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Topic Review
Isocitrate Dehydrogenase Mutations in Glioma
Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate, which impacts cellular epigenetics and metabolism. IDH mutation establishes distinctive patterns in metabolism, cancer biology, and the therapeutic sensitivity of glioma. Thus, a deeper understanding of the roles of IDH mutations is of great value to improve the therapeutic efficacy of glioma and other malignancies that share similar genetic characteristics.
  • 1.2K
  • 25 Jun 2021
Topic Review
Heart Rhythm Complexity and PH
Pulmonary hypertension (PH) is a progressive, complex, and fatal disease. It involves heterogenous etiologies and different mechanisms, and eventually leads to right heart failure. The mortality of PH patients is high even after contemporary treatment. A non-invasive and convenient tool can measure PH risk by assessing heart rate variability (HRV), namely, heart rhythm complexity analysis.
  • 1.2K
  • 02 Jul 2021
Topic Review
4-1BBL
The ability of tumor cells to evade the immune system is one of the main challenges we confront in the fight against cancer. Multiple strategies have been developed to counteract this situation, including the use of immunostimulant molecules that play a key role in the anti-tumor immune response. Such a response needs to be tumor-specific to cause as little damage as possible to healthy cells and also to track and eliminate disseminated tumor cells. Therefore, the combination of immunostimulant molecules and tumor-associated antigens has been implemented as an anti-tumor therapy strategy to eliminate the main obstacles confronted in conventional therapies. The immunostimulant 4-1BBL belongs to the tumor necrosis factor (TNF) family and it has been widely reported as the most effective member for activating lymphocytes.
  • 1.2K
  • 09 Jul 2021
Topic Review
Sustainable Interior Architecture and Design
Sustainable Interior Architecture and Design (SIAD) is a holistic approach that reduces the negative economic, social, and environmental implications of design decisions, and takes into consideration the physical and psychological well-being of all users regardless of their abilities.
  • 1.2K
  • 29 Sep 2021
Topic Review
Non-Nutritive Sweeteners and Metabolic Syndrome
Artificial sweeteners have gained increasing attention as dietary assessment tools to help combat the obesity epidemic by providing a sweet taste without the extra calories. Individuals widely use non-nutritive sweeteners (NNS) in attempts to lower their overall daily caloric intake, lose weight, and sustain a healthy diet. Recent studies have suggested that NNS consumption can induce gut microbiota dysbiosis and promote glucose intolerance in healthy individuals that may result in the development of type 2 diabetes mellitus (T2DM).
  • 1.2K
  • 30 Sep 2021
Topic Review
Intellectual Disability and Physical Activity Participation Perceived Barriers
Individuals with intellectual disability (ID) tend to have a sedentary lifestyle, with low physical fitness and an increased risk of chronic diseases. One reason for the prevalence of a sedentary lifestyle is the existence of barriers to participation in physical activity (PA).
  • 1.2K
  • 29 Mar 2022
Topic Review
Ischemic Stroke Genetics
The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic causes make a significant contribution to ischemic stroke genesis, especially in early-onset stroke. Several stroke classification systems based on genetic information corresponding to various stroke phenotypes were proposed. Twin and family history studies, as well as candidate gene approach, are common methods to discover genetic causes of stroke, however, both have their own limitations. Genome-wide association studies and next generation sequencing are more efficient, promising and increasingly used for daily diagnostics. Some monogenic disorders, despite covering only about 7% of stroke etiology, may cause well-known clinical manifestations that include stroke. Polygenic disorders are more frequent, causing about 38% of all ischemic strokes, and their identification is a rapidly developing field of modern stroke genetics. Current advances in human genetics provide opportunity for personalized prevention of stroke and novel treatment possibilities. Genetic risk scores (GRS) and extended polygenic risk scores (PRS) estimate cumulative contribution of known genetic factors to a specific outcome of stroke. Combining those scores with clinical information and risk factor profiles might result in better primary stroke prevention. Some authors encourage the use of stroke gene panels for stroke risk evaluation and further stroke research. Moreover, new biomarkers for stroke genetic causes and novel targets for gene therapy are on the horizon.
  • 1.2K
  • 14 Jan 2022
Topic Review
The Financial Outcome of Successful Green Innovation
Climate change, pollution of the environment, and the consecutive challenges for the 21st century have been increasingly recognized by governments, policymakers, and industry over the last decade. It is therefore vital to transition from environment- and resource-intensive trajectories to more sustainable growth paths for the global economy. This also requires corporate environmentalism and (green) technological innovation. To realize sustainable growth paths, green innovation and technology diffusion must be financially and commercially attractive to convince corporate decision makers to introduce environmentalism. The current strand of literature on the financial attractiveness of green innovation can be divided into two parts: the traditional view follows Friedman and considers green innovation as firm-value decreasing, while the Porter hypothesis argues that environmental policies, adoption of corporate environmentalism, and green innovation increase profits of firms by reducing costs and increasing revenues. In fact, prior studies provide empirical evidence to support the Porter hypothesis for many cases. Therefore, scholars have suggested intervention by governments to overcome these barriers. Government organizations included environmental issues into their agendas for multiple decades now. As a result, different forms of intervention were introduced, ranging from regulatory (e.g., forced shutdowns or investments) to market-based, economic measures (e.g., supply-push and demand-pull). One of the most important green growth strategies from a governmental perspective is the development of green technologies through appropriate innovation to stimulate corporate environmentalism, particularly green innovation policies.
  • 1.2K
  • 11 Apr 2022
Topic Review
Spherical Autonomous Underwater Vehicle
The spherical autonomous underwater vehicle (SAUV) is a particularly interesting architecture alternative for an underwater vehicle that must operate within entanglement-prone, complex environments such as confined spaces and littoral environments.
  • 1.2K
  • 08 Jun 2022
Topic Review
Anti-Corruption Disclosure and Political Corporate Social Responsibility
Corruption is a major concern globally, particularly in developing countries, such as Bangladesh, where it is the main obstacle to economic development. Corruption is also mentioned as the major impediment to accomplishing sustainable development. Corruption is the main impediment to economic development in Bangladesh. The country’s financial sector is under threat due to issues such as illegal money transfers, money laundering, and terrorist financing. The Paradise Papers and The Panama Papers scandals have found many Bangladeshi business people and politicians involved in offshore businesses globally. The recent misappropriation of the financial sector, financial heist of the Central Bank (BB), liquidity crises, share market scandal, and political intervention on banks have left the financial sector in turmoil. Companies provide more Corporate Social Responsibility (CSR) expenditure in order to signal to stakeholders about their motivation and determination to social responsibility in relation to enhancing transparency and accountability. Working in a high or low corruption environment, CSR expenditure has significant value because the expenditure increases visibility to the market, improving reputation.
  • 1.2K
  • 28 Jun 2022
Topic Review
Complement Cascade for Dry Age-Related Macular Degeneration Treatment
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the elderly population. AMD is characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium cell layer (dry type). Regarding the latter type, there is growing evidence supporting an association between the pathophysiology of dry AMD and key proteins in the complement cascade. The complement cascade works as a central part of the innate immune system by defending against foreign pathogens and modified self-tissues. Through three distinct pathways, a series of plasma and membrane-associated serum proteins are activated upon identification of a foreign entity. Several of these proteins have been implicated in the development and progression of dry AMD. Potential therapeutic targets include C1q, C3, C5, complement factors (B, D, H, I), membrane attack complex, and properdin.
  • 1.2K
  • 22 Aug 2022
Topic Review
Yaghan Language
Yagán (originally Yahgan, but also now spelled Yaghan, Jagan, Iakan), also known as Yámana, Háusi Kúta, and Yagankuta, is one of the indigenous languages of Tierra del Fuego, spoken by the Yaghan people. It is regarded as a language isolate, although some linguists have attempted to relate it to Kawésqar and Chono. Yahgan was also spoken briefly on Keppel Island in the Falkland Islands at a missionary settlement. Following the death of 84-year-old Emelinda Acuña (1921 – October 12, 2005), only one native speaker remains, Cristina Calderón of Villa Ukika on Navarino Island, Chile . Calderón (often referred to as simply Abuela) is the sister-in-law of Acuña. In 2017, Chile's National Corporation of Indigenous Development convened a workshop to plan an educational curriculum in the Yagán language, and in June 2019 it plans to inaugurate a language nest in the community of Bahía Mejillones, near Puerto Williams. The government is also funding the publication of a "concise and illustrated dictionary" of the Yagán language.
  • 1.2K
  • 26 Oct 2022
Topic Review
Memory Augmentation
Memory augmentation is the process by which one's ability to retain information is increased. The retrieval of memory has been theorized to be untrustworthy, and it can be partially inaccurate and not totally reliable (see more: Recovered memory.) Ubiquitous Memory Systems have been invented in order to reduce these memory mistakes. A study conducted by students of the Information Science Department in Nara, Japan sought to measure different types of memory augmentation. They used a computer system, the "Ubiquitous Memories," to demonstrate if the technology aided to augmentation better than other methods such as notes with a pen and paper, portraits used in a previous trial experiment, and just plain human memory. The results were that the Ubiquitous Memories aided in retrieving memory, and decreased the likelihood of mistakes in comparison to other methods. Some researchers have even gone so far as to create mixed-reality simulations to assist individuals in improving their memories. Many of these systems implement the method of loci which involves using the spatial layout of a familiar place to help individuals remember certain things. For example, one might attempt to remember a packing list for a trip by imagining the items around their room. Memory augmentation not only refers to our ability to recall information accurately, it also refers to our ability to encode long-term information quickly. Some researchers suggest that through using augmented reality interfaces, we have the ability to memorize information and store it in our long-term memory after only being exposed to it once. Specifically, the function of these interfaces is to stimulate parts of the brain that are essential to memory such as the hippocampus, neocortex, and entorhinal cortex which would result in the acquisition of episodic memory for things we would normally use long-term semantic memory to recall.
  • 1.2K
  • 09 Nov 2022
Topic Review
Deception Technology
Deception technology is a category of cyber security defense. Deception technology products can detect, analyze, and defend against zero-day and advanced attacks, often in real time. They are automated, accurate, and provide insight into malicious activity within internal networks which may be unseen by other types of cyber defense. Deception technology enables a more proactive security posture by seeking to deceive the attackers, detect them and then defeat them, allowing the enterprise to return to normal operations. Existing defense-in-depth cyber technologies have struggled against the increasing wave of sophisticated and persistent human attackers. These technologies seek primarily to defend a perimeter, but both firewalls and endpoint security cannot defend a perimeter with 100% certainty. Cyber-attackers can penetrate these networks and move unimpeded for months, stealing data and intellectual property. Heuristics may find an attacker within the network, but often generate so many alerts that critical alerts are missed. Since 2014, attacks have accelerated and there is evidence that cyber-attackers are penetrating traditional defenses at a rapidly increasing rate. Deception technology considers the human attacker's point of view and method for exploiting and navigating networks to identify and exfiltrate data. It integrates with existing technologies to provide new visibility into the internal networks, share high probability alerts and threat intelligence with the existing infrastructure.
  • 1.2K
  • 10 Nov 2022
Topic Review
Lattice Gauge Theory
In physics, lattice gauge theory is the study of gauge theories on a spacetime that has been discretized into a lattice. Gauge theories are important in particle physics, and include the prevailing theories of elementary particles: quantum electrodynamics, quantum chromodynamics (QCD) and particle physics' Standard Model. Non-perturbative gauge theory calculations in continuous spacetime formally involve evaluating an infinite-dimensional path integral, which is computationally intractable. By working on a discrete spacetime, the path integral becomes finite-dimensional, and can be evaluated by stochastic simulation techniques such as the Monte Carlo method. When the size of the lattice is taken infinitely large and its sites infinitesimally close to each other, the continuum gauge theory is recovered.
  • 1.2K
  • 25 Nov 2022
Topic Review
Security in V2I Communications
The number of vehicles equipped with wireless connections has increased considerably. The impact of that growth in areas such as telecommunications, infotainment, and automatic driving is enormous. More and more drivers want to be part of a vehicular network, despite the implications or risks that, for instance, the openness of wireless communications, its dynamic topology, and its considerable size may bring. Undoubtedly, this trend is because of the benefits the vehicular network can offer. Generally, a vehicular network has two modes of communication (V2I and V2V). The advantage of V2I over V2V is roadside units’ high computational and transmission power, which assures the functioning of early warning and driving guidance services. Researchers have identified the non-resistance to attacks, the regular updating and exposure of keys, and the high dependence on certification authorities as main vulnerabilities. 
  • 1.2K
  • 09 Dec 2022
Topic Review
Contrast Agents during Pregnancy
Contrast agents can be defined as any substance introduced into the body during imaging examinations, to improve the visualization and detection rate of internal structures.
  • 1.2K
  • 26 Dec 2022
Topic Review
Chemical, Biological, Radiological, and Nuclear Agents
Combating chemical, biological, radiological, and nuclear (CBRN) threats with novel solutions reduces disasters and accident risks and, at the same time, aids sustainability.
  • 1.2K
  • 16 Feb 2023
Topic Review
Food Polyphenols and Type II Diabetes Mellitus
Type II diabetes mellitus and its related complications are growing public health problems. Many natural products present in our diet, including polyphenols, can be used in treating and managing type II diabetes mellitus and different diseases, owing to their numerous biological properties. Anthocyanins, flavonols, stilbenes, curcuminoids, hesperidin, hesperetin, naringenin, and phenolic acids are common polyphenols found in blueberries, chokeberries, sea-buckthorn, mulberries, turmeric, citrus fruits, and cereals. These compounds exhibit antidiabetic effects through different pathways.
  • 1.2K
  • 22 May 2023
Topic Review
Physical-Chemical Active Substances Encapsulation Approaches in Pharmaceutical Industry
Encapsulation is a valuable method used to protect active substances and enhance their physico-chemical properties. It can also be used as protection from unpleasant scents and flavors or adverse environmental conditions. Encapsulation has demonstrated effectiveness and versatility in multiple industries, such as food, nutraceutical, and pharmaceuticals. Moreover, the selection of appropriate encapsulation methods is critical for the effective encapsulation of specific active compounds. 
  • 1.2K
  • 16 Jun 2023
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