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Topic Review
Network-Based Drug Repurposing in Psychiatry
Drug repurposing offers a more efficient pathway compared with de novo drug discovery with lower cost and less risk. Various computational approaches have been applied to mine the vast amount of biomedical data generated over recent decades. Aligned well with the poly-pharmacology paradigm shift in drug discovery, network-based approaches offer great opportunities to discover repurposing candidates for complex psychiatric disorders.
  • 1.2K
  • 05 Aug 2022
Topic Review
Thermal and Hurdle Approaches in Microbial Inactivation
Thermal processing of packaged fruit and vegetable products is targeted at eliminating microbial contaminants (related to spoilage or pathogenicity) and extending shelf life using microbial inactivation or/and by reducing enzymatic activity in the food. The conventional process of thermal processing involves sterilization (canning and retorting) and pasteurization. The parameters used to design the thermal processing regime depend on the time (minutes) required to eliminate a known population of bacteria in a given food matrix under specified conditions. However, due to the effect of thermal exposure on the sensitive nutrients such as vitamins or bioactive compounds present in fruits and vegetables, alternative technologies and their combinations are required to minimize nutrient loss. The novel moderate thermal regimes aim to eliminate bacterial contaminants while retaining nutritional quality. 
  • 1.2K
  • 05 Sep 2022
Topic Review
Nickel Nanoparticles
Methicillin-resistant Staphylococcus aureus (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel drugs, seeking efficient alternative approaches for the eradication of drug-resistant bacterial agents seems to be an unmet requirement. Nickel nanoparticles (NiNPs) have been applied as prognostic and therapeutic cheap agents to various aspects of biomedical sciences. Their antibacterial effects are exerted via the disruption of the cell membrane, the deformation of proteins, and the inhibition of DNA replication. NiNPs proper traits include high-level chemical stability and binding affinity, ferromagnetic properties, ecofriendliness, and cost-effectiveness. They have outlined pleomorphic and cubic structures. The combined application of NiNPs with CuO, ZnO, and CdO has enhanced their anti-MRSA effects. The NiNPs at an approximate size of around 50 nm have exerted efficient anti-MRSA effects, particularly at higher concentrations. NiNPs have conferred higher antibacterial effects against MRSA than other nosocomial bacterial pathogens. The application of green synthesis and low-cost materials such as albumin and chitosan enhance the efficacy of NPs for therapeutic purposes.
  • 1.2K
  • 20 Sep 2022
Topic Review
Sun Ray
The Sun Ray was a stateless thin client computer (and associated software) aimed at corporate environments, originally introduced by Sun Microsystems in September 1999 and discontinued by Oracle Corporation in 2014. It featured a smart card reader and several models featured an integrated flat panel display. The idea of a stateless desktop was a significant shift from, and the eventual successor to, Sun's earlier line of diskless Java-only desktops, the JavaStation.
  • 1.2K
  • 10 Nov 2022
Topic Review
Open Source in Kosovo
The first project in open source in Kosovo was the adjustment of Open Office Packet in December 2003. On 28 July 2004 the Albanian team, users of Linux (GGSL), was one of the first public organizations for the purpose of getting information about the field of open source. This conference was called "Software Freedom Day". Software Freedom Day is known as the first initiative about FOSS in Kosovo in the level of conference. The purpose of that conference was to promote the free and open software. Some of the issues that were discussed were about Linux, what is free software and open sources in general. Another issue that was discussed in that conference was about the operative system Linux and its benefits. KDE and GNOME were the last issues that were discussed in conference. Ati-Kos has made some surveys in five municipal assemblies of Kosovo in May 2005. According to this survey about 98.6% wanted software box in mother tongue, in Albanian. In another survey, the majority of the participants believed that a software box like Open Office would help in increasing the productivity in different fields because of the interface in Albanian.
  • 1.2K
  • 15 Nov 2022
Topic Review
Timeline of STS-51-L
STS-51-L mission timeline is a detailed timeline of events from the ignition of Challenger's main engines to the remote destruction of the two Solid rocket boosters (SRBs), and includes a transcript of crew conversations from the cockpit voice recorder on board the orbiter. STS-51-L was the twenty-fifth flight in the American Space Shuttle program, and marked the first time a civilian had flown aboard the Space Shuttle. The mission used Space Shuttle Challenger, which lifted off from launch pad 39B (LC-39B) on January 28, 1986, from Kennedy Space Center, Florida. The mission ended in disaster following the destruction of Challenger 73 seconds after lift-off, because of the failure of an O-ring seals on Challenger's right solid rocket booster, which led to the rapid disintegration of the Space Shuttle stack from overwhelming aerodynamic pressures. The seven-member crew was killed when the crew compartment hit the Atlantic Ocean at 333 km/h (207 mph), after two and a half minutes of freefall.
  • 1.2K
  • 22 Nov 2022
Topic Review
Post-Stroke Movement with Motion Capture and Musculoskeletal Modeling
Research of post-stroke locomotion via musculoskeletal (MSK) modeling has offered an unprecedented insight into pathological muscle function and its interplay with skeletal geometry and external stimuli. Advances in solving the dynamical system of post-stroke effort and the generic MSK models used have triggered noticeable improvements in simulating muscle activation dynamics of stroke populations.
  • 1.2K
  • 09 Dec 2022
Topic Review
Vestibular Schwannoma for Hearing Preservation Surgery
Vestibular schwannoma is a clinically benign schwannoma that arises from the vestibulocochlear nerve that causes sensorineural hearing loss. This tumor is clinically and oncologically regarded as a benign tumor as it does not metastasize or invade surrounding tissues. Despite being a benign tumor, its management is difficult and controversial due to the potential serious complications, such as irreversible sensorineural hearing loss, of the interventions. Therefore, preventing hearing loss due to the natural course of the disease and complications of surgery is a challenging issue for an otologist.
  • 1.2K
  • 19 Dec 2022
Topic Review
Modular Construction in the UK
Offsite modular construction has emerged as a popular solution to tackle the chronic housing shortage and attain net-zero carbon targets in the UK. This technique involves the prefabrication of building components, sub-assemblies, and parts in off-site factories, which are then transferred and assembled on site as integral parts of a larger structure. These modular units may either constitute a small fraction of the overall project or form the entire building. Accordingly, the proliferation of modular construction is frequently justified by the promise of superior quality and precision in manufacturing, as well as economies of scale in mass-producing numerous standardised units, leading to enhanced productivity, rapid production, reduction of waste, and efficient allocation of resources.
  • 1.2K
  • 26 May 2023
Topic Review
cfDNA Analysis
Degraded DNA fragments released into the blood or other fluids are known as cfDNA. Its first detection dates back to 1948 in patients with systemic lupus erythematosus.
  • 1.2K
  • 20 Jun 2023
Topic Review
Intrusion Detection System in IoT Wi-Fi Networks
The Internet of Things (IoT) is a network of billions of interconnected devices embedded with sensors, software, and communication technologies. Wi-Fi is one of the main wireless communication technologies essential for establishing connections and facilitating communication in IoT environments. However, IoT networks are facing major security challenges due to various vulnerabilities, including de-authentication and disassociation DoS attacks that exploit IoT Wi-Fi network vulnerabilities. Traditional intrusion detection systems (IDSs) improved their cyberattack detection capabilities by adapting machine learning approaches, especially deep learning (DL). However, DL-based IDSs still need improvements in their accuracy, efficiency, and scalability to properly address the security challenges including de-authentication and disassociation DoS attacks tailored to suit IoT environments. The main purpose of this research was to overcome these limitations by designing a transfer learning (TL) and convolutional neural network (CNN)-based IDS for deauthentication and disassociation DoS attack detection with better overall accuracy compared to various current solutions. 
  • 1.2K
  • 15 Oct 2023
Topic Review
Smart Factory
In the manufacturing sector, industrial, academic, and research entities have been making joint efforts to move beyond process automation and help the industry build intelligent factories that autonomously recognize and control the work situation by incorporating technologies such as artificial intelligence (AI), cloud, big data, and 5G with existing manufacturing processes. 
  • 1.2K
  • 18 Oct 2023
Topic Review
Anaerobic Co-Digestion
The anaerobic mono-digestion treatment of organic waste can be challenging due to nutrient imbalances and a lack of microbial diversity. However, anaerobic co-digestion has been shown to effectively address both challenges without the need for additives.
  • 1.2K
  • 27 Oct 2023
Topic Review
Ringtail
The Ringtail (Bassariscus astutus), a small carnivorous mammal with a distinctive appearance, is an intriguing and elusive member of the Procyonidae family. Renowned for its cat-like face, long tail banded with dark rings, and agile movements, the Ringtail is often referred to as a "miner's cat" due to its historical presence in rocky mining areas of the southwestern United States.
  • 1.2K
  • 08 Feb 2024
Topic Review
Human-Relevant NAMs for Developmental Toxicity Testing
Developmental toxicity testing urgently requires the implementation of human-relevant new approach methodologies (NAMs) that better recapitulate the peculiar nature of human physiology during pregnancy, especially the placenta and the maternal/fetal interface, which represent a key stage for human lifelong health. Fit-for-purpose NAMs for the placental–fetal interface are desirable to improve the biological knowledge of environmental exposure at the molecular level and to reduce the high cost, time and ethical impact of animal studies.
  • 1.2K
  • 07 Dec 2022
Topic Review
Rhodococci
Rhodococci are relatively new objects of environmental and industrial biotechnologies. Their metabolic potential for biodegradation and inactivation of complex pollutants, in addition to their mechanisms of stress resistance, are far from being exhausted. However, one should be conscious that some members of this genus are pathogens, and their number is gradually expanding, which clearly limits the practical application of rhodococci.
  • 1.2K
  • 24 Nov 2021
Topic Review
Types of Membranes for CO2 Capture and Utilization
Membranes are a promising technology platform for CO2 capture because they are modular, scalable, and compact. This makes them desirable for process intensification and reducing energy costs. Biocatalytic membranes encompass many different types of materials and functionality.
  • 1.2K
  • 25 Apr 2023
Topic Review
Electrospun Nanofibers for Chemical Separation
The separation and purification of specific chemicals from a mixture have become necessities for many environments, including agriculture, food science, and pharmaceutical and biomedical industries. Electrospun nanofiber membranes are promising materials for the separation of various species such as particles, biomolecules, dyes, and metals from liquids because of the combined properties of a large specific surface, light weight, high porosity, good connectivity, and tunable wettability. This paper reviews the recent progress in the design and fabrication of electrospun nanofibers for chemical separation. Different capture mechanisms including electrostatic, affinity, covalent bonding, chelation, and magnetic adsorption are explained and their distinct characteristics are highlighted. Finally, the challenges and future aspects of nanofibers for membrane applications are discussed.
  • 1.2K
  • 28 Oct 2020
Topic Review
Aarskog-Scott syndrome
Aarskog-Scott syndrome is a genetic disorder that affects the development of many parts of the body. This condition mainly affects males, although females may have mild features of the syndrome.
  • 1.2K
  • 23 Dec 2020
Topic Review
ATR-X Syndrome
Alpha thalassemia X-linked intellectual disability syndrome is an inherited disorder that affects many parts of the body. This condition occurs almost exclusively in males.
  • 1.2K
  • 04 Jan 2021
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