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Topic Review
Scientific Advances in Rheumatic Fever/Rheumatic Heart Disease Control
Despite the fact that rheumatic fever (RF) and rheumatic heart disease (RHD) have largely been eradicated from high-income countries, the disease spectrum remains endemic in many low- and middle-income countries (LMICs), extacting a grim health and socioeconomic impact. Over 33 million people are believed to be living with RHD worldwide, claiming nearly a third of a million lives annually. Regrettably, the neglect of RHD as a global health priority was further exacerbated by competing infectious disease outbreaks, chief among them the human immunodeficiency virus (HIV) epidemic. Nevertheless, the prior two decades have seen a slowly resurgence of interest in RF/RHD control. Substantial recent advances in the field of RF/RHD continuum control, however, have been realized over this time period. Such primary advances include a better understanding the genetic predisposition to RHD, progress in Group A Streptococcus (GAS) vaccine development, and improved diagnostic strategies for GAS pharyngitis. Echocardiographic screening for RHD, in particular, has represented a major advance which has unearthed the prevailing high burden of RHD. Lastly, the recent demonstration of benefit of secondary antibiotic prophylaxis on halting progression of latent RHD has marked a major step forward in averting progression of end-stage valvular disease in LMIC settings.
  • 1.0K
  • 19 May 2022
Topic Review
Ultra-Processed Food Availability
UPF are described as “processed ingredients typically combined with the sophisticated use of additives to make them edible, palatable and habit forming”.
  • 1.0K
  • 04 Aug 2021
Topic Review
Diagnosis Application of MINI and BERT
Researchers propose a mental health diagnosis application for Arabic-speaking patients using both The MINI-International Neuropsychiatric Interview (MINI) and the supervised machine learning BERT model to equip the psychiatry department of the Military Hospital of Instruction of Tunis with a rapid and intelligent tool handling the high number of patients treated every day.
  • 1.0K
  • 29 Jan 2022
Topic Review
Lung Nodule Segmentation
The accurate segmentation of lung nodules is challenging due to their small size, especially at the edge of the lung and near the blood vessels. Lung nodule segmentation is relatively broad and varies in terms of architecture, image pre-processing, and training strategy.
  • 1.0K
  • 24 Feb 2022
Topic Review
Sustainable Employability Based on the swAge-Model
Sustainable employability commonly refers to the ability of employees to participate in work and the labour market during their lifetimes. The swAge-model, a tool that helps us understand how to make working life more sustainable and healthier for all ages, can be the basis of sustainable employability.
  • 1.0K
  • 29 Dec 2021
Topic Review
Vitamin D and Preeclampsia
Preeclampsia (PE) is a set of clinical symptoms that appears after the 20th week of pregnancy. It is a multi-organ disease characterized by hypertension and proteinuria, and in the absence of proteinuria—an impairment of the functions of the internal organs. With regard to the multiple mechanisms of action of Vit D, its deficiency seems to be one of the possible factors conducive to PE development. It has been suggested that the consequence of low Vit D levels may be the appearance of an early, severe form of PE, and its supplementation may be a protective factor against its recurrence in subsequent pregnancies [232]. The relationship between Vit D and PE development may explain its impact on implantation, angiogenesis, and endothelial status, regulation of the immune response, effect on RAAS, and calcium metabolism. 
  • 1.0K
  • 17 Nov 2021
Topic Review
COVID-19 Vaccine Candidates
COVID-19 vaccines are indispensable, with the number of cases and mortality still rising, and currently no medicines are routinely available for reducing morbidity and mortality, apart from dexamethasone, although others are being trialed and launched. 
  • 1.0K
  • 13 Jan 2022
Topic Review
Sleep Dysfunction in COVID-19 Patients
Sleep is an important factor for human well being in order to maintain daily functions, while lack of sleep may lead to an increase in accidents, mood changes, impaired psychological functioning and concentration, and decreased immune response.Sleep problems appear to be rather common in COVID-19 patients and are related to higher levels of psychological distress such as traumatic stress, depression and anxiety and worse coronavirus related outcomes including severity and mortality.Effective programs for the treatment of sleep problems, may lead to the reduction of psychological distress and vice versa and improving the sleep quality of infected patients may improve their outcomes. There is a need for appropriate and tailored management strategies and interventions across different populations including the general public and high risk groups such as Healthcare providers and COVID-19 patients including improved sleep hygiene, identification of various risk factors at individual, interpersonal, institutional and community levels and early and accurate recognition of sleep dysfunction and psychological distress.
  • 1.0K
  • 15 Dec 2021
Topic Review
High-Intensity Interval Training
High-Intensity Interval Training (HIIT) could have effects on inflammatory biomarkers, based on the investigation conducted of an anti-inflammatory nature, provided that its characteristics are able to trigger the necessary impact to do so.
  • 1.0K
  • 07 Apr 2025
Topic Review
Comprehensive Framework for Active Health Governance
Health policies are regarded as a governance mechanism crucial for reducing health inequity and improving overall health outcomes. However, the current literature in health policy largely focused on some specific health policy changes and their tangible outcomes, or on specific inequality of health policies in gender, age, racial, or socio-economic status, short of comprehensively responding to and addressing the shift from disease-centered to active-health-oriented. A comprehensive framework is proposed to identify the main elements of a well-defined active health governance and the interactions between these elements. The proposed framework is composed of four elements and three approaches that are dynamically interacted to achieve two active health outcomes. 
  • 1.0K
  • 21 Feb 2022
Topic Review
Long-Term Effects of Human Papillomavirus Vaccination
The preventive effect of Human papillomavirus (HPV) vaccines against anogenital and oropharyngeal cancers has been proven in both clinical trials and real-world data. The longest period of preventive effect for the bivalent, 4-valent, and 9-valent vaccine were 11 years in the Costa Rica trial, 14 years in the FUTURE II, and 8 years in the LTFU extension study of V503-002 and the Scandinavian study, respectively. The sustained clinical effect during the observation period was longest for the 4-valent vaccine. In real-world data, the longest observation period of the vaccine effectiveness was 12 years in an Australian study for the 4-valent vaccine. For the bivalent vaccine, additional long-term follow-up studies may not have been planned due to the launch of the 4-valent and 9-valent vaccines. In some studies of the 9-valent vaccine, the results have not yet been published because of the short observation period. The additional results are expected in the future. In a national immunization program, most girls and boys are inoculated with HPV vaccine by the time puberty begins; thus, it is important to monitor the vaccine effect at least until the sexually active period in their 20s and 30s.
  • 1.0K
  • 25 Feb 2022
Topic Review
Bacteria in Healthcare Units
Healthcare units consist of numerous people circulating daily, such as workers, patients, and companions, and these people are vehicles for the transmission of microorganisms, such as bacteria. Bacteria species may have different allergenic, pathogenic, infectious, or toxic properties that can affect humans.
  • 1.0K
  • 07 Mar 2022
Topic Review
Clinical Reasoning and Clinical Decision-Making Systems
Due to COVID period many people have become recreational runners. Recreational running is a regular way to keep active and healthy at any age. Additionally, running is a popular physical exercise that offers numerous health advantages. However, recreational runners report a high incidence of musculoskeletal injuries due to running. The proposed intelligent system uses data mining algorithms for the rehabilitation guidance of recreational runners with musculoskeletal discomfort. The system classifies recreational runners based on a questionnaire that has been built according to the severity, irritability, nature, stage, and stability model and advise them on the appropriate treatment plan/exercises to follow. 
  • 1.0K
  • 24 Nov 2023
Topic Review
Blockchain Technology in Healthcare
Blockchain technology, a distributed ledger based on peer to peer networks, has been gaining high popularity in healthcare.
  • 1.0K
  • 23 Nov 2021
Topic Review
Facilitating Healthier Eating at Restaurants
Restaurants are understudied yet increasingly important food environment institutions for tackling diet-related diseases. This scoping review analyzes research and gray literature (n = 171 records) to assess which healthy eating promotion strategies have been implemented in restaurants and the associated motivations, barriers, and outcomes, compared by restaurant type (corporate/chain vs. independently owned restaurants) and initiator (restaurant-initiated vs. investigator-initiated). We found that the most commonly reported strategy was the increase of generally healthy offerings and the promotion of such offerings. Changes in food availability were more common among corporate restaurants and initiated by restaurants, while environmental facilitators were more commonly initiated by investigators and associated with independently owned restaurants. Aside from those associated with revenue, motivations and barriers for healthy eating promoting strategies varied by restaurant type. While corporate restaurants were also motivated by public health criticism, independently owned restaurants were motivated by interests to improve community health. Revenue concerns were followed by food sourcing issues in corporate restaurants and lack of interest among independently owned restaurants. Among reporting sources, most outcomes were revenue positive. This study shows the need for practice-based evidence and accounting for restaurant business models to tailor interventions and policies for sustained positive changes in these establishments.
  • 1.0K
  • 25 May 2021
Topic Review
Unlocking the Potential of Fish to Improve Food
Approximately one-third of the global population suffering from chronic hunger are in sub-Saharan Africa (SSA). In addition to high prevalence of chronic hunger, millions of people suffer from micronutrient deficiencies. Meanwhile, there is growing consensus across scientific disciplines concurring that fish plays a crucial role in improving food and nutrition security.
  • 1.0K
  • 13 Jan 2022
Topic Review
Meibomian Gland Dysfunction
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease and loss of ocular surface homeostasis. Increasingly, several observational clinical studies suggest that dyslipidemia (elevated blood cholesterol, triglyceride, or lipoprotein levels) can initiate the development of MGD. 
  • 1.0K
  • 23 Nov 2021
Topic Review
PCN in Malignancy-Associated Ureteric Obstruction
Malignant ureteric obstruction occurs in a variety of cancers and has been typically associated with a poor prognosis. Percutaneous nephrostomy (PCN) can potentially help increase patient longevity by establishing urinary drainage and treating renal failure. PCN is to put a small tube through a kidney to drain urine.
  • 1.0K
  • 29 Jun 2021
Topic Review
Income Inequality and Race/Ethnicity Drive Obesity
Obesity is a major public health problem both globally and within the U.S. It varies by multiple factors, including but not limited to income and sex. After controlling for potential covariates, there is little evidence to determine the association between income and obesity and how obesity may be moderated by sex and family income. We examined the association between income and obesity in U.S. adults aged 20 years and older, and tested whether this relationship differs by race or ethnicity groups. For this analysis, we used data from the 1999–2016 National Health and Nutrition Examination Surveys (NHANES). Obesity was determined using Body Mass Index ≥ 30 kg/m2; the Gini coefficient (GC) was calculated to measure income inequality using the Poverty Income Ratio (PIR). We categorized the PIR into five quintiles to examine the relationship between income inequality and obesity. For the first set of analyses, we used a modified Poisson regression in a sample of 36,665 adults, with an almost equal number of men and women (women’s ratio was 50.6%), including 17,303 white non-Hispanics (WNH), 7475 black non-Hispanics (BNHs), and 6281 Mexican Americans. The models included age, racial/ethnic groups, marital status, education, health behaviors (smoking and drinking status and physical activities), health insurance coverage, self-reported health, and household structure (live alone and size of household). Adjusting for potential confounders, our findings showed that the association between PIR and obesity was positive and significant more frequently among WNH and BNH in middle and top PIR quintiles than among lower-PIR quintiles; this association was not significant in Mexican Americans (MAs). Results of GC in obese women showed that in comparison with WNHs (GC: 0.34, S.E.: 0.002), BNHs (GC: 0.38, S.E.: 0.004) and MAs (GC: 0.41, S.E.: 0.006) experienced higher income inequality, and that BNH obese men experienced the highest income inequality (GC: 0.45, S.E.: 0.011). The association between PIR and obesity was significant among WNHs and BNHs men in the 3rd, 4th and 5th PIR quintiles. The same association was not found for women. In treating obesity, policymakers should consider not only race/ethnicity and sex, but also strategies to reduce inequality in income. 
  • 1.0K
  • 28 Oct 2021
Topic Review
Spiritual Needs in Post-Secular Contexts
It was found that it can be challenging to incorporate spiritual care in daily practice, not least in post-secular, culturally entwined, and pluralist contexts.
  • 1.0K
  • 01 Mar 2022
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