Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Inertial Sensors
Inertial sensors are sensors which do not need any referential points. They are based on inertia. Accelerometers and inclinometers are one of the most popular used in Structural Health Monitoring (SHM).
  • 1.7K
  • 28 Oct 2020
Topic Review
Polymeric Nanoparticles in Cardiovascular Diseases
Nanoparticles, including biodegradable polymeric nanoparticles, are able to increase the efficiency and reduce the degradability of natural polyphenols, thus increasing their beneficial abilities in the target tissues. Resveratrol-, quercetin-, or curcumin-loaded polymeric nanoparticles have been shown to markedly reduce reactive oxygen species formation, the inflammatory process, apoptosis, lipid peroxidation, cardiac hypertrophy, and even to delay myocardium injury due to ischemia/reperfusion. Thus, polymeric nanoparticles represent a promising tool for the delivery of natural polyphenols to target tissues and enhance their desirable effects in the cardiovascular system.
  • 1.7K
  • 27 Oct 2020
Topic Review
Coronavirus Disease 2019
Review of the effect of COVID-19 on pulmonary circulation
  • 1.7K
  • 20 Aug 2020
Topic Review
Measuring Urban Shrinkage
Most of the shrinking cities experience an unbalanced de-urbanization across different urban areas in cities. However, traditional ways of measuring urban shrinkage are focused on tracking population loss at the city level and are unable to capture the spatially heterogeneous shrinking patterns inside a city. Consequently, the spatial mechanism and patterns of urban shrinkage inside a city remain less understood, which is unhelpful for developing accommodation strategies for shrinkage. The smart city initiatives and practices have provided a rich pool of geospatial big data resources and technologies to tackle the complexity of urban systems. Given this context, we propose a new measure for the delineation of shrinking areas within cities by introducing a new concept of functional urban shrinkage, which aims to capture the mismatch between urban built-up areas and the areas where significantly intensive human activities take place. Taking advantage of a data fusion approach to integrating multi-source geospatial big data and survey data, a general analytical framework is developed to construct functional shrinkage measures. Combining geospatial big data with urban land-use functions obtained from land surveys and Points-Of-Interests data, the framework further enables the comparison between cities from dimensions characterized by indices of spatial and urban functional characteristics and the landscape fragmentation; thus, it has the capacity to facilitate an in-depth investigation of fundamental causes and internal mechanisms of urban shrinkage. 
  • 1.7K
  • 05 Nov 2020
Topic Review
Gold Nanoparticle-Based Combined Cancer Therapy
The integrated development of innovative nanoparticle (NP) based approaches will be a key to address one of the main issues in both radiotherapy and chemotherapy: normal tissue toxicity. Among other inorganic NP systems, gold nanoparticle (GNP) based systems offer the means to further improve chemotherapy through controlled delivery of chemotherapeutics, while local radiotherapy dose can be enhanced by targeting the GNPs to the tumor.
  • 1.7K
  • 31 Aug 2020
Topic Review
Tauopathies
Tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule associated protein Tau (MAPT) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. These diseases include frontotemporal dementia (FTD) and Alzheimer’s disease (AD) and can be sporadic or inherited when caused by mutations in the MAPT gene. Despite an incredibly high socio-economic burden worldwide, there are still no effective disease-modifying therapies and few Tau-focused experimental drugs have reached clinical trials. One major hindrance for therapeutic development is the knowledge gap in molecular mechanisms of Tau-mediated neuronal toxicity and death. For the promise of precision medicine for brain disorders to be fulfilled, it is necessary to integrate known genetic causes of disease, i.e., MAPT mutations, with understanding of the dysregulated molecular pathways that constitute potential therapeutic targets. Here, the growing understanding of known and proposed mechanisms of disease etiology will be reviewed, together with promising experimental Tau-directed therapeutics, such as recently developed Tau degraders. A particular focus will be given to the application of patient-specific stem cell models to study disease, and a number ofCurrent challenges faced by the fields of Tau research and drug discovery will alsobe addressed, including Tau pathophysiology unanswered questions, limitations of model systems and current challenges faced in developing cell-permeable small molecules that target Tau in disease.
  • 1.7K
  • 07 Dec 2020
Topic Review
Hypermethioninemia
Hypermethioninemia is an excess of a particular protein building block (amino acid), called methionine, in the blood. This condition can occur when methionine is not broken down (metabolized) properly in the body.
  • 1.7K
  • 23 Dec 2020
Topic Review
GSH/NO in Skeletal Muscle Physiology
Glutathione (GSH) is the main non-enzymatic antioxidant playing an important role in detoxification and signal transduction by modulation of protein thiols redox status and direct scavenging of radicals. The latter function is not only performed against reactive oxygen species (ROS) but GSH also has a fundamental role in buffering nitric oxide (NO), a physiologically-produced molecule having multifaceted functions. The efficient rate of GSH synthesis and high levels of GSH-dependent enzymes are characteristic features of healthy skeletal muscle where, besides the canonical functions, it is also involved in muscle contraction regulation. 
  • 1.7K
  • 03 Sep 2021
Topic Review
Distribution and Diagnostics of Invasive Candidiasis
Invasive candidiasis (IC) is a systemic life-threatening infection of immunocompromised humans, but remains a relatively neglected disease among public health authorities. Ongoing assessments of disease epidemiology are needed to identify and map trends of importance that may necessitate improvements in disease management and patient care. Well-established incidence increases, largely due to expanding populations of patients with pre-disposing risk factors, has led to increased clinical use and pressures on antifungal drugs. This has been exacerbated by a lack of fast, accurate diagnostics that have led treatment guidelines to often recommend preventative strategies in the absence of proven infection, resulting in unnecessary antifungal use in many instances. The consequences of this are multifactorial, but a contribution to emerging drug resistance is of primary concern, with high levels of antifungal use heavily implicated in global shifts to more resistant Candida strains.
  • 1.7K
  • 24 Jun 2022
Topic Review
Social Value Orientations
In social psychology, social value orientation (SVO) is a person's preference about how to allocate resources (e.g. money) between the self and another person. SVO corresponds to how much weight a person attaches to the welfare of others in relation to the own. Since people are assumed to vary in the weight they attach to other peoples' outcomes in relation to their own, SVO is an individual difference variable. The general concept underlying SVO has become widely studied in a variety of different scientific disciplines, such as economics, sociology, and biology under a multitude of different names (e.g. social preferences, other-regarding preferences, welfare tradeoff ratios, social motives, etc.).
  • 1.7K
  • 25 Oct 2022
Topic Review
Lojong
Lojong (Tib. བློ་སྦྱོང་,Wylie: blo sbyong) is a mind training practice in the Tibetan Buddhist tradition based on a set of aphorisms formulated in Tibet in the 12th century by Chekawa Yeshe Dorje. The practice involves refining and purifying one's motivations and attitudes. The fifty-nine or so slogans that form the root text of the mind training practice are designed as a set of antidotes to undesired mental habits that cause suffering. They contain both methods to expand one's viewpoint towards absolute bodhicitta, such as "Find the consciousness you had before you were born" and "Treat everything you perceive as a dream", and methods for relating to the world in a more constructive way with relative bodhicitta, such as "Be grateful to everyone" and "When everything goes wrong, treat disaster as a way to wake up." Prominent teachers who have popularized this practice in the West include Pema Chödrön, Ken McLeod, Alan Wallace, Chögyam Trungpa, Sogyal Rinpoche, Kelsang Gyatso, Norman Fischer and the 14th Dalai Lama.
  • 1.7K
  • 28 Nov 2022
Topic Review
Heteronuclear Metal Complexes with Anticancer Activity
Transition metal complexes have been deeply studied for different applications, such as catalysis, antimicrobial, and also antitumoral drugs. Platinum complexes are probably the most well-known and studied in the field of anticancer compounds, also thanks to the omnipresence of cisplatin and its derivatives as a starting point. Two promising new strategies to increase the efficacy of transition metal-based complexes have been described. First, the possibility of assembling two biologically active fragments containing different metal centres into the same molecule were considered, thus obtaining a heterobimetallic complex. Secondly, the conjugation of metal-based complexes to a targeting moiety was discussed.
  • 1.7K
  • 09 Jan 2023
Topic Review Peer Reviewed
Modern Methods of Prediction
Humans have always wanted to know what the future holds in store for them. In earlier centuries, people often sought clues to the future from sacred texts. Today, more secular approaches are increasingly used, although the older approaches to the future persist. Modern methods for prediction include trend extrapolation, the Delphi method, mathematical modeling, and scenario analysis, including backcasting. Extrapolation was only possible when reliable past data became available. The Delphi method relies on the judgement of experts in the subject matter. Mathematical modeling has been very successful in the physical sciences, and, in the form of integrated assessment models (IAMs), has been applied to problems such as assessing future energy use. Scenario analysis looks at a number of possible futures and develops internally consistent story lines around each. It is often used in conjunction with IAMs. Each of the four methods, including both their strengths and weaknesses, are discussed in turn. Finally, this entry looks at the future of prediction, and concludes that despite progress in each of the four approaches treated, predicting the future, never easy, is now harder than ever.
  • 1.7K
  • 28 Apr 2023
Topic Review
L-Dopa Extraction and Analytical Determination in Plant Matrices
L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family contain significant amounts of L-dopa. Due to its low stability, the unambiguous determination of L-dopa in plant matrices requires appropriate technologies. Several analytical methods have been developed for the determination of L-dopa in different plants. The most used for quantification of L-dopa are mainly based on capillary electrophoresis or chromatographic methods, i.e., high-performance liquid chromatography (HPLC), coupled to ultraviolet-visible or mass spectrometric detection. HPLC is most often used. 
  • 1.7K
  • 01 Sep 2022
Topic Review
Biofilms in Space
The impacts of biofilms are well known in the medical, agricultural, commercial, and industrial spaces. It less known that biofilms are undermining many facets of space travel and that their effects need to be understood and addressed for future space missions. Biofilms can damage space crew health and spoil limited food supply. Yet, at the same time, they can benefit plant systems for food growth, nutrient development, and other biological systems that are being explored for use in space travel. Various biofilm removal techniques have been studied to mitigate the hazards posed by biofilm persistence during space travel. Because the presence of biofilms can advance or hinder humanity’s space exploration efforts, an understanding of their impacts over the duration of space flights is of paramount importance. 
  • 1.6K
  • 03 Nov 2020
Topic Review
Wearable Sensors in Para-Sports
Wearable sensors provide a promising opportunity to quantitatively assess the individual functional capacities of an athlete with disability in an ecological environment. The available evidence for the application of wearable sensors in sport for athletes with disabilities is mainly focused on performance assessment and characterization for training optimization, mirroring classic aspects of sports biomechanics in non-disabled athletes. Applications specific to sports for people with disability, such as athlete classification and injury prevention, are limited but indicate possible directions for further development. Finally, since the equipment is frequently of particular importance in sports for persons with disability, the literature indicates that wearable systems are promising to support the customization of equipment to meet the athlete's individual needs.
  • 1.6K
  • 25 Apr 2021
Topic Review
ACT Therapy for Solid Tumors
Adoptive cell therapy (ACT) with tumor-infiltrating T cells (TILs) has emerged as a promising therapy for the treatment of unresectable or metastatic solid tumors. One challenge to finding a universal anticancer treatment is the heterogeneity present between different tumors as a result of genetic instability associated with tumorigenesis. As the epitome of personalized medicine, TIL-ACT bypasses the issue of intertumoral heterogeneity by utilizing the patient’s existing antitumor immune response. Despite being one of the few therapies capable of inducing durable, complete tumor regression, many patients fail to respond. Recent research has focused on increasing therapeutic efficacy by refining various aspects of the TIL protocol, which includes the isolation, ex vivo expansion, and subsequent infusion of tumor specific lymphocytes.
  • 1.6K
  • 05 May 2021
Topic Review
Autonomous Driving Systems
Autonomous vehicles are increasingly becoming a necesAutonomous vehicles are increasingly becoming a necessary trend towards building the smart cities of the future. Numerous proposals have been presented in recent years to tackle particular aspects of the working pipeline towards creating a functional end-to-end system, such as object detection, tracking, path planning, sentiment or intent detection, amongst others. Nevertheless, few efforts have been made to systematically compile all of these systems into a single proposal that also considers the real challenges these systems will have on the road, such as real-time computation, hardware capabilities, etc.
  • 1.6K
  • 11 May 2021
Topic Review
Bioavailability of Lingonberry Polyphenols
Lingonberry (Vaccinium vitis-idaea) is less prevalent in the daily human diet because they are collected from the wild, and plant breeding of lingonberry is still on a small scale. Lingonberries are classed as “superfruits” with the highest content of antioxidants among berries and a broad range of health-promoting effects. Many studies showed various beneficial effects of lingonberries, such as anti-inflammatory, antioxidant, and anticancer activities. Lingonberries have been shown to prevent low-grade inflammation and diet-induced obesity in diabetic animals. Moreover, lingonberry intake has been associated with a beneficial effect on preventing and treating brain aging and neurodegenerative disorders.
  • 1.6K
  • 03 Jun 2021
Topic Review
Lipid-Based Nanocarrier for Nutraceuticals Delivery
Nutraceuticals possess several health benefits and functions; however, most nutraceuticals are prone to degradation in the gastrointestinal environment and have poor bioavailability. Application of a novel carrier system is of increasing importance to overcome obstacles and provide efficient applicability. Lipid-based nanocarriers provide a large surface-to-mass ratio, enhanced intestinal absorption by solubilization in the intestinal milieu, intestinal lymphatic transport, and altering enterocyte-based transport.
  • 1.6K
  • 23 Sep 2021
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback