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Topic Review
Benzimidazole
Benzimidazole is an important heterocyclic fragment, present in many biologically active compounds with a great variety of therapeutic purposes. Most of the benzimidazole activities are explained through the existence of 1,3-tautomeric equilibrium. As the binding affinity of each tautomer to a protein target depends on an established bioactive conformation, the effect of tautomers on the ligand protein binding mechanism is determinant.
  • 5.0K
  • 27 Oct 2022
Topic Review
Green Extraction Techniques for Active Ingredients in Tea
The so-called “Green Extraction”—which is based on the design of different extraction processes for the reduction in energy consumption, as well as the usage of alternative solvents and renewable natural materials —was developed.
  • 5.0K
  • 17 Feb 2023
Topic Review
Physical Body
In physics, a physical body or physical object (or simply a body or object) is an identifiable collection of matter, which may be constrained by an identifiable boundary, and may move as a unit by translation or rotation, in 3-dimensional space. In common usage, an object is a collection of matter within a defined contiguous boundary in 3-dimensional space. The boundary must be defined and identified by the properties of the material. The boundary may change over time. The boundary is usually the visible or tangible surface of the object. The matter in the object is constrained (to a greater or lesser degree) to move as one object. The boundary may move in space relative to other objects that it is not attached to (through translation and rotation). An object's boundary may also deform and change over time in other ways. Also in common usage, an object is not constrained to consist of the same collection of matter. Atoms or parts of an object may change over time. An object is defined by the simplest representation of the boundary consistent with the observations. However the laws of Physics only apply directly to objects that consist of the same collection of matter. Each object has a unique identity, independent of any other properties. Two objects may be identical, in all properties except position, but still remain distinguishable. In most cases the boundaries of two objects may not overlap at any point in time. The property of identity allows objects to be counted. Examples of models of physical bodies include, but are not limited to a particle, several interacting smaller bodies (particles or other), and continuous media. The common conception of physical objects includes that they have extension in the physical world, although there do exist theories of quantum physics and cosmology which may challenge this. In modern physics, "extension" is understood in terms of the spacetime: roughly speaking, it means that for a given moment of time the body has some location in the space, although not necessarily a point. A physical body as a whole is assumed to have such quantitative properties as mass, momentum, electric charge, other conserving quantities, and possibly other quantities. A body with known composition and described in an adequate physical theory is an example of physical system.
  • 5.0K
  • 12 Dec 2022
Topic Review
Bovine Colostrum in the Treatment of Cancer
Bovine colostrum (BC) has attracted the interest of numerous researchers investigating its anti-cancer potential in humans. Dressings loaded with BC are beneficial in treating chronic wounds and diabetic foot ulcers. Lactoferrin, a glycoprotein with potent anti-oxidant, anti-inflammatory, anti-cancer, and anti-microbial effects, is abundant in BC. The BC pills successfully promote the regression of low-grade cervical intraepithelial neoplasia when administered intravaginally. The biological, genetic, and molecular mechanisms driving BC remain to be determined. Oral BC supplements are generally well-tolerated, but some flatulence and nausea may happen. 
  • 5.0K
  • 21 Dec 2022
Topic Review
Mental Chronometry
Mental chronometry is the study of reaction time (RT; also referred to as "response time") in perceptual-motor tasks to infer the content, duration, and temporal sequencing of mental operations. Mental chronometry is one of the core methodological paradigms of human experimental and cognitive psychology, but is also commonly analyzed in psychophysiology, cognitive neuroscience, and behavioral neuroscience to help elucidate the biological mechanisms underlying perception, attention, and decision-making across species. Mental chronometry uses measurements of elapsed time between sensory stimulus onsets and subsequent behavioral responses. It is considered an index of processing speed and efficiency indicating how fast an individual can execute task-relevant mental operations. Behavioral responses are typically button presses, but eye movements, vocal responses, and other observable behaviors can be used. RT is constrained by the speed of signal transmission in white matter as well as the processing efficiency of neocortical gray matter. Conclusions about information processing drawn from RT are often made with consideration of task experimental design, limitations in measurement technology, and mathematical modeling.
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  • 10 Oct 2022
Topic Review
Ascorbic Acid-Induced Reactions
Ascorbic acid is the most well-known vitamin found in different types of food. It has tremendous medical applications in several different fields such as in pharmaceuticals, cosmetics, and in organic synthesis. Ascorbic acid can be used as a substrate or mediator in organic synthesis. In this review, we report ascorbic acid-catalyzed reactions in organic synthesis. Several examples are included in this review to demonstrate that ascorbic acid is a versatile catalyst for the synthesis of diverse organic compounds. Reactions catalyzed by ascorbic acid are performed in organic or aqueous media. The readily available and easy handling features of ascorbic acid make these procedures highly fascinating.
  • 5.0K
  • 25 Nov 2020
Topic Review
Electronic Trading
Electronic or scripless trading, sometimes called e-trading or paperless trading is a method of trading securities (such as stocks, and bonds), foreign exchange or financial derivatives electronically. Information technology is used to bring together buyers and sellers through an electronic trading platform and network to create virtual market places. They can include various exchange-based systems, such as NASDAQ, NYSE Arca and Globex, as well as other types of trading platforms, such as electronic communication networks (ECNs), alternative trading systems, crossing networks and "dark pools". Electronic trading is rapidly replacing human trading in global securities markets. Electronic trading is in contrast to older floor trading and phone trading and has a number of advantages, but glitches and cancelled trades do still occur.
  • 5.0K
  • 14 Oct 2022
Topic Review
Cheese By-Products
Cheese whey (CW) is nowadays recognized as a source of functional and bioactive compounds, especially proteins and peptides. However, a large proportion of the whey produced worldwide is still not valorized. This results from the fact that small and medium size dairy industries lack dimension to make the necessary investments for CW valorization. In some countries such as Portugal, Spain, Italy and Turkey, CW is employed in the production of whey cheeses. The liquid remaining after whey cheese production represents more than 90% of the original whey and is called second cheese whey (SCW). SCW is a poorly studied by-product and there is little interest in its recovery. SCW is a poorly studied by-product and there is little interest in its recovery. Some authors studied the use of SCW for conversion into biofuel and as a biotechnological substrate for fermented products while others studied its potential for the production of fermented drinks. However, half of CW and almost all SCW are not valorized for human consumption. This review presents several alternatives for the valorization of both by-products.
  • 5.0K
  • 20 May 2021
Topic Review
Sorbent-Based Microextraction of Natural Toxins from Food Samples
Natural toxins are chemical substances that are not toxic to the organisms that produce them, but which can be a potential risk to human health when ingested through food. Thus, it is of high interest to develop advanced analytical methodologies to control the occurrence of these compounds in food products. Current trends in sample preparation involve moving towards “greener” approaches by scaling down analytical operations, miniaturizing the instruments and integrating new advanced materials as sorbents. The combination of these new materials with sorbent-based microextraction technologies enables the development of high-throughput sample preparation methods, which improve conventional extraction and clean-up procedures.
  • 5.0K
  • 05 Nov 2021
Topic Review
Fountain (Duchamp)
Fountain is a readymade sculpture produced by Marcel Duchamp in 1917: a porcelain urinal signed "R.Mutt". In April 1917, an ordinary piece of plumbing chosen by Duchamp was rotated 90 degrees on its axis and submitted for an exhibition of the Society of Independent Artists, the first annual exhibition by the Society to be staged at The Grand Central Palace in New York. Fountain was not rejected by the committee but it was removed from the show area, since Society rules stated that all works would be accepted from artists who paid the fee. Following that removal, Fountain was photographed at Alfred Stieglitz's studio, and the photo published in The Blind Man. The original has been lost. The work is regarded by art historians and theorists of the avant-garde as a major landmark in 20th-century art. Sixteen replicas were commissioned by Duchamp in the 1950s and 1960s and made to his approval. Some scholars have suggested that the original work was by a female artist rather than Duchamp, but this is a minority view among historians.
  • 5.0K
  • 28 Nov 2022
Topic Review
Guccifer 2.0
"Guccifer 2.0" is a persona which claimed to be the hacker(s) that hacked into the Democratic National Committee (DNC) computer network and then leaked its documents to the media, the website WikiLeaks, and a conference event. Some of the documents "Guccifer 2.0" released to the media appear to be forgeries cobbled together from public information and previous hacks, which had been mixed with disinformation. According to indictments in February 2018, the persona is operated by Russian military intelligence agency GRU. On July 13, 2018, Special Counsel Robert Mueller indicted 12 GRU agents for allegedly perpetrating the cyberattacks. The U.S. Intelligence Community concluded that some of the genuine leaks from "Guccifer 2.0" were part of a series of cyberattacks on the DNC committed by two Russian military intelligence groups, and that "Guccifer 2.0" is actually a persona created by Russian intelligence services to cover for their interference in the 2016 U.S. presidential election. This conclusion is based on analyses conducted by various private sector cybersecurity individuals and firms, including CrowdStrike, Fidelis Cybersecurity, FireEye's Mandiant, SecureWorks, ThreatConnect, Trend Micro, and the security editor for Ars Technica. The Russian government denies involvement in the theft, and "Guccifer 2.0" denied links to Russia. WikiLeaks founder Julian Assange said multiple parties had access to DNC emails and that there was "no proof" Russia was behind the attack. In March 2018, Special Counsel Robert Mueller took over investigation of Guccifer 2.0 from the FBI while it was reported that forensic determination had found the Guccifer 2.0 persona to be a "particular military intelligence directorate (GRU) officer working out of the agency's headquarters on Grizodubovoy Street in Moscow".
  • 5.0K
  • 10 Oct 2022
Topic Review
Community
Community refers to a social group or a gathering of people who share common interests, values, beliefs, or goals and who interact with each other within a specific geographic area or virtual space. Communities can take various forms and sizes, ranging from small, close-knit neighborhoods to large, global online communities. Whether formed around geographic proximity, cultural ties, or common hobbies, communities play a vital role in shaping social interactions, providing support, and contributing to the overall well-being of individuals. Recognizing the significance of communities is essential for fostering a sense of connection, understanding, and shared humanity in the complex fabric of human societies.
  • 5.0K
  • 25 Jan 2024
Topic Review
Evolution of Digital Twins
A digital twin can be described as a digital replica of a real-world entity. It simulates the physical state and maybe the biological state and behavior of the real-world entity based on input data. It helps in predicting, optimizing, and improving decision making. It has revolutionized the industrial world, particularly the manufacturing industry, construction and healthcare sector, smart cities, and energy industry. 
  • 5.0K
  • 13 May 2021
Topic Review
Messerschmitt Me 323
The Messerschmitt Me 323 Gigant ("Giant") was a German military transport aircraft of World War II. It was a powered variant of the Me 321 military glider and was the largest land-based transport aircraft of the war. A total of 213 are recorded as having been made, 15 being converted from the Me 321.
  • 5.0K
  • 17 Oct 2022
Topic Review
Modern Computing in Iran
Iran’s modern computing history can be divided into four distinct periods: (1) Computers were first introduced to Iran in 1962. As a result, the introduction of computers in Iran occurred approximately ten years after introducing computers in developed countries. (2) Computer development, Iran’s computer development era began in 1971 and lasted until 1981. This path was followed by a lot of competition to buy hardware, introduce massive software systems, recruit more manpower, and follow rigorous programs based on the country’s technological realities. (3) Computer revisit: As a result of the Islamic Revolution, improvements and innovations in computers occurred, and a series of general reviews were conducted until 1980. (4) Technological maturity and growth in Iran: Following the reopening of universities in 1983, the next stage of computer development began, with software and hardware becoming widely available. The Persian language and script processing is among this century’s most important works.
  • 5.0K
  • 29 Aug 2022
Topic Review
Messiah
In Abrahamic religions, a messiah or messias (Hebrew: מָשִׁיחַ‎, romanized: māšîaḥ; Greek: μεσσίας, romanized: messías, Arabic: مسيح) is a saviour or liberator of a group of people. The concepts of mashiach, messianism, and of a Messianic Age originated in Judaism, and in the Hebrew Bible; a mashiach (messiah) is a king or High Priest traditionally anointed with holy anointing oil. Messiahs were not exclusively Jewish: the Book of Isaiah refers to Cyrus the Great, king of the Achaemenid Empire, as a messiah for his decree to rebuild the Jerusalem Temple. Ha mashiach (המשיח, 'the Messiah', 'the anointed one'),[lower-alpha 1] often referred to as melekh mashiach (מלך המשיח 'King Messiah'), is to be a human leader, physically descended from the paternal Davidic line through King David and King Solomon. He is thought to accomplish predetermined things in only one future arrival, including the unification of the tribes of Israel, the gathering of all Jews to Eretz Israel, the rebuilding of the Temple in Jerusalem, the ushering in of a Messianic Age of global universal peace, and the annunciation of the world to come. In Christianity, the Messiah is called the Christ, from Greek: χριστός, romanized: khristós, translating the Hebrew word of the same meaning. The concept of the Messiah in Christianity originated from the Messiah in Judaism. However, unlike the concept of the Messiah in Judaism, Jesus is considered by Christians additionally to be the Son of God. Christ became the accepted Christian designation and title of Jesus of Nazareth, because Christians believe that the messianic prophecies in the Old Testament were fulfilled in his mission, death, and resurrection. These specifically include the prophecies of him being descended from the Davidic line, and being declared King of the Jews which happened on the day of his crucifixion. They believe that Christ will fulfill the rest of the messianic prophecies, specifically that he will usher in a Messianic Age and the world to come at his Second Coming. Some Christian denominations, such as Catholicism, instead believe in amillenialist theology, but the Catholic Church has not adopted this term. In Islam, Jesus was a prophet and the Masîḥ (مسيح), the Messiah sent to the Israelites, and he will return to Earth at the end of times, along with the Mahdi, and defeat al-Masih ad-Dajjal, the false Messiah. In Ahmadiyya theology, these prophecies concerning the Mahdi and the second coming of Jesus have been fulfilled in Mirza Ghulam Ahmad (1835–1908), the founder of the Ahmadiyya Movement, and the terms 'Messiah' and 'Mahdi' are synonyms for one and the same person. In Chabad messianism, Yosef Yitzchak Schneersohn (r. 1920–1950), sixth Rebbe (spiritual leader) of Chabad Lubavitch, and Menachem Mendel Schneerson (1902–1994), seventh Rebbe of Chabad, are Messiah claimants. Resembling early Christianity, the deceased Schneerson is believed to be the Messiah among some adherents of the Chabad movement; his second coming is believed to be imminent.
  • 5.0K
  • 11 Nov 2022
Topic Review
Aircraft Livery
An aircraft livery is a set of comprehensive insignia comprising color, graphic, and typographical identifiers which operators (airlines, governments, Air force s and occasionally private and corporate owners) apply to their aircraft. As aircraft liveries evolved in the years after the Second World War, they became a leading subset of the emerging disciplines of corporate identity and branding and among the most prominent examples of fashion. They have provided an arena for the work of distinguished designers and eminent lay people like Raymond Loewy, Alexander Girard, and Jacqueline Kennedy Onassis. The term is an adaptation of the word livery: the uniform-style clothing worn by servants of wealthy families and government representatives until the early/mid-20th century. With the advent of stagecoaches, railway trains, and steamships, the term livery spread to their decoration. Since the 1950s, elements of airline liveries permeated ground vehicles, advertising, proprietary airport furniture, airline promotional materials and aircrew uniforms in an increasingly integrated manner, spreading to airline websites in the 1990s. Since the 1950s and 60s, aircraft liveries have usually been uniform livery across an entire fleet. One-off custom-designs might be applied from time to time to individual fleet members to highlight set occasions.
  • 5.0K
  • 21 Oct 2022
Topic Review
Corn Processing by-Products
As an important food crop, corn has an important impact on people’s lives. The processing of corn produces many by-products, such as corn gluten meal, corn husk, and corn steep liquor, which are rich in protein, oil, carbohydrates, and other nutrients, all of which are inexpensive. Their accumulation in large quantities during the production process not only results in a burden on the environment but also the loss of potentially valuable food materials that can be processed. In fact, the by-products of corn processing have been partially used in functional foods, nutrients, feed, and other industries. There is no doubt that the secondary utilization of these by-products can not only solve the problem of waste pollution caused by them, but also produce high value-added products and improve the economic benefits of corn. 
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  • 01 Dec 2022
Topic Review Peer Reviewed
Age-Friendly Built Environment
Age-friendly built environments have been promoted by the World Health Organisation (WHO, Geneva, Switzerland) under the Global Age-friendly Cities (AFC) movement in which three domains are related to the built environment. These are: housing, transportation, outdoor spaces and public buildings. The aim is to foster active ageing by optimising opportunities for older adults to maximise their independent living ability and participate in their communities to enhance their quality of life and wellbeing. An age-friendly built environment is inclusive, accessible, respects individual needs and addresses the wide range of capacities across the course of life. Age-friendly housing promotes ageing in familiar surroundings and maintains social connections at the neighbourhood and community levels. Both age-friendly housing and buildings provide barrier-free provisions to minimise the needs for subsequent adaptations. Age-friendly public and outdoor spaces encourage older adults to spend time outside and engage with others against isolation and loneliness. Age-friendly public transport enables older adults to get around and enhances their mobility. For achieving an age-friendly living environment, a holistic approach is required to enable independent living, inclusion and active participation of older adults in society. The eight domains of the AFC movement are not mutually exclusive but overlap and support with one another.
  • 5.0K
  • 13 Apr 2022
Topic Review
Gyro-Stabilized Camera Systems
Gyro-stabilized camera systems use modern electronic position data to correct for movements of the platforms they are mounted on to enable a high degree of stabilization. The systems often use a multi-axis gyro stabilization to enable the use of zoom lenses and high definition capture, despite the high amounts of vibrations and movements in aircraft, helicopters or other vehicles. The applications range from security and military operations, law enforcement, ENG, sports broadcasting documentary, natural history, and feature film productions..
  • 5.0K
  • 14 Oct 2022
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