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Topic Review
Wearable Body Sensors
The use of wearable body sensors for health monitoring is a quickly growing field with the potential of offering a reliable means for clinical and remote health management. This includes both real-time monitoring and health trend monitoring with the aim to detect/predict health deterioration and also to act as a prevention tool. The aim of this systematic review was to provide a qualitative synthesis of studies using wearable body sensors for health monitoring. The synthesis and analysis have pointed out a number of shortcomings in prior research. Major shortcomings are demonstrated by the majority of the studies adopting an observational research design, too small sample sizes, poorly presented, and/or non-representative participant demographics (i.e., age, gender, patient/healthy). These aspects need to be considered in future research work.
  • 2.2K
  • 29 Oct 2020
Topic Review
SHORT Syndrome
Short stature, hyperextensibility, hernia, ocular depression, Rieger anomaly, and teething delay, commonly known by the acronym SHORT syndrome, is a rare disorder that affects many parts of the body.
  • 2.2K
  • 04 Jan 2021
Topic Review
MOFs for Mercury Detection
The advantages of metal organic frameworks (MOFs) are: existence of porosity to adsorb specific analyte, improved aqueous solubility, exceptional photophysical and chemical properties. MOFs are noted as exceptional candidates towards the detection and removal of specific analytes, particular for the detection/removal of environmental contaminants, such as heavy metal ions, toxic anions, hazardous gases, explosives, etc. Among heavy metal ions, mercury has been noted as a global hazard because of its high toxicity in the elemental (Hg0), divalent cationic (Hg2+), and methyl mercury (CH3Hg+) forms. To secure the environment and living organisms, many countries have imposed stringent regulations to monitor mercury at all costs. Regarding the detection/removal requirements of mercury, researchers have proposed and reported all kinds of MOFs-based luminescent/non-luminescent probes towards mercury.This review provides valuable information about the MOFs which have been engaged in detection and removal of elemental mercury and Hg2+ ions. Moreover, the involved mechanisms or adsorption isotherms related to sensors or removal studies are clarified for the readers. Finally, advantages and limitations of MOFs in mercury detection/removal are described together with future scopes.
  • 2.2K
  • 01 Jul 2021
Topic Review
Antarctic Marine Fungi
Despite the harsh conditions, fungi are ubiquitously present in Antarctic ecosystems. The key to fungal success can be due to the vast array of specialized molecules, which allowed their colonization in almost every habitat of our Planet. In Antarctic marine environments, the fungal specific adaptions to low temperatures lead to the production of structurally novel enzymes and secondary metabolites that provide competitive advantages over other microorganisms. The bioprospecting of Antarctic fungi for new bioactive compounds and enzymes is important not only for elucidating their ecological role but also useful for developing blue biotechnologies. 
  • 2.2K
  • 01 Jun 2021
Topic Review
Nootropics
Nootropics, also known as “smart drugs” are a diverse group of medicinal substances whose action improves human thinking, learning, and memory, especially in cases where these functions are impaired. An up-to-date overview of the potential effectiveness and importance of nootropics are introduced. Based on their nature and their effects, this heterogeneous group of drugs has been divided into four subgroups: classical nootropic compounds, substances increasing brain metabolism, cholinergics, and plants and their extracts with nootropic effects.
  • 2.2K
  • 06 Sep 2022
Topic Review
BTSB Anti-D Scandal
In 1994, the Irish Blood Transfusion Service Board (BTSB) informed the Minister for Health that a blood product they had distributed in 1977 for the treatment of pregnant mothers had been contaminated with the Hepatitis C virus. Following a report by an expert group, it was discovered that the BTSB had produced and distributed a second infected batch in 1991. The Government established a Tribunal of Inquiry to establish the facts of the case and also agreed to establish a tribunal for the compensation of victims but seemed to frustrate and delay the applications of these, in some cases terminally, ill women. This controversy also sparked an examination of the BTSB's lax procedures for screening blood products for the treatment of Haemophilia and exposed the infection of many Haemophiliacs with HIV, Hepatitis B and Hepatitis C.
  • 2.2K
  • 30 Nov 2022
Topic Review Peer Reviewed
Wayfinding Strategies for Non-Emergency Services in Australian Hospitals
Wayfinding refers to the process of guiding individuals through built spaces, particularly in environments where navigation may be challenging due to complex layouts. In hospital settings, efficient wayfinding is essential as it directly impacts the experiences of patients, visitors, and staff. This entry focuses on wayfinding strategies in Australian hospitals, where research on this topic is limited. The entry uses a comparative case study approach to analyse various wayfinding techniques for non-emergency services, including physical signage, digital navigation systems, and spatial design elements across six hospitals in Australia. The findings indicate that combining visual cues, digital tools, and spatial planning improves navigation efficiency. However, the hospital size and layout significantly influence the effectiveness of these systems. This entry provides insights into the current wayfinding strategies and challenges in Australian hospitals and suggests further research on global case studies using the comparative framework and definitions provided here.
  • 2.2K
  • 06 Jan 2025
Topic Review
Predictive Biomarkers of Neoadjuvant Chemotherapy in Breast Cancer
Pathological complete response (pCR) after neoadjuvant chemotherapy in patients with early breast cancer is correlated with better survival. Meanwhile, an expanding arsenal of post-neoadjuvant treatment strategies have proven beneficial in the absence of pCR, leading to an increased use of neoadjuvant systemic therapy in patients with early breast cancer and the search for predictive biomarkers of response. The better prediction of response to neoadjuvant chemotherapy could enable the escalation or de-escalation of neoadjuvant treatment strategies, with the ultimate goal of improving the clinical management of early breast cancer. 
  • 2.2K
  • 28 Oct 2022
Topic Review
Targeting CDK4/6 for Anticancer Therapy
Cyclin-dependent kinase 4/6 (CDK4/6) are key regulators of the cell cycle and are deemed as critical therapeutic targets of multiple cancers. Various approaches have been applied to silence CDK4/6 at different levels, i.e., CRISPR to knock out at the DNA level, siRNA to inhibit translation, and drugs that target the protein of interest. Here we summarize the current status in this field, highlighting the mechanisms of small molecular inhibitors treatment and drug resistance.
  • 2.2K
  • 12 Apr 2022
Topic Review
Donkey Milk Properties and Mammary Gland Morphological Characteristics
Donkey milk (DM) is produced by the female animals of the house donkey (Equus asinus). DM is known for their nutritional and nutraceutical properties for human consumption. DM compared to milk from other dairy animals such cow, buffalo, goat and sheep is most likely to resemble human breast milk. The average daily milk yield of a female donkey over the entire lactation season is 1.57 kg/day and fluctuated between 0.20 and 6.00 kg/day. Furthermore, the average milk concentration of fat, protein, lactose, total solids and ash in DM are 0.63%, 1.71%, 6.34%, 9.11% and 0.39%, respectively. It is noteworthy that DM is rich in whey proteins, polyunsaturated fatty acids such as linoleic acid C18:2 and linolenic acid C18:3 and vitamin C. In addition, the average lysozyme concentration of DM is approximately 1.07 g/L, similar to human milk (0.30-1.10 g/L). The high lysozyme content may be the cause of low bactarial count of DM and also makes this milk useful for preventing intestinal infections in infants. Due to the significantly lower casein content, many people with a cows milk protein allergy can tolerate DM, as they find DM do not trigger an allergy reaction.
  • 2.2K
  • 15 Apr 2022
Topic Review
Real Estate Bubble
A real estate bubble or property bubble (or housing bubble for residential markets) is a type of economic bubble that occurs periodically in local or global real estate markets, and typically follow a land boom. A land boom is the rapid increase in the market price of real property such as housing until they reach unsustainable levels and then decline. This period, during the run up to the crash, is also known as froth. The questions of whether real estate bubbles can be identified and prevented, and whether they have broader macroeconomic significance, are answered differently by schools of economic thought, as detailed below. Bubbles in housing markets are more critical than stock market bubbles. Historically, equity price busts occur on average every 13 years, last for 2.5 years, and result in about 4 percent loss in GDP. Housing price busts are less frequent, but last nearly twice as long and lead to output losses that are twice as large (IMF World Economic Outlook, 2003). A recent laboratory experimental study also shows that, compared to financial markets, real estate markets involve longer boom and bust periods. Prices decline slower because the real estate market is less liquid. The financial crisis of 2007–2008 was related to the bursting of real estate bubbles that had begun in various countries during the 2000s.
  • 2.2K
  • 19 Oct 2022
Topic Review
List of Maglev Train Proposals
This is a list of proposed maglev trains worldwide. Some proposals may have been rejected.
  • 2.2K
  • 27 Oct 2022
Topic Review
Microsoft HoloLens 2 in Medical and Healthcare Context
Microsoft® HoloLens was developed and manufactured by Microsoft (MS) and can be presented as a pair of mixed reality smart glasses able to describe an environment in which real and virtual elements appear to coexist. More specifically, the Microsoft® HoloLens is a novel MR-based HMD that makes the user the protagonist of an immersive experience and allows him to interact with the surrounding environment using holograms whilst engaging their senses throughout. It is used in a variety of applications such as medical and surgical aids and systems, medical education and simulation, architecture and several engineering fields (civil, industrial and so on). The use of HoloLens 2 in a medical and healthcare context was analyzed by dividing contributions into the following sub-field applications: surgical navigation, AR-BCI (Brain-Computer Interface) systems integration and human computer interaction (HCI), gait analysis and rehabilitation, medical education and training/virtual teaching/tele-mentoring/tele-consulting and other applications.
  • 2.2K
  • 10 Nov 2022
Topic Review
Polyphenols in Apple-Processing By-Products
Polyphenols of plant origin are a broad family of secondary metabolites that range from basic phenolic acids to more complex compounds such as stilbenes, flavonoids, and tannins, all of which have several phenol units in their structure. Considerable health benefits, such as having prebiotic potential and cardio-protective and weight control effects, have been linked to diets based on polyphenol-enriched foods and plant-based products, indicating the potential role of these substances in the prevention or treatment of numerous pathologies. The most representative phenolic compounds in apple pomace are phloridzin, chlorogenic acid, and epicatechin, with major health implications in diabetes, cancer, and cardiovascular and neurocognitive diseases. 
  • 2.2K
  • 01 Dec 2022
Topic Review
Uremic Toxins
Some uremic toxins such as indol acetic acid, indoxyl sulfate, p-cresyl sulfate hippuric acid, phenyl sulfate, trimethylamine N-oxide, and hydrogen sulfide in the blood of CKD patients come from the metabolism of bacteria in the gut. As a result of the conducted research, the list of potential uremic toxins is constantly being modified. For example, it is suggested that the current list of cytokines that are considered potential uremic toxins is incomplete and excessive.
  • 2.2K
  • 28 Jun 2021
Topic Review
Lymphedema
Secondary lymphedema is a common complication of lymph node dissection or radiation therapy for cancer treatment. Conventional therapies such as compression sleeve therapy, complete decongestive physiotherapy, and surgical therapies decrease edema; they are not curative because they cannot modulate the pathophysiology of lymphedema.
  • 2.2K
  • 28 Jul 2022
Topic Review
Liquid Mirror Telescope
Liquid mirror telescopes are telescopes with mirrors made with a reflective liquid. The most common liquid used is mercury, but other liquids will work as well (for example, low melting alloys of gallium). The liquid and its container are rotated at a constant speed around a vertical axis, which causes the surface of the liquid to assume a paraboloidal shape, suitable for use as the primary mirror of a reflecting telescope. The rotating liquid assumes the paraboloidal shape regardless of the container's shape. To reduce the amount of liquid metal needed, and thus weight, a rotating mercury mirror uses a container that is as close to the necessary parabolic shape as possible. Liquid mirrors can be a low cost alternative to conventional large telescopes. Compared to a solid glass mirror that must be cast, ground, and polished, a rotating liquid metal mirror is much less expensive to manufacture. Isaac Newton noted that the free surface of a rotating liquid forms a circular paraboloid and can therefore be used as a telescope, but he could not actually build one because he had no way to stabilize the speed of rotation. The concept was further developed by Ernesto Capocci of the Naples Observatory (1850), but it was not until 1872 that Henry Skey of Dunedin, New Zealand constructed the first working laboratory liquid mirror telescope. Another difficulty is that a liquid metal mirror can only be used in zenith telescopes, i.e., that look straight up, so it is not suitable for investigations where the telescope must remain pointing at the same location of inertial space (a possible exception to this rule may exist for a mercury mirror space telescope, where the effect of Earth's gravity is replaced by artificial gravity, perhaps by rotating the telescope on a very long tether, or propelling it gently forward with rockets). Only a telescope located at the North Pole or South Pole would offer a relatively static view of the sky, although the freezing point of mercury and the remoteness of the location would need to be considered. A very large telescope already exists at the South Pole, but the North Pole is located in the Arctic Ocean. The mercury mirror of the Large Zenith Telescope in Canada was the largest liquid metal mirror ever built. It had a diameter of six meters, and rotated at a rate of about 8.5 revolutions per minute. It is now decommissioned. This mirror was a test, built for $1 million but it was not suitable for astronomy because of the test site's weather. They are now planning to build a larger 8 meter liquid mirror telescope ALPACA for astronomical use and a larger project called LAMA with 66 individual 6.15 meter telescopes with a total collecting power equal to a 55 meter telescope, resolving power of a 70 meter scope.
  • 2.2K
  • 08 Oct 2022
Topic Review
Warburg Effect
Otto Warburg discovered that cancer cells use a fermentative rather than oxidative metabolism even though the former is more inefficient in terms of energy production per molecule of glucose. Cancer cells increase the use of this fermentative metabolism even in the presence of oxygen, and this process is called aerobic glycolysis or the Warburg effect.
  • 2.2K
  • 14 Jun 2023
Topic Review
Bike-Sharing Systems
The idea behind Bike-Sharing Systems (BSS) is simple: a pool of publicly available bicycles placed around the city and ready to be used for a low payment BSS have raised in popularity in the last years due to their potential share in sustainable cities. Although the first attempts to implement a bike-sharing public service date back to 1965 (Amsterdam), their widespread use arrived with the millennium becoming a vibrant research area whose activity has increased steadily in the last decade.
  • 2.2K
  • 02 Mar 2021
Topic Review
Mg-Zn-{Y, Ce} Alloys: Thermodynamic Modeling and Mechanical Properties
Magnesium alloys are a strong candidate for various applications in automobile and aerospace industries due to their low density and specific strength. Micro-alloying magnesium with zinc, yttrium, and cerium enhances mechanical properties of magnesium through grain refinement and precipitation hardening. 
  • 2.2K
  • 31 Dec 2021
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