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Topic Review
Vaccinia
Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It has a linear, double-stranded DNA genome approximately 190 kbp in length, which encodes approximately 250 genes. The dimensions of the virion are roughly 360 × 270 × 250 nm, with a mass of approximately 5–10 fg. The vaccinia virus is the source of the modern smallpox vaccine, which the World Health Organisation used to eradicate smallpox in a global vaccination campaign in 1958–1977. Although smallpox no longer exists in the wild, vaccinia virus is still studied widely by scientists as a tool for gene therapy and genetic engineering. Smallpox had been an endemic human disease that had a 30% fatality rate. In 1796, the British doctor Edward Jenner proved that an infection with the relatively mild cowpox virus would also confer immunity to the deadly smallpox. Jenner referred to cowpox as variolae vaccinae (smallpox of the cow). However, the origins of the smallpox vaccine became murky over time, especially after Louis Pasteur developed laboratory techniques for creating vaccines in the 19th century. Allan Watt Downie demonstrated in 1939 that the modern smallpox vaccine was serologically distinct from cowpox, and vaccinia was subsequently recognized as a separate viral species. Whole-genome sequencing has revealed that vaccinia is most closely related to horsepox, and the cowpox strains found in Great Britain are the least closely related to vaccinia.
  • 1.7K
  • 19 Oct 2022
Biography
Sarah Teichmann
Sarah Amalia Teichmann (born 1975)[1] FMedSci[2] is Head of Cellular Genetics at the Wellcome Sanger Institute[3] and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI).[4][5] She is also a Director of Research (equivalent to Professor)[6] in the Cavendish Laboratory,[7] at the University of Cambridge and a Senior Research Fellow at Churchill College, Cambridge.
  • 1.7K
  • 24 Nov 2022
Topic Review
Glucosepane
Glucosepane is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose. It is an irreversible, covalent cross-link product that has been found to make intermolecular and intramolecular cross-links in the collagen of the extracellular matrix (ECM) and crystallin of the eyes. Covalent protein cross-links irreversibly link proteins together in the ECM of tissues. Glucosepane is present in human tissues at levels 10 to 1000 times higher than any other cross-linking AGE, and is currently considered to be the most important cross-linking AGE.
  • 1.7K
  • 23 Nov 2022
Biography
Mustafa Akyol
Mustafa Akyol (born 20 February 1972) is a Turkish writer and journalist. He is the author of Islam without Extremes: A Muslim Case for Liberty, long-listed in 2012 for the Lionel Gelber Prize, a literary award for the world's best non-fiction book in English. He became a contributing opinion writer for the International New York Times in 2013. He is mainly famous in the western world for his ar
  • 1.6K
  • 11 Nov 2022
Biography
Birutė Galdikas
Birutė Marija Filomena Galdikas or Birutė Mary Galdikas, OC (born 10 May 1946), is a Lithuanian-Canadian[1] anthropologist, primatologist, conservationist, ethologist, and author. She is a professor at Simon Fraser University. In the field of primatology, Galdikas is recognized as a leading authority on orangutans.[2] Prior to her field study of orangutans, scientists knew little about the spe
  • 1.6K
  • 16 Nov 2022
Biography
Varadaraja V. Raman
Varadaraja V. Raman (born May 28, 1932) is Emeritus Professor of Physics and Humanities at the Rochester Institute of Technology. He has lectured and written Indian heritage and culture and authored numerous books, book reviews and articles on science and religion. He is considered expert in the Hindu religion, espectially as how it relates to modern science.[1] In 2005 he was elected Senior Fel
  • 1.6K
  • 22 Nov 2022
Biography
Oleg D. Jefimenko
Oleg Dmitrovich Jefimenko (October 14, 1922, Kharkiv, Ukraine – May 14, 2009, Morgantown, West Virginia, United States) was a physicist and Professor Emeritus at West Virginia University. Jefimenko received his B.A. degree at Lewis and Clark College in 1952 and his M. A. degree at the University of Oregon in 1954. He received his Ph.D. degree at the University of Oregon in 1956. Jefimenko w
  • 1.6K
  • 16 Dec 2022
Biography
Otto Laporte
Otto Laporte (July 23, 1902 – March 28, 1971) was a German-born United States physicist who made contributions to quantum mechanics, electromagnetic wave propagation theory, spectroscopy, and fluid dynamics. His name is lent to the Laporte rule in spectroscopy and to the Otto Laporte Award of the American Physical Society.[1] Laporte’s ancestors came from French Huguenot families who fled
  • 1.6K
  • 20 Dec 2022
Topic Review
Ly6c as New Marker of Mouse Blood Vessels
During our research we have observed that Ly6c, which is traditionally only used as a classic and non-classical monocyte / macrophage differentiating antigen, can be used as a new specific marker of the mouse vasculature and to assess qualitatively and quantitatively vascular changes in health and disease. Researchers believe that this innovative application of Ly6c immunodetection, which has shown three advantages (brighter signal, homogeneous staining and greater selectivity) compared to traditional vessel markers such as IB4 isolectin, will be of high interest to researchers in this field.
  • 1.6K
  • 28 Mar 2022
Biography
Ignatius L. Donnelly
Ignatius Loyola Donnelly (November 3, 1831 – January 1, 1901) was a U.S. Congressman, populist writer, and amateur scientist. He is known primarily now for his theories concerning Atlantis, Catastrophism (especially the idea of an ancient impact event affecting ancient civilizations), and Shakespearean authorship, which many modern historians consider to be pseudoscience and pseudohistory. Don
  • 1.6K
  • 23 Nov 2022
Topic Review
Neurotechnology
Neurotechnology encompasses any method or device in which electronics interface with the nervous system to monitor or modulate neural activity. Common design goals for neurotechnologies include using neural activity readings to control external devices such as neuroprosthetics, altering neural activity via neuromodulation to repair or normalize function affected by neurological disorders, or augmenting cognitive abilities. In addition to their therapeutic or commercial uses, neurotechnologies also constitute powerful research tools to advance fundamental neuroscience knowledge. Some examples of neurotechnologies include deep brain stimulation, optogenetics, transcranial magnetic stimulation, and brain–computer interfaces, such as cochlear implants.
  • 1.6K
  • 20 Oct 2022
Topic Review
Pneumocystis Pneumonia
Pneumocystis pneumonia (PCP), also known as Pneumocystis jirovecii pneumonia (PJP), is a form of pneumonia that is caused by the yeast-like fungus Pneumocystis jirovecii. Pneumocystis specimens are commonly found in the lungs of healthy people although it is usually not a cause for disease. However, they are a source of opportunistic infection and can cause lung infections in people with a weak immune system or other predisposing health conditions. PCP is seen in people with HIV/AIDS (who account for 30-40% of PCP cases), those using medications that suppress the immune system, and people with cancer, autoimmune or inflammatory conditions, and chronic lung disease.
  • 1.6K
  • 17 Oct 2022
Topic Review
AI&ML for Medical Sector
This work represents a comprehensive analysis of the potential AI, ML, and IoT technologies for defending against the COVID-19 pandemic. The existing and potential applications of AI, ML, and IoT, along with a detailed analysis of the enabling tools and techniques are outlined. A critical discussion on the risks and limitations of the aforementioned technologies are also included.
  • 1.6K
  • 21 Jan 2021
Biography
Magdalena Gornik
Magdalena Gornik (also Gornikova Lenčka or Alenka; 19 July 1835 – 23 February 1896) was a Slovenian Roman-catholic mystic, theologian and stigmatic. Magdalena Gornik was born on July 19, 1835 at 4 Janeži 4 (today #11), to parents Jožef and Ana Gornik. That day, she was carried to the local church of Our Lady of the Snows for her baptism by her godparents Mihael Levstek and Marjeta Košir
  • 1.6K
  • 09 Dec 2022
Topic Review
Aerogel-Based Materials for Biomedical Applications
Aerogel is one of the most interesting materials globally. The network of aerogel consists of pores with nanometer widths, which leads to a variety of functional properties and broad applications. Aerogel is categorized as inorganic, organic, carbon, and biopolymers, and can be modified by the addition of advanced materials and nanofillers.
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  • 06 Apr 2023
Topic Review
Sleep Medicine
Sleep medicine is a medical specialty or subspecialty devoted to the diagnosis and therapy of sleep disturbances and disorders. From the middle of the 20th century, research has provided increasing knowledge and answered many questions about sleep-wake functioning. The rapidly evolving field has become a recognized medical subspecialty in some countries. Dental sleep medicine also qualifies for board certification in some countries. Properly organized, minimum 12-month, postgraduate training programs are still being defined in the United States. In some countries, the sleep researchers and the physicians who treat patients may be the same people. The first sleep clinics in the United States were established in the 1970s by interested physicians and technicians; the study, diagnosis and treatment of obstructive sleep apnea were their first tasks. As late as 1999, virtually any American physician, with no specific training in sleep medicine, could open a sleep laboratory. Disorders and disturbances of sleep are widespread and can have significant consequences for affected individuals as well as economic and other consequences for society. The US National Transportation Safety Board has, according to Charles Czeisler, member of the Institute of Medicine and Director of the Harvard University Medical School Division of Sleep Medicine at Brigham and Women's Hospital, discovered that the leading cause (31%) of fatal-to-the-driver heavy truck crashes is fatigue related (though rarely associated directly with sleep disorders, such as sleep apnea), with drugs and alcohol as the number two cause (29%). Sleep deprivation has also been a significant factor in dramatic accidents, such as the Exxon Valdez oil spill, the nuclear incidents at Chernobyl and Three Mile Island and the explosion of the space shuttle Challenger.
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  • 27 Sep 2022
Topic Review
Chronic Dialysis Patients and Creatine
Creatine is a natural nitrogenous organic acid that is integral to energy metabolism, and is crucial for proper cell functioning [8,9]. Creatine can be charged to the high-energy product phosphocreatine by creatine kinase and ATP. In the human body, the majority of creatine (>90%) is present in skeletal muscle, cardiac muscle, smooth muscle, the brain, and in the nervous tissue. Furthermore, smaller amounts are present in other tissues and cell types, including the kidney, erythrocytes, and leucocytes.
  • 1.6K
  • 20 Aug 2021
Topic Review
MET in Cancer Initiation and Driver Mutations
The MET gene, known as MET proto-oncogene receptor tyrosine kinase, was first identified to induce tumor cell migration, invasion, and proliferation/survival through canonical RAS-CDC42-PAK-Rho kinase, RAS-MAPK, PI3K-AKT-mTOR, and β-catenin signaling pathways, and its driver mutations, such as MET gene amplification (METamp) and the exon 14 skipping alterations (METex14), activate cell transformation, cancer progression, and worse patient prognosis, principally in lung cancer through the overactivation of their own oncogenic and MET parallel signaling pathways. Because of this, MET driver alterations have become recognized as actionable alterations in lung adenocarcinomas since the FDA approval target therapies for METamp and METex14 in 2020. 
  • 1.6K
  • 06 Dec 2022
Biography
Frans Vera
Dr Frans Vera (born Franciscus Wilhelmus Maria Vera; Amsterdam, 4 June 1949)[1] is a Dutch biologist and conservationist. He has played a key part in devising the current ecological strategy for the Netherlands. He has hypothesised that Western European primeval forests at the end of the Pleistocene epoch did not consist only of "closed-canopy" high-forest conditions, but also included pastures
  • 1.6K
  • 07 Dec 2022
Biography
Jeremy Bernstein
Jeremy Bernstein (born December 31, 1929, in Rochester, New York) is an American theoretical physicist and science essayist. Bernstein's parents, Philip S. Bernstein, a Reform rabbi, and Sophie Rubin Bernstein named him after the biblical Jeremiah, the subject of his father's masters thesis. Philip's parents were immigrants from Lithuania, while Sophie was of Russian-Jewish descent. The famil
  • 1.6K
  • 27 Dec 2022
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