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Topic Review
Antihypertensives’ around the Clock
Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable, and that variability occurs in cycles. So allostatic model has emerged as the first challenge to homeostasis. Circadian variation is the predominant variation in the body. As there is strong scientific and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further by ensuring better patients' adherence throughout the development and approval process for the use of pulsatile drug release systems which can be considered as an option for an even more convenient dosage regimen of the medicines needed.
  • 2.0K
  • 20 May 2021
Topic Review
Pseudomonas aeruginosa Virulence Factors
Pseudomonas (P.) aeruginosa is an opportunistic pathogen that causes serious infections and hospital-acquired pneumonia in immunocompromised patients. The poor clinical outcome of P. aeruginosa-induced pneumonia is ascribed to its ability to disrupt lung barrier integrity, leading to the development of lung edema and bacteremia. Airway epithelial and endothelial cells are important architecture blocks that protect the lung from invading pathogens. P. aeruginosa produces a number of virulence factors that can modulate barrier function, directly or indirectly, through exploiting cytoskeleton networks and intercellular junctional complexes in eukaryotic cells.
  • 2.0K
  • 13 Dec 2021
Topic Review
Transposable Elements
Transposable elements (TEs) are mobile DNA sequences that can jump from one genomic locus to another and that have colonized the genomes of all living organisms. While TE mobilization is an important source of genomic innovations that greatly contribute to the host species evolution, it is also a major threat to genome integrity that can lead to pathologies.
  • 2.0K
  • 26 May 2022
Topic Review
Caregiver Stress
Caregiver syndrome or caregiver stress is a condition that strongly manifests exhaustion, anger, rage, or guilt resulting from unrelieved caring for a chronically ill patient. This condition is not listed in the United States' Diagnostic and Statistical Manual of Mental Disorders, although the term is often used by many healthcare professionals in that country. The equivalent used in many other countries, the ICD-11, does include the condition. Over 1 in 5 Americans are providing care to those who are ill, aged, and/or disabled. Over 13 million caregivers provide care for their own children as well. Caregiver syndrome is acute when caring for an individual with behavioral difficulties, such as: fecal incontinence, memory issues, sleep problems, wandering, impulse control problems , executive dysfunction, and/or aggression. Typical symptoms of the caregiver syndrome include fatigue, insomnia and stomach complaints with the most common symptom being depression.
  • 2.0K
  • 30 Sep 2022
Topic Review
Alpha Crucis
Alpha Crucis (α Crucis, abbreviated Alpha Cru, α Cru) is a multiple star system 321 light-years from the Sun in the constellation of Crux and part of the asterism known as the Southern Cross. With a combined visual magnitude of 0.76, it is the brightest star in Crux and the 13th brightest star in the night sky. It is the southernmost first-magnitude star, 2.3 degrees more southerly than Alpha Centauri. To the naked eye Alpha Crucis appears as a single star, but it is actually a multiple star system. Two components are visually distinguishable: α1 Crucis and α2 Crucis; alternatively designated α Crucis A and α Crucis B. Both are B-type stars, and are many times more massive and luminous than the Sun. α1 Crucis is itself a spectroscopic binary with components designated α Crucis Aa (also named Acrux) and α Crucis Ab. Its two component stars orbit every 76 days at a separation of about 1 astronomical unit (au).
  • 2.0K
  • 08 Oct 2022
Topic Review
Flow Field Design of PEMFC
Climate change and the major threat it poses to the environment and human lives is the major challenge the world faces today. To overcome this challenge, it is recommended that future automobiles have zero carbon exhaust emissions. Even though battery electric vehicles reduce carbon emissions relative to combustion engines, a carbon footprint still remains in the overall ecosystem unless the battery is powered by renewable energy sources. The proton exchange membrane fuel cell (PEMFC) is an alternate source for automotive mobility which, similar to battery electric vehicles, has zero carbon emissions from its exhaust pipe. Moreover, the typical system level efficiency of a PEMFC is higher than an equivalent internal combustion powertrain.
  • 2.0K
  • 27 Sep 2023
Topic Review
Construction Risks Due to Fast-Track Activity Overlapping
Concurrent engineering through overlapping of activities (i.e., fast-tracking) has been used as a schedule acceleration technique. Fast-track construction projects are generally recognized as riskier and subject to risks arising due to the concurrency of work.
  • 2.0K
  • 01 Dec 2023
Topic Review
9 Track Tape
The IBM System/360, announced in 1964, introduced what is now generally known as 9 track tape. The ​1⁄2 inch (12.7 mm) wide magnetic tape media and reels are the same size as the earlier IBM 7 track format it replaced, but the new format has eight data tracks and one parity track for a total of nine parallel tracks. Data is stored as 8-bit characters, spanning the full width of the tape (including the parity bit). Various recording methods have been employed during its lifetime as tape speed and data density increased, including PE (phase encoding), GCR (group coded recording) and NRZI (non-return-to-zero, inverted, sometimes pronounced "nur-zee"). Tapes come in various sizes up to 3,600 feet (1,100 m) in length. The standard size of a byte was effectively set at eight bits with the S/360 and nine-track tape. For over 30 years the format dominated offline storage and data transfer, but by the end of the 20th century it was obsolete, and the last manufacturer of tapes ceased production in early 2002, with drive production ending the next year.
  • 2.0K
  • 14 Oct 2022
Topic Review
Land Use Land Cover Modeling
Land use land cover (LULC) modeling is considered as the best tool to comprehend and unravel the dynamics of future urban expansion.
  • 2.0K
  • 06 Feb 2023
Topic Review
CRISPR FokI Dead Cas9 System
FokI–dCas9 (fdCas9) or RNA-guided FokI nuclease (RFN) is a genome editing tool engineered by fusing  the catalytic domain of the FokI endonuclease to the N-terminal catalytic inactive Cas9 protein. The fdCas9 system is active only as a heterodimer, requiring the simultaneous binding of two fdCas9/sgRNAs monomers at adjacent target sites in a PAM-out orientation, and a specific spacer distance separating the two binding sites of the two sgRNAs. The five engineered and published constructs induce significant gene editing activities and specificities, as tested on various gene targets and overcome the off-target effects associated with other genome editing tools, including ZFNs, TALENs, and CRISPR/Cas systems.
  • 2.0K
  • 30 Nov 2020
Topic Review
Battery-Less RFID-Based Wireless Sensors
Wireless sensors are becoming increasingly popular in the home and industrial sectors and are used for a range of applications, from temperature or humidity monitoring to food-quality inspection of products being sold on the market. One of the main reasons for using wireless technology is that it affords non-contact, non-invasive sensing. This ability eliminates the need for long cables required for information transfer and reduces the spread of germs and brings comfort to the users.
  • 2.0K
  • 27 Jul 2021
Topic Review
POWER10
POWER10 designates a proposed superscalar, multithreading, multi-core microprocessor family, based on the open source Power ISA, and announced in August 2020 at the Hot Chips conference; systems with POWER10 CPUs are intended to reach customers in the fourth quarter of 2021. The processor is designed to have 15 cores available, but a spare core will be included during manufacture to cost-effectively allow for yield issues. POWER10-based processors will be manufactured by Samsung using a 7 nm process with 18 layers of metal and 18 billion transistors on a 602 mm2 silicon die. The main features of POWER10 are higher performance per watt, and better memory and I/O architectures, with a focus on artificial intelligence (AI) workloads.
  • 2.0K
  • 18 Oct 2022
Topic Review
Zawiyet Sidi Boumerdassi
Zawiyet Sidi Boumerdassi (Arabic: زاوية سيدي البومرداسي) or Zawiyet Ouled Boumerdès is a zawiya located within Boumerdès Province in Algeria.
  • 2.0K
  • 14 Nov 2022
Topic Review
Almaguin Highlands
The Almaguin Highlands Region (colloquially known as Almaguin, also referred to as 'the Highlands') in Ontario, Canada, covers approximately 5,200 km2 (2,000 sq mi) comprising the eastern half of Parry Sound District. It is bounded by Muskoka in the south, and by Lake Nipissing and Nipissing District in the north. The eastern edge abuts the western boundary of Algonquin Provincial Park, whereas the western boundary of the Almaguin Highlands is generally regarded to be the mid east-west point of Parry Sound District. Originally derived from the words, Algonquin, Magnetawan, and Seguin. Almaguin is now used to describe the marketing region of East Parry Sound.
  • 2.0K
  • 01 Dec 2022
Topic Review
Mechanical Properties of Animal Tendons
In medical and bioengineering research, animal tendons are commonly utilized as surrogates for human ones for mechanical testing. Due to the differences among human tendons of different anatomical districts, different animal species can be better suited for specific purposes. Indeed, the mechanical response of animal tendons to an external load is strictly related to its complex and highly organized hierarchical structure, which ranges from nano- to macroscale. In a broader sense, the mechanical properties of tendons during tensile tests are affected by several distinct factors, due in part to tendon nature (anatomical site, age, training, injury, etc.) but also depending on the experimental setup and settings. Thus, there are similarities between animal and human tendons that should be considered in the biomechanical evaluation. 
  • 2.0K
  • 12 Mar 2022
Topic Review
Public Electric Vehicle Charging Infrastructures Planning and Operation
Planning public electric vehicle (EV) charging infrastructure has gradually become a key factor in the electrification of mobility and decarbonization of the transport sector. In order to achieve a high level of electrification in mobility, different studies have been presented, proposing novel practices and methodologies for the planning and operation of electric vehicles charging infrastructure. 
  • 2.0K
  • 19 Sep 2023
Topic Review
Elementary Charge and Vacuum Energy
Classical electrodynamics was introduced by James Clear Maxwell nearly 150 years ago and it is a subject that had been thoroughly explored over these years. Notwithstanding this long term scrutiny of this subject, there are hidden features in classical electrodynamics that actually heralds the emergence of Quantum electrodynamics in the future. Such examples can be found when analyzing the electromagnetic radiation generated by antennas working in both frequency and time domain and in the case of transition radiation generated by decelerating electrons. Here we discuss one such case. Consider the radiation generated by an antenna working in frequency domain. One can show that the energy dissipated as radiation within half a period of oscillation, say U, satisfies the inequality U ≥ hf →q ≥ e where q  is the magnitude of the oscillating charge in the antenna, e is the elementary charge, f is the frequency of oscillation and h is the Planck constant. This result is derived while adhering strictly to the principles of classical electrodynamics alone. Combining this result with the concept of photons burrowed from quantum mechanics, one can derive an expression for the elementary charge as a function of other natural constants and the energy density of vacuum. The expression predicts the value of elementary charge to an accuracy higher than about 0.1%.
  • 2.0K
  • 01 Nov 2020
Topic Review
Glutathione in the Brain
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the antioxidant defense system and the maintenance of redox homeostasis in neurons.
  • 2.0K
  • 13 May 2021
Topic Review
Atrial Fibrillation Arrhythmia Detection Methods
Atrial fibrillation (AF) is still a major cause of disease morbidity and mortality, making its early diagnosis desirable and urging researchers to develop efficient methods devoted to automatic AF detection. Till now, the analysis of electrocardiography (Holter-ECG) recordings remains the gold-standard technique to screen AF. This is usually achieved by studying either RR interval time series analysis, P-wave detection or combinations of both morphological characteristics. After extraction and selection of meaningful features, each of the AF detection methods might be conducted through univariate and multivariate data analysis. Many of these automatic techniques have been proposed over the last years. 
  • 2.0K
  • 12 Jul 2022
Topic Review
Salicylic Acid in Plants Exposed to Heavy Metals
Salicylic acid (SA) is a very simple phenolic compound (a C7H6O3 compound composed of an aromatic ring, one carboxylic and a hydroxyl group) and this simplicity contrasts with its high versatility and the involvement of SA in several plant processes either in optimal conditions or in plants facing environmental cues, including heavy metal (HM) stress. 
  • 2.0K
  • 29 Jul 2022
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