Topic Review
Uterosacral Ligament
The uterosacral ligaments (USLs) are extraperitoneal structures that extend backward from the posterior surface of the cervix and upper vagina to the second-to-fourth sacral vertebrae, forming the lateral boundaries of the rectouterine and rectovaginal spaces. They are composed mainly of connective tissue along with vessels and splanchnic nerve fibers.
  • 6.7K
  • 08 Feb 2021
Topic Review
Hindu Views on Monotheism
Hinduism incorporates diverse views on the concept of God. Different traditions of Hinduism have different theistic views, and these views have been described by scholars as polytheism, monotheism, henotheism, panentheism, pantheism, monism, agnostic, humanism, atheism or Nontheism. Monotheism is the belief in a single creator God and the lack of belief in any other Creator. Hinduism is not a monolithic faith and different sects may or may not posit or require such a belief. Religion is considered a personal belief in Hinduism and followers are free to choose the different interpretations within the framework of Karma and reincarnation. Many forms of Hinduism believe in a monotheistic God, such as Krishna followers, Vedanta, Arya samaj, Samkhya school of Vedas etc, Many traditions within Hinduism share the Vedic idea of a metaphysical ultimate reality and truth called Brahman instead. According to Jan Gonda, Brahman denoted the "power immanent in the sound, words, verses and formulas of Vedas" in the earliest Vedic texts. The early Vedic religious understanding of Brahman underwent a series of abstractions in the Hindu scriptures that followed the Vedic scriptures. These scriptures would reveal a vast body of insights into the nature of Brahman as originally revealed in the Vedas. These Hindu traditions that emerged from or identified with the Vedic scriptures and that maintained the notion of a metaphysical ultimate reality would identify that ultimate reality as Brahman. Hindu adherents to these traditions within Hinduism revere Hindu deities and, indeed, all of existence, as aspects of the Brahman. The deities in Hinduism are not considered to be almighty, omnipotent, omniscient and omnibenevolent, and spirituality is considered to be seeking the ultimate truth that is possible by a number of paths. Like other Indian religions, in Hinduism, deities are born, they live and they die in every kalpa (eon, cycle of existence). In Hindu philosophy, there are many different schools. Its non-theist traditions such as Samkhya, early Nyaya, Mimamsa and many within Vedanta such as Advaita do not posit the existence of an almighty, omnipotent, omniscient, omnibenevolent God (monotheistic God), while its theistic traditions posit a personal God left to the choice of the Hindu. The major schools of Hindu philosophy explain morality and the nature of existence through the karma and samsara doctrines, as in other Indian religions. Contemporary Hinduism can be categorized into four major traditions: Vaishnavism, Shaivism, Shaktism, and Smartism. Vaishnavism, Shaivism, and Shaktism worship Vishnu, Shiva, and Devi — the Divine Mother — as the Supreme respectively, or consider all Hindu deities as aspects of the formless Supreme Reality or Brahman. Other minor sects such as Ganapatya and Saura focus on Ganesha and Surya as the Supreme. A sub-tradition within the Vaishnavism school of Hinduism that is an exception is dualistic Dvaita, founded by Madhvacharya in the 13th-century (where Vishnu as Krishna is a monotheistic God). This tradition posits a concept of monotheistic God so similar to Christianity that Christian missionaries in colonial India suggested that Madhvacharya was likely influenced by early Christians who migrated to India, a theory that has been discredited by scholars. Furthermore, many adherents consider these similarities to be superficial and insubstantial; for example, Madhvacharya postulates three co-eternal fundamental realities, consisting of Supreme Being (Vishnu or paramathma), individual souls (jīvātman), and inanimate matter.
  • 6.7K
  • 15 Nov 2022
Topic Review
Quantum Biology and Non-Targeted Effects
Non-targeted effects (NTE) are an intriguing phenomenon where the biological responses observed in cells or tissues are not directly exposed to a stressor (e.g., ionizing radiation or chemical agents). onventional radiation biology approaches have predominantly focused on the macroscopic effects of ionizing radiation, overlooking the quantum-scale interactions that may play a crucial role in NTE. Quantum biology (QB) offers a unique perspective to explore and understand the intricate and subtle processes underlying NTE.
  • 6.7K
  • 04 Dec 2023
Topic Review Peer Reviewed
Domestic Environmental Experience Design
The term 'domestic environmental experience' was defined as users' experiences of cognitive perceptions and physical responses to their domestic built environments. Domestic environments can be enriched through the implementation of environmental experience design (EXD) by combining users' environmental, spatial and contextual factors that may accommodate occupants' needs and demands as well as their health and wellbeing. Here, an EXD theoretical concept has been developed based on the 'User-Centred Design' thematical framework.
  • 6.7K
  • 13 Apr 2022
Topic Review
Royal Marriages Act 1772
The Royal Marriages Act 1772 was an act of the Parliament of Great Britain which prescribed the conditions under which members of the British royal family could contract a valid marriage, in order to guard against marriages that could diminish the status of the royal house. The right of veto vested in the sovereign by this act provoked severe adverse criticism at the time of its passage. It was repealed as a result of the 2011 Perth Agreement, which came into force on 26 March 2015. Under the Succession to the Crown Act 2013, the first six people in the line of succession need permission to marry if they and their descendants are to remain in the line of succession.
  • 6.7K
  • 02 Nov 2022
Topic Review
Fedora (Operating System)
Fedora is a Linux distribution developed by the community-supported Fedora Project which is sponsored primarily by Red Hat, a subsidiary of IBM, with additional support from other companies. Fedora contains software distributed under various free and open-source licenses and aims to be on the leading edge of free technologies. Fedora is the upstream source of the commercial Red Hat Enterprise Linux distribution and for CentOS. Fedora is a fork of Red Hat Linux since RHL was discontinued in 2003. Since the release of Fedora 30, five different editions are currently available: Workstation, focused on the personal computer, Server for servers, CoreOS, focused on cloud computing, Silverblue, focused on an immutable desktop specialized to container-based workflows and IoT, focused on IoT devices. (As of February 2016), Fedora has an estimated 1.2 million users, including Linus Torvalds ((As of May 2020)), creator of the Linux kernel.
  • 6.7K
  • 27 Oct 2022
Topic Review
Ex Nihilo
Ex nihilo is Latin for "out of nothing": when phrased as ex nihilo nihil fit, "nothing comes from nothing", it means that the universe was formed from eternal matter; as creatio ex nihilo, "creation out of nothing", it means that matter is not eternal but had to be created by some eternal uncaused cause, frequently defined as God. Creation ex nihilo is a theistic answer to the question of how the universe comes to exist: the Big Bang theory, by contrast, is a scientific theory; it offers no explanation of cosmic existence but only a description of the first few moments of that existence.
  • 6.7K
  • 28 Sep 2022
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