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Topic Review
MiRNAs in IR and EC
Endometrial cancer (EC) remains one of the most common cancers of the female reproductive system. Epidemiological and clinical data implicate insulin resistance (IR) and its accompanying hyperinsulinemia as key factors in the development of EC. MicroRNAs (miRNAs) are short molecules of non-coding endogenous RNA that function as post-transcriptional regulators. Accumulating evidence has shown that the miRNA expression pattern is also likely to be associated with EC risk factors. 
  • 659
  • 18 Sep 2020
Topic Review
GP1BA Gene
Glycoprotein Ib platelet subunit alpha
  • 659
  • 22 Dec 2020
Topic Review
KRT6A Gene
Keratin 6A
  • 659
  • 01 May 2021
Topic Review
SAMD9L Gene
sterile alpha motif domain containing 9 like
  • 659
  • 24 Dec 2020
Topic Review
RRM2B Gene
ribonucleotide reductase regulatory TP53 inducible subunit M2B
  • 658
  • 24 Dec 2020
Topic Review
HIVEP2-Related Intellectual Disability
HIVEP2-related intellectual disability is a neurological disorder characterized by moderate to severe developmental delay and intellectual disability and mild physical abnormalities (dysmorphic features).
  • 657
  • 23 Dec 2020
Topic Review
KCNQ4 Gene
Potassium voltage-gated channel subfamily Q member 4
  • 657
  • 23 Dec 2020
Topic Review
Nail-patella Syndrome
Nail-patella syndrome is characterized by abnormalities of the nails, knees, elbows, and pelvis. The features of nail-patella syndrome vary in severity between affected individuals, even among members of the same family.
  • 657
  • 23 Dec 2020
Topic Review
Leptin Receptor Deficiency
Leptin receptor deficiency is a condition that causes severe obesity beginning in the first few months of life.
  • 657
  • 24 Dec 2020
Topic Review
CLN6 Gene
CLN6, transmembrane ER protein
  • 657
  • 24 Dec 2020
Topic Review
HSPB8 Gene
Heat shock protein family B (small) member 8
  • 656
  • 23 Dec 2020
Topic Review
MYH11 Gene
myosin heavy chain 11
  • 655
  • 23 Dec 2020
Topic Review
RAB27A Gene
RAB27A, member RAS oncogene family
  • 655
  • 23 Dec 2020
Topic Review
D-bifunctional Protein Deficiency
D-bifunctional protein deficiency is a disorder that causes deterioration of nervous system functions (neurodegeneration) beginning in infancy.
  • 655
  • 24 Dec 2020
Topic Review
TFAP2B Gene
Transcription factor AP-2 beta: The TFAP2B gene provides instructions for making a protein called transcription factor AP-2β.
  • 655
  • 25 Dec 2020
Topic Review
MMP20 Gene
matrix metallopeptidase 20
  • 654
  • 12 Apr 2021
Topic Review
Gnathodiaphyseal Dysplasia
Gnathodiaphyseal dysplasia is a disorder that affects the bones.
  • 654
  • 23 Dec 2020
Topic Review
PSAP Gene
prosaposin
  • 654
  • 23 Dec 2020
Topic Review
Microphthalmia Family Translocation Renal Cell Carcinoma
The microphthalmia-associated transcription factor/transcription factor E (MiT/TFE) family of transcription factors are evolutionarily conserved, basic helix–loop–helix leucine zipper (bHLH-Zip) transcription factors, consisting of MITF, TFEB, TFE3, and TFEC. MiT/TFE proteins, with the exception of TFEC, are involved in the development of renal cell carcinoma (RCC). Most of the MiT/TFE transcription factor alterations seen in sporadic RCC cases of MiT family translocation renal cell carcinoma (tRCC) are chimeric proteins generated by chromosomal rearrangements. These chimeric MiT/TFE proteins retain the bHLH-Zip structures and act as oncogenic transcription factors. 
  • 653
  • 16 Jan 2023
Topic Review
Second Tumors in Retinoblastoma Survivors after Ionizing Radiation
Retinoblastoma (RB) is the most common ocular neoplasm in children, whose development depends on two mutational events that occur in both alleles of the retinoblastoma susceptibility gene (RB1). Regarding the nature of these mutational events, RB can be classified as hereditary if the first event is a germline mutation and the second one is a somatic mutation in retina cells or nonhereditary if both mutational events occur in somatic cells. Although the rate of survival of RB is significantly elevated, the incidence of second malignant neoplasms (SMNs) is a concern, since SMNs are the main cause of death in these patients. Furthermore, evidence confirms that hereditary RB survivors are at a higher risk for SMNs than nonhereditary RB survivors. This risk seems to increase with the use of ionizing radiation in some therapeutic approaches commonly used in the treatment of RB.
  • 653
  • 20 Nov 2023
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