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Topic Review
Morphea
Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients' quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects.
  • 7.0K
  • 12 Aug 2021
Topic Review
Polymers for Pharmaceutical Coating
Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. As tablet coating is a process driven by technology, it relies on advancements in coating techniques, equipment used for the coating process, evaluation of coated tablets, and coated material used. Although different techniques were employed for coating purposes, which may be based on the use of solvents or solvent-free, each of the methods used has its advantages and disadvantages, and the techniques need continued modification too. During the process of film coating, several inter-and intra-batch uniformity of coated material on the tablets is considered a critical point that ensures the worth of the final product, particularly for those drugs that contain an active medicament in the coating layer. Meanwhile, computational modeling and experimental evaluation were actively used to predict the impact of the operational parameters on the final product quality and optimize the variables in tablet coating. The efforts produced by computational modeling or experimental evaluation not only save cost in optimizing the coating process but also saves time.
  • 7.0K
  • 13 Sep 2022
Topic Review
Black Belt (U.S. Region)
The Black Belt is a region of the Southern United States. The term originally described the prairies and dark fertile soil of central Alabama and northeast Mississippi. Because this area in the 19th century was historically developed for cotton plantations based on enslaved African American labor, the term became associated with these conditions. It was generally applied to a much larger agricultural region in the Southern United States, which was characterized by a history of cotton plantation agriculture in the 19th century and a high percentage of African Americans outside metropolitan areas. The enslaved peoples were freed after the American Civil War, and many continued to work in agriculture afterward. Their descendants make up much of the African-American population of the United States. During the first half of the 19th Century, as many as one million enslaved Africans were transported through sales in the domestic slave trade to the Deep South in a forced migration to work as laborers for the region's cotton plantations. After having lived enslaved for several generations in the area, many remained as rural workers, tenant farmers and sharecroppers after the Civil War and emancipation. Beginning in the early 20th century and up to 1970, a total of six million black people left the South in the Great Migration to find work and other opportunities in the industrial cities of the Northeast, Midwest, and West. Because of relative isolation and lack of economic development, the rural communities in the Black Belt have historically faced acute poverty, rural exodus, inadequate education programs, low educational attainment, poor health care, urban decay, substandard housing, and high levels of crime and unemployment. In December 2017, the Special Rapporteur of the Office of the United Nations High Commissioner for Human Rights declared that Alabama was the most impoverished area in the developed world. Given the history of decades of racial segregation into the late 20th century, African-American residents have been the most disproportionately affected, although these problems apply broadly to all ethnic groups in the rural Black Belt. The region and its boundaries have varying definitions, but it is generally considered a band through the center of the Deep South, although stretching from as far north as Delaware to as far west as East Texas.
  • 7.0K
  • 31 Oct 2022
Topic Review
Digital twins in pharmaceutical manufacturing
The development and application of emerging technologies of Industry 4.0 enable the realization of digital twins (DT), which facilitates the transformation of the manufacturing sector to a more agile and intelligent one. DTs are virtual constructs of physical systems that mirror the behavior and dynamics of such physical systems. A fully developed DT consists of physical components, virtual components, and information communications between the two. Integrated DTs are being applied in various processes and product industries. Although the pharmaceutical industry has evolved recently to adopt Quality-by-Design (QbD) initiatives and is undergoing a paradigm shift of digitalization to embrace Industry 4.0, there has not been a full DT application in pharmaceutical manufacturing. Therefore, there is a critical need to examine the progress of the pharmaceutical industry towards implementing DT solutions. The aim of this entry is to give an overview of the current status of DT development and its application in pharmaceutical and biopharmaceutical manufacturing. State-of-the-art Process Analytical Technology (PAT) developments, process modeling approaches, and data integration studies are reviewed. Challenges and opportunities for future research in this field are also discussed.
  • 7.0K
  • 09 Mar 2022
Topic Review
Intel MCS-51
The Intel MCS-51 (commonly termed 8051) is a single chip microcontroller (MCU) series developed by Intel in 1980 for use in embedded systems. The architect of the Intel MCS-51 instruction set was John H. Wharton. Intel's original versions were popular in the 1980s and early 1990s and enhanced binary compatible derivatives remain popular today. It is an example of a complex instruction set computer, and has separate memory spaces for program instructions and data. Intel's original MCS-51 family was developed using N-type metal-oxide-semiconductor (NMOS) technology like its predecessor Intel MCS-48, but later versions, identified by a letter C in their name (e.g., 80C51) use complementary metal–oxide–semiconductor (CMOS) technology and consume less power than their NMOS predecessors. This made them more suitable for battery-powered devices. The family was continued in 1996 with the enhanced 8-bit MCS-151 and the 8/16/32-bit MCS-251 family of binary compatible microcontrollers. While Intel no longer manufactures the MCS-51, MCS-151 and MCS-251 family, enhanced binary compatible derivatives made by numerous vendors remain popular today. Some derivatives integrate a digital signal processor (DSP). Beyond these physical devices, several companies also offer MCS-51 derivatives as IP cores for use in field-programmable gate array (FPGA) or application-specific integrated circuit (ASIC) designs.
  • 7.0K
  • 14 Oct 2022
Topic Review
Rolls-Royce Phantom VII
The Rolls-Royce Phantom VII is a full-sized luxury saloon car made by Rolls-Royce Motor Cars. Launched in 2003, it was the first Rolls-Royce developed and introduced after BMW purchased the right to use the Rolls-Royce name and logo in 1998. It is credited with successfully reviving the Rolls-Royce brand and restoring Rolls-Royce's reputation as a maker of luxury cars. The Phantom Drophead Coupé and Phantom Coupé are two-door derivatives of the Phantom launched in 2007 and 2008, respectively. From 2003 until the launch of the smaller Ghost in 2009, the Phantom was the only car produced by Rolls-Royce. The Phantom acted as the company's flagship model, but was less exclusive than all previous Phantoms (none of which surpassed the 600 per year).
  • 7.0K
  • 05 Dec 2022
Topic Review
Colorectal Cancer Development
Colorectal cancer (CRC) is a disorder that occurs exclusively in the colon or rectum and is caused by the colon’s aberrant proliferation of glandular epithelial cells.
  • 7.0K
  • 19 Apr 2022
Topic Review
Propranolol in Post-Traumatic Stress Disorder
Propranolol, a non-cardioselective β1,2 blocker, is most commonly recognised for its application in the therapy of various cardiovascular conditions, such as hypertension, coronary artery disease, and tachyarrhythmias. However, due to its ability to cross the blood–brain barrier and affinity towards multiple macromolecules, not only adrenoreceptors, it has also found application in other fields. For example, it is one of the very few medications successfully applied in the treatment of stage fright. 
  • 7.0K
  • 07 Sep 2022
Topic Review
Acoustic Extinguishing
In the fire-extinguishing process, in principle, one of the components in the fire tetrahedron must be removed. For example, a natural gas fire occurring on a stovetop burner can be extinguished in various ways: Eliminating the fuel source by shutting off the gas supply may be the first option. Another option is to completely cover the flame to block any oxidizer that is present, such as oxygen in the air, during combustion.
  • 7.0K
  • 25 Mar 2022
Topic Review
Human Genetic Clustering
Human genetic clustering is the degree to which human genetic variation can be partitioned into a small number of groups or clusters. A leading method of analysis uses mathematical cluster analysis of the degree of similarity of genetic data between individuals and groups in order to infer population structures and assign individuals to hypothesized ancestral groups. A similar analysis can be done using principal component analysis, and several recent studies deploy both methods. Analysis of genetic clustering examines the degree to which regional groups differ genetically, the categorization of individuals into clusters, and what can be learned about human ancestry from this data. There is broad scientific agreement that a relatively small fraction of human genetic variation occurs between populations, continents, or clusters. Researchers of genetic clustering differ, however, on whether genetic variation is principally clinal or whether clusters inferred mathematically are important and scientifically useful.
  • 7.0K
  • 23 Nov 2022
Topic Review
Wife-carrying
Wife carrying (Finnish: eukonkanto or akankanto, Estonian: naisekandmine, Swedish: kärringkånk) is a contest in which male competitors race while each carrying a female teammate. The objective is for the male to carry the female through a special obstacle track in the fastest time. The sport was first introduced at Sonkajärvi, Finland . Several types of carrying may be practised: either a classic piggyback, a fireman's carry (over the shoulder), or Estonian-style (wife upside-down on his back with her legs over the neck and shoulders).
  • 7.0K
  • 11 Oct 2022
Topic Review
Synthesis of Fragrances via Cycloaddition or Formal Cycloaddition
Fragrances, short for fragrance ingredients, is a type of compounds with a sweet smell or pleasant odor that has wide applications in the fine chemical industry, especially in perfumes, cosmetics, detergents and food additives. Since the discovery of the Diels–Alder reaction, the cycloaddition of π reactants serves as one of the most powerful methods for the construction of carbocycles, which has a broad application in the fragrance industry.
  • 7.0K
  • 21 Jun 2022
Topic Review
Hazard
A hazard is an agent which has the potential to cause harm to a vulnerable target. The terms "hazard" and "risk" are often used interchangeably. However, in terms of risk assessment, they are two very distinct terms. A hazard is any agent that can cause harm or damage to humans, property, or the environment. Risk is defined as the probability that exposure to a hazard will lead to a negative consequence, or more simply, a hazard poses no risk if there is no exposure to that hazard. Hazards can be dormant or potential, with only a theoretical probability of harm. An event that is caused by interaction with a hazard is called an incident. The likely severity of the undesirable consequences of an incident associated with a hazard, combined with the probability of this occurring, constitute the associated risk. If there is no possibility of a hazard contributing towards an incident, there is no risk. Hazards can be classified as different types in several ways. One of these ways is by specifying the origin of the hazard. One key concept in identifying a hazard is the presence of stored energy that, when released, can cause damage. Stored energy can occur in many forms: chemical, mechanical, thermal, radioactive, electrical, etc. Another class of hazard does not involve release of stored energy, rather it involves the presence of hazardous situations. Examples include confined or limited egress spaces, oxygen-depleted atmospheres, awkward positions, repetitive motions, low-hanging or protruding objects, etc. Hazards may also be classified as natural, anthropogenic, or technological. They may also be classified as health or safety hazards, by the populations that may be affected, and the severity of the associated risk. In most cases a hazard may affect a range of targets, and have little or no effect on others. Identification of hazards assumes that the potential targets are defined, and is the first step in performing a risk assessment.
  • 7.0K
  • 26 Oct 2022
Topic Review
List of Academic Journals by Preprint Policy
This is a list of academic journals by their submission policies regarding the use of preprints prior to publication, such as the arXiv, and bioRxiv. Journals focusing on physics and mathematics are excluded because they routinely accept manuscripts that have been posted to preprint servers. Publishers' policies on self-archiving (including preprint versions) can also be found at SHERPA/RoMEO.
  • 7.0K
  • 29 Dec 2022
Topic Review
Aquaporin Inhibitors
Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ system. The structural biology of the AQP family is well-established and many functions for AQPs have been reported in health and disease. AQP expression is linked to numerous pathologies including tumor metastasis, fluid dysregulation, and traumatic injury. The targeted modulation of AQPs therefore presents an opportunity to develop novel treatments for diverse conditions. Various techniques such as video microscopy, light scattering and fluorescence quenching have been used to test putative AQP inhibitors in both AQP-expressing mammalian cells and heterologous expression systems. The inherent variability within these methods has caused discrepancy and many molecules that are inhibitory in one experimental system (such as tetraethylammonium, acetazolamide, and anti-epileptic drugs) have no activity in others. Some heavy metal ions (that would not be suitable for therapeutic use) and the compound, TGN-020, have been shown to inhibit some AQPs. Clinical trials for neuromyelitis optica treatments using anti-AQP4 IgG are in progress. However, these antibodies have no effect on water transport. More research to standardize high-throughput assays is required to identify AQP modulators for which there is an urgent and unmet clinical need.
  • 7.0K
  • 06 Sep 2021
Topic Review
Pelagic Zone
The pelagic zone consists of the water column of the open ocean, and can be further divided into regions by depth (as illustrated on the right). The word pelagic is derived from grc πέλαγος (pélagos) 'open sea'. The pelagic zone can be thought of as an imaginary cylinder or water column between the surface of the sea and the bottom. Conditions in the water column change with depth: pressure increases; temperature and light decrease; salinity, oxygen, micronutrients (such as iron, magnesium and calcium) all change. Marine life is affected by bathymetry (underwater topography) such as the seafloor, shoreline, or a submarine seamount, as well as by proximity to the boundary between the ocean and the atmosphere at the ocean surface, which brings light for photosynthesis, predation from above, and wind stirring up waves and setting currents in motion. The pelagic zone refers to the open, free waters away from the shore, where marine life can swim freely in any direction unhindered by topographical constraints. The oceanic zone is the deep open ocean beyond the continental shelf, which contrasts with the inshore waters near the coast, such as in estuaries or on the continental shelf. Waters in the oceanic zone plunge to the depths of the abyssopelagic and further to the hadopelagic. Coastal waters are generally the relatively shallow epipelagic. Altogether, the pelagic zone occupies 1,330 million km3 (320 million mi3) with a mean depth of 3.68 km (2.29 mi) and maximum depth of 11 km (6.8 mi). Pelagic life decreases as depth increases. The pelagic zone contrasts with the benthic and demersal zones at the bottom of the sea. The benthic zone is the ecological region at the very bottom, including the sediment surface and some subsurface layers. Marine organisms such as clams and crabs living in this zone are called benthos. Just above the benthic zone is the demersal zone. Demersal fish can be divided into benthic fish, which are denser than water and rest on the bottom, and benthopelagic fish, which swim just above the bottom. Demersal fish are also known as bottom feeders and groundfish.
  • 7.0K
  • 14 Nov 2022
Topic Review Peer Reviewed
High-Speed Railway
Union Internationale des Chemins (UIC) defines the high-speed railway (HSR) as a high-speed railway system that contains the infrastructure and the rolling stock. The infrastructure can be newly built dedicated lines enabled for trains to travel with speed above 250 km/h or upgraded conventional lines with a speed up to 200 or even 220 km/h. HSR requires specially built trains with increased power to weight ratio and must have an in-cab signalling system as traditional signalling systems are incapable of above 200 km/h.
  • 7.0K
  • 18 Apr 2022
Topic Review
Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (P-ANCA)
Perinuclear anti-neutrophilic cytoplasmic antibodies (P-ANCA) recognize heterogeneous antigens, including myeloperoxidase (MPO), lactoferrin, elastase, cathepsin-G and bactericidal/permeability-increasing protein. Although P-ANCA have diagnostic utility in vasculitides, they may also be found in patients with various other systemic autoimmune rheumatic diseases (SARDs). Nevertheless, the clinical significance and the targets recognized by P-ANCA in such patients remain unclear. For this purpose, herein we investigated the occurrence of ANCA-related antigenic specificities in 82 P-ANCA-positive sera by multiplex ELISA, as well as their association with other autoantibodies. The P-ANCA-positive sera corresponded to patients with vasculitides (n = 24), systemic lupus erythematosus (n = 28), antiphospholipid syndrome (n = 5), Sjögren’s syndrome (n = 7), rheumatoid arthritis (n = 3), systemic scleroderma (n = 1), sarcoidosis (n = 1) and Hashimoto′s thyroiditis (n = 13). In most P-ANCA-positive patients studied (51/82, 62.3%), these autoantibodies occurred in high titers (>1:160). The analysis of P-ANCA-positive sera revealed reactivity to MPO in only 50% of patients with vasculitides, whereas it was infrequent in the other disease groups studied. Reactivity to other P-ANCA-related autoantigens was also rarely detected. Our findings support that high P-ANCA titers occur in SARD. The P-ANCA-positive staining pattern is associated with MPO specificity in vasculitides, while in other autoimmune diseases, it mostly involves unknown autoantigens. 
  • 7.0K
  • 27 Aug 2021
Topic Review
Microalgae/Cyanobacteria in Biodegradation of Plastics
Cyanobacteria (e.g., Synechocystis sp. PCC 6803, and Synechococcus elongatus PCC 7942), which are photosynthetic prokaryotes and were previously identified as blue-green algae, are currently under close attention for their abilities to capture solar energy and the greenhouse gas carbon dioxide for the production of high-value products. In the last few decades, these microorganisms have been exploited for different purposes (e.g., biofuels, antioxidants, fertilizers, and ‘superfood’ production). Microalgae (e.g., Chlamydomonas reinhardtii, and Phaeodactylum tricornutum) are also suitable for environmental and biotechnological applications based on the exploitation of solar light. In recent years, several studies have been targeting the utilization of microorganisms for plastic bioremediation. Among the different phyla, the employment of wild-type or engineered cyanobacteria may represent an interesting, environmentally friendly, and sustainable option (e.g., mismanaged plastics as source of carbons for their cultivation: the connection between their simultaneous utilization for biofuels or chemicals production and microplastics consumption on the surface of basins).
  • 7.0K
  • 05 Jan 2021
Topic Review
Hungarian Soviet Republic
The Hungarian Soviet Republic, literally the Republic of Councils in Hungary (Hungarian: Magyarországi Tanácsköztársaság), also known as the Hungarian Socialist Federative Soviet Republic (Hungarian: Magyarországi Szocialista Szövetséges Tanácsköztársaság) was a short-lived (133 days) communist rump state. When the Republic of Councils in Hungary was established in 1919, it controlled approximately 23% of the territory of Hungary's classic pre-World War I territories (325 411 km2). It was the successor of the first Hungarian People's Republic and lasted from only 21 March to 1 August 1919. Though the de jure leader of the Hungarian Soviet Republic was president Sándor Garbai, the de facto power was in the hands of foreign minister Béla Kun, who maintained direct contact with Lenin via radiotelegraph. It was Lenin who gave the direct orders and advice to Béla Kun via constant radio communication with the Kremlin. It was the second socialist state in the world to be formed, preceded by only the October Revolution in Russia which brought the Bolsheviks to power. The Hungarian Republic of Councils had military conflicts with the Kingdom of Romania, the Kingdom of Serbs, Croats and Slovenes and the evolving Czechoslovakia. It ended on 1 August 1919 when Hungarians sent representatives to negotiate their surrender to the Romanian forces. Due to the mistranslation, it is often referred to as "Hungarian Soviet republic" in English sources, despite the literal name "Republic of Councils in Hungary" was chosen for the purpose to avoid any strong ethnic connotation with Hungarian people, and express the Proletarian internationalist doctrine of the new Communist regime.
  • 7.0K
  • 20 Oct 2022
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