You're using an outdated browser. Please upgrade to a modern browser for the best experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
3D Bioprinting of Musculoskeletal Tissue
The musculoskeletal system is a vital body system that protects internal organs, supports locomotion, and maintains homeostatic function. Unfortunately, musculoskeletal disorders are the leading cause of disability worldwide. Although implant surgeries using autografts, allografts, and xenografts have been conducted, several adverse effects, including donor site morbidity and immunoreaction, exist. To overcome these limitations, various biomedical engineering approaches have been proposed based on an understanding of the complexity of human musculoskeletal tissue. In this review, the leading edge of musculoskeletal tissue engineering using 3D bioprinting technology and musculoskeletal tissue-derived decellularized extracellular matrix bioink is described. In particular, studies on in vivo regeneration and in vitro modeling of musculoskeletal tissue have been focused on. Lastly, the current breakthroughs, limitations, and future perspectives are described.
  • 1.6K
  • 03 Mar 2022
Topic Review
Blood-Plasma Self-Separation in Self-Driven Microfluidics
Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consuming. Therefore, in the Lab-on-a-chip (LOC) field, an effective microfluidic blood plasma separation platform attracts researchers’ attention globally. Blood plasma self-separation technologies are usually divided into two categories: active self-separation and passive self-separation. Passive self-separation technologies, in contrast with active self-separation, only rely on microchannel geometry, microfluidic phenomena and hydrodynamic forces. Passive self-separation devices are driven by the capillary flow, which is generated due to the characteristics of the surface of the channel and its interaction with the fluid. Comparing to the active plasma separation techniques, passive plasma separation methods are more considered in the microfluidic platform, owing to their ease of fabrication, portable, user-friendly features.
  • 1.6K
  • 12 Jul 2021
Topic Review
Finite Element Analysis for Studying Knee Osteoarthritis
Osteoarthritis (OA) is a degenerative disease that affects the synovial joints, especially the knee joint, diminishing the ability of patients to perform daily physical activities. Finite element analysis (FEA) has been considered a promising computational method to be developed for knee OA management. The FEA pipeline consists of three well-established phases: pre-processing (to prepare the model), processing (to solve the mathematical problem), and post-processing (to analyze the results). Each of these phases requires extensive expertise to conduct them properly, as there exist several different approaches with selection-specific limitations.
  • 1.6K
  • 10 Feb 2022
Topic Review
AI&ML for Medical Sector
This work represents a comprehensive analysis of the potential AI, ML, and IoT technologies for defending against the COVID-19 pandemic. The existing and potential applications of AI, ML, and IoT, along with a detailed analysis of the enabling tools and techniques are outlined. A critical discussion on the risks and limitations of the aforementioned technologies are also included.
  • 1.6K
  • 21 Jan 2021
Topic Review
Actuators for Implantable Devices
The choice of actuators dictates how an implantable biomedical device moves. Specifically, the concept of implantable robots consists of the three pillars: actuators, sensors, and powering. Robotic devices that require active motion are driven by a biocompatible actuator. Depending on the actuating mechanism, different types of actuators vary remarkably in strain/stress output, frequency, power consumption, and durability. Most reviews to date focus on specific type of actuating mechanism (electric, photonic, electrothermal, etc.) for biomedical applications. With a rapidly expanding library of novel actuators, however, the granular boundaries between subcategories turns the selection of actuators a laborious task, which can be particularly time-consuming to those unfamiliar with actuation. 
  • 1.6K
  • 07 Dec 2022
Topic Review
Application of Hydrogels for Bone Regeneration
Hydrogels are versatile biomaterials characterized by three-dimensional, cross-linked, highly hydrated polymeric networks. These polymers exhibit a great variety of biochemical and biophysical properties, which allow for the diffusion of diverse molecules, such as drugs, active ingredients, growth factors, and nanoparticles. Meanwhile, these polymers can control chemical and molecular interactions at the cellular level. The polymeric network can be molded into different structures, imitating the structural characteristics of surrounding tissues and bone defects. Interestingly, the application of hydrogels in bone tissue engineering (BTE) has been gathering significant attention due to the beneficial bone improvement results that have been achieved.
  • 1.6K
  • 29 Jun 2023
Topic Review
Hepatic Vessel Skeletonization
Hepatic vessel skeletonization serves as an important means of hepatic vascular analysis and vessel segmentation. Skeletonization provides an effective and compact representation of an image object by reducing its dimensionality to a centerline while preserving the original topologic and geometric properties. Hepatic vascular analysis plays a critical role in the diagnosis and treatment of many liver diseases, classification of liver function regions and inquiry into the nature of vascular growth. Hepatic vessel skeletonization serves as an important means of hepatic vascular analysis, particularly because a hepatic vessel is a kind of thin tubular object satisfying the growth principle of Murray’s law.
  • 1.6K
  • 15 Apr 2022
Topic Review
Forefoot Function after Hallux Valgus Surgery
The load integrals (impulse) over the central metatarsal region significantly increased, indicating that surgeries increased the risk of transfer metatarsalgia. There is no solid evidence that hallux valgus (HV) surgeries could improve forefoot functions from a biomechanical point perspective. Surgeries might reduce the plantar load over the hallux and adversely affect push-off function. 
  • 1.6K
  • 16 Feb 2023
Topic Review
Applications of Magnetic Hydrogels
Magnetic hydrogels (MHGs) are a special class of hydrogel that contain at least one magnetic component in their composition. Generally, MNPs are dispersed in a polymer gel matrix to form MHGs. These hydrogels are special because they are prone to show fluctuations in their physical properties in the presence of an externally applied magnetic field.
  • 1.6K
  • 08 Dec 2021
Topic Review
Detection of Viruses Using Electrochemical Biosensors
Electrochemical biosensors have tremendous potential for point-of-care virus detection due to their portability and simple detection methods. The main limitation of this method is its sensitivity. Numerous studies have been conducted in an attempt to enhance the key elements of electrochemical-based biosensing systems.
  • 1.6K
  • 13 Sep 2022
Topic Review
Glycerol in nano oxides synthesis
The transformation of biomass and the utilization of all the by products derived from chemical conversion of biomass resources is one of the most important challenges nowadays. The impact in society and the level of awareness that already exists inside and outside the scientific community, makes the challenge of improving conversion of biomass to commodities a hot topic. Glycerol, a by-product obtained from the biodiesel production, is a key player compound due to its chemical versatility. The possibility of being used as solvent, reagent, reducing agent (in the polyol method), and so forth, makes glycerol an extremely appealing commodity. When used within nanotechnology, namely combined with nanomaterials, its potential becomes even higher.
  • 1.6K
  • 14 Dec 2020
Topic Review
Electrode Array Design
Cochlear implants are neural implant devices that aim to restore hearing in patients with severe sensorineural hearing impairment.
  • 1.6K
  • 08 Aug 2022
Topic Review
NanoBubble-Mediated Oxygenation for Hypoxic Pathologies
Nanobubbles also known as ultra-fine bubbles or sub-micron bubbles, are extremely small gas-filled spherical bodies enclosed by an interface (gas–liquid or gas–solid) with a diameter of less than 1000 nm (i.e., ranging in size from tens to hundreds of nanometers in diameter). In other words, nanobubbles are composed of gas, such as oxygen or nitrogen, encapsulated within a liquid, typically water, and stabilized by a thin layer of molecules at the gas–liquid interface.
  • 1.6K
  • 05 Dec 2023
Topic Review
EPS Cyanobacterial Bioprocess Development
Cyanobacteria have the potential to become an industrially sustainable source of functional biopolymers. Their exopolysaccharides (EPS) harbor chemical complexity, which predicts bioactive potential. Cyanobacterial EPS, from the bioprocess point of view, is seen as a by-product of biomass and/or metabolite production such as proteins and to a lesser extent lipid. The slimy texture of culture medium after EPS production hinders handling while structure elucidation and productivities gave a tough reputation to these classes of polysaccharides within the industrial sector; however, the uniqueness of the few resolved structures has opened markets to these polysaccharides. To develop an EPS cyanobacterial bioprocess (Cyano-EPS) three steps are highlighted: the selection of the cyanobacterial host; optimization of production parameters; downstream processing. 
  • 1.6K
  • 27 Oct 2020
Topic Review
Surface-Enhanced Raman Scattering for Illicit Drug Detection
The rapid increase in illicit drug use and its adverse health effects and socio-economic consequences have reached alarming proportions in recent years. Surface-enhanced Raman scattering (SERS) has emerged as a highly sensitive analytical tool for the detection of low dosages of drugs in liquid and solid samples.
  • 1.6K
  • 25 May 2022
Topic Review
Preclinical Cold Atmospheric Plasma Cancer Treatment
Cold atmospheric plasma (CAP) is generated in a rapid yet low-energy input streamer-discharge process under atmospheric pressure conditions and environment. CAP is an ionized gas with a low ionization degree and plenty of reactive species and radicals. These reactive components, and their near-room temperature nature, make CAP a powerful tool in medical applications, particularly cancer therapy. Here, researchers systematically introduced the research status of the preclinical application of CAP in cancer therapy, particularly in vivo studies.
  • 1.6K
  • 22 Jul 2022
Topic Review
Hydroxyapatite in Oral Care Products
Calcium phosphate compounds form the inorganic phases of our mineralised tissues such as bone and teeth, playing an important role in hard tissue engineering and regenerative medicine. In dentistry and oral care products, hydroxyapatite (HA) is a stable and biocompatible calcium phosphate with low solubility being used for various applications such as tooth remineralisation, reduction of tooth sensitivity, oral biofilm control, and tooth whitening. 
  • 1.5K
  • 08 Sep 2021
Topic Review
Liquid Biopsy-Based Biosensors
Globally, non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths. The 5-year survival rate has remained at 16% for the past forty years despite advancements in chemotherapy and targeted therapies. Minimal residual disease (MRD) is described as the existence of either isolated tumour cells or circulating tumour cells in biological liquid of patients after removal of the primary tumour without any clinical signs of cancer. Recently, liquid biopsy has been promising as a non-invasive method of disease monitoring and treatment guidelines as an MRD marker. Liquid biopsy could be used to detect and assessment of earlier stages of NSCLC, post-treatment MRD, resistance to targeted therapies, immune checkpoint inhibitors (ICIs) and tumour mutational burden. MRD surveillance has been proposed as a potential marker for lung cancer relapse. Principally biosensors provide the quantitative analysis of various materials by converting biological functions into quantifiable signals. Biosensors are usually operated to detect antibodies, enzymes, DNA, RNA, EVs, and whole cells. Here we present a category of biosensors based on the signal transduction method for identifying biosensor-based biomarkers in liquid biopsy specimens to monitor lung cancer treatment
  • 1.5K
  • 22 Oct 2021
Topic Review
M13 Bacteriophage-Based Biosensors
New virus-based sensor systems that operate on M13 bacteriophage infrastructure have attracted considerable attention. These systems can detect a range of chemicals with excellent sensitivity and selectivity. Filaments consistent with M13 bacteriophages can be ordered by highly established forms of self-assembly. This allows M13 bacteriophages to build a homogeneous distribution and infiltrate the network structure of nanostructures under mild conditions.
  • 1.5K
  • 07 Jun 2021
Topic Review
Aptamer Sensors
Recently, aptamers have attracted attention in the biosensing field as signal recognition elements because of their high binding affinity toward specific targets such as proteins, cells, small molecules, and even metal ions. Aptamers have intrinsic advantages, such as their availability for both chemical modifications and conjugation with different labels, facilitating their ability to be used to construct a sensitive and highly selective platform sensor. Aptamers can be easily functionalized and engineered, providing several signaling modes such as colorimetric, fluorometric, and electrochemical, in what is known as aptasensors.
  • 1.5K
  • 17 Jun 2021
  • Page
  • of
  • 27
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of COVID-19
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Academic Video Service
Feedback