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Topic Review
Locomotion Assistive Devices
Locomotion assistive devices equipped with a microprocessor can potentially automatically adapt their behavior when the user is transitioning from one locomotion mode to another. Many developments in the field have come from machine learning driven controllers on locomotion assistive devices that recognize/predict the current locomotion mode or the upcoming one.
  • 1.0K
  • 24 Nov 2020
Topic Review
Indoor Positioning System
The indoor positioning system (IPS) provides continuous real-time localization of objects or people within an enclosed space in different environments, using a network of transmitters and receivers. Indoor localization is more complex than outdoor localization because the indoor communication channel varies significantly with the environment and depends heavily on many factors, such as building structure, room layout, and construction materials.
  • 1.0K
  • 16 Dec 2022
Topic Review
Detection of Viruses Using Electrochemical Biosensors
Electrochemical biosensors have tremendous potential for point-of-care virus detection due to their portability and simple detection methods. The main limitation of this method is its sensitivity. Numerous studies have been conducted in an attempt to enhance the key elements of electrochemical-based biosensing systems.
  • 1.0K
  • 13 Sep 2022
Topic Review
Sensors Based on Electrical Activity for HR Monitoring
Heart rate (HR) is the rate at which the heart pumps and is measured by the number of contractions (beats) of the heart per minute (bpm). Extramural monitoring opens the way to a prolonged and extended evaluation of the heart rhythm, which has several advantages for both the diagnosis of pathology and the prevention of adverse events related to heart disease.
  • 1.0K
  • 06 Jun 2022
Topic Review
Liquid Biopsy-Based Biosensors
Globally, non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths. The 5-year survival rate has remained at 16% for the past forty years despite advancements in chemotherapy and targeted therapies. Minimal residual disease (MRD) is described as the existence of either isolated tumour cells or circulating tumour cells in biological liquid of patients after removal of the primary tumour without any clinical signs of cancer. Recently, liquid biopsy has been promising as a non-invasive method of disease monitoring and treatment guidelines as an MRD marker. Liquid biopsy could be used to detect and assessment of earlier stages of NSCLC, post-treatment MRD, resistance to targeted therapies, immune checkpoint inhibitors (ICIs) and tumour mutational burden. MRD surveillance has been proposed as a potential marker for lung cancer relapse. Principally biosensors provide the quantitative analysis of various materials by converting biological functions into quantifiable signals. Biosensors are usually operated to detect antibodies, enzymes, DNA, RNA, EVs, and whole cells. Here we present a category of biosensors based on the signal transduction method for identifying biosensor-based biomarkers in liquid biopsy specimens to monitor lung cancer treatment
  • 1.0K
  • 22 Oct 2021
Topic Review
Blood-Plasma Self-Separation in Self-Driven Microfluidics
Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consuming. Therefore, in the Lab-on-a-chip (LOC) field, an effective microfluidic blood plasma separation platform attracts researchers’ attention globally. Blood plasma self-separation technologies are usually divided into two categories: active self-separation and passive self-separation. Passive self-separation technologies, in contrast with active self-separation, only rely on microchannel geometry, microfluidic phenomena and hydrodynamic forces. Passive self-separation devices are driven by the capillary flow, which is generated due to the characteristics of the surface of the channel and its interaction with the fluid. Comparing to the active plasma separation techniques, passive plasma separation methods are more considered in the microfluidic platform, owing to their ease of fabrication, portable, user-friendly features.
  • 1.0K
  • 12 Jul 2021
Topic Review
Actuators for Implantable Devices
The choice of actuators dictates how an implantable biomedical device moves. Specifically, the concept of implantable robots consists of the three pillars: actuators, sensors, and powering. Robotic devices that require active motion are driven by a biocompatible actuator. Depending on the actuating mechanism, different types of actuators vary remarkably in strain/stress output, frequency, power consumption, and durability. Most reviews to date focus on specific type of actuating mechanism (electric, photonic, electrothermal, etc.) for biomedical applications. With a rapidly expanding library of novel actuators, however, the granular boundaries between subcategories turns the selection of actuators a laborious task, which can be particularly time-consuming to those unfamiliar with actuation. 
  • 1.0K
  • 07 Dec 2022
Topic Review
Surface Plasmon Resonance-Based Biosensors for Advanced Bioprocess Monitoring
Biomanufacturers are being incited by regulatory agencies to transition from a quality by testing framework, where they extensively test their product after their production, to more of a quality by design or even quality by control framework. This requires powerful analytical tools and sensors enabling measurements of key process variables and/or product quality attributes during production, preferably in an online manner. As such, the demand for monitoring technologies is rapidly growing. In this context, researchers believe surface plasmon resonance (SPR)-based biosensors can play a role in enabling the development of improved bioprocess monitoring and control strategies.
  • 999
  • 22 Dec 2021
Topic Review
Optoacoustic Imaging
Optoacoustic or photoacoustic imaging (OAI/PAI) has the unique ability and scalability to visualize, monitor, and understand the molecular mechanisms of inflammation.
  • 984
  • 20 May 2021
Topic Review
Finite Element Analysis for Studying Knee Osteoarthritis
Osteoarthritis (OA) is a degenerative disease that affects the synovial joints, especially the knee joint, diminishing the ability of patients to perform daily physical activities. Finite element analysis (FEA) has been considered a promising computational method to be developed for knee OA management. The FEA pipeline consists of three well-established phases: pre-processing (to prepare the model), processing (to solve the mathematical problem), and post-processing (to analyze the results). Each of these phases requires extensive expertise to conduct them properly, as there exist several different approaches with selection-specific limitations.
  • 979
  • 10 Feb 2022
Topic Review
Cr-free High-Temperature Water-Gas Shift Catalysts
Replacement of toxic Cr in the industrial Fe-oxide based High-Temperature Water-Gas Shift (HT-WGS) catalysts has been the focus of intense research in the past decades. In the current manuscript, we examine the promotion effect of Ca, Ni, Co and Ge as possible Cr substituents, and Ca and Ni are found to improve catalysts performance relative to Cr promotion. The current study, besides finding two promising Cr substitutes (Ca and Ni) for the HT-WGS reaction catalyst, also emphasizes on the qualities a promoter must possess to become a suitable substitution of Cr. The remarkable performance of Ca and Ni promoters are related to their ability to stabilize the surface area of the respective catalysts by making partial or complete solid solution with the bulk Fe-oxide phase and by promoting highly redox Cu0-FeOx interfacial sites on the catalyst surface. The poorer performance exhibited by Co and Ge promoters is related to the lack of their ability to promote the highly active Cu0-FeOx interfacial sites along with inability of Co to stabilize the surface area. All the promoters follow a redox type mechanism for the HT-WGS reaction.
  • 972
  • 09 Nov 2020
Topic Review
Brain Stroke Monitoring
Stroke is a medical disease that affects millions of people worldwide per year, which leads to permanent disabilities or even death. It occurs when the regular flow of rich-oxygen blood through a brain vessel is interrupted due to a clot or a burst of it, triggering the death of brain cells and requiring prompt diagnosis and intervention after its onset to improve the prognosis significantly. The two main types of stroke are hemorrhagic and ischemic ones.
  • 968
  • 27 Oct 2020
Topic Review
Spinal Robotic Orthoses
Osteoporotic spine fractures (OSF) are common sequelae of osteoporosis. OSF are directly correlated with increasing age and incidence of osteoporosis. OSF are treated conservatively or surgically. We review the current state of the art in the field of wearable robots for trunk support.
  • 966
  • 19 Feb 2021
Topic Review
Glioblastoma Cells
Glioblastoma multiforme (GBM) is the most common brain cancer in adults. GBM starts from a small fraction of poorly differentiated and aggressive cancer stem cells (CSCs) responsible for aberrant proliferation and invasion. Due to extreme tumor heterogeneity, actual therapies provide poor positive outcomes, and cancers usually recur. Therefore, alternative approaches, possibly targeting CSCs, are necessary against GBM.
  • 966
  • 31 Mar 2022
Topic Review
Skin Lesion Datasets and Image Preprocessing
Skin lesions affect millions of people worldwide. They can be easily recognized based on their typically abnormal texture and color but are difficult to diagnose due to similar symptoms among certain types of lesions.
  • 965
  • 18 Apr 2023
Topic Review
MIMO Radars
This entry reports a thorough overview on the last developments concerning the vital sign detection and the human localization employing the multiple-input-multiple-output (MIMO) technology. The wireless motion and vital sign detection represents an outstanding research area aimed at monitoring the health conditions of human subjects and at detecting their presence in different environments with minimal concern. MIMO radars exhibit several interesting advantages over conventional single-input-single-output architectures mainly related to their angle detection capabilities and enhanced signal-to-noise ratio. This paper describes the main features and details the operating principles of MIMO technology. Thereafter, it summarizes the state-of-the-art of the available solutions with the purpose of fueling the research activities on this hot topic.
  • 955
  • 17 Sep 2020
Topic Review
Bone Marrow
Bone marrow (BM) is a reliable source of multipotent mesenchymal stromal cells (MSCs), which have been successfully used for treating osteonecrosis.
  • 955
  • 31 Jan 2022
Topic Review
Aptamer Sensors
Recently, aptamers have attracted attention in the biosensing field as signal recognition elements because of their high binding affinity toward specific targets such as proteins, cells, small molecules, and even metal ions. Aptamers have intrinsic advantages, such as their availability for both chemical modifications and conjugation with different labels, facilitating their ability to be used to construct a sensitive and highly selective platform sensor. Aptamers can be easily functionalized and engineered, providing several signaling modes such as colorimetric, fluorometric, and electrochemical, in what is known as aptasensors.
  • 952
  • 17 Jun 2021
Topic Review
Recent Advances of Wearable Sweat-Sensing Devices
A sweat-sensing device requires a wearable device for the temporary attachment of its main components, including sensors, sweat collection devices, and electronic devices to the body’s skin region.
  • 950
  • 21 Oct 2022
Topic Review
Biomechanical Energy Harvesting from the Human Body
Energy harvesters serve as continuous and long-lasting sources of energy that can be integrated into wearable and implantable sensors and biomedical devices. Biomechanical energy is one of the largest categories and one of the most utilized among all other energy sources.
  • 948
  • 28 Nov 2022
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