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Topic Review
Bone Health in Patients with Dyslipidemias
Despite the high heterogeneity and the variable quality of evidence, dyslipidemia, mainly high TC and LDL-C and, to a lesser extent, TG concentrations, seems to be associated with low bone mass and increased fracture risk. This detrimental effect may be mediated directly through the increased oxidative stress and systemic inflammation that dyslipidemia is associated with, leading to increased osteoclastic activity and reduced bone formation, or through the atherosclerotic process, which affects bone’s vascularization. Other mechanisms, such as low estrogen, vitamin D and K status, and increased concentrations of PTH, homocysteine, and lipid oxidation products, may also contribute to this interplay. Regarding the effect of lipid-lowering therapy on bone metabolism, statins may slightly increase BMD, with a tendency to reduce fracture risk as shown in case-control and cohort studies, although available RCTs have not shown any effect of statins on fracture risk. This is also the case for omega-3 FA, whereas inconsistent or insufficient evidence exists for other commonly used lipid-lowering medications, such as ezetimibe, fibrates, and niacin. There is an exigent need for prospective, well-designed studies in males and females to elaborate on the putative association between lipids and bone strength.
  • 1.2K
  • 14 Feb 2022
Topic Review
Basic Properties of Iron
Iron is a vital nutrient, the deficiency of which is responsible for several symptoms of anemia. Iron is responsible for the regulation of several cell functions.
  • 1.2K
  • 26 Jul 2022
Topic Review
Political Libel
The criminal statutes protecting nobility from criticism in 16th- and 17th-century England eventually evolved into various categories of political libel (see slander and libel for the modern incarnation of this law). Cases of political libel and eventually damages actions were handled by the infamous Star Chamber until its abolition in 1641. By the end of that century, many elements of the common law of libel had been established. Modern slander and libel law evolved since then to mostly eradicate the use of libel laws to intimidate active political participants during a public debate. Accordingly, this is now a matter of historical interest only in all jurisdictions other than Canada, where use of the law by government, political and religious groups is common, and often used against defendants outside Canada.
  • 1.2K
  • 18 Oct 2022
Topic Review
The World (Descartes)
The World, also called Treatise on the Light (French title: Traité du monde et de la lumière), is a book by René Descartes (1596–1650). Written between 1629 and 1633, it contains a nearly complete version of his philosophy, from method, to metaphysics, to physics and biology. Descartes espoused mechanical philosophy, a form of natural philosophy popular in the 17th century. He thought everything physical in the universe to be made of tiny "corpuscles" of matter. Corpuscularianism is closely related to atomism. The main difference was that Descartes maintained that there could be no vacuum, and all matter was constantly swirling to prevent a void as corpuscles moved through other matter. The World presents a corpuscularian cosmology in which swirling vortices explain, among other phenomena, the creation of the Solar System and the circular motion of planets around the Sun. The World rests on the heliocentric view, first explicated in Western Europe by Copernicus. Descartes delayed the book's release upon news of the Roman Inquisition's conviction of Galileo for "suspicion of heresy" and sentencing to house arrest. Descartes discussed his work on the book, and his decision not to release it, in letters with another philosopher, Marin Mersenne. Some material from The World was revised for publication as Principia philosophiae or Principles of Philosophy (1644), a Latin textbook at first intended by Descartes to replace the Aristotelian textbooks then used in universities. In the Principles the heliocentric tone was softened slightly with a relativist frame of reference. The last chapter of The World was published separately as De Homine (On Man) in 1662. The rest of The World was finally published in 1664, and the entire text in 1677.
  • 1.2K
  • 19 Oct 2022
Topic Review
Blue Diamond
Blue diamond is a type of diamond which exhibits all of the same inherent properties of the mineral except with the additional element of blue color in the stone. They are colored blue by trace amounts of boron that contaminate the crystalline lattice structure. Blue diamonds belong to a subcategory of diamonds called fancy color diamonds, the generic name for diamonds that exhibit intense color. Blue diamonds range in grade from Flawless to Included, just as in the case of white diamonds.
  • 1.2K
  • 04 Nov 2022
Topic Review
Mitochondrial Regulation of Inflammation in Diabetic Kidney Disease
Diabetes is the leading cause of chronic kidney disease worldwide. Despite the burden, the factors contributing to the development and progression of diabetic kidney disease (DKD) remain to be fully elucidated. Increasing evidence suggests that mitochondrial dysfunction is a pathological mediator in DKD as the kidney is a highly metabolic organ rich in mitochondria. Furthermore, low-grade chronic inflammation also contributes to the progression of DKD, and several inflammatory biomarkers have been reported as prognostic markers to risk-stratify patients for disease progression and all-cause mortality.
  • 1.2K
  • 23 Nov 2022
Topic Review
Antibiotics Used for Urinary Tract Infections in Pregnancy
Urinary tract infection (UTI) is considered to be a major problem in pregnant women. It is also one of the most prevalent infections during pregnancy, being diagnosed in as many as 50–60% of all gestations. Therefore, UTI treatment during pregnancy is extremely important and management guidelines have been published worldwide to assist physicians in selecting the right antibiotic for each patient, taking into account the maternal and fetal safety profile.
  • 1.2K
  • 29 Dec 2022
Topic Review
Transformers in Natural Language Processing Applications
The field of Natural Language Processing (NLP) has undergone a significant transformation with the introduction of Transformers. From the first introduction of this technology in 2017, the use of transformers has become widespread and has had a profound impact on the field of NLP.
  • 1.2K
  • 24 May 2023
Topic Review
Oropharyngeal Mucosal Epithelium in HIV-1 Transmission
The oropharyngeal mucosal epithelia have a polarized organization, which is critical for maintaining a highly efficient barrier as well as innate immune functions. In human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) disease, the barrier and innate immune functions of the oral mucosa are impaired via a number of mechanisms.
  • 1.2K
  • 25 May 2023
Topic Review
Nanofiltration Membranes Characteristics
The presence of heavy metal ions in polluted wastewater represents a serious threat to human health, making proper disposal extremely important. The utilization of nanofiltration (NF) membranes has emerged as one of the most effective methods of heavy metal ion removal from wastewater due to their efficient operation, adaptable design, and affordability. NF membranes created from advanced materials are becoming increasingly popular due to their ability to depollute wastewater in a variety of circumstances.
  • 1.2K
  • 17 Jul 2023
Topic Review
Supply Chain Management Using Blockchain
Blockchain is a groundbreaking technology widely adopted in industrial applications for improving supply chain management (SCM). The SCM and logistics communities have paid close attention to the development of blockchain technology. The primary purpose of employing a blockchain for SCM is to lower production costs while enhancing the system’s security. Blockchain-related SCM research has drawn much interest, and it is fair to state that this technology is now the most promising option for delivering reliable services/goods in supply chain networks.
  • 1.2K
  • 25 Sep 2023
Topic Review
Mega Infrastructure Projects in China
The “trillion-dollar era” of megaprojects has increased the demand for the scope of mega infrastructure. To address the requirement for high-quality “investment, construction, and operation” integration, the EPC and PPP models must be combined.
  • 1.2K
  • 09 Nov 2023
Topic Review
Lung Extracellular Matrix
The lung extracellular matrix (ECM) comprises of a network of protein–protein and protein–proteoglycan interactions that modulate the biophysical environment of cells through ECM stiffness, porosity, topography and insolubility. In response, the lung ECM is remodelled by cells, whereby its components are deposited, degraded or modified in a reciprocal relationship. Changes in the ECM dynamics is associated with chronic fibrotic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. 
  • 1.2K
  • 21 Jul 2021
Topic Review
Perceived Security in Childhood on Adult Self-Concept
Secure attachment, developed through consistent relationships with attachment figures in childhood, is a crucial factor in fostering healthy interpersonal relationships and a positive self-perception. The ability to cope with adversity and personal acceptance underlie the impact of perceived security on self-concept. It is recommended to promote family intervention programs framed within positive parenting that focus on fostering secure attachment given its influence on adult life. 
  • 1.2K
  • 11 Sep 2023
Topic Review
Heart Health Monitoring Service Platform
Heart Health Monitoring Service Platform is a concept that allows medical device manufacturers to offer diagnosis support for a range of diseases to healthcare providers. The proposed platform is based on heart rate monitoring and the diagnosis support is achieved with deep learning. 
  • 1.2K
  • 17 Feb 2021
Topic Review
Ascorbic Acid against Chronic Diseases
Ascorbic acid (ASC) is a key nutrient that serves as an antioxidant and a cofactor for numerous enzymatic reactions. However, humans, unlike most mammals, are unable to synthesize it. Consequently, ASC must be obtained through dietary sources, especially fresh fruit and vegetables. The value of administering exogenous micronutrients, to reestablish antioxidant concentrations in patients with severe disease, has been recognized for decades. Despite the suggestion that ASC supplementation may reduce oxidative stress and prevent several chronic conditions, few large, randomized clinical trials have tested it in patients with severe illness. This article reviews the recent literature on the pharmacological profile of ASC and the role of its supplementation in critically ill patients.
  • 1.2K
  • 11 Dec 2020
Topic Review
GNAS Gene
GNAS complex locus
  • 1.2K
  • 23 Dec 2020
Topic Review
Cherubism
Cherubism is a disorder characterized by abnormal bone tissue in the jaw. Beginning in early childhood, both the lower jaw (the mandible) and the upper jaw (the maxilla) become enlarged as bone is replaced with painless, cyst-like growths. These growths give the cheeks a swollen, rounded appearance and often interfere with normal tooth development. In some people the condition is so mild that it may not be noticeable, while other cases are severe enough to cause problems with vision, breathing, speech, and swallowing. Enlargement of the jaw usually continues throughout childhood and stabilizes during puberty. The abnormal growths are gradually replaced with normal bone in early adulthood. As a result, many affected adults have a normal facial appearance.
  • 1.2K
  • 24 Dec 2020
Topic Review
Human Endogenous Retroviruses
Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. 
  • 1.2K
  • 05 Feb 2021
Topic Review
Flavonoids Targeting HIF-1
Flavonoids, widely occurring in various plants, exert a broad spectrum of beneficial effects on human health, and are potentially powerful therapeutic tools against cancer. Recent evidences identified numerous natural flavonoids and their derivatives as inhibitors of HIF-1, associated with the regulation of critical glycolytic components in cancer cells, including pyruvate kinase M2(PKM2), lactate dehydrogenase (LDHA), glucose transporters (GLUTs), hexokinase II (HKII), phosphofructokinase-1 (PFK-1), and pyruvate dehydrogenase kinase (PDK). Here, authors discuss the results of most recent studies evaluating the impact of flavonoids on HIF-1 accompanied by the regulation of critical enzymes contributing to the Warburg phenotype. Besides, flavonoid effects on glucose metabolism via regulation of HIF-1 activity represent a promising avenue in cancer-related research. At the same time, only more-in depth investigations can further elucidate the mechanistic and clinical connections between HIF-1 and cancer metabolism.
  • 1.2K
  • 10 Feb 2021
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