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Topic Review
Proto-Norse
Proto-Norse (also called Ancient Nordic, Ancient Scandinavian, Primitive Norse, Proto-Nordic, Proto-Scandinavian, Proto-North Germanic and North Proto-Germanic) was an Indo-European language spoken in Scandinavia and a reconstructed proto-language of Old Norse that is thought to have evolved as a northern dialect of Proto-Germanic in the first centuries CE. It is the earliest stage of a characteristically North Germanic language, and the language attested in the oldest Scandinavian Elder Futhark inscriptions, spoken from around the 2nd to the 8th centuries CE (corresponding to the late Roman Iron Age and the Germanic Iron Age). It evolved into the dialects of Old Norse at the beginning of the Viking Age around 800 CE, which later themselves evolved into the modern North Germanic languages (Faroese, Icelandic, the three Continental Scandinavian languages, and their dialects).
  • 2.1K
  • 17 Nov 2022
Topic Review
Plasma Proteins
Blood contains various plasma proteins and cells to which endogenous and exogenous molecules can bind together to be transported throughout the circulatory system. Among the different plasma proteins, the binding of small molecular weight drug molecules is mostly associated with serum albumin and alpha-1 acid glycoprotein and, to a lesser extent globulins and lipoproteins. Although linear binding applies for most clinically used drugs, some physiopathological factors and/or dietary-drug interactions may lead to alterations of the drug-protein binding, which in turn may result in clinically changes in the pharmacokinetics and pharmacodynamics of the drug. As polyphenols (flavonoids and non-flavonoids) are widely present in plant-derived feeds, beberages, herbal medicines, and dietary supplements, the knowledge of how they bind to plasma proteins can prevent/avoid such interactions.
  • 2.1K
  • 30 Dec 2020
Topic Review
Fungi in the Cocoa Production
The role of fungi in cocoa crops is mainly associated with plant diseases and contamination of harvest with unwanted metabolites such as mycotoxins that can reach the final consumer. However, they can be play a positive role as endophytic promoting plant protection and growth; in addition they could play an important role in the fermentation step providing extracellular enzymes important to the pulp bean degradation. 
  • 2.1K
  • 10 May 2021
Topic Review
Cyber Mimic Defense
From the inspiration of defensive guise behaviors based on mimic phenomenon in biology, Cyber Mimic Defense (CMD) introduces the mechanism of dynamic multi-dimensional reconfiguration into a dissimilar redundancy structure (DRS) which is widely used in the field of reliability. It addresses certain or uncertain threats in cyberspace by the principle of uncertain defense, and provides the strategic varieties and transformations of DRS elements inside objects in quantity or type, time or space dimension under the condition of unchanged visual functions. It provides a generally innovative defense theory and method to deal with the “known unknown risk” and “unknown unknown risk” which exist in related application levels of different areas of cyberspace and are based on unknown vulnerabilities, backdoors, viruses, Trojans, etc. This method can provide not only endogenous security gains which are independent of traditional security means and achieved via integrated structural technologies for critical infrastructures or key information equipment, but also resilient or restorable service ability with intensive attributes inherited from the architecture. Further it acquires super nonlinear effects combining mature defense technologies. It's aimed at creating a non-closed, self-controlled and sustainable-developed ecological environment which adapts to globalization technologies and industrial development models and integrates with win-win cooperation and open sources.
  • 2.1K
  • 02 Nov 2022
Topic Review
2019 in Politics and Government
Events pertaining to world affairs in 2019, national politics, public policy, government, world economics, and international business, that took place in various nations, regions, organizations, around the world in 2019.
  • 2.1K
  • 08 Nov 2022
Topic Review
Kouvola
Kouvola (Finnish pronunciation: [ˈkou̯ʋolɑ]) is a city and municipality in southeastern Finland. It is located along the Kymijoki River in the region of Kymenlaakso, 62 kilometres (39 mi) kilometers east of Lahti, 87 kilometres (54 mi) west of Lappeenranta and 134 kilometres (83 mi) northeast of the capital, Helsinki. With Kotka, Kouvola is one of the capital centers and is the largest city in the Kymenlaakso region. Kouvola is bordered by the municipalities of Hamina, Heinola, Iitti, Kotka, Lapinjärvi, Loviisa, Luumäki, Miehikkälä, Mäntyharju, Pyhtää and Savitaipale. Kouvola, which had population growth as late as the 1980s, has suffered a loss of migration since the 1990s. Over time, the loss has only deepened, so that at the end of the 2010s Kouvola was Finland's worst migration loss area. Natural demographics have also trended downward; in 2017, more than 450 more people died in the city than new ones were born. The reasons for the emigration are thought to be largely due to job losses in the region.
  • 2.1K
  • 28 Nov 2022
Topic Review
Ginkgo Biloba and Long COVID
Coronavirus infections are neuroinvasive and can provoke injury to the central nervous system (CNS) and long-term illness consequences. They may be associated with inflammatory processes due to cellular oxidative stress and an imbalanced antioxidant system. The ability of phytochemicals with antioxidant and anti-inflammatory activities, such as Ginkgo biloba, to alleviate neurological complications and brain tissue damage has attracted strong ongoing interest in the neurotherapeutic management of long COVID. Ginkgo biloba leaf extract (EGb) contains several bioactive ingredients, e.g., bilobalide, quercetin, ginkgolides A–C, kaempferol, isorhamnetin, and luteolin. They have various pharmacological and medicinal effects, including memory and cognitive improvement. Ginkgo biloba, through its anti-apoptotic, antioxidant, and anti-inflammatory activities, impacts cognitive function and other illness conditions like those in long COVID.
  • 2.1K
  • 06 Jun 2023
Topic Review
 m6A RNA Methylation Mechanism
Epitranscriptomic modifications can affect every aspect of RNA biology, including stability, transport, splicing, and translation, participate in global intracellular mRNA metabolism, and regulate gene expression and a variety of biological processes. N6-methyladenosine (m6A) as the most prevalent modification contributes to normal embryonic brain development and memory formation. 
  • 2.1K
  • 08 Jun 2022
Topic Review
Vickrey Auction
A Vickrey auction is a type of sealed-bid auction. Bidders submit written bids without knowing the bid of the other people in the auction. The highest bidder wins but the price paid is the second-highest bid. This type of auction is strategically similar to an English auction and gives bidders an incentive to bid their true value. The auction was first described academically by Columbia University professor William Vickrey in 1961 though it had been used by stamp collectors since 1893. In 1797 Johann Wolfgang von Goethe sold a manuscript using a sealed-bid, second-price auction. Vickrey's original paper mainly considered auctions where only a single, indivisible good is being sold. The terms Vickrey auction and second-price sealed-bid auction are, in this case only, equivalent and used interchangeably. When either a divisible good or multiple identical goods are sold in a single auction, however, these terms are used differently. In the case of multiple identical goods, the bidders submit inverse demand curves and pay the opportunity cost. Vickrey auctions are much studied in economic literature but uncommon in practice. Generalized variants of the Vickrey auction for multiunit auctions exist, such as the generalized second-price auction used in Google's and Yahoo!'s online advertisement programmes (not incentive compatible) and the Vickrey-Clarke-Grove Auction (incentive compatible).
  • 2.1K
  • 04 Nov 2022
Topic Review
Integrated Landscape Management
Integrated landscape management is a way of managing a landscape that brings together multiple stakeholders, who collaborate to integrate policy and practice for their different land use objectives, with the purpose of achieving sustainable landscapes. Integrated landscape management is one approach to addressing the major global challenges of poverty, food security, climate change, water scarcity, deforestation and loss of biodiversity at the local level. Proponents of integrated landscape management argue that as these challenges are interconnected, coordinated approaches are needed to address them, in order for landscapes (heterogenous geographic areas) to generate multiple benefits. For example, one river basin can supply water for towns and agriculture, timber and food crops for smallholders and industry, and habitat for biodiversity; the way in which each one of these sectors pursues its goals can have impacts on the others. The integrated approach goes beyond traditional sector-based practices that manage these different land uses independently of each other, even where they depend on the same resource base. The intention is to manage landscapes in a joined-up way, so that society's needs can be met in the short term, and in the long term. Integrated landscape management is increasingly recognised and taken up by intergovernmental bodies, government initiatives, research institutes, and some of the world's largest conservation NGOs, resulting in an increase in the number of examples of the approach in practice. However, barriers to uptake include difficulties in monitoring integrated landscape management and the proliferation of definitions and terms relating to it.
  • 2.1K
  • 07 Oct 2022
Topic Review
Rhizome
Rhizome is an American not-for-profit arts organization that supports and provides a platform for new media art.
  • 2.1K
  • 14 Nov 2022
Topic Review
RT-11
RT-11 (Real-time 11) is a discontinued small, low-end, single-user real-time operating system for the full line of Digital Equipment Corporation PDP-11 16-bit computers. RT-11 was first implemented in 1970. It was widely used for real-time computing systems, process control, and data acquisition across all PDP-11s. It was also used for low-cost general-use computing.
  • 2.1K
  • 22 Nov 2022
Topic Review
Dexamethasone Suppression Test in Psychiatry
The dexamethasone suppression test (DST) assesses the functionality of the HPA axis and can be regarded as the first potential biomarker in psychiatry. In 1981, a group of researchers at the University of Michigan published a groundbreaking paper regarding its use for diagnosing melancholic depression, reporting a diagnostic sensitivity of 67% and a specificity of 95%.
  • 2.1K
  • 24 May 2023
Topic Review
Greenwashing Behavior in Hotels Industry
Greenwashing has become a pervasive phenomenon in the tourism and hospitality sector, posing significant challenges and potential reputational damage to green hotels.
  • 2.1K
  • 02 Feb 2024
Biography
Thomas J.R. Hughes
Thomas Joseph Robert Hughes (born 1943) is a Professor of Aerospace Engineering and Engineering Mechanics and currently holds the Computational and Applied Mathematics Chair III in the Institute for Computational Engineering and Sciences at The University of Texas at Austin.[1][2] Hughes has been listed as an ISI Highly Cited Author in Engineering by the ISI Web of Knowledge, Thomson Scientific
  • 2.1K
  • 16 Nov 2022
Topic Review
Colorectal Cancer Cells
The majority of deaths related to colorectal cancer (CRC) are associated with the metastatic process. Alternative therapeutic strategies, such as traditional folk remedies, deserve attention for their potential ability to attenuate the invasiveness of CRC cells. The aim of this study is to investigate the biological activity of brown Cuban propolis (CP) and its main component nemorosone (NEM) and to describe the molecular mechanism(s) by which they inhibit proliferation and metastatic potential of 2 CRC cell lines. CP and NEM significantly decreased cell viability and inhibited clonogenic capacity of CRC cells in a dose and time-dependent manner, by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Furthermore, CP and NEM downregulated BCL2 gene expression and upregulated the expression of the proapoptotic genes TP53 and BAX, with a consequent activation of caspase 3/7. They also attenuated cell migration and invasion by inhibiting MMP9 activity, increasing E-cadherin and decreasing β-catenin and vimentin expression, proteins involved in the epithelial–mesenchymal transition (EMT). NEM, besides displaying antiproliferative activity on CRC cells, is able to decrease their metastatic potential by modulating EMT-related molecules. These findings provide new insights about the antitumoral properties of CP, due to NEM content.  
  • 2.1K
  • 01 Nov 2020
Topic Review
Angiotensin II Type 2 Receptor
Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system.   Studies of brain AT2R distribution and function are outshining the recent findings about AT2R in peripheral sensoryneurons and pain modulation. While AT2R, as an atypical G protein-coupled receptor, and its related signaling are still under investigation, pharmacological studies have shown that stimulation of AT2R leads to neuritogenesis in vitro and in vivo. This review aims to report the evidence of potential neuroprotective and neuroregenerative roles of AT2R in the peripheral nervous system (PNS).
  • 2.1K
  • 10 Mar 2021
Topic Review
Post-Operative Endodontic Pain Management
Endodontic treatment comprises the overall management of pre-, intra- and post-operative symptoms, including post-operative endodontic pain, considered as a complication susceptible of chronicization. Post-operative pain is very common and highly unpreventable and has a multi-factorial etiology and a potential pathogenic link to the acute inflammation of the periapical area, secondary to localized chemical, mechanical, host and/or microbial damage occurring during endodontic treatment. 
  • 2.1K
  • 05 May 2022
Topic Review
Machine Learning Models for On-Street Parking Prediction
Due to massive urbanization, traffic volume in urban areas has grown, making urban life very congested and polluted, leading to many negative impacts on human life, such as higher energy consumption, global warming, and airborne diseases. The goal of sustainable transport in smart cities is to ensure efficient traffic movement while minimizing a negative impact on the environment and public health.
  • 2.1K
  • 28 Jun 2022
Biography
Anne Treisman
Anne Marie Treisman (née Taylor; 27 February 1935[1] – 9 February 2018)[2][3][4] was an English psychologist who specialised in cognitive psychology. Treisman researched visual attention, object perception, and memory. One of her most influential ideas is the feature integration theory of attention, first published with Garry Gelade in 1980. Treisman taught at the University of Oxford, Unive
  • 2.1K
  • 18 Nov 2022
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