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Topic Review
Norm
Norms are concepts (sentences) of practical import, oriented to effecting an action, rather than conceptual abstractions that describe, explain, and express. Normative sentences imply "ought-to" types of statements and assertions, in distinction to sentences that provide "is" types of statements and assertions. Common normative sentences include commands, permissions, and prohibitions; common normative abstract concepts include sincerity, justification, and honesty. A popular account of norms describes them as reasons to take action, to believe, and to feel.
  • 1.6K
  • 06 Oct 2022
Topic Review
Al-Based Metal Foams
Metal Foams (MF) are tridimensional metal matrices which can be defined as mixtures of metal and gas (generally gas volume fraction is higher than 70% and relative density is lower than 0.3). MF can have open or closed cells, which means that porosity can be interconnected or not, respectively.  Metal foams are extremely interesting due to their low density, high specific stiffness, and impact energy/vibration absorption ability. The use of metal foams as permanent cores in casting can be an opportunity to improve the properties of cast components and to simplify the technological processes (e.g., no need for core removal/treatment/recycling). 
  • 1.6K
  • 08 Jan 2021
Topic Review
Chronic Inflammation in PCOS
PCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15% of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are often associated with the disease. Furthermore, PCOS represents a status of chronic inflammation with permanently elevated levels of inflammatory markers including IL-6 and IL-18, TNF-α, and CRP. Inflammation, as discovered only recently, consists of two processes occurring concomitantly: active initiation, involving “classical” mediators including prostaglandins and leukotrienes, and active resolution processes based on the action of so-called specialized pro-resolving mediators (SPMs). These novel lipid mediator molecules derive from the essential ω3-poly-unsaturated fatty acids (PUFAs) DHA and EPA and are synthesized via specific intermediates. The role and benefits of SPMs in chronic inflammatory diseases like obesity, atherosclerosis, and Diabetes mellitus has become a subject of intense research during the last years and since PCOS features several of these pathologies, this review aims at summarizing potential roles of SPMs in this disease and their putative use as novel therapeutics. 
  • 1.6K
  • 28 Jan 2021
Topic Review
Skin Models for Perspiration Simulation
Skin models offer an in vitro alternative to human trials without their high costs, variability, and ethical issues. Perspiration models, in particular, have gained relevance lately due to the rise of sweat analysis and wearable technology.
  • 1.6K
  • 26 Apr 2021
Topic Review
AR-HCFs for Sensing Applications
Specialty fibers have enabled a wide range of sensing applications. Particularly, with the recent advancement of anti-resonant effects, specialty fibers with hollow structures offer a unique sensing platform to achieve highly accurate and ultra-compact fiber optic sensors with large measurement ranges. Enabled by the specialty fiber manufacturing industry, AR-HCFs have shown great potential in optical fiber communication and sensing. AR-HCFs have very low transmission loss, optical nonlinearity, and chromatic dispersion over a broad bandwidth. They also have intrinsic advantages of high sensitivity, compact structures, and robust operation. All these remarkable advantages promote diversified sensing applications of AR-HCF. As a functionalized device, it has been extensively used for common parameter sensing, including solid, gas, and liquid.
  • 1.6K
  • 11 May 2021
Topic Review
Creatine in Health and Disease
Creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particularly during metabolically stressed states, and limitations in the ability to transport and/or store creatine can impair metabolism. 
  • 1.6K
  • 10 Jun 2021
Topic Review
Optical Coherence Tomography (OCT) Findings
The main OCT biomarkers related to progression to advanced AMD include drusen volume, hyperreflective foci (HRF), reticular pseudodrusen or subretinal drusenoid deposits (SDD), incomplete retinal pigment epithelial and outer retinal atrophy (iRORA), hyper-transmission defects, and OCT-reflective drusen substructures (ODS).
  • 1.6K
  • 07 Jan 2022
Topic Review
Ly6c as New Marker of Mouse Blood Vessels
During our research we have observed that Ly6c, which is traditionally only used as a classic and non-classical monocyte / macrophage differentiating antigen, can be used as a new specific marker of the mouse vasculature and to assess qualitatively and quantitatively vascular changes in health and disease. Researchers believe that this innovative application of Ly6c immunodetection, which has shown three advantages (brighter signal, homogeneous staining and greater selectivity) compared to traditional vessel markers such as IB4 isolectin, will be of high interest to researchers in this field.
  • 1.6K
  • 28 Mar 2022
Topic Review
Machine Learning in T- and B-Cell Epitope Prediction
An antigenic determinant (AD) is a portion of an antigen molecule known as an epitope that is recognized by the human immune system, specifically by antibodies or T and B cells. Recognition of epitopes is considered important in EBPV design to contain pandemics, epidemics, and endemics due to the outbreak of infectious diseases. To design an effective and viable EBPV against different strains of a pathogen, it is important to identify the putative T- and B-cell epitopes. Using the wet-lab experimental approach to identify these epitopes is time-consuming and costly because the experimental screening of a vast number of potential epitope candidates is required. Fortunately, various available machine learning (ML)-based prediction methods have reduced the burden related to the epitope mapping process by decreasing the potential epitope candidate list for experimental trials. Moreover, these methods are also cost-effective, scalable, and fast. 
  • 1.6K
  • 16 Feb 2022
Topic Review
Goji Berry
Goji berry fruits demonstrated anti-oxidative properties that are associated with age-related diseases such as diabetes, atherosclerosis and antitumor and immunoregulatory activities. Bioactive secondary metabolites contained in fruit lead to positive effects for human vision, while other biochemicals contained in the root bark have shown hepatoprotective and inhibitory actions on the rennin/angiotensin system.
  • 1.6K
  • 30 Mar 2022
Topic Review
Ailanthus altissima as a Source of Natural Pesticides
The extensive use of pesticides may negatively affect human health. Additionally, it is one of the main reasons for the decline of pollinators and is thus a hazard for most crops and biodiversity as a whole. Good candidates for the replacement of pesticides with ones less toxic to humans and pollinators are natural products (bioactive compounds extracted from plants), even though it should be kept in mind that some of them can be toxic too. Ailanthus altissima (Mill.), swingle, known also as tree of heaven, (Simaroubaceae) is one of the most aggressive alien invasive plants. It demonstrates a high tolerance to various habitat conditions and a potent propagation ability. This plant has a prominent ability to suppress the seed development of local vegetation.
  • 1.6K
  • 06 Sep 2022
Topic Review
Lipid-Based Nanoparticles as a Versatile Drug Delivery System
Liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid nanocarriers, and lipid–polymer hybrid nanoparticles are developed for cancer treatment which is well confirmed and documented. cancer nanotechnology that overcomes the drawbacks of conventional drug delivery systems starting from small-scale barricades such as intracellular trafficking and site-specific targeting to large-scale barriers such as biodistribution.
  • 1.6K
  • 27 Sep 2022
Topic Review
MOS Technology VIC-II
The VIC-II (Video Interface Chip II), specifically known as the MOS Technology 6567/8562/8564 (NTSC versions), 6569/8565/8566 (PAL), is the microchip tasked with generating Y/C video signals (combined to composite video in the RF modulator) and DRAM refresh signals in the Commodore 64 and C128 home computers. Succeeding MOS's original VIC (used in the VIC-20), the VIC-II was one of the two chips mainly responsible for the C64's success (the other chip being the 6581 SID).
  • 1.6K
  • 10 Nov 2022
Topic Review
Apple Cinema Display
The Apple Cinema Display is a line of flat-panel computer monitors developed and sold by Apple Inc. between 1999 and 2011. It was initially sold alongside the older line of Studio Displays, but eventually replaced them. Apple offered 20-, 22-, 23-, 24-, 27- and 30-inch sizes, with the last model being a 27-inch size with LED backlighting. There have been three designs for the Cinema Display, one featuring polycarbonate plastic and two featuring anodized aluminum. The first displays were designed to match the colorful plastic of the Power Mac G3 and later the Power Mac G4, while the second revisions were designed to match the aluminum aesthetics of the Power Mac G5 and PowerBook G4. The last available design matched the unibody laptops released in October 2008. The Apple Cinema Display name was retired in July 2011 with the introduction of the Apple Thunderbolt Display, and the Cinema Display models were no longer offered on the Apple Store website as of August 2014.
  • 1.6K
  • 05 Dec 2022
Topic Review
Microparticles on Fungal Fermentation
Ranging from simple food ingredients to complex pharmaceuticals, value-added products via microbial fermentation have many advantages over their chemically synthesized alternatives. Some of such advantages are environment-friendly production pathways, more specificity in the case of enzymes as compared to the chemical catalysts and reduction of harmful chemicals, such as heavy metals or strong acids and bases. Fungal fermentation systems include yeast and filamentous fungal cells based on cell morphology and culture conditions.
  • 1.6K
  • 21 Dec 2022
Topic Review
ABC Transporters in the Innate Immune System
The ATP-binding cassette transporters (ABC transporters) are a large family of proteins that transport a variety of substrates across cell plasma membranes. Because of this, they are involved in many physiological processes. It is of interest to note that many ABC transporters are involved in the transport of various lipids. In addition, this function may be related to the innate immune system. 
  • 1.6K
  • 22 Dec 2022
Topic Review
Blue Carbon Ecosystems
Blue carbon was established as a metaphor to highlight that, apart from terrestrial ecosystems, coastal ecosystems also contribute significantly to carbon sequestration. Apart from being recognized as a helpful carbon sink, blue carbon ecosystems provide various other services, including shelter for different migratory birds, fishes, and crabs. It is also vital in minimizing net carbon emissions. 
  • 1.6K
  • 10 Feb 2023
Topic Review
Camelina sativa
Camelina sativa (L.) Crantz, also called gold-of-pleasure, false flax, or linseed dodder, is an oilseed crop belonging to the tribe Camelineae of the mustard family (Brassicaceae). Camelina is a hardy plant that adapts very well to different types of soil and grows best in cool semi-arid climates. The great potential of this crop is also being exploited to obtain a sustainable feedstock for its different applications, and to improve dryland agriculture. Camelina can be used to improve the quality of foods, such as dairy products and meat, and the consumption of its oil has potential benefits for human health.
  • 1.6K
  • 23 May 2023
Topic Review
Bacterial Mechanosensitive Channels
Bacteria accumulate osmolytes to prevent cell dehydration during hyperosmotic stress. A sudden change to a hypotonic environment leads to a rapid water influx, causing swelling of the protoplast. To prevent cell lysis through osmotic bursting, mechanosensitive channels detect changes in turgor pressure and act as emergency-release valves for the ions and osmolytes, restoring the osmotic balance.
  • 1.6K
  • 11 Jul 2022
Topic Review
Bacterial Degradation of Hydrocarbons
Hydrocarbons occur in fossil fuels such as crude oil and consist mainly of hydrogen and carbon. They are natural chemicals, crude oil refining results in commercial products with new physico-chemical properties, which can increase their complexity and toxicity, and hamper their degradation. The presence of biodiverse natural microbial communities is a prerequisite for an effective homeostatic response to the various hydrocarbons, that contaminate ecosystems.
  • 1.6K
  • 13 Feb 2023
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