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Topic Review
Fragile X Syndrome
Fragile X syndrome is a genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment. Usually, males are more severely affected by this disorder than females.
  • 1.1K
  • 25 Dec 2020
Topic Review
Epileptic seizures and deep learning
Chronic diseases are growing exponentially. Today, there are over 900 million individuals suffering with some chronic diseases around the world. For this reason, e-health systems are being developed to design a better quality of life for patients. For instance, we have systems for detection of epilepsy, monitoring of vital signs, control of diabetes, among others. Deep learning has being an important technique embedded in these systems to predict and sort the data without the need of a 24-hour monitoring specialist. However, by combining e-health systems and deep learning techniques also brings several challenges that need to be overcome. 
  • 1.1K
  • 05 Nov 2022
Topic Review
Oral Cancer Diagnosis
Oral cancer is a malignant condition on the lips or in the oral cavity including the tongue, gingiva, mouth floor, parotid, salivary glands, and throat. More than 90% of oral cancer is oral squamous cell carcinoma (OSCC). Fourier transform infrared spectroscopy (FTIR) is a modern diagnostic tool with great potential to provide rapid, objective and accurate early diagnosis of oral cancer, as well as accurate OSCC grading for better cancer management. 
  • 1.1K
  • 22 Sep 2021
Topic Review
Tryptophan Metabolites
The metabolism of tryptophan is intimately associated with the differential regulation of diverse physiological processes, including in the regulation of responses to severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2) infection that underpins the COVID-19 pandemic.
  • 1.1K
  • 29 Jan 2022
Topic Review
Titanium Dioxide-Derived Materials with Superwettability
Titanium dioxide (TiO2) is widely used in various fields both in daily life and industry owing to its excellent photoelectric properties and its induced superwettability. Generally, superwettability refers to superhydrophilic, superhydrophobic, superamphiphilic, and superamphiphobic surfaces; the mechanism of the superwettability property can be explained based on the surface structure of materials, surface molecules, and external influencing factors. Over the past several decades, various methods have been reported to improve the wettability of TiO2 and plenty of practical applications have been developed. The TiO2-derived materials with different morphologies display a variety of functions including photocatalysis, self-cleaning, oil-water separation, etc. 
  • 1.1K
  • 14 Apr 2021
Topic Review
Animal Leishmaniosis
Infection with Leishmania parasites can lead to severe disease in humans and dogs, which act as a reservoir in zoonotic transmission. The identification of additional animal species recognised zoonotic reservoirs is of great importance to leishmaniasis control programs. In addition, Leishmanis spp. can cause considerable disease in animals other than dogs.
  • 1.1K
  • 07 May 2021
Topic Review
Endocrine Challenges with Continuous-Flow LVADs
Heart failure (HF) remains a leading cause of morbidity, hospitalization, and mortality worldwide. Advancement of mechanical circulatory support technology has led to the use of continuous-flow left ventricular assist devices (LVADs), reducing hospitalizations, and improving quality of life and outcomes in advanced HF. Recent studies have highlighted how metabolic and endocrine dysfunction may be a consequence of, or associated with, HF, and may represent a novel (still neglected) therapeutic target in the treatment of HF. On the other hand, it is not clear whether LVAD support, may impact the outcome by also improving organ perfusion as well as improving the neuro-hormonal state of the patients, reducing the endocrine dysfunction. Moreover, endocrine function is likely a major determinant of human homeostasis, and is a key issue in the recovery from critical illness. Care of the endocrine function may contribute to improving cardiac contractility, immune function, as well as infection control, and rehabilitation during and after a LVAD placement.
  • 1.1K
  • 02 Jul 2021
Topic Review
Algal Metabolites as an Immune Booster against COVID-19
Algae and algae-derived products are rich sources of natural products or metabolites synthesized during metabolism. Algae are a rich source of compounds such as lectins and sulfated polysaccharides, which have potent antiviral and immunity-boosting properties. Moreover, Algae-derived compounds or metabolites can be used as antibodies and vaccine raw materials against COVID-19. Furthermore, some algal species can boost immunity, reduce viral activity in humans and be recommended for usage as a COVID-19 preventative measure.
  • 1.1K
  • 18 Mar 2022
Topic Review
Regulatory Focus and Consumers’ Attitudes toward Artificial Meat
While production and consumption of meat cast a shadow over the prospects for sustainable development, artificial meat may be the solution. However, consumer acceptability of artificial meat is a major impediment to its use as a suitable alternative. Here analyzed the relationship between regulatory focus and consumer acceptance of artificial meat using randomized controlled trial data. Results showed that promotion focus results in a higher acceptance of artificial meat products due to a higher perceived benefit and lower perceived risk, whereas prevention focus results in a lower acceptance of artificial meat products due to perceived benefit being lower and perceived risk being higher. The moderating effect of the message framing was investigated employing structural equation modeling (SEM). It was discovered that a gain-oriented message framing could greatly strengthen the association between promotion focus and perceived benefit, whereas an avoidance oriented message framing could significantly diminish the relationship between prevention focus and perceived risk. 
  • 1.1K
  • 23 May 2022
Topic Review
Allelopathic Potential of Lemna minor L.
Allelopathy is an interaction that releases allelochemicals (chemicals that act allelopathically) from plants into the environment that can limit or stimulate the development, reproduction, and survival of target organisms and alter the environment. Lemna minor L. contains chemicals that are allelopathic, such as phenolic acids. Chemical compounds contained in L. minor may have a significant impact on the development and the rate of multiplication and lead to stronger competition, which may enhance the allelopathic potential. Allelopathic potential may exist between L. minor and C. glomerata (L) Kütz. because they occupy a similar space in the aquatic ecosystem, have a similar preference for the amount of light, and compete for similar habitat resources. L. minor and C. glomerata can form dense populations on the water surface. Allelopathy can be seen as a wish to dominate one of the plants in the aquatic ecosystem. By creating a place for the development of extensive mats, an interspecific interaction is created and one of the species achieves competitive success. It is most effective as a result of the release of chemicals by macrophytes into the aquatic environment. Therefore, allelopathy plays a significant role in the formation, stabilization, and dynamics of the structure of plant communities.
  • 1.1K
  • 28 Jun 2022
Topic Review
Bet Hedging
Biological bet hedging occurs when organisms suffer decreased fitness in their typical conditions in exchange for increased fitness in stressful conditions. Biological bet hedging was originally proposed to explain the observation of a seed bank, or a reservoir of ungerminated seeds in the soil. For example, an annual plant's fitness is maximized for that year if all of its seeds germinate. However, if a drought occurs that kills germinated plants, but not ungerminated seeds, plants with seeds remaining in the seed bank will have a fitness advantage. Therefore, it can be advantageous for plants to "hedge their bets" in case of a drought by producing some seeds that germinate immediately and other seeds that lie dormant. Other examples of biological bet hedging include female multiple mating, foraging behavior in bumble bees, nutrient storage in rhizobia, and bacterial persistence in the presence of antibiotics.
  • 1.1K
  • 11 Oct 2022
Topic Review
Seongcheol
Seongcheol (April 6, 1912 – November 4, 1993) is the dharma name of a Korean Seon (Zen) Master. He was a key figure in modern Korean Buddhism, being responsible for significant changes to it from the 1950s to 1990s. Seongcheol was widely recognized in Korea as having been a living Buddha, due to his extremely ascetic lifestyle, the duration and manner of his meditation training, his central role in reforming Korean Buddhism in the post-World War II era, and the quality of his oral and written teachings.
  • 1.1K
  • 12 Oct 2022
Topic Review
Sexual and Reproductive Health and Rights
Sexual and reproductive health and rights or SRHR is the concept of human rights applied to sexuality and reproduction. It is a combination of four fields that in some contexts are more or less distinct from each other, but less so or not at all in other contexts. These four fields are sexual health, sexual rights, reproductive health and reproductive rights. In the concept of SRHR, these four fields are treated as separate but inherently intertwined. Distinctions between these four fields are not always made. Sexual health and reproductive health are sometimes treated as synonymous to each other, as are sexual rights and reproductive rights. In some cases, sexual rights are included in the term sexual health, or vice versa. Not only do different non-governmental organisations (NGOs) and governments organisations use different terminologies, but different terminologies are often used within the same organization. Some of the notable global NGOs that fight for sexual and reproductive health and rights include IPPF (International Planned Parenthood Federation), ILGA (International Lesbian and Gay Alliance), WAS (World Association for Sexual Health - formerly known as World Association for Sexology), the Center for Health and Gender Equity, and International HIV/AIDS Alliance.
  • 1.1K
  • 17 Oct 2022
Topic Review
Forms of Parkinson Disease Epigenetic Aspects
Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting approximately 1% of the population over the age of 50. PD is the second most common neurodegenerative disorder, and the estimated prevalence is 94 cases per 100,000 people, or approximately 0.3 percent in the general population 40 years of age and older. The yearly incidence of new cases ranges from 8 to 18.6 per 100,000 person-years. PD is clinically characterized by uncontrollable tremors at rest, rigidity, slowness of movement and postural impairment. In addition to violations of motor function, PD is accompanied by gastrointestinal, olfactory, sleep, and cognitive pathologies and other disorders. PD is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). These neurons release dopamine (DA) from nerve endings in the striatum and control muscle tone and multiple brain functions including a broad array of behavioral processes such as mood, reward, addiction, and stress. Morphologically PD is characterized by the presence of intracellular inclusions called Lewy bodies (LB) consisting mainly of aggregated α-synuclein (αSyn) inside nerve cells including SNpc. The onset of PD is dependent on both genetic and environmental factors. The latter can alter gene expression by causing epigenetic changes, such as DNA methylation, and the post-translational modification of histones and non-coding RNAs (ncRNAs, the most studied of which are microRNAs or miRNAs). The regulation of genes responsible for monogenic forms of PD may also be involved in sporadic PD.
  • 1.1K
  • 12 Sep 2023
Topic Review
Development of the Human Cortex
The development of the human cortex is a process known as corticogenesis in which the cortex of the brain is formed during neural development. The cortex is the outer layer of the brain and is composed of up to six layers. Neurons formed in the ventricular zone migrate to their final locations in one of the six layers of the cortex The process occurs from embryonic day 10 to 17 in mice and between gestational weeks seven to 18 in humans.
  • 1.1K
  • 25 Nov 2022
Topic Review
Trop-2 as a Therapeutic Target in Breast Cancer
Trop-2 is an exciting, new target for the treatment of breast cancer. Trop-2 is found at high levels in multiple cancers such as prostate, pancreatic, urothelial, lung, and breast cancer. Among different breast cancer subtypes, Trop-2 is most highly expressed in triple negative breast cancer. Drugs that inhibit Trop-2 are now an important treatment option for patients with metastatic triple negative breast cancer, for whom few treatment options exist.
  • 1.1K
  • 07 Dec 2022
Topic Review
Natural Killer Cell-Derived Extracellular Vesicles for Cancer
Cancer is the second leading contributor to global deaths caused by non-communicable diseases. The cancer cells are known to interact with the surrounding non-cancerous cells, including the immune cells and stromal cells, within the tumor microenvironment (TME) to modulate the tumor progression, metastasis and resistance. Chemotherapy and radiotherapy are the standard treatments for cancers. A new generation of immunotherapy using natural killer (NK) cells, cytotoxic CD8+ T-lymphocytes or macrophages was developed to achieve tumor-specific targeting and circumvent the adverse effects.
  • 1.1K
  • 21 Feb 2023
Topic Review
Metabolites of Aspergillus nidulans and Their Bioactivities
Fungi serve as a depository of fascinating, structurally unique metabolites with considerable therapeutic significance. Aspergillus genus represents one of the most prolific genera of filamentous fungi. Aspergillus nidulans Winter G. is a well-known and plentiful source of bioactive metabolites with abundant structural diversity, including terpenoids, benzophenones, sterols, alkaloids, xanthones, and polyketides, many of which display various bioactivities, such as cytotoxicity, antioxidant, anti-inflammatory, antiviral, and antimicrobial activities. 
  • 1.1K
  • 31 Mar 2023
Topic Review
Carbon Dioxide Storage
Carbon capture utilization and storage (CCUS) technologies are regarded as an economically feasible way to minimize greenhouse gas emissions. By chemically reacting CO2 with calcium or magnesium-containing minerals, mineral carbonation technology creates stable carbonate compounds that do not require ongoing liability or monitoring. In addition, using industrial waste residues as a source of carbonate minerals appears as an option because they are less expensive and easily accessible close to CO2 emitters and have higher reactivity than natural minerals. Among those geological formations for CO2 storage, carbon microbubbles sequestration provides the economic leak-free option of carbon capture and storage. 
  • 1.1K
  • 23 May 2023
Topic Review
The Automated Test of Embodied Cognition (ATEC)
The Automated Test of Embodied Cognition (ATEC) uses video administration of cognitively demanding physical tasks and motion capture technology to assess cognition in action. Embodied cognition is a radical departure from conventional approaches to cognitive assessment and is in keeping with contemporary neuroscience.
  • 1.1K
  • 14 Jun 2023
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