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Topic Review
Microprobe System for Coordinate Metrology
A coordinate measuring machine (CMM) is a measuring instrument that can measure three-dimensional (3D) shapes of an object, including a probing system to detect an object’s surface, a positioning stage system to move either the probing system or the object, length scales to determine the coordinate of detected points by the probing system, as well as software to control the entire measurement.  Micro-coordinate measuring machines (micro-CMMs) for measuring microcomponents require a probe system with a probe tip diameter of several tens to several hundreds of micrometers. Scale effects work for such a small probe tip, i.e., the probe tip tends to stick on the measurement surface via surface adhesion forces. These surface adhesion forces significantly deteriorate probing resolution or repeatability. 
  • 1.2K
  • 30 Jan 2022
Topic Review
Photovoltaic Cell Energy Conversion
Efficient photon to charge (PTC) transfer is considered to be the cornerstone of technological improvements in the photovoltaic (PV) industry, while it constitutes the most common process in nature. 
  • 1.2K
  • 01 Jun 2021
Topic Review
Heavy Metals Levels in Adolescents
In the Milazzo-Valle del Mela area, the presence of industrial plants and the oil refinery make local residents concerned for their health. For this reason, we evaluated the levels of heavy metals in 226 children aged 12–14 years, living in the 7 municipalities of the area. A control age-matched population (n = 29) living 45 km far from the industrial site was also enrolled. Arsenic, cadmium, chromium, mercury, nickel, and vanadium were analysed in 24 h urine samples, while lead concentration was evaluated in blood samples. A questionnaire regarding life style and risk perception was also administered. Adolescents from Milazzo-Valle del Mela had cadmium levels significantly higher compared to either controls (P < 0.0001) or the reference values of the European Germany Environmental Survey (GerES-IV) and the American National Health and Nutrition Examination Survey (NHANES). Furthermore, children had higher perception of living in a high-risk environment. The present data, for the first time, clearly indicate that adolescents living in Milazzo-Valle del Mela have increased body concentration of cadmium, which may be harmful to human health. These results deserve particular attention by the local and regional government to initiate prevention programmes in this susceptible population.
  • 1.2K
  • 01 Nov 2020
Topic Review
Root Invasion by Ralstonia solanacearum
The plant pathogenic bacterium Ralstonia solanacearum, causal agent of the devastating bacterial wilt disease, is a soil-borne microbe that infects host plants through their roots. The initial mutual recognition between host plants and bacteria and the ensuing invasion of root tissues by R. solanacearum are critical steps in the establishment of the infection, and can determine the outcome of the interaction between plant and pathogen.
  • 1.2K
  • 10 Nov 2020
Topic Review
DispHred
DispHred is the first disorder predictor that includes the effect of the solution pH in its calculations. The DispHred key feature is profiling the pH-dependence disorder of a protein sequence across a pH interval, identifying pH-induced order/disorder protein transitions. DispHred is freely available for academic users at https://ppmclab.pythonanywhere.com/DispHred.
  • 1.2K
  • 02 Feb 2021
Topic Review
Trans-Olecranon Fracture-Dislocations
Anterior dislocation of the elbow in which compromise of the ulnohumeral articulation occurs through an often complex injury to the proximal ulna
  • 1.2K
  • 10 Dec 2020
Topic Review
Spastic Paraplegia Type 2
Spastic paraplegia type 2 is part of a group of genetic disorders known as hereditary spastic paraplegias. These disorders are characterized by progressive muscle stiffness (spasticity) and the development of paralysis of the lower limbs (paraplegia). Hereditary spastic paraplegias are divided into two types: pure and complex. The pure types involve the lower limbs. The complex types involve the lower limbs and can also affect the upper limbs to a lesser degree; the structure or functioning of the brain; and the nerves connecting the brain and spinal cord to muscles and sensory cells that detect sensations such as touch, pain, heat, and sound (the peripheral nervous system). Spastic paraplegia type 2 can occur in either the pure or complex form.  
  • 1.2K
  • 23 Dec 2020
Topic Review
Gordon Holmes Syndrome
Gordon Holmes syndrome is a rare condition characterized by reproductive and neurological problems.
  • 1.2K
  • 23 Dec 2020
Topic Review
Chikungunya Virus
Arboviruses, in general, are a global threat due to their morbidity and mortality, which results in an important social and economic impact. Chikungunya virus (CHIKV), one of the most relevant arbovirus currently known, is a re-emergent virus that causes a disease named chikungunya fever, characterized by a severe arthralgia (joint pains) that can persist for several months or years in some individuals. Until now, no vaccine or specific antiviral drug is commercially available. Nitrogen heterocyclic scaffolds are found in medications, such as aristeromycin, favipiravir, fluorouracil, 6-azauridine, thioguanine, pyrimethamine, among others. New families of natural and synthetic nitrogen analogous compounds are reported to have significant anti-CHIKV effects. In the present work, we focus on these nitrogen-based heterocyclic compounds as an important class with CHIKV antiviral activity.
  • 1.2K
  • 16 Jan 2021
Topic Review
Genomic Landscape of Hodgkin Lymphoma
Hodgkin lymphoma (HL) is composed of many reactive and only a few cancer cells, so-called Hodgkin and Reed-Sternberg (HRS) or lymphocyte predominant (LP) cells. 
  • 1.2K
  • 23 Feb 2021
Topic Review
Mesenchymal Stromal/Stem Cells
Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support homeostasis during tissue regeneration.
  • 1.2K
  • 01 Mar 2021
Topic Review
Nanoparticles-Based Targeted Drug Delivery
Several organic and inorganic nanoplatforms that have been designed exploiting the distinctive features of the tumor microenvironment and tumor cells offer favorable physicochemical properties and pharmacokinetic profiles of a parent drug, with delivery of higher amounts of the drug to the pathological site and its controlled release, thereby improving the balance between its efficacy and toxicity. Advances to this front have included the design and construction of targeted nanoparticles by conjugating homing devices like peptide, ligand, and Fab on the surface of nanomaterials to navigate nanoparticle drug complexes towards the target tumor cell with minimal destruction of healthy cells. Furthermore, actively targeting nanoparticles can facilitate the delivery and cellular uptake of nanoparticle-loaded drug constructs via binding with specific receptors expressed aberrantly on the surface of a tumor cell. Herein, we present an overview of the principle of targeted delivery approaches, exploiting drug-nanoparticle conjugates with multiple targeting moieties to target specific receptors of breast cancer cells and highlighting therapeutic evaluation in preclinical studies. We conclude that an understanding of the translational gap and challenges would show the possible future directions to foster the development of novel targeted nanotherapeutics. 
  • 1.2K
  • 11 Mar 2021
Topic Review
Peroxiredoxin
Peroxiredoxin (Prx) is a relatively recently discovered antioxidant enzyme family that scavenges peroxides and is known to be present in organisms from biological taxa ranging from bacteria to multicellular eukaryotes, including photosynthetic organisms.
  • 1.2K
  • 24 Mar 2021
Topic Review
Fatty Acid Ethanolamides and Receptors
Oleoylethanolamide and palmitoylethanolamide are members of the fatty acid ethanolamide family, also known as acylethanolamides. Their physiological effects, including glucose homeostasis, anti-inflammation, anti-anaphylactic, analgesia, and hypophagia, have been reported. They have affinity for different receptor proteins, including nuclear receptors such as PPARα, channels such as TRPV1, and membrane receptors such as GPR119 and GPR55. In the present review, the pathophysiological functions of fatty acid ethanolamides have been discussed from the perspective of receptor pharmacology and drug discovery.
  • 1.2K
  • 30 Apr 2021
Topic Review
Tropical Cyclone
Tropical cyclones (TCs) plague coastal communities around the world, threatening millions of lives and causing many billions of dollars in damage to infrastructure. The primary hazards responsible for many of the fatalities and damage in coastal communities include storm surge and wind damage, while further inland hazards include torrential rainfall and severe weather that often accompany landfalling TCs. The danger from these hazards is only increasing due to greater coastal development worldwide, increasing sea surface temperature, and sea level rise.
  • 1.2K
  • 17 Jun 2021
Topic Review
Sulfated Polysaccharides from Marine Algae
Wound healing involves a complex cascade of cellular, molecular, and biochemical responses and signaling processes. It consists of successive interrelated phases, the duration of which depends on a multitude of factors. Wound treatment is a major healthcare issue that can be resolved by the development of effective and affordable wound dressings based on natural materials and biologically active substances. The proper use of modern wound dressings can significantly accelerate wound healing with minimum scar mark. Sulfated polysaccharides from seaweeds, with their unique structures and biological properties, as well as with a high potential to be used in various wound treatment methods, now undoubtedly play a major role in innovative biotechnologies of modern natural interactive dressings.
  • 1.2K
  • 25 Jun 2021
Topic Review
PIPAC
Theoretical considerations as well as comprehensive preclinical and clinical data suggest that optimizing physical parameters of intraperitoneal drug delivery might help to circumvent initial or acquired resistance of peritoneal metastasis (PM) to chemotherapy. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel minimally invasive drug delivery system systematically addressing the current limitations of intraperitoneal chemotherapy. The rationale behind PIPAC is: (1) optimizing homogeneity of drug distribution by applying an aerosol rather than a liquid solution; (2) applying increased intraperitoneal hydrostatic pressure to counteract elevated intratumoral interstitial fluid pressure; (3) limiting blood outflow during drug application; (4) steering environmental parameters (temperature, pH, electrostatic charge etc.) in the peritoneal cavity for best tissue target effect. In addition, PIPAC allows repeated application and objective assessment of tumor response by comparing biopsies between chemotherapy cycles. 
  • 1.2K
  • 09 Aug 2021
Topic Review
Biometric Systems De-Identification
Biometric de-identification is an emerging topic of research within the information security domain that integrates privacy considerations with biometric system development. A comprehensive overview of research in the context of authentication applications spanning physiological, behavioral, and social-behavioral biometric systems and their privacy considerations is discussed. Three categories of biometric de-identification are introduced, namely complete de-identification, auxiliary biometric preserving de-identification, and traditional biometric preserving de-identification. An overview of biometric de-identification in emerging domains such as sensor-based biometrics, social behavioral biometrics, psychological user profile identification, and aesthetic-based biometrics is presented. The article provides a rich avenue for subsequent explorations of biometric de-identification in the context of information privacy.
  • 1.2K
  • 19 Oct 2021
Topic Review
Post-Harvest Operations to Generate High-Quality Medicinal Cannabis Products
Cannabis has been a traditional medicinal herb in central Asia, with reports of such usage back to 4700 B.P. in China, India, Persia, Egypt, Greece and Rome. It is now also cultivated and used as a drug crop in at least 172 countries and territories worldwide. It is classified as Cannabis Sativa, C. Indica and C. Ruderalis based on genetics, phenotypic properties and chemical structure. The Cannabis industry is rapidly growing; therefore, there is no medicinal cannabis that can be produced without optimising drying methods. Producing high-quality medical products have been a hot topic in recent years.
  • 1.2K
  • 11 Mar 2022
Topic Review
Magnetic Solid Nanoparticles and Their Counterparts
Cancer is a malignant disease involving uncontrolled and rapid growth of aberrant and nonfunctional cells as a result of epigenetic and genetic modifications. These have the capacity to metastasize to distant organs of the body. Within the cancer field, magnetic nanoparticles (MNPs) have gained interest as highly functionalized tools that can be applied to diagnosis, monitorization, and therapy. Their relative straightforward synthesis, functionalization, purification, and characterization, together with their usually good biodegradability and diagnostic platform potential, confer major advantages for their use in cancer theranostics. Magnetic solid lipid nanoparticles (mSLNs) represent a new class of functional nanoplatforms that usually consist of inorganic magnetic nanoparticles incorporated in solid lipid nano-matrices and which have great applicability in the medical field.
  • 1.2K
  • 11 Mar 2022
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