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Topic Review
Toxic Effects of Poly-Fluoroalkyl Substances in Organisms
More than 7000 synthetic compounds known as per- and poly-fluoroalkyl substances (PFAS) are applied to food packaging and other materials to provide fat, fire, and/or water resistance properties. These compounds have exceptional environmental stability and persistence due to the strong C-F chemical bond, earning them the moniker “forever chemicals”. Emission of PFAS from industrial waste leads to water, air, and soil contamination. Due to this ubiquitous nature, combined with the fact that PFAS in humans are known to have carcinogenic and reprotoxic effects and to cause vaccine resistance and depression of the immunity system, PFAS may constitute a major threat to human health. For this reason, the attention of the scientific community and of control bodies is increasing and as a consequence legislation and the scientific literature on PFAS are constantly evolving.
  • 547
  • 19 Jun 2023
Topic Review
Comprehensive Sexuality Education for Students with Disabilities
Comprehensive sexuality education (CSE) is an important framework utilized worldwide to provide students and young people with accurate, affirming, and socially conscious sexuality education.
  • 546
  • 25 Oct 2023
Topic Review
Environmental Pollution and the Risk of Metabolic Disorders
Metabolic disorders are a spectrum of diseases that affect normal metabolic functioning and regulation. More than 500 metabolic disorders exist, two of the most common being diabetes mellitus and obesity. Obesity is a multifactorial disorder involving the interaction of genetics, lifestyle and environment. It results in excessive adipose tissue deposition and is defined by a body mass index (BMI) greater than 30 kg/m2. In addition, obesity is the leading cause of metabolic syndrome and insulin resistance. Type 2 diabetes is characterized by an elevated blood glucose level, a chronic hyperglycemic state caused by a combination of pancreatic β-cell loss through apoptosis and insulin resistance in peripheral tissues, such as skeletal muscle. By contrast, type 1 diabetes is caused by autoimmune attack upon pancreatic β-cells, causing an almost complete loss of insulin production and secretion. Whilst a genetic predisposition can underlie the onset of type 1 diabetes, with particular loci of interest having been identified, environmental factors may also contribute. Well-established risk factors for type 2 diabetes and obesity are a sedentary lifestyle, poor nutrition, insulin resistance, environmental factors and genetics.
  • 544
  • 08 Jun 2023
Topic Review
Mercury and Prenatal Growth
The intrauterine environment is critical for healthy prenatal growth and affects neonatal survival and later health. Mercury is a toxic metal which can freely cross the placenta and disrupt a wide range of cellular processes. Many observational studies have investigated mercury exposure and prenatal growth, but no prior review has synthesised this evidence. Four relevant publication databases (Embase, MEDLINE/PubMed, PsycINFO, and Scopus) were systematically searched to identify studies of prenatal mercury exposure and birth weight, birth length, or head circumference. Study quality was assessed using the NIH Quality Assessment Tool, and results synthesised in a narrative review. Twenty-seven studies met the review criteria, these were in 17 countries and used 8 types of mercury biomarker. Studies of birth weight (total = 27) involving populations with high levels of mercury exposure, non-linear methods, or identified as high quality were more likely to report an association with mercury, but overall results were inconsistent. Most studies reported no strong evidence of association between mercury and birth length (n = 14) or head circumference (n = 14). 
  • 541
  • 07 Jul 2021
Topic Review
Marine Cyanobacterial Peptides in Neuroblastoma
Neuroblastoma is the most prevalent extracranial solid tumor in pediatric patients, originating from sympathetic nervous system cells. Metastasis can be observed in approximately 70% of individuals after diagnosis, and the prognosis is poor. The current care methods used, which include surgical removal as well as radio and chemotherapy, are largely unsuccessful, with high mortality and relapse rates. Marine cyanobacteria are a key source of physiologically active metabolites, which have recently received attention owing to their anticancer potential. Marine peptides possess several advantages over proteins or antibodies, including small size, simple manufacturing, cell membrane crossing capabilities, minimal drug–drug interactions, minimal changes in blood–brain barrier (BBB) integrity, selective targeting, chemical and biological diversities, and effects on liver and kidney functions.
  • 541
  • 05 Jun 2023
Topic Review
Anticancer Strategies Targeting JWA
JWA is a microtubule-associated protein and an environmental response gene. JWA has been identified as a potential therapeutic target for several cancers. 
  • 538
  • 08 Oct 2022
Topic Review
Air Pollution on Chronic Rhinosinusitis and Asthma
Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer. 
  • 538
  • 08 Feb 2023
Topic Review
Pioglitazone Use and Sepsis Mortality
The pioglitazone use via the PPARγ agonist in sepsis patients is inconclusive. It was based on a great number of animal studies. However, except for information from animal studies, there are merely no data of human for reference. This study was conducted by a unique database including 1.6 million of diabetic patients. From 1999 to 2013, a total of 145,327 type 2 diabetic patients, first admitted for sepsis, were enrolled. Propensity score matching was conducted in a 1:5 ratio between pioglitazone users and nonusers. Multivariate logistic regression was conducted to evaluate the adjusted odds ratios (aORs) of hospital mortality in pioglitazone users. Further stratification analysis and Kaplan-Meier plot were utilized. A total of 9,310 sepsis pioglitazone users (defined as "ever" use pioglitazone in any dose within 3 months prior to the first admission for sepsis) and 46,550 matched nonusers were retrieved, respectively. In the multivariate logistic regression model, the cohort of pioglitazone users (9,310) had a decreased aOR = 0.95 (95% CI, 0.89-1.02) of sepsis mortality. Further stratification analysis demonstrated that "chronic pioglitazone users" (defined as "at least" 4 weeks drug use within 3 months) (3,399) was much associated with significant aOR = 0.80 (95% CI, 0.72-0.89) in reducing sepsis mortality. This first human cohort study demonstrated the potential protective effect of chronic pioglitazone use in type 2 diabetic sepsis patients.
  • 537
  • 16 Mar 2021
Topic Review
High-Polyphenol-Content Waters Using Biotechnological Approaches
Polyphenols and their intermediate metabolites are natural compounds that are spread worldwide. Polyphenols are antioxidant agents beneficial for human health, but exposure to some of these compounds can be harmful to humans and the environment. A number of industries produce and discharge polyphenols in water effluents. These emissions pose serious environmental issues, causing the pollution of surface or groundwater (which are used to provide drinking water) or harming wildlife in the receiving ecosystems. The treatment of high-polyphenol-content waters is mandatory for many industries.
  • 534
  • 16 Jan 2023
Topic Review
Children Health and Air Pollution
The developmental origins of health and disease (DOHaD) hypothesis links adverse fetal exposures with developmental mal-adaptations and morbidity later in life. Short- and long-term exposures to air pollutants are known contributors to health outcomes. Air pollution is an established risk factor for morbidity and mortality that affects the general population. The developmental origins of health and disease (DOHaD) hypothesis states that adverse fetal, infant, and childhood growth patterns are causally linked to disease development in adulthood. The literature on cardiovascular and metabolic, respiratory, allergic, and neuropsychological health outcomes, from prenatal development through early childhood, associated with early-life exposures to outdoor air pollutants, including traffic-related and wildfire-generated air pollutants are summarized.
  • 533
  • 26 Aug 2022
Topic Review
Viral Eco-Genomic Tools for Aquatic Biomonitoring
Enteric viruses (EVs) occurrence within aquatic environments varies and leads to significant risk on public health of humans, animals, and diversity of aquatic taxa. Early and efficacious recognition of cultivable and fastidious EVs in aquatic systems are important to ensure the sanitary level of aquatic water and implement required treatment strategies. In combination with bioinformatics techniques, genetic tools including cloning sequencing analysis, DNA microarray, next-generation sequencing (NGS), and metagenomic sequencing technologies are implemented to make informed decisions about the global burden of waterborne EVs-associated diseases.
  • 533
  • 05 Sep 2022
Topic Review
Noise Levels in University Dental Clinic
Noise levels in a dental office can be produced by different specialty instruments. Exposure to high levels of noise (unwanted sounds) may cause auditory and non-auditory health problems in dentists.
  • 533
  • 16 Oct 2023
Topic Review
Corporate Climate Change Impacts and Due Diligence
Climate change has been described as one of the greatest threats to people and the planet. Its impacts affect virtually the entire spectrum of internationally recognised human rights as well as the environment in and of itself. In relation to human rights, there is a growing consensus that companies should exercise human rights due diligence in order to identify and prevent their actual and potential adverse impacts.
  • 532
  • 27 Sep 2023
Topic Review
Dyslexia
Developmental dyslexia is a common complex neurodevelopmental disorder that persists well into adulthood and, thus, could have lifelong detrimental effects. Dyslexia has been defined as “deficient literacy acquisition despite adequate intellectual ability and sufficient educational exposure”.  It can be looked  from latest neuroscientific models.
  • 531
  • 02 Mar 2023
Topic Review
Road Safety Near a Landfill Assessment in Europe
In Europe, many governments are struggling with the ambitious target of zero road deaths by 2050. On the other hand, they are facing remediation of illegal waste dumps, subject to European infringement procedures and involving a lot of workers and heavy materials transportation. In Italy, a specific department was started in 2017 to carry out the remediation of 200 illegal landfills of urban/industrial solid waste. According to the Italian legislative framework on construction site management, risk assessment should also include risks for the external context caused by the working site.
  • 531
  • 26 May 2023
Topic Review
Obstructive Sleep Apnea(OSA)
Obstructive sleep apnea (OSA) is a common sleep disorder that affects all age groups and is associated with many co-morbid diseases (especially cardiovascular diseases). Continuous positive airway pressure (CPAP) is the gold standard for treating OSA. However, and with increasing prevalence of CPAP non-adherence, other therapeutic interventions have emerged. Hypoglossal nerve stimulation is a novel modality of treating patients with moderate to severe OSA who are not adherent to CPAP.
  • 529
  • 02 Mar 2021
Topic Review
Effectiveness of Physical-Activity-Based Interventions Targeting Overweight and Obesity
Overweight and obesity, including their prevalence and consequences, reflect a leading public health problem. Studies have already shown that physical activity leads to a reduction in body weight in children and adults. It is already known that physical activity is an essential component of combating overweight and obesity. Being overweight causes cardiovascular diseases, diabetes, musculoskeletal disorders, and different types of cancer. According to the WHO, the prevalence of obesity has almost tripled since 1975. In 2016, 1.9 billion people aged 18 years and older were overweight, of which 650 million individuals were considered obese.
  • 528
  • 01 Sep 2022
Topic Review
Alleviate Job Burnout in Construction Workers in China
Burnout is at all-time highs across modern professions. As a typical labor-intensive industry, the high-pressure and task-driven nature of the construction industry makes construction workers more prone to burnout. It is still unclear whether increasing the professionalization level can lessen the many harmful consequences of job burnout on construction workers’ employment.
  • 528
  • 17 Jan 2023
Topic Review
Sports Involvement on Body Image Perception and Ideals
Concerns about body image may affect athletes, mainly because of specific sports models to achieve successful performance.
  • 527
  • 06 May 2023
Topic Review
Benefits of Exercise for Lowering Cardiovascular Stress Reactivity
Exaggerated cardiovascular reactivity to and delayed recovery from stress increase the risk of cardiovascular diseases in the future. It is evident that exercise training and aerobic fitness are associated with reduced cardiovascular reactivity and enhanced recovery from stress, but the effects with acute exercise are less characterized. This research sought to explore the range and variety of available studies using acute exercise to lower stress-induced cardiovascular reactivity and recovery. In general, acute exercise particularly of the moderate-intensity, aerobic type effectively reduced stress-induced Blood pressure (BP) reactivity in the healthy population and in those with high blood pressure. This shows that with just a single bout of exercise can help to lower cardiovascular reactivity in response to stress without having to undergo extensive exercise training. Further research would be recommended to establish if other forms of exercise intensity or type are equally beneficial to lower exaggerated cardiovascular responses to stress.
  • 527
  • 15 Apr 2022
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