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Topic Review Peer Reviewed
Secondary Education and COVID-19
Secondary education is the second stage of formal education and traditionally begins after primary school, usually about age 11 to 13. The COVID-19 pandemic caused immeasurable changes to the educational system which inevitably greatly impacted secondary education. The current entry describes the changes in secondary education imposed by the pandemic and explores the accompanying challenges.
  • 3.7K
  • 14 Apr 2022
Topic Review
Aryl-hydrocarbon Receptor
The aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates numerous cellular responses. Originally investigated in toxicology because of its ability to bind environmental contaminants, AhR has attracted enormous attention in the field of immunology in the last 20 years. In addition, the discovery of endogenous and plant-derived ligands points to AhR also having a crucial role in normal cell physiology. Thus, AhR is emerging as a promiscuous receptor that can mediate either toxic or physiologic effects upon sensing multiple exogenous and endogenous molecules. Within this scenario, several factors appear to contribute to the outcome of gene transcriptional regulation by AhR, including the nature of the ligand as such and its further metabolism by AhR-induced enzymes, the local tissue microenvironment, and the presence of coregulators or specific transcription factors in the cell.
  • 3.7K
  • 07 Dec 2021
Topic Review
Taboo Language in Audiovisual Translation
Translating taboo language is a daunting task and solving it with spatial-temporal constraints makes it even more challenging. Taboo language, or emotionally charged language, is often toned down in audiovisual translation (AVT) by deleting the words and expressions, if space is limited, or by using euphemisms. Studies have focused on increasingly diverse subtitling strategies and techniques in rendering taboo language in professional and non-professional subtitling (NPS). Some scholars noted the fluidity, heterogeneity, and fuzziness of NPS. One of the main issues is that this NPS term implies the lack of professional training and thus poor translation quality, neglecting the creative and flexible nature of this kind of subtitling practice.
  • 3.7K
  • 23 Jun 2022
Topic Review Peer Reviewed
Limbic Encephalitis Associated with COVID-19
Limbic encephalitis (LE) is an inflammatory disease of the brain, in which lesion is anatomically limited in structures of the limbic system. In some cases, LE can start with symptoms of limbic dysfunction with further involvement of other regions of the brain. Classic LE syndrome includes such symptoms as the development of personality disorders, depression, sleep disorders, epileptic seizures, hallucinations and cognitive disorders (short-term and long-term memory impairment). The information of clinical examination, electroencephalogram (EEG), magnetic resonance imaging (MRI) and cerebrospinal fluid studies (CSF) suggest the diagnosis of LE in most patients with Coronavirus Disease 2019 (COVID-19).
  • 3.7K
  • 13 Apr 2022
Topic Review
Plain Meaning Rule
The plain meaning rule, also known as the literal rule, is one of three rules of statutory construction traditionally applied by English courts. The other two are the "mischief rule" and the "golden rule". The plain meaning rule dictates that statutes are to be interpreted using the ordinary meaning of the language of the statute. In other words, a statute is to be read word for word and is to be interpreted according to the ordinary meaning of the language, unless a statute explicitly defines some of its terms otherwise or unless the result would be cruel or absurd. Ordinary words are given their ordinary meaning, technical terms are given their technical meaning, and local, cultural terms are recognized as applicable. The plain meaning rule is the mechanism that prevents courts from taking sides in legislative or political issues. Additionally, it is the mechanism that underlies textualism and, to a certain extent, originalism.
  • 3.7K
  • 30 Oct 2022
Topic Review
Tyk2 Targeting in Immune-Mediated Inflammatory Diseases
Genetic linkage has related dysfunction of Tyrosine kinase 2 (Tyk2)—the first member of the Jak family that was described—to protection from psoriasis. Furthermore, Tyk2 dysfunction has been related to IMID prevention, without increasing the risk of serious infections; thus, Tyk2 inhibition has been established as a promising therapeutic target, with multiple Tyk2 inhibitors under development.
  • 3.7K
  • 20 Feb 2023
Topic Review
Coenzyme Q10
Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning of the immune system. These include its essential role as an electron carrier in the mitochondrial respiratory chain, enabling the process of oxidative phosphorylation to occur with the concomitant production of ATP, together with its role as a potential lipid-soluble antioxidant, protecting the cell against free radical-induced oxidation. Furthermore, CoQ10 has also been reported to have an anti-inflammatory role via its ability to repress inflammatory gene expression. Recently, CoQ10 has also been reported to play an important function within the lysosome, an organelle central to the immune response.
  • 3.7K
  • 27 May 2021
Topic Review
Sustainable Project Management
Sustainability is one of the most important challenges of our time. Enterprises are integrating ideas of sustainability in their marketing, corporate communication, annual reports and in their actions. The concept of sustainability has more recently also been linked to project management. Sustainable project management means implementing projects that will serve to support future generations and society in social, economic and environmental benefits. Therefore, it is important to focus on the critical factors that lead to successful project management.
  • 3.7K
  • 05 Jul 2021
Topic Review
Surface-Functionalized Nanoparticles for Bio-Application
Surface functionalization of nanoparticles applies to the use of covalent and non-covalent bonds—such as hydrogen bonds, electrostatic force, and the van der Waals interactions—to integrate diverse organic and inorganic molecules at the nanoscale. Typically, multiple linker molecules are used to form covalent bonds between ligands and the surfaces of nanoparticles (NPs).
  • 3.7K
  • 20 Apr 2022
Topic Review
Digital Anthropometry for Body Circumference Measurements
Anthropometry is the study of the measurements and proportions of the human body. Weight, stature (standing height), length (e.g., limb lengths), skinfold thickness, breadth (e.g., shoulder, wrist, etc.), and circumference are examples of anthropometric measures widely adopted in daily medical practice for monitoring growth and aging as well as for the clinical management of patients.
  • 3.7K
  • 08 Jun 2022
Topic Review
Narrative Therapy
Narrative therapy (or Narraive Practice) is a form of psychotherapy that seeks to help patients identify their values and the skills associated with them. It provides the patient with knowledge of their ability to live these values so they can effectively confront current and future problems. The therapist seeks to help the patient co-author a new narrative about themselves by investigating the history of those values. Narrative therapy claims to be a social justice approach to therapeutic conversations, seeking to challenge dominant discourses that it claims shape people's lives in destructive ways. While narrative work is typically located within the field of family therapy, many authors and practitioners report using these ideas and practices in community work, schools and higher education. Narrative therapy has come to be associated with collaborative as well as person-centered therapy.
  • 3.7K
  • 31 Oct 2022
Topic Review
Collagen in Wound Healing
Collagens are the most abundant protein found throughout the body. In the healing wound, these collagens are synthesized by cells such as fibroblasts and modified into complex morphologies . The type, amount and organization of collagen changes in the healing wound and determines the tensile strength of the healed skin. Collagen III is the first to be synthesized in the early stages of wound healing and is replaced by collagen I, the dominant skin collagen. The initial random deposition of collagen during the granulation tissue formation is further enhanced by lysyl oxidase enzyme-induced covalent cross-linking. This process matures the collagen into complex structures that are reoriented for tensile strength restoration. Collagen remodeling continues for months after wound closure and the tensile strength of the repaired tissue increases to about 80–85% of normal tissue if all processes proceed without any perturbations.In the skin, the fibrillar collagens types I, III and V are the most common, followed by fibril-associated collagens type XII, XIV, XVI, and VI. The non-fibrillar collagens type IV, XVIII are found in the basement membrane of the skin
  • 3.7K
  • 23 Jun 2021
Topic Review
Boron-Doped Diamond
Boron-doped diamond (BDD) acts as an excellent p-type conductive material for high-temperature, high-power and radiation-proof photoelectronic devices with its large band gap at room temperature (5.47 eV) and high thermal conductivity.
  • 3.7K
  • 06 Jan 2021
Topic Review
Sustainable Employability
Sustainable employability (SE) generally refers to employees’ capacities to function in work and on the labor market throughout their working lives. However, several definitions have been forwarded in the scientific literature that differ in nuanced ways. A recent overview of existing definitions is provided by Fleuren, de Grip, Jansen, Kant, and Zijlstra (2020).[1]
  • 3.7K
  • 29 Oct 2020
Topic Review
Censorship of YouTube
The video-sharing platform YouTube is the second-most popular website as of August 2019, according to Alexa Internet. According to the company's press page, YouTube has more than one billion users, and each day, those users watch more than one billion hours of video. Censorship of it has occurred and continues to occur to varying degrees in most countries throughout the world.
  • 3.7K
  • 25 Oct 2022
Topic Review
Technical Lignin
Lignin, the term commonly used in literature, represents a group of heterogeneous aromatic compounds of plant origin. 
  • 3.7K
  • 16 Feb 2021
Topic Review
Bee-Products in Male Reproductive Impairment
Bee products are sources of functional food that have been used in complementary medicine to treat a variety of acute and chronic illnesses in many parts of the world. The products vary from location to location as well as country to country. 
  • 3.7K
  • 08 Jun 2021
Topic Review
Social Security Number
In the United States, a Social Security number (SSN) is a nine-digit number issued to U.S. citizens, permanent residents, and temporary (working) residents under section 205(c)(2) of the Social Security Act, codified as 42 U.S.C. § 405(c)(2). The number is issued to an individual by the Social Security Administration, an independent agency of the United States government. Although the original purpose for the number was for the Social Security Administration to track individuals, the Social Security number has become a de facto national identification number for taxation and other purposes. A Social Security number may be obtained by applying on Form SS-5, Application for a Social Security Number Card.
  • 3.7K
  • 25 Oct 2022
Topic Review
Gendered Associations of Pink and Blue
The colors pink and blue are associated with girls and boys respectively, in the United States, the United Kingdom and some other European countries. Originating as a trend in the mid-19th century and applying primarily to clothing, gendered associations with pink and blue became more widespread from the 1950s onward. Since the 1990s, these gendered associations have also increasingly applied to toys as well, especially in the case of pink toys for girls. Despite popular belief—including from various academic and popular sources—a reported "pink-blue reversal", wherein the gendered associations of both colors were "flipped" sometime during the 20th century, most likely never occurred, and instead is likely to have been a misunderstanding of earlier reporting.
  • 3.7K
  • 19 Oct 2022
Topic Review
Avalanche (Consensus Protocol)
Avalanche is a protocol for solving consensus in a network of unreliable machines, where failures may be crash-fault or Byzantine. The protocol was anonymously introduced on IPFS on May 2018 and was formalized in more detail by Cornell University researchers in 2019. The protocol has four basic interrelated mechanisms that compose structural support of the consensus tool. These four mechanisms are Slush, Snowflake, Snowball, and Avalanche. By using uses randomized sampling and metastability to ascertain and persist transactions, It represents a new protocol family. Although the original paper focused on a single protocol, namely Avalanche, it implicitly introduced a broad spectrum of voting-based, or quorum-based consensus protocols, called the Snow family. While Avalanche is a single instantiation, the Snow family seems to be able to generalize all quorum-based voting protocols for replica control. Unlike prior quorum-based work, the Snow family enables arbitrarily parametrizable failure probability at the quorum intersection level. Standard quorum-based protocols define this failure probability to be precisely zero, but by introducing errors in the quorum intersection, a larger set of consensus protocol design is available.
  • 3.7K
  • 03 Nov 2022
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