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Topic Review
Recovery of phosphorus from wastewater
Mined phosphate rock is the largest source of phosphorus (P) for use in agriculture and agro-industry, but it also is a finite resource irregularly distributed around the world. Alternatively, waste water is a renewable source of P, available at the local scale. In waste water treatment, biological nitrogen (N) removal is applied according to a wide range of variants targeting the abatement of the ammonium content. Ammonium oxidation to nitrate can also be considered to mitigate ammonia emission, while enabling N recovery. Different alternatives exist for coupling biological N treatment and phosphate precipitation when treating waste water in view of producing P-rich materials easily usable as fertilisers. Phosphate precipitation can be applied before (upstream configuration), together with (concomitant configuration), and after (downstream configuration) N treatment; i.e., chemically induced as a conditioning pre-treatment, biologically induced inside the reactor, and chemically induced as a refining post-treatment. Characteristics of the recovered products differ significantly depending on the case studied. Currently (year 2020), precipitated phosphate salts are not typified in the European fertiliser regulation, and this fact limits marketability. Nonetheless, this topic is in progress according to potential requirements to be complied by these materials. Integrated approaches for waste water treatment including P recovery must consider significant needs for subsequent agronomic valorisation of the recovered phosphate salts following the paradigms of the circular economy, sustainability, and environmental protection.
  • 1.2K
  • 27 Oct 2020
Topic Review
Streamflow Duration
Streamflow Duration: The length of time a stream has surface flow or conversely, has no surface flow. It is one of several dimensions that characterize flow regimes of streams[1]. Streamflow duration is used to differentiate reaches into discrete classes (e.g., perennial, intermittent, and ephemeral) for water resource management.  
  • 1.2K
  • 21 Sep 2020
Topic Review
Osteoimmunological Disorders and Breast Cancer
The term "osteoimmunology" was first used in 2000 by Choi et al. to define a new paradigm describing the crosstalk between the immune system and osteoclastogenesis. The multiplicity of osteoimmunological disorders is due to the variety of stimuli responsible for the immune system activation.
  • 1.2K
  • 17 Dec 2020
Topic Review
Bladder Cancer
The overwhelming majority of bladder cancers are transitional cell carcinomas. Albeit mostly monotonous, carcinomas in the bladder may occasionally display a broad spectrum of histological features that should be recognized by pathologists because some of them represent a diagnostic problem and/or lead prognostic implications. Sometimes these features are focal in the context of conventional transitional cell carcinomas, but some others are generalized across the tumor making its recognition a challenge. For practical purposes, the review distributes the morphologic spectrum of changes in architecture and cytology. Thus, nested and large nested, micropapillary, myxoid stroma, small tubules and adenoma nephrogenic-like, microcystic, verrucous, and diffuse lymphoepithelioma-like, on one hand, and plasmacytoid, signet ring, basaloid-squamous, yolk-sac, trophoblastic, rhabdoid, lipid/lipoblastic, giant, clear, eosinophilic (oncocytoid), and sarcomatoid, on the other, are revisited. Key histological and immunohistochemical features useful in the differential diagnosis are mentioned. In selected cases, molecular data associated with the diagnosis, prognosis, and/or treatment are also included.
  • 1.2K
  • 30 Dec 2020
Topic Review
Lead Halide Perovskites Opto-Electronic Devices
In Lead Halide Perovskites Opto-Electronic Devices, we will discuss the development in the LHP-based functional devices in recent years. After a brief presentation of the LHP's properties, we will focus on the functional devices including lasers, photodetectors, and modulators. Then the fabrication of the LHP-based devices will be presented, which is followed by the summary and outlook.
  • 1.2K
  • 29 Apr 2021
Topic Review
Polyphenols in Tea
A diet high in polyphenols is associated with a diversified gut microbiome. Tea is the second most consumed beverage in the world, after water. The health benefits of tea might be attributed to the presence of polyphenol compounds such as flavonoids (e.g., catechins and epicatechins), theaflavins, and tannins. 
  • 1.2K
  • 18 May 2021
Topic Review
Ketogenic Diet in Cancer Prevention/Therapy
The ketogenic diet (KD) has recently emerged as a metabolic therapy in cancer treatment, targeting cancer cell metabolism rather than a conventional dietary approach. The ketogenic diet (KD), a high-fat and very-low-carbohydrate with adequate amounts of protein, has shown antitumor effects by reducing energy supplies to cells. This low energy supply inhibits tumor growth, explaining the ketogenic diet’s therapeutic mechanisms in cancer treatment.
  • 1.2K
  • 12 Jul 2021
Topic Review
MiRNA Epitranscriptomic Modifications in Cancer
MicroRNAs are small non-coding RNAs, acting as post-transcriptional regula- tors of gene expression. In the last two decades, their role in cancer as oncogenes (oncomir), as well as tumor suppressors, has been extensively demonstrated. Recently, epitranscriptomics, namely the study of RNA modifications, has emerged as a new field of great interest, being an additional layer in the regulation of gene expression. Almost all classes of eukaryotic RNAs, including miRNAs, undergo epitranscriptomic modifications. Alterations of RNA modification pathways have been de- scribed for many diseases—in particular, in the context of malignancies. 
  • 1.2K
  • 20 Jul 2021
Topic Review
Cytoskeletal Filaments in Coronaviridae
The cytoskeleton is an intricate network of filaments running through the cytoplasm that helps cells to maintain their shape and internal organization. Coronaviruses such as SARS-CoV-2 are intimately involved in cytoskeleton-related physiological and pathological processes. The discovery of the exact mechanisms of the subversion of host cells by SARS-CoV-2 is critical to the validation of specific drug targets and effective treatments.
  • 1.2K
  • 24 Nov 2021
Topic Review
Dendritic Cells and Dentinogenesis
Using several in vivo designs, antigen-presenting cells, including macrophages and dendritic cells (DCs), are identified in the pulpal tissue before tertiary dentin deposition under the afflicted area. However, the precise nature of this phenomenon and its relationship to inherent pulp cells are not yet clarified. This literature review aims to discuss the role of pulpal DCs and their relationship to progenitor/stem cells, odontoblasts or odontoblast-like cells, and other immunocompetent cells during physiological and pathological dentinogenesis.
  • 1.2K
  • 13 Aug 2021
Topic Review
Sildenafil and Infertility Treatments
One of the adjuvants that showed potential beneficial effects on endometrial thickening in women undergoing infertility treatments is sildenafil citrate, a 5-phosphodiesterase inhibitor widely used for male erectile dysfunction. The Sildenafil pharmacological effect of Sildenafil is based on the prevention of cGMP breakdown thereby increasing smooth muscle relaxation and vasodilation. At the endometrium level, Sildenafil may increase uterine artery flow and exert a positive effect on endometrial growth in response to estrogenic stimulation. Moreover, it may improve endometrial tolerance to the embryo through decreasing local natural killer cell activity and favoring the accomplishment of proper embryo implantation.
  • 1.2K
  • 15 Oct 2021
Topic Review
Thiazolidinedione Derivatives
Thiazolidinediones (TZDs) are a kind of DMII drug. The data revealed that compounds (4–6) have higher potency than the reference drugs. Compounds (4–7) were able to regulate hyperlipidemia levels (cholesterol, triglyceride, high-density lipoproteins and low- and very-low-density lipoproteins) to nearly normal value at the 30th day.
  • 1.2K
  • 29 Jan 2022
Topic Review
Monocytes in Chronic Heart Failure
A long-term condition known as chronic heart failure (CHF) is an ongoing difficulty of the heart in pumping blood enriched in oxygen and required nutrients around the body’s tissues. CHF pathogenesis is associated with various causes, and inflammation is one of the most important factors promoting the condition. In addition, monocytes, a group of cells present in the blood and infiltrating tissues, are known to participate in both pro- and anti-inflammatory processes and thus affect myocardial remodeling over time.
  • 1.2K
  • 14 Feb 2022
Topic Review
Scientific Production on Health Literacy and Health Education
There has been an emphasis on the importance of health literacy (HL) and health education (HE) as basic tools to empower individuals and the community. The increasing interest in HL and HE has been observed through the evolution of publications and the nature of the main trends in the last few years. Knowing how HL and HE have evolved in scientific publications can help to identify trends and set  priorities in this scope.
  • 1.2K
  • 20 Apr 2022
Topic Review
Direct Type Electrochemical Glycated Hemoglobin Sensors
Glycated hemoglobin (HbA1c) is the gold standard for measuring glucose levels in the diagnosis of diabetes due to the excellent stability and reliability of this biomarker. HbA1c is a stable glycated protein formed by the reaction of glucose with hemoglobin (Hb) in red blood cells, which reflects average glucose levels over a period of two to three months without suffering from the disturbance of the outside environment. A number of simple, high-efficiency, and sensitive electrochemical sensors have been developed for the detection of HbA1c. Direct type sensors determine HbA1c by detecting the changes in electrical signals including current, potential, and impedance before and after HbA1c is bound to biological affinity molecules pre-fixed on the electrode surface. Direct sensors are divided into amperometric sensors, potentiometric sensors, and impedimetric sensors.
  • 1.2K
  • 22 Apr 2022
Topic Review
Military Relevance of Vaccine-Preventable Infectious Diseases
The military worldwide have always been challenged with the issue of infectious diseases, which may deeply influence the outcome of battles/wars. The military are particularly exposed to the risk of infectious diseases for a series of reasons, including the community life, often in precarious environmental conditions regarding the hygiene of water and food supply, sanitation, the traumatism with contaminated wounds, and the possibility to be exposed to extreme temperatures and to diseases unknown in their country of origin, for which no natural immunization has, therefore, been developed.
  • 1.2K
  • 31 Aug 2022
Topic Review
Probation and Parole Officer
A probation and parole officer is an official appointed to investigate, report on, and supervise the conduct of convicted offenders on probation and/or those released from incarceration to community supervision such as parole. Most probation and parole officers are employed by the government of the jurisdiction in which they operate, although some are employed by private companies that provide contracted services to the government.
  • 1.2K
  • 08 Oct 2022
Topic Review
List of Matrices
This page lists some important classes of matrices used in mathematics, science and engineering. A matrix (plural matrices, or less commonly matrixes) is a rectangular array of numbers called entries. Matrices have a long history of both study and application, leading to diverse ways of classifying matrices. A first group is matrices satisfying concrete conditions of the entries, including constant matrices. An important example is the identity matrix given by Further ways of classifying matrices are according to their eigenvalues or by imposing conditions on the product of the matrix with other matrices. Finally, many domains, both in mathematics and other sciences including physics and chemistry have particular matrices that are applied chiefly in these areas.
  • 1.2K
  • 29 Nov 2022
Topic Review
Technical Features of Polysaccharide-Based Hydrogels in Drug Delivery
Hydrogels are a form of highly hydrophilic biomaterials with three-dimensional architecture that can retain a significant amount of water and swell without disintegrating. Hydrogels can be either synthetic, natural, or hybrid forms. Natural polymer hydrogels are those derived from naturally sourced polymers, including polysaccharides, polynucleotides, and proteins. Neutral, cationic, and anionic categories describe the chemical properties of natural sources of polymers. These polymers are easily accessible, ubiquitous, affordable, non-toxic, renewable, and have other appealing biological features.
  • 1.2K
  • 22 Dec 2022
Topic Review
Senescent Cells in Cutaneous Wound Healing
Cellular senescence has gained increasing attention in the field of aging research. Senescent cells have been implicated in biological aging processes, tumorigenesis, development, and wound repair amongst other processes and pathologies. Recent findings reveal that senescent cells can both promote and inhibit cutaneous wound healing processes. 
  • 1.2K
  • 26 Dec 2022
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