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Topic Review
The Oncogenic Potential of SARS-CoV-2
Some viruses are known to be associated with the onset of specific cancers. Seven of these microorganisms, recognized as oncogenic viruses or oncoviruses, promote tumorigenesis in humans, converting normal cells into cancer cells through the modulation of central metabolic pathways or the impairment of genomic integrity mechanisms, consequently inhibiting the apoptotic machinery and/or enhancing cell proliferation. Actually, research indicates that SARS-CoV-2 infection and COVID-19 progression may predispose recovered patients to cancer onset and accelerate cancer development. This hypothesis is based on the growing evidence regarding the ability of SARS-CoV-2 to modulate oncogenic pathways, promoting chronic low-grade inflammation and causing tissue damage. As for SARS-CoV-2, its role as an oncogenic virus seems to occur through the inhibition of oncosuppressors or controlling the metabolic and autophagy pathways in the infected cells. On the other hand, looking at the SARS-CoV-2─cancer relationship from an opposite perspective, oncolytic effects and anti-tumor immune response were triggered by SARS-CoV-2 infection in some cases.
  • 3.3K
  • 11 May 2023
Topic Review
Sunscreens and UV Protection
Excessive UV (ultraviolet) radiation exposure is harmful to skin cells since sunburn is accompanied by oxidative burst, leading to a rapid increase in skin cancer. However, the insufficient UV photoprotection of approved sunscreens and the negative impact of their compositions on ecosystems and human health makes the utility of sunscreen a questionable recommendation. Therefore, discovering UV filters with significant antioxidant activity and improved topical performance and photostability is an urgent need.
  • 3.3K
  • 17 Mar 2023
Topic Review
Niacin
Niacin (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).
  • 3.3K
  • 17 Feb 2022
Topic Review
Marine-Derived Phenolic Compounds
Phenolic metabolites are organic compounds with at least one or more hydroxyl groups attached to arylic systems with simple variations to highly polymerized molecules.
  • 3.3K
  • 10 Mar 2022
Topic Review
Membrane Protein
Membrane proteins are polypeptides integrated into or associated with biological membranes. They are present at roughly equal weight to phospholipids in plasma membranes of cells, in outer membranes of bacteria, mitochondria, chloroplasts and in other organelles. Membrane proteins govern the active functions of membranes, such as transport, signalling, asymmetry and polarisation. Membrane proteins follow characteristic folding patterns and have hydrophobic domains that make them compatible with the amphipathic lipid biayers.
  • 3.2K
  • 24 Dec 2020
Topic Review
Bioactive Compounds from Marine Sponges
Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit various bioactivities, such as antimicrobial, antitumor and general cytotoxicity.
  • 3.2K
  • 25 May 2021
Topic Review
Organelle-Targeted Fluorescent Probes
Fluorescent chemical probes have been extensively used to study biochemical events within live cells. The advent of super-resolution imaging techniques and the availability of a wide variety of fluorescent probes enable effective subcellular tracking of transient metabolites and signaling molecules that are involved in important physiological processes. Probes targeting specific organelles such as mitochondria and lysosomes have been used routinely to monitor organelle functions and have become invaluable tools for the investigation of disease-relevant pathways. These probes efficiently target subcellular organelles; however, considering the complexity and diversity of biochemical processes inside the cells, probes that are not only specific to target organelles but also tailored to applications are highly desirable. 
  • 3.2K
  • 18 Jan 2021
Topic Review
Type I Collagen
Type I collagen, the predominant protein of vertebrates, assembles into fibrils that orchestrate the form and function of bone, tendon, skin, and other tissues. Collagen plays roles in hemostasis, wound healing, angiogenesis, and biomineralization, and its dysfunction contributes to fibrosis, atherosclerosis, cancer metastasis, and brittle bone disease.
  • 3.2K
  • 26 Jan 2021
Topic Review
Thin-Layer Chromatography Bioautography
Thin-layer chromatography (TLC) bioautography is a methodological technique that integrates the separation and analysis technology of TLC with biological activity detection technology, which is used to isolate, locate and evaluate the active constituents of natural creatures based on the guidance of activity.
  • 3.2K
  • 06 Aug 2021
Topic Review
Modulation of the Nrf2 pathways
The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that acts through antioxidant-responsive elements (ARE) in the promoter region of deoxyribonucleic acid (DNA) and it transcriptionally promotes the expression of Phase 2 metabolism/antioxidant enzymes, such as glutathione S-transferase (GST), nicotinamide adenine dinucleotide (phosphate)  (NAD(P)H) quinone oxidoreductase-1 (NQO-1), and heme oxygenase-1 (HO-1).  The Nrf2-mediated pathway is now recognized to occupy a central position in cell defense mechanisms. Here, we discuss the historical discovery of Nrf2 and the regulatory mechanism of the Nrf2-mediated pathway, focusing on the interacting proteins and post-translational modifications. 
  • 3.2K
  • 06 Sep 2020
Topic Review
Reactive Oxygen Species
Reactive oxygen species (ROS) can directly activate HSCs or induce inflammation or programmed cell death, especially pyroptosis, in hepatocytes, which in turn activates HSCs and fibroblasts to produce ECM proteins.
  • 3.2K
  • 27 Jan 2022
Topic Review
Mechanisms of Exosome Biogenesis
Exosomes are nanometer-sized vesicles released by different cells that are important in the normal functioning of the body. In cancer, exosomes have been found to promote tumor growth and metastasis by carrying functional biomolecules and acting on different target sites in the body. Understanding the mechanism by which cancers modulate exosome secretion is crucial to studying cancer biology and developing new therapeutic approaches.
  • 3.2K
  • 18 Apr 2023
Topic Review
The Proteasome System
The proteasome system is a large and complex molecular machinery responsible for the degradation of misfolded, damaged, and redundant cellular proteins. When proteasome function is impaired, unwanted proteins accumulate, which can lead to several diseases including age-related and neurodegenerative diseases. Enhancing proteasome-mediated substrate degradation with small molecules may therefore be a valuable strategy for the treatment of various neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and Huntington’s diseases. 
  • 3.2K
  • 24 Mar 2022
Topic Review
Perfume and Flavor Engineering
The Perfumery Ternary Diagram enables us to determine the dominant odor for each perfume composition.
  • 3.2K
  • 29 Jun 2021
Topic Review
Glucosinolates
Glucosinolates (GSLs) are secondary plant metabolites abundantly found in plant order Brassicales. GSLs are constituted by an S-β-d-glucopyrano unit anomerically connected to O-sulfated (Z)-thiohydroximate moiety. The side-chain of the O-sulfate thiohydroximate moiety, which is derived from a different amino acid, contributes to the diversity of natural GSL, with more than 130 structures identified and validated to this day. Both the structural diversity of GSL and their biological implication in plants have been biochemically studied. While intact GSLs are biologically inactive, various products, including isothiocyanates, nitriles, epithionitriles, and cyanides obtained through enzyme-catalyzed hydrolysis of GSLs, exhibit many different biological activities, among which several therapeutic benefits have been suggested. 
  • 3.1K
  • 12 Oct 2020
Topic Review
Molecular Biology of the ERBB2 Signaling Pathway
Notably, 5% of metastatic colorectal cancer (mCRC) cases harbor Erb-B2 receptor tyrosine kinase 2 (ERBB2) alterations. ERBB2, commonly referred to as human epidermal growth factor receptor 2, is a member of the human epidermal growth factor receptor family of protein tyrosine kinases. In addition to being a recognized therapeutic target in the treatment of gastric and breast malignancies, it is considered crucial in the management of colorectal cancer (CRC). 
  • 3.1K
  • 01 Nov 2022
Topic Review
High-density lipoprotein in skin diseases
From an evolutionary perspective, lipoproteins are not only lipid transporters, but they also have important functions in many aspects of immunity. High-density lipoprotein (HDL) particles are the most abundant lipoproteins and the most heterogeneous in terms of their composition, structure, and biological functions. Despite strong evidence that HDL potently influences the activity of several immune cells, the role of HDL in skin diseases is poorly understood. Alterations in HDL-cholesterol levels have been observed in atopic dermatitis (eczema), psoriasis, urticaria, and angioedema. HDL-associated apolipoprotein (apo) A-I, apoA-IV, and apoC-III, and lyso-phosphatidylcholines potently suppress immune cell effector responses. Interestingly, recent studies provided evidence that skin diseases significantly affect HDL composition, metabolism, and function, which, in turn, could have a significant impact on disease progression, but may also affect the risk of cardiovascular disease and infections. Interestingly, not only a loss in function, but also, sometimes, a gain in function of certain HDL properties is observed.
  • 3.1K
  • 15 Dec 2020
Topic Review
Grape Phenolics
Grapes are rich in primary and secondary metabolites. Among the secondary metabolites, polyphenolic compounds are the most abundant in grape berries. Besides their important impacts on grape and wine quality, this class of compounds has beneficial effects on human health. Due to their antioxidant activity, polyphenols and phenolic acids can act as anti-inflammatory and anticancerogenic agents, and can modulate the immune system. In grape berries, polyphenols and phenolic acids can be located in the pericarp and seeds, but distribution differs considerably among these tissues. Although some classes of polyphenols and phenolic acids are under strict genetic control, the final content is highly influenced by environmental factors, such as climate, soil, vineyard, and management. 
  • 3.1K
  • 13 Jan 2021
Topic Review
P62
P62 is a versatile protein involved in the delicate balance between cell death and survival, which is fundamental for cell fate decision in the context of both cancer and neurodegenerative diseases. As an autophagy adaptor, p62 recognizes polyubiquitin chains and interacts with LC3, thereby targeting the selected cargo to the autophagosome with consequent autophagic degradation. Beside this function, p62 behaves as an interactive hub in multiple signalling including those mediated by Nrf2, NF-κB, caspase-8, and mTORC1. The protein is thus crucial for the control of oxidative stress, inflammation and cell survival, apoptosis, and metabolic reprogramming, respectively. As a multifunctional protein, p62 falls into the category of those factors that can exert opposite roles in the cells. Chronic p62 accumulation was found in many types of tumors as well as in stress granules present in different forms of neurodegenerative diseases. However, the protein seems to have a Janus behaviour since it may also serve protective functions against tumorigenesis or neurodegeneration. 
  • 3.1K
  • 04 Aug 2020
Topic Review
Carboxylases for CO2 Biotransformation
The rapid growth of atmospheric CO2 concentration by continuous consumption of fossil fuels is one of the main causes of global warming. Turning CO2 into fuels and chemicals through biotransformation offers a win-win strategy to both decrease atmospheric CO2 and efficiently exploit carbon resources. The overall efficiency of CO2 biotransformation in vitro and CO2 assimilation in vivo is generally determined by the biochemical properties of carboxylases. Herein, we summarized carboxylases based on catalytic mechanism and CO2 biotransformation in vitro and CO2 assimilation in vivo based on newly mined or designed carboxylases. 
  • 3.1K
  • 04 Mar 2021
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