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Topic Review
Lifelong Disadvantage and Late Adulthood Frailty
Frailty is a complex state of objective and subjective vulnerability. It tends to increase with age, but the process is influenced by previous life course, especially previous disadvantages. Results show that while frailty increases with age, there is also evidence of an accumulation of risks: the longer the periods of adult life affected by unemployment, stress, financial hardship or, most importantly, bad health, the frailer individuals are in their late years. Furthermore, periods of coexisting disadvantages in adulthood translate into additional frailty in late life. 
  • 1.1K
  • 17 Jan 2022
Topic Review
Antivirals on the Cardiovascular Conditions
The COVID-19 pandemic has resulted in a complex clinical challenge, caused by a novel coronavirus, partially similar to previously known coronaviruses but with a different pattern of contagiousness, complications, and mortality. Safety profiles of antivirals are largely questioned and addressed by health agencies, in consideration of COVID-19 cardiac and pro-thrombotic complications generally experienced by predisposed subjects.
  • 1.1K
  • 25 Feb 2022
Topic Review
Inguinal Hernia in Nonhuman Primates
A herniation is a condition in which there is a protrusion of an organ, fascia, fat, or omentum through the wall of the cavity in which it is contained. A hernia may be classified into different categories based on the cause, location, size, recurrence, reducibility, contents, and symptoms. Inguinal hernia is described as a bulge of the peritoneum through a defect (congenital or acquired) in the muscular and fascial structures of the abdominal wall; a defect in the myofascial plane of the oblique and transversalis muscles and fascia. Inguinal hernias are classified into (1) indirect hernia, (2) direct hernia, (3) scrotal or giant hernia, (4) femoral hernia, and (5) others, i.e., rare hernias such as Spigelian hernias. Inguinal hernias are relatively common in both humans and domestic animal species, and surgery to repair an inguinal hernia is a nonurgent, routine procedure. However, every hernia carries a hazard of incarceration and strangulation, warranting immediate surgical treatment.
  • 1.1K
  • 22 Jun 2022
Topic Review
Exercise Training Effects on Heart Failure
Heart failure (HF) is a major public health issue worldwide with increased prevalence and a high number of hospitalizations. Patients with chronic HF and either reduced ejection fraction (HFrEF) or mildly reduced ejection fraction (HFmrEF) present vascular endothelial dysfunction and significantly decreased circulating levels of endothelial progenitor cells (EPCs).
  • 1.1K
  • 25 Jul 2022
Topic Review
Microbiological Perspectives in COVID-19 Pandemics
The COVID-19 pandemic caused by SARS-CoV-2 remains a significant issue for global health, the economy, and society. When SARS-CoV-2 began to spread, the most recent serious infectious disease of this century around the world, with its high morbidity and mortality rates, it is understandable why such infections have generally been spread in the past, mainly from international travel movements. Microbiology is a branch of medicine and biology that studies the structure and functions of microorganisms (i.e., all those single-celled, multicellular or acellular living organisms not visible to the naked eye such as bacteria, Archaea, some types of fungi, algae, protozoa, viruses and prions).
  • 1.1K
  • 02 Sep 2022
Topic Review
Melatonin Function under Normal and Stressful Conditions
Plants are exposed to a variety of environmental stresses (biotic and abiotic) during the course of development. Stressful conditions alter the basic metabolism of the affected plants. Plants must cope with environmental constraints to effectively complete their life cycle. Plant produce and regulate various biomolecules to adapt to adverse environmental conditions. Melatonin (N-acetyl-5-methoxytryptamine) is a ubiquitous molecule that is present in plants, animals, and microorganisms. It has been revealed as an indolic chemical compound with structural similarities with other vital compounds such as tryptophan, serotonin, and indole-3-acetic acid (IAA). In plants, melatonin is a putative hormone involved in the regulation of plant growth and productivity, even under biotic and abiotic stress conditions.
  • 1.1K
  • 27 Sep 2022
Topic Review
Red Eye
A red eye is an eye that appears red due to illness or injury. It is usually injection and prominence of the superficial blood vessels of the conjunctiva, which may be caused by disorders of these or adjacent structures. Conjunctivitis and subconjunctival hemorrhage are two of the less serious but more common causes. Management includes assessing whether emergency action (including referral) is needed, or whether treatment can be accomplished without additional resources. Slit lamp examination is invaluable in diagnosis but initial assessment can be performed using a careful history, testing vision (visual acuity), and carrying out a penlight examination.
  • 1.1K
  • 27 Oct 2022
Topic Review
Simultaneously Extracted Metals and Acid-Volatile Sulfide
Simultaneously extracted metals/Acid-volatile sulfide (SEM-AVS) is an approach used in the field of aquatic toxicology to assess the potential for metal ions found in sediment to cause toxic effects in organisms dwelling in the sediment. In this approach, the amounts of several heavy metals in a sediment sample are measured in a laboratory; at the same time, the amount of acid-volatile sulfide (sulfide which can be liberated from the sediment by treatment with hydrochloric acid) is determined. Based on the chemical interactions between heavy metals (SEM) and acid-volatile sulfide (AVS), the concentrations of these two components can be used to assess the potential for toxicity to sediment-dwelling organisms.
  • 1.1K
  • 07 Nov 2022
Topic Review
Sport for Employability
Most definitions of employability highlight how individual skills, knowledge, or characteristics enable people to find and maintain employment, though some argue that definitions should consider the broader personal and external factors that drive employability. Many current employability recommendations focus on the importance of soft skills and, increasing, sport has been positioned as promising vehicle to develop these skills. This connection between sport and skills has led numerous sport for development (SFD) programmes to explicitly target (youth) employability. In this entry, the background of employability and the general pathways around sport-for-employability programmes are presented. 
  • 1.1K
  • 10 Jan 2023
Topic Review
Melanoma Phenotypic Plasticity, Melanoma Cell Invasion and Metastasis
Melanoma, a highly heterogeneous tumor, is comprised of a functionally diverse spectrum of cell phenotypes and subpopulations, including stromal cells in the tumor microenvironment (TME). Melanoma has been shown to dynamically shift between different transcriptional states or phenotypes. This is referred to as phenotype switching in melanoma, and it involves switching between quiescent and proliferative cell cycle states, and dramatic shifts in invasiveness, as well as changes in signaling pathways in the melanoma cells, and immune cell composition in the TME.
  • 1.1K
  • 02 Feb 2023
Topic Review
Dust-Associated Perfluoroalkyl and Polyfluoroalkyl Substances
The occurrence of sand and dust storms (SDSs) is essential for the geochemical cycling of nutrients; however, it is considered a meteorological hazard common to arid regions because of the adverse impacts that SDSs brings with them. One common implication of SDSs is the transport and disposition of aerosols coated with anthropogenic contaminants. Studies have reported the presence of such contaminants in desert dust; however, similar findings related to ubiquitous emerging contaminants, such as per- and poly-fluoroalkyl substances (PFAS), have been relatively scarce in the literature. 
  • 1.1K
  • 17 Apr 2023
Topic Review
Oxidative Stress in Red Blood Cell Diseases
Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that affect the structure, function, or production of red blood cells (RBCs). These disorders can lead to various clinical manifestations, including anemia, hemolysis, inflammation, and impaired oxygen-carrying capacity. Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense mechanisms, plays a significant role in the pathophysiology of red cell diseases.
  • 1.1K
  • 29 Aug 2023
Topic Review
Hydrological Droughts
Hydrological droughts may be referred to as sustained and regionally extensive water shortages as reflected in streamflows that are noticeable and gauged worldwide. The analysis of hydrological droughts is largely conducted using the truncation level approach to represent the desired demand level of water equivalent to the median, mean, or any other flow quantile of an annual, monthly, or weekly flow sequence.
  • 1.1K
  • 07 Mar 2024
Topic Review
Periodontal NETs: Beneficence & Maleficence
Periodontitis is a general term for diseases characterised by inflammatory destruction of tooth-supporting tissues, gradual destruction of the marginal periodontal ligament and resorption of alveolar bone. Early-onset periodontitis is due to disturbed neutrophil extracellular trap (NET) formation and clearance. Indeed, mutations that inactivate the cysteine proteases cathepsin C result in deficient NET formation and concomitant early-onset periodontitis. In contrast, exaggerated NET formation due to polymorphonuclear neutrophil (PMN) hyper-responsiveness drives the pathology of late-onset periodontitis by damaging and ulcerating the gingival epithelium and retarding epithelial healing. Periodontitis progression ends with almost complete loss of the periodontal ligament and subsequent tooth exfoliation. 
  • 1.1K
  • 28 Jan 2021
Topic Review
Yoga Using Intelligent Internet of Things
The detection and monitoring of the yoga postures are possible with the Intelligent Internet of Things (IIoT), which is the integration of intelligent approaches (machine learning) and the Internet of Things (IoT). Considering the increment in yoga practitioners, the integration of IIoT and yoga has led to the successful implementation of IIoT-based yoga training systems.
  • 1.1K
  • 24 Apr 2023
Topic Review
Energy Management Systems in Microgrids
Microgrids usually employ distributed energy resources such as wind turbines, solar photovoltaic modules, etc. When multiple distributed generation resources with different features are used in microgrids, managing these resources becomes an important problem. The generated power of solar photovoltaic modules and wind turbines used in microgrids is constantly changing with solar irradiation and wind speed. Due to this impermanent and uncertain nature of renewable energy resources, generally, energy storage systems are employed in microgrid systems. To control the distributed energy resources and energy storage units and sustain the supply and demand balance within the microgrid and provide sustainable and reliable energy to the loads, energy management systems are used. Many methods are used to realize and optimize energy management in microgrids. 
  • 1.1K
  • 26 Feb 2024
Topic Review
MAGIC-f Gel in Cancer Research
Much of the complex medical physics work requires radiation dose delivery, which requires dosimeters to accurately measure complex three-dimensional dose distribution with good spatial resolution. MAGIC-f polymer gel is one of the emerging new dosimeters widely used in medical physics research. The purpose of this study was to present an overview of polymer gel dosimetry, using MAGIC-f gel, including its composition, manufacture, imaging, calibration, and application to medical physics research.
  • 1.1K
  • 10 Sep 2021
Topic Review
Silver Nanoparticles in Sensors for Aquatic Environmental Analysis
With rapidly increasing environmental pollution, there is an urgent need for the development of fast, low-cost, and effective sensing devices for the detection of various organic and inorganic substances. Silver nanoparticles (AgNPs) are well known for their superior optoelectronic and physicochemical properties, and have, therefore, attracted a great deal of interest in the sensor arena. The introduction of AgNPs onto the surface of two-dimensional (2D) structures, incorporation into conductive polymers, or within three-dimensional (3D) nanohybrid architectures is a common strategy to fabricate novel platforms with improved chemical and physical properties for analyte sensing.
  • 1.1K
  • 05 Jun 2023
Topic Review
Human Drug-Drug Interactions
Patients suffering from complex diseases (infectious diseases, oncology) or several conditions (co-morbidities) require combination therapies of different drugs. Combining different drugs will potentially lead to drug-drug interactions, influencing the efficacy and safety of the treatment. Development of novel drugs that are intended to be used in combination should consider drug-drug interactions as early as possible. Even with limited data, drug-drug interactions in humans can be predicted using model-informed drug discovery and development (MID3). The concept to utilize and integrate data from in vitro combination experiments combined with preclinical in vivo data on the exposure-response relationships of the drugs in combination through a computational model-informed approach, is introduced here with tuberculosis as case study.
  • 1.1K
  • 29 May 2021
Topic Review
Immunotherapy Biomarkers Renal Cell Carcinoma
The treatment of metastatic renal cell carcinoma has evolved quickly over the last few years from a disease managed primarily with sequential oral tyrosine kinase inhibitors (TKIs) targeting the vascular endothelial growth factor (VEGF) pathway, to now with a combination of therapies incorporating immune checkpoint blockade (ICB). Patient outcomes have improved with these innovations, however, controversy persists regarding the optimal sequence and patient selection amongst the available combinations. Ideally, predictive biomarkers would aid in guiding treatment decisions and personalizing care.
  • 1.1K
  • 26 Nov 2020
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