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Topic Review
Osteoblasts Topography Sensing Molecular Mechanisms
Bone is a specialized tissue formed by different cell types and a multiscale, complex mineralized matrix. The architecture and the surface chemistry of this microenvironment can be factors of considerable influence on cell biology, and can affect cell proliferation, commitment to differentiation, gene expression, matrix production and/or composition. It has been shown that osteoblasts encounter natural motifs in vivo, with various topographies (shapes, sizes, organization), and that cell cultures on flat surfaces do not reflect the total potential of the tissue. Therefore, studies investigating the role of topographies on cell behavior are important in order to better understand the interaction between cells and surfaces, to improve osseointegration processes in vivo between tissues and biomaterials, and to find a better surface topography to enhance bone repair.
  • 402
  • 12 Mar 2021
Topic Review
Glycemic Control Biomarkers
Diabetes mellitus (DM) is a worldwide-spread chronic metabolic disease that occurs when the pancreas fails to produce enough insulin levels or when the body fails to effectively use the secreted pancreatic insulin, eventually resulting in hyperglycemia. According to the International Diabetes Federation, in 2021, 537 million adults were suffering from DM, resulting in 6.7 million deaths and a 966 billion dollars healthcare cost. Systematic glycemic control is the only procedure at the disposal to prevent diabetes long-term complications such as cardiovascular disorders, kidney diseases, nephropathy, neuropathy, and retinopathy. The gold standard for glycemic control assessment in clinics is the glycated hemoglobin (HbA1c) measurement,  but glycated albumin (GA) has recently gained more and more attention as a control biomarker thanks to its shorter lifespan and wider reliability compared to HbA1c. Continuous glucose monitoring (CGM) and blood glucose monitoring (BGM) remain useful individual tools for diabetes self-management. 
  • 401
  • 05 Sep 2022
Topic Review
Three-Dimensional Electrochemical Sensors for Food Safety Applications
Considering the increasing concern for food safety, electrochemical methods for detecting specific ingredients in the food are currently the most efficient method due to their low cost, fast response signal, high sensitivity, and ease of use. 
  • 401
  • 26 May 2023
Topic Review
Green Extraction Techniques for Bioactive Natural Products
Green extraction techniques represent a paradigm shift in the field of NP extraction, emphasizing sustainability, environmental consciousness, and efficiency. These methods prioritize minimizing the environmental impact associated with traditional extraction processes. Their importance lies in addressing the limitations of conventional techniques, such as low yields, substantial solvent usage, and the risk of degrading heat-sensitive compounds. The benefits of green extraction include enhanced efficiency, reduced solvent consumption, and the preservation of valuable bioactive compounds. Examples of green extraction techniques encompass “supercritical fluid extraction (SFE), subcritical water extraction (SWE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE)”, among others. The significance and advantages of each method contribute to a more sustainable and eco-friendly approach to NP extraction. Detailed discussions on each green extraction technique are provided below, highlighting their unique principles, applications, and advantages in obtaining bioactive natural products.
  • 400
  • 29 Dec 2023
Topic Review
Pufferfish Optimization Algorithm
Optimization problems are a kind of problem that have more than one feasible solution. According to this, optimization is the process of obtaining the best optimal solution among all feasible solutions for an optimization problem.
  • 399
  • 18 Feb 2024
Topic Review
3D Printing Technology in Fighting the COVID-19 Pandemic
The coronavirus disease 2019 (COVID-19) rapidly spread to over 180 countries and abruptly disrupted production rates and supply chains worldwide. Since then, 3D printing, also recognized as additive manufacturing (AM) and known to be a novel technique that uses layer-by-layer deposition of material to produce intricate 3D geometry, has been engaged in reducing the distress caused by the outbreak. During the early stages of this pandemic, shortages of personal protective equipment (PPE), including facemasks, shields, respirators, and other medical gear, were significantly answered by remotely 3D printing them. Amidst the growing testing requirements, 3D printing emerged as a potential and fast solution as a manufacturing process to meet production needs due to its flexibility, reliability, and rapid response capabilities.
  • 398
  • 12 Oct 2022
Topic Review
Application of SiNW-FET Biosensor with High Sensitivity
As a new type of one-dimensional semiconductor nanometer material, silicon nanowires (SiNWs) possess good application prospects in the field of biomedical sensing. SiNWs have excellent electronic properties for improving the detection sensitivity of biosensors. The combination of SiNWs and field effect transistors (FETs) formed one special biosensor with high sensitivity and target selectivity in real-time and label-free. Recently, SiNW-FETs have received more attention in fields of biomedical detection.
  • 398
  • 10 Aug 2023
Topic Review
Geopolymer Materials for Bone Tissue Applications
Geopolymers (alkali-activated materials) are amorphous inorganic polymeric systems with aluminosilicate bases produced by alkalinising natural or waste substances, such as metallurgical, industrial, urban, and agricultural wastes. There is increasing academic interest in geopolymer materials for biomedical applications.
  • 397
  • 02 Mar 2023
Topic Review
Electrical Stimulation Bioreactors
Electrical Stimulation (ES) bioreactors are defined here as any bioreactor capable of providing some type of ES to cells and organoids cultured within the device. Although there are several approaches to providing ES to cells, such as capacitive coupling and inductive stimulation, the most common method is direct stimulation.
  • 397
  • 08 Aug 2023
Topic Review
Wearable Technology for Monitoring Electrocardiograms in Adults
In the rapidly evolving landscape of continuous electrocardiogram (ECG) monitoring systems, there is a heightened demand for non-invasive sensors capable of measuring ECGs and detecting heart rate variability (HRV) in diverse populations, ranging from cardiovascular patients to sports enthusiasts. Challenges like device accuracy, patient privacy, signal noise, and long-term safety impede the use of wearable devices in clinical practice.
  • 396
  • 27 Feb 2024
Topic Review
Small Diameter Cell-Free Tissue-Engineered Vascular Grafts
Vascular grafts (VGs) are medical devices intended to replace the function of a blood vessel. Available VGs in the market present low patency rates for small diameter applications setting the VG failure. This event arises from the inadequate response of the cells interacting with the biomaterial in the context of operative conditions generating chronic inflammation and a lack of regenerative signals where stenosis or aneurysms can occur. Tissue Engineered Vascular grafts (TEVGs) aim to induce the regeneration of the native vessel to overcome these limitations. Besides the biochemical stimuli, the biomaterial and the particular micro and macrostructure of the graft will determine the specific behavior under pulsatile pressure. The TEVG must support blood flow withstanding the exerted pressure, allowing the proper compliance required for the biomechanical stimulation needed for regeneration.
  • 393
  • 06 Sep 2022
Topic Review
Design and Formulation of Hyaluronic-Acid-Based Hydrogels
Hyaluronic acid (HA) is a natural polymer that is widely distributed in the human body and plays a significant role in numerous physiological processes such as cell migration, tissue hydration, and wound healing. Hydrogels based on HA and its derivatives have gained popularity as potential treatments for bone-related diseases. HA-based hydrogels have been extensively studied for their ability to mimic the natural extracellular matrix of bone tissue and provide a suitable microenvironment for cell support and tissue regeneration. The physical and chemical properties of HA can be modified to improve its mechanical strength, biocompatibility, and osteogenic potential.
  • 392
  • 07 Aug 2023
Topic Review
Cell Therapies for Treatment of Volumetric Muscle Loss
Volumetric muscle loss (VML) is the traumatic, surgical or degenerative loss of a substantial portion of bulk skeletal muscle in a manner that overwhelms the endogenous repair capacity of the muscle and results in impaired scar tissue formation. Cell-based therapies have emerged as a promising approach to promote skeletal muscle regeneration following injury and/or disease. Stem cell populations, such as muscle stem cells, mesenchymal stem cells and induced pluripotent stem cells (iPSCs), have shown a promising capacity for muscle differentiation. Support cells, such as endothelial cells, nerve cells or immune cells, play a pivotal role in providing paracrine signaling cues for myogenesis, along with modulating the processes of inflammation, angiogenesis and innervation. 
  • 390
  • 10 Jan 2022
Topic Review
Gait Analysis in Neurorehabilitation
Gait analysis can be performed through laboratory systems, non-wearable sensors (NWS), and/or wearable sensors (WS). Using these tools, physiotherapists and neurologists have more objective measures of motion function and can plan tailored and specific gait and balance training early to achieve better outcomes and improve patients’ quality of life. 
  • 390
  • 06 Jul 2023
Topic Review
Biodegradable Magnesium Alloys for Biomedical Implants
Biomedical devices made from high-modulus and hardness materials play a critical role in enhancing the quality of life for people with bone-related ailments. While these materials have been successfully used in orthopedic applications, concerns including stress-shielding have necessitated the exploration of alternative solutions. An ideal biomedical implant requires a delicate balance of mechanical performance, corrosion resistance, tissue biocompatibility, and other properties such as tribological performance and osseointegration. Materials such as stainless steel, titanium, and cobalt alloys remain non-degradable throughout the implant’s lifespan. In contrast, certain magnesium alloys can be engineered to degrade safely and under controlled conditions within the body.
  • 390
  • 15 Jan 2024
Topic Review
Kinect-Based Assessment of Lower Limbs during Gait
Several studies have explored the potentiality, accuracy, and effectiveness of this 3D optical sensor as an easy-to-use and non-invasive clinical measurement tool for the assessment of gait parameters in several pathologies. Focusing on stroke individuals, some of the available studies aimed to directly assess and characterize their gait patterns. In contrast, other studies focused on the validation of Kinect-based measurements with respect to a gold-standard reference. Although the Kinect-only based approach for motion analysis is not yet fully used to evaluate gait patterns in clinical settings, its use as a complementary tool with laboratory-grade systems is encouraged, the usefulness of a Kinect-based gait analysis has been demonstrated as a low-cost tool that can overcome the typical limitations of measurements in indoor laboratory environments, such as high cost, dependency on trained personnel, and the need to wear limited clothing.
  • 388
  • 18 Jul 2022
Topic Review
Microwave Imaging/Sensing Techniques for Breast Cancer Detection
Medical imaging techniques, including X-ray mammography, ultrasound, and magnetic resonance imaging, play a crucial role in the timely identification and monitoring of breast cancer. However, these conventional imaging modalities have their limitations, and there is a need for a more accurate and sensitive alternative. Microwave imaging has emerged as a promising technique for breast cancer detection due to its non-ionizing, non-invasive, and cost-effective nature.
  • 386
  • 26 Jul 2023
Topic Review
Magnetic Particle Spectroscopy (MPS): Mechanisms and Theories
Since its first report in 2006, magnetic particle spectroscopy (MPS)-based biosensors have flourished over the past decade. MPS is used for a wide range of applications, such as disease diagnosis, foodborne pathogen detection, etc.
  • 384
  • 22 May 2023
Topic Review
Factors Affecting Adoption of Wearable and Soft Robotics
The advent of soft robotics has changed the landscape of wearable technologies. Soft robots are highly compliant and malleable, thus ensuring safe human-machine interactions. A wide variety of actuation mechanisms have been studied and adopted into a multitude of soft wearables for use in clinical practice, such as assistive devices and rehabilitation modalities. Much research effort has been put into improving their technical performance and establishing the ideal indications for which rigid exoskeletons would play a limited role.
  • 383
  • 31 Jul 2023
Topic Review
Bioengineering Immunotherapeutics for the Treatment of Glioblastoma
Improvements in bioengineering methodology and tools have allowed for significant progress in the development of therapeutics and diagnostics in medicine, as well as progress in many other industries, such as materials manufacturing, food and agriculture, and consumer goods. Glioblastomas present significant challenges to adequate treatment, in part due to their immune-evasive nature. Rational-design bioengineering using novel scaffolds, bio-based materials, and inspiration across disciplines can push the boundaries in treatment development to create effective therapeutics for glioblastomas.
  • 382
  • 13 Jan 2022
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