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Topic Review
Calcareous Tufa
The term calcareous tufa, or freshwater travertine, is widely used in the scientific literature to describe carbonate deposits precipitated from cool groundwaters of meteoric origin enriched in CO2 (carbon dioxide) by percolating through organic soils.
  • 4.0K
  • 11 May 2023
Topic Review
Current Sensing Methods in Power Electronics Applications
A current sensor is a device exploited to measure electric currents, either alternating current (AC) or direct current (DC). These devices are used in various applications, including detecting faults, monitoring performance (for control or prognostics), and detecting changes in system behavior. Power applications employ various current-monitoring products to control, characterize, and monitor the current flow. Current sensors, for example, are used in power lines to measure the flow of the current, for controlling current flow, or detect overcurrent or excess currents.
  • 4.0K
  • 10 Aug 2023
Topic Review
Stable Packaging and Producer Cell Lines for AAV
Today, recombinant adeno-associated virus (rAAV) vectors represent the vector systems which are mostly used for in vivo gene therapy for the treatment of rare and less-rare diseases. Although most of the past developments have been performed by using a transfection-based method and more than half of the authorized rAAV-based treatments are based on transfection process, the tendency is towards the use of stable inducible packaging and producer cell lines because their use is much more straightforward and leads in parallel to reduction in the overall manufacturing costs.
  • 4.0K
  • 29 Feb 2024
Topic Review
Mitogen-Activated Protein Kinases (MAPKs)
Kinases are considered the largest protein family in the human proteome, and approximately 2% of eukaryotic genes encode kinase superfamily members. These enzymes catalyze the transference of the γ-phosphate from ATP to serine, threonine, or tyrosine amino acid residues of a downstream protein substrate, creating a communication cascade that is fundamental to eukaryotic cells. 
  • 4.0K
  • 26 Apr 2021
Topic Review
Dead Space (Video Game)
Dead Space is a 2008 survival horror video game developed by EA Redwood Shores and published by Electronic Arts for the PlayStation 3, Xbox 360 and Microsoft Windows. Released in October 2008, the title was the first in the Dead Space franchise and drew inspiration from other works of horror, notably Resident Evil 4 and the Silent Hill series. Set on a mining spaceship overrun by monsters called Necromorphs, the player controls engineer Isaac Clarke from the third-person perspective as he navigates the spaceship, fights Necromorphs, and struggles with increasing psychosis. The player explores areas on the station through the narrative, solving environmental puzzles while finding ammunition and equipment to survive. Isaac wields engineering equipment as weapons. Dead Space was pitched in early 2006 and fit Electronic Arts' priority of creating new intellectual properties. A prototype of the game was developed for the original Xbox console and lasted 18 months. The team aimed for realism and innovation in design. In the pursuit of these goals, the team removed set spawn points for enemies and omitted the heads-up display in favor of presenting information in the world. Immersive and frightening sound design was a large priority during production, and the score by Jason Graves was noted by critics cause of evoke tension and unease. Dead Space debuted weak in sales but eventually sold over a million copies worldwide. The game was met with universal acclaim: reviewers praised its atmosphere, gameplay and sound design. It won and was nominated for multiple industry awards and has been ranked by journalists as one of the greatest video games ever made. To following of the game success, spawned an adaptation for mobile phones, two numbered sequels (released in 2011 and 2013), several spin-off titles, and other related media, including a comic book prequel and an animated film. A remake of Dead Space is currently in development by EA's Motive Studios that set for release in early 2023.
  • 4.0K
  • 14 Oct 2022
Topic Review
Mathematical Economics
Mathematical economics is the application of mathematical methods to represent theories and analyze problems in economics. Often, these applied methods are beyond simple geometry, and may include differential and integral calculus, difference and differential equations, matrix algebra, mathematical programming, or other computational methods. Proponents of this approach claim that it allows the formulation of theoretical relationships with rigor, generality, and simplicity. Mathematics allows economists to form meaningful, testable propositions about wide-ranging and complex subjects which could less easily be expressed informally. Further, the language of mathematics allows economists to make specific, positive claims about controversial or contentious subjects that would be impossible without mathematics. Much of economic theory is currently presented in terms of mathematical economic models, a set of stylized and simplified mathematical relationships asserted to clarify assumptions and implications. Formal economic modeling began in the 19th century with the use of differential calculus to represent and explain economic behavior, such as utility maximization, an early economic application of mathematical optimization. Economics became more mathematical as a discipline throughout the first half of the 20th century, but introduction of new and generalized techniques in the period around the Second World War, as in game theory, would greatly broaden the use of mathematical formulations in economics. This rapid systematizing of economics alarmed critics of the discipline as well as some noted economists. John Maynard Keynes, Robert Heilbroner, Friedrich Hayek and others have criticized the broad use of mathematical models for human behavior, arguing that some human choices are irreducible to mathematics.
  • 4.0K
  • 31 Oct 2022
Topic Review
Identification of Optimal Binders for Torrefied Biomass Pellets
The pretreatment of biomass through torrefaction is an effective means of improving the fuel quality of woody biomass and its suitability for use in existing facilities burning thermal coal. Densification of torrefied biomass produces a fuel of similar energy density, moisture content, and fixed carbon content to low-grade coals. Additionally, if the torrefaction conditions are optimized, the produced torrefied pellet will be resistant to weathering and biological degradation, allowing for outdoor storage and transport in a manner similar to coal. In untreated biomass, lignin is the primary binding agent for biomass pellets and is activated by the heat and pressures of the pellet extrusion process. The thermal degradation of lignin during torrefaction reduces its binding ability, resulting in pellets of low durability not suitable for transportation. The use of a binding agent can increase the durability of torrefied pellets/briquettes through a number of different binding mechanisms depending on the binder used.
  • 4.0K
  • 19 Apr 2023
Topic Review
Synthesis of Hydrogels
Hydrogels are polymeric materials with a characteristic hydrophilic structure that enables the storage of large amounts of water and biological fluids in their three-dimensional (3D) network. For hydrogel synthesis, the incorporation of a cross-linking agent is important to achieve a better structuring due to its ability to form new polymeric chains within the structure through a large variety of reactions between different polymeric molecules or fibrous proteins.
  • 4.0K
  • 16 Aug 2022
Topic Review
Momo Challenge Hoax
The "Momo Challenge" was a hoax and an Internet urban legend about a nonexistent social media challenge that was spread on Facebook and other media outlets. It was reported that children and adolescents were being enticed by a user named Momo to perform a series of dangerous tasks including violent attacks, self-harm and suicide. Despite claims that the phenomenon had reached worldwide proportions in July 2018, the number of actual complaints was relatively small and no law enforcement agency has confirmed that anyone was harmed as a direct result of it. Concern and distress registered by children was primarily driven by media reports rather than as a result of "Momo", leading children's charities to view warnings against the alleged phenomenon as causing more harm than good by leading to a self-fulfilling prophecy which may encourage children to look up violent material on the Internet. The challenge was reported to become "a worldwide phenomenon" in 2018 after an Indonesian newspaper reported that it had caused a 12-year-old girl to kill herself. Awareness grew in February 2019 after the Police Service of Northern Ireland posted a public warning on Facebook, and American media personality Kim Kardashian posted on her Instagram Story pleading for YouTube to remove alleged "Momo" videos.
  • 4.0K
  • 01 Dec 2022
Topic Review
SoftEther VPN
SoftEther VPN is free open-source, cross-platform, multi-protocol VPN client and VPN server software, developed as part of Daiyuu Nobori's master's thesis research at the University of Tsukuba. VPN protocols such as SSL VPN, L2TP/IPsec, OpenVPN, and Microsoft Secure Socket Tunneling Protocol are provided in a single VPN server. It was released using the GPLv2 license on January 4, 2014. The license was switched to Apache License 2.0 on January 21, 2019. SoftEther VPN supports NAT traversal, making it useful to run VPN servers on computers that are behind residential gateways, facility routers, and firewalls. Firewalls performing deep packet inspection are unable to detect SoftEther's VPN transport packets as a VPN tunnel because HTTPS is used to camouflage the connection. SoftEther VPN optimizes performance by using full Ethernet frame utilization, reducing memory copy operations, parallel transmission, and clustering. Together, these reduce latency normally associated with VPN connections while increasing throughput. The SoftEther VPN Server is unable to bind to specific IP addresses on a machine, negating one of its biggest features. A server running an SSL website cannot run SoftEther on the same machine, thereby preventing it from using the SSL-VPN tunnel functionality that the software is famous for.
  • 4.0K
  • 30 Oct 2022
Topic Review
MecA (Gene)
The mecA gene is a gene found in bacterial cells which allows a bacterium to be resistant to antibiotics such as methicillin, penicillin and other penicillin-like antibiotics. The most commonly known carrier of the mecA gene is the bacterium known as Methicillin-resistant Staphylococcus aureus (MRSA). In Staphylococcus species, mecA is spread on the SCCmec genetic element. Resistant strains are responsible for many infections originating in hospitals. The mecA gene does not allow the ringlike structure of penicillin-like antibiotics to bind to the enzymes that help form the cell wall of the bacterium (transpeptidases), and hence the bacteria is able to replicate as normal. mecA is located on the staphylococcal chromosome cassette mec. The gene encodes the protein PBP2A (penicillin binding protein 2A). PBP2A has a low affinity for beta-lactam antibiotics such as methicillin and penicillin. This enables transpeptidase activity in the presence of beta-lactams, preventing them from inhibiting cell wall synthesis.
  • 4.0K
  • 03 Nov 2022
Topic Review
Muscle Memory
Muscle memory is a form of procedural memory that involves consolidating a specific motor task into memory through repetition, which has been used synonymously with motor learning. When a movement is repeated over time, a long-term muscle memory is created for that task, eventually allowing it to be performed with little to no conscious effort. This process decreases the need for attention and creates maximum efficiency within the motor and memory systems. Muscle memory is found in many everyday activities that become automatic and improve with practice, such as riding bicycles, driving motor vehicles, playing ball sports, typing on keyboards, entering PINs, playing musical instruments, poker, martial arts, and dancing.
  • 4.0K
  • 04 Nov 2022
Topic Review
Memory Span
In psychology and neuroscience, memory span is the longest list of items that a person can repeat back in correct order immediately after presentation on 50% of all trials. Items may include words, numbers, or letters. The task is known as digit span when numbers are used. Memory span is a common measure of working memory and short-term memory. It is also a component of cognitive ability tests such as the WAIS. Backward memory span is a more challenging variation which involves recalling items in reverse order.
  • 4.0K
  • 20 Oct 2022
Topic Review
Friction Stir Processing
Friction stir processing (FSP) is a material processing technique developed in 1999 derived from friction stir welding (FSW). Developed by Mishra et al., this process utilizes localized plastic deformation by rotating a specialized pin through the working piece. 
  • 4.0K
  • 22 Sep 2021
Topic Review
O-Linked Glycosylation
O-linked glycosylation is the attachment of a sugar molecule to the oxygen atom of serine (Ser) or threonine (Thr) residues in a protein. O-glycosylation is a post-translational modification that occurs after the protein has been synthesised. In eukaryotes, it occurs in the endoplasmic reticulum, Golgi apparatus and occasionally in the cytoplasm; in prokaryotes, it occurs in the cytoplasm. Several different sugars can be added to the serine or threonine, and they affect the protein in different ways by changing protein stability and regulating protein activity. O-glycans, which are the sugars added to the serine or threonine, have numerous functions throughout the body, including trafficking of cells in the immune system, allowing recognition of foreign material, controlling cell metabolism and providing cartilage and tendon flexibility. Because of the many functions they have, changes in O-glycosylation are important in many diseases including cancer, diabetes and Alzheimer's. O-glycosylation occurs in all domains of life, including eukaryotes, archaea and a number of pathogenic bacteria including Burkholderia cenocepacia, Neisseria gonorrhoeae and Acinetobacter baumannii.
  • 4.0K
  • 25 Nov 2022
Topic Review
Rural Landscape Using CiteSpace
This study visualizes and quantifies extant publications of rural landscape research (RLR) in Web of Science using CiteSpace for a wide range of research topics, from a multi-angle analysis of the overall research profile, while providing a method and approach for quantitative analysis of massive literature data. First, it presents the number of papers published, subject distribution, author network, the fundamental condition of countries, and research organizations involved in RLR through network analysis. Second, it identifies the high-frequency and high betweenness-centrality values of the basic research content of RLR through keyword co-occurrence analysis and keyword time zones. Finally, it identifies research fronts and trending topics of RLR in the decade from 2009 to 2018 by using co-citation clustering, and noun-term burst detection. The results show that basic research content involves protection, management, biodiversity, and land use. Five clearer research frontier pathways and top 20 research trending topics are extracted to show diversified research branch development. All this provides the reader with a general preliminary grasp of RLR, showing that cooperation and analysis involving multiple disciplines, specialties, and angles will become a dominant trend in the field.
  • 4.0K
  • 27 Oct 2020
Topic Review
Methicilin-Susceptible Staphylococcus aureus
Antibiotic resistance is a global health challenge nowadays, and methicillin-sensitive Staphylococcus aureus (MSSA) is a skin infection presents as pimples, boils, abscesses, or infected cuts and is not resistant to certain antibiotics. MSSA affects people of all ages and is known to cause epidemics among sports teams, families, prison inmates, and people who live and work in close quarters and is a global health challenge nowadays, creating problems in antibiotic therapy.
  • 4.0K
  • 10 Nov 2020
Topic Review
Characterization of MXene's Terminations
MXene, 2D transition metal carbides, nitrides, and carbonitrides with a unique 2D structure, inspired a series of function applications related to energy storage and conversion, biometrics and sensing, lighting, purification, and separation. Its surface terminations are confined by the adjacent MXene layers, and form the 2D planar space with symmetrical surfaces, which is similar to a 2D nanoreactor that can be utilized and determined MXene’s function. Accurate characterization of MXene surface terminations is the prerequisite for studying the regulatory methods and the influence of properties and performance. Because the surface termination of MXene presents two-dimensional plane distribution and the collision probability of atoms, molecules, electrons, and optical signals is low. MXene prepared by chemical methods has certain impurity content. In addition, most surface terminations do not exist in a stable state, which leads to the difficulty of the accurate characterization of MXene surface terminations. At present, XPS, EDX, XAS and EELS are often used for qualitative and quantitative analysis of MXene surface terminations.
  • 4.0K
  • 09 Nov 2022
Topic Review
Psychiatric Survivors Movement
The psychiatric survivors movement (more broadly consumer/survivor/ex-patient movement) is a diverse association of individuals who either currently access mental health services (known as consumers or service users), or who are survivors of interventions by psychiatry, or who are ex-patients of mental health services. The psychiatric survivors movement arose out of the civil rights movement of the late 1960s and early 1970s and the personal histories of psychiatric abuse experienced by some ex-patients. The key text in the intellectual development of the survivor movement, at least in the USA, was Judi Chamberlin's 1978 text, On Our Own: Patient Controlled Alternatives to the Mental Health System. Chamberlin was an ex-patient and co-founder of the Mental Patients' Liberation Front. Coalescing around the ex-patient newsletter Dendron, in late 1988 leaders from several of the main national and grassroots psychiatric survivor groups felt that an independent, human rights coalition focused on problems in the mental health system was needed. That year the Support Coalition International (SCI) was formed. SCI's first public action was to stage a counter-conference and protest in New York City , in May, 1990, at the same time as (and directly outside of) the American Psychiatric Association's annual meeting. In 2005 the SCI changed its name to MindFreedom International with David W. Oaks as its director. Common themes are "talking back to the power of psychiatry", rights protection and advocacy, and self-determination. While activists in the movement may share a collective identity to some extent, views range along a continuum from conservative to radical in relation to psychiatric treatment and levels of resistance or patienthood.
  • 4.0K
  • 23 Nov 2022
Topic Review
Production of Edible Films and Coatings
Generally, edible films and coatings are the primary forms of edible food packaging. The differences between edible films and coatings lie in their physical form and application process. Edible films are obtained as solid laminated sheets and then used as a food wrap that can be removed or consumed with food, whereas coatings are applied to foods in liquid form by coating, spraying, and immersion. After drying, an edible layer over the food is formed, and it can either be removed or consumed.
  • 4.0K
  • 21 Jul 2023
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