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Topic Review
CUBN Gene
Cubilin: The CUBN gene provides instructions for making a protein called cubilin. 
  • 635
  • 23 Dec 2020
Topic Review
ZAP70 Gene
Zeta chain of T cell receptor associated protein kinase 70
  • 635
  • 24 Dec 2020
Topic Review
RFXAP Gene
regulatory factor X associated protein
  • 635
  • 24 Dec 2020
Topic Review
KCNQ1OT1 Gene
KCNQ1 opposite strand/antisense transcript 1
  • 634
  • 23 Dec 2020
Topic Review
Role of PAX7 in Muscular Dystrophies
Myogenesis is a series of progressive development of skeletal muscle tissue over a lifetime where myoblasts, the early mononucleated committed precursor cells of skeletal muscle fuse together and differentiate into myotubes, the multinucleated muscle cells that later undergo further differentiation and fusion to form myofibers. Myoblast heterogeneity stems from three types of myoblasts: embryonic, fetal, and adult myoblasts with distinct genetic backgrounds that are traditionally distinguished by desmin, myogenin (MyoG), and myosin heavy chain isoform (MyHC) expression. These myoblast transitions are thought to overlap at multiple points during myogenesis, due to the activation of several factors. Four myogenic regulatory factors (MRF), Myogenic factor 5 (Myf5), Mrf4, Myogenic Differentiation 1 (MyoD), and MyoG play critical roles in the precise differentiation of progenitor myoblasts into myofibers during embryonic-to-adult myogenesis. Pax7 is closely associated with myogenesis, which is governed by various signaling pathways throughout a lifetime and is frequently used as an indicator in muscle research. 
  • 634
  • 11 Sep 2023
Topic Review
PDGFRB-Associated Chronic Eosinophilic Leukemia
PDGFRB-associated chronic eosinophilic leukemia is a type of cancer of blood-forming cells.
  • 634
  • 24 Dec 2020
Topic Review
TBC1D20 Gene
TBC1 domain family member 20: The TBC1D20 gene provides instructions for making a protein that helps regulate the activity of other proteins called GTPases, which control a variety of functions in cells. 
  • 633
  • 24 Dec 2020
Topic Review
GUCY2D Gene
Guanylate cyclase 2D, retinal
  • 632
  • 22 Dec 2020
Topic Review
Mucopolysaccharidosis Type VI
Mucopolysaccharidosis type VI (MPS VI), also known as Maroteaux-Lamy syndrome, is a progressive condition that causes many tissues and organs to enlarge and become inflamed or scarred. Skeletal abnormalities are also common in this condition. The rate at which symptoms worsen varies among affected individuals.
  • 632
  • 23 Dec 2020
Topic Review
Exploring Large MAF Transcription Factors
Large musculoaponeurotic fibrosarcoma (MAF) transcription factors contain acidic, basic, and leucine zipper regions. Four types of MAF have been elucidated in mice and humans, namely c-MAF, MAFA, MAFB, and NRL.
  • 632
  • 13 Oct 2023
Topic Review
Hypomagnesemia with Secondary Hypocalcemia
Hypomagnesemia with secondary hypocalcemia is an inherited condition caused by the body's inability to absorb and retain magnesium that is taken in through the diet. As a result, magnesium levels in the blood are severely low (hypomagnesemia).
  • 630
  • 23 Dec 2020
Topic Review
IFT122 Gene
Intraflagellar transport 122
  • 629
  • 23 Dec 2020
Topic Review
ITGB2 Gene
Integrin subunit beta 2
  • 629
  • 23 Dec 2020
Topic Review
MIR17HG Gene
miR-17-92a-1 cluster host gene
  • 626
  • 22 Dec 2020
Topic Review
RANBP2 Gene
RAN binding protein 2
  • 626
  • 23 Dec 2020
Topic Review
BPH-Resistance Gene Mapping
The brown planthopper (Nilaparvata lugens Stål, BPH) is one of the most serious pests that harm rice production. N. lugens soaks up phloem sap by inserting needle-like stylets into the vascular tissue of rice (Oryza sativa L.). Utilizing the inherent resistance has been widely considered as the most cost-effective method for sustainable BPH control. To date, more than 49 BPH-resistance genes/QTLs have been detected and rice varieties containing one or more BPH-resistance genes/QTLs have been developed to reduce the loss of rice yield induced by BPH feeding.
  • 626
  • 05 Dec 2023
Topic Review
Pseudohypoaldosteronism Type 2
Pseudohypoaldosteronism type 2 (PHA2) is caused by problems that affect regulation of the amount of sodium and potassium in the body. Sodium and potassium are important in the control of blood pressure, and their regulation occurs primarily in the kidneys.
  • 626
  • 24 Dec 2020
Topic Review
Mucolipidosis II Alpha/Beta
Mucolipidosis II alpha/beta (also known as I-cell disease) is a progressively debilitating disorder that affects many parts of the body. Most affected individuals do not survive past early childhood.
  • 625
  • 23 Dec 2020
Topic Review
EIF2B5 Gene
Eukaryotic translation initiation factor 2B subunit epsilon
  • 625
  • 24 Dec 2020
Topic Review
HESX1 Gene
HESX homeobox 1
  • 624
  • 22 Dec 2020
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