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Topic Review
Prediction Models for Venous Thromboembolism
Venous thromboembolism (VTE) is a significant cause of mortality in patients with lung cancer. Despite the availability of a wide range of anticoagulants to help prevent thrombosis, thromboprophylaxis in ambulatory patients is a challenge due to its associated risk of haemorrhage. As a result, anticoagulation is only recommended in patients with a relatively high risk of VTE. Efforts have been made to develop predictive models for VTE risk assessment in cancer patients, but the availability of a reliable predictive model for ambulate patients with lung cancer is unclear. 
  • 871
  • 05 Jul 2021
Topic Review
Microneedles for SARS-CoV-2 Mass Vaccination
Vaccination is an effective measure to prevent infectious diseases. Protective immunity is induced when the immune system is exposed to a vaccine formulation with appropriate immunogenicity. However, traditional injection vaccination is always accompanied by fear and severe pain. As an emerging vaccine delivery tool, microneedles overcome the problems associated with routine needle vaccination, which can effectively deliver vaccines rich in antigen-presenting cells (APCs) to the epidermis and dermis painlessly, inducing a strong immune response. In addition, microneedles have the advantages of avoiding cold chain storage and have the flexibility of self-operation, which can solve the logistics and delivery obstacles of vaccines, covering the vaccination of the special population more easily and conveniently. 
  • 871
  • 10 May 2023
Topic Review
Ozone Therapy
ozone therapy can induce an adaptive antioxidant and anti-inflammatory response, which could be potentially useful in the management of chemotherapy-induced peripheral neuropathy. 
  • 870
  • 31 Jan 2022
Topic Review
Side Effects and Efficacy of COVID-19 Vaccines
Coronavirus vaccines were well-tolerated, safe, and produced an immune response against the virus in most cases. Most postvaccine side effects were mild to moderate, which indicated the building of immunity by the body for protection.
  • 870
  • 16 Jan 2022
Topic Review
Lower Cardiovascular Disease Risk in Midlife Black Women
Midlife Black women suffer disproportionately from cardiovascular disease (CVD) and stroke in comparison to White women of similar age and demographic. Risks factors  for CVD and stroke are largely considered to be modifiable yet, CVD prevention and awareness campaigns have been less effective among Black women. Decreased awareness of personal CVD risk is associated with delays in the presentation of women to the emergency room or health care providers for symptoms of myocardial infarction. The Midlife Black Women’s Stress and Wellness (B-SWELL) program was co-designed with the community to increase awareness about CVD risk factors, stress, and healthy lifestyle behaviors among midlife Black women.
  • 869
  • 14 Feb 2022
Topic Review
Strategies to Manage an Outbreak for Avian Influenza
Avian influenza (AI) is a contagious disease among the poultry population with high avian mortality, which generates significant economic losses and elevated costs for disease control and outbreak eradication. AI is caused by an RNA virus part of the Orthomyxoviridae family; however, only Influenzavirus A is capable of infecting birds. AI pathogenicity is based on the lethality, signs, and molecular characteristics of the virus. Low pathogenic avian influenza (LPAI) virus has a low mortality rate and ability to infect, whereas the highly pathogenic avian influenza (HPAI) virus can cross respiratory and intestinal barriers, diffuse to the blood, damage all tissues of the bird, and has a high mortality rate.
  • 868
  • 26 Apr 2023
Topic Review
Neurobehavioral Phenotype and Dysexecutive Syndrome of Preterm Children
The neurodevelopmental outcome of the premature infant is characterized by a set of minor-to-moderate dysfunctions in the developmental fields (language, praxis, executive, behavioral and attention disorders, social interaction disorders, etc.). These dysfunctions tend to cumulate, even to potentiate, which impacts school learning and the daily life of these children and their parents. Executive functions, such as high-level cognitive operations, play a preponderant role in learning and social adaptation via the regulation of children’s behavior and emotions. Thus, the notion of executive dysfunctions as an underlying mechanism of neurodevelopmental difficulties in VP children is now well documented. Executive deficit is central to the neurodevelopmental phenotype of preterm infants and their learning difficulties, both from a cognitive and a behavioral or social point of view.
  • 867
  • 25 Mar 2022
Topic Review
Effectiveness of Constraint-Induced Movement Therapy for Balance
Constraint-induced movement therapy (CIMT) is one of the most popular treatments for enhancing upper and lower extremity motor activities and participation in patients following a stroke. However, the effect of CIMT on balance is unclear and needs further clarification. Recent evidence indicate that CIMT interventions can improve balance-related motor function better than neuro developmental treatment, modified forced-use therapy and conventional physical therapy in patients after a stroke.
  • 866
  • 02 Apr 2022
Topic Review
Non-Pharmacological Interventions for Wandering in Patients with Dementia
Aberrant motor behaviour or wandering refers to aimless movement without a specific purpose. Wandering is common in patients with dementia and leads to early institutionalization and caregivers’ burden. Non-pharmacological interventions should be also considered as a first-line solution for the wandering because current pharmacological treatment has serious side-effects. 
  • 865
  • 20 Jan 2022
Topic Review
Natural Polyphenols and Cancer
Natural compounds with anticancer properties are capable of killing transformed or cancerous cells without being toxic to healthy cells. Most fruits and vegetables consumed with food are made up of bioactive molecules belonging to the family of polyphenols, a group of natural compounds widely distributed in the plant kingdom; this group is varied, and to date, more than 8000 phenolic structures are known. Polyphenols are classified according to chemical structure, and their subdivision is represented in.
  • 864
  • 04 Nov 2021
Topic Review
SiRNA and Pancreatic Cancer Therapy
Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for development of PC. Small interfering RNA (siRNA) is a powerful genetic tool that can bind to its target and reduces expression level of a specific gene. The various critical genes involved in PC progression can be effectively targeted using diverse siRNAs. 
  • 863
  • 29 Mar 2022
Topic Review
Selenium Status in Patients with Chronic Liver Disease
The potential role of selenium in preventing chronic liver diseases remains controversial. Both body selenium status and selenium intake were negatively associated with hepatitis, cirrhosis, and liver cancer. However, the associations for fatty liver diseases were conflicting and need to be established in prospective trials.
  • 863
  • 11 Mar 2022
Topic Review
The Laboratory Diagnosis of Malaria
Even if malaria is rare in Europe, it is a medical emergency and programs for its control should ensure both an early diagnosis and a prompt treatment within 24–48 h from the onset of the symptoms. The increasing number of imported malaria cases as well as the risk of the reintroduction of autochthonous cases encouraged laboratories in non-endemic countries to adopt diagnostic methods/algorithms. Microscopy remains the gold standard, but with limitations. Rapid diagnostic tests have greatly expanded the ability to diagnose malaria for rapid results due to simplicity and low cost, but they lack sensitivity and specificity. PCR-based assays provide more relevant information but need well-trained technicians.
  • 862
  • 22 Jan 2024
Topic Review
Neuropsychological Outcomes Associated with COVID-19
Survivors of COVID-19 often report subjective, cognitive complaints following infection, grossly characterized by cognitive inefficiency or “brain fog”. The nature of their objective, neuropsychological presentations are only beginning to be characterized. Risk factors predictive of neuropsychological outcomes post-infection remain under study. The contagiousness and quick rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, as well as the significant impact of COVID-19 disease on public health, make the study of COVID-19 on neuropsychological functioning particularly important. 
  • 861
  • 05 May 2022
Topic Review
Relationship between Severe Asthma and Nasal Polyps
Chronic rhinosinusitis is a common disease worldwide and can be categorized into chronic rhinosinusitis with nasal polyps and chronic rhinosinusitis without nasal polyps. Chronic rhinosinusitis with nasal polyps is common in patients with asthma and, particularly, severe asthma. Severe asthma is effectively treated with biologics and the coexistence of severe asthma with chronic rhinosinusitis with nasal polyps presents a phenotype that is more likely to respond to such treatment.
  • 861
  • 02 Jul 2022
Topic Review
Immunosenescence in Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) is one of the most important causes of vascular dementia. Immunosenescence and inflammatory response, with the involvement of the cerebrovascular system, constitute the basis of this disease. Immunosenescence identifies a condition of deterioration of the immune organs and consequent dysregulation of the immune response caused by cellular senescence, which exposes older adults to a greater vulnerability. A low-grade chronic inflammation status also accompanies it without overt infections, an “inflammaging” condition. The correlation between immunosenescence and inflammaging is fundamental in understanding the pathogenesis of age-related CSVD (ArCSVD). The production of inflammatory mediators caused by inflammaging promotes cellular senescence and the decrease of the adaptive immune response. Vice versa, the depletion of the adaptive immune mechanisms favours the stimulation of the innate immune system and the production of inflammatory mediators leading to inflammaging. Furthermore, endothelial dysfunction, chronic inflammation promoted by senescent innate immune cells, oxidative stress and impairment of microglia functions constitute, therefore, the framework within which small vessel disease develops: it is a concatenation of molecular events that promotes the decline of the central nervous system and cognitive functions slowly and progressively.
  • 861
  • 05 Sep 2022
Topic Review
Histoplasmosis in Children
Histoplasmosis is a systemic fungal infection caused by a dimorphic fungi and occurring globally. It is endemic in the Ohio and Mississippi river valleys of the United States of America, India and Southeast Asia. The clinical presentation of histoplasmosis mimics features seen in tuberculosis (TB) and may be misdiagnosed as such. 
  • 860
  • 12 Jul 2021
Topic Review
Human-Animal Interaction in Animal-Assisted Interventions (AAI)s
Animal-assisted interventions (AAI)s are planned activities carried out in multidisciplinary teams with educational, therapeutic, and ludic-recreational purposes. The multidisciplinary and integrated character identifies AAIs as the expression of one health. While AAIs offer many advantages to subjects, they could be exposed to several zoonotic-pathogens transmissions. Therefore, positive animal welfare, as preventive medicine to avoid accidents or zoonotic transmissions, is a relevant aspect with implications for human and animal health and welfare. The knowledge of several pathogens causing zoonoses in the animal species employed during the AAIs, as well as the preventive measures aimed at reducing and/or preventing the risk, guarantee their safety for patients. 
  • 859
  • 18 May 2023
Topic Review
Dietary Assessment Tools and Metabolic Syndrome
Metabolic syndrome (MS) is associated with a range of chronic diseases, for which lifestyle interventions are considered the cornerstone of treatment. Dietary interventions have primarily focused on weight reduction, usually via energy restricted diets. While this strategy can improve insulin sensitivity and other health markers, weight loss alone is not always effective in addressing all risk factors associated with MS.
  • 858
  • 13 Apr 2022
Topic Review
ERK5 Expression and Function in Cancer
Extracellular signal-regulated kinase 5 (ERK5) is a unique kinase among MAPKs family members, given its large structure characterized by the presence of a unique C-terminal domain. Despite increasing data demonstrating the relevance of the ERK5 pathway in the growth, survival, and differentiation of normal cells, ERK5 has recently attracted the attention of several research groups given its relevance in inflammatory disorders and cancer.
  • 856
  • 20 Jan 2022
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