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Topic Review
The Urban Realm in the Digital Era
Digitalisation and the future city paradigm are becoming a trend in recent research and practices. Literature discusses digitalisation and its applications as the main gear in the transformation to the ideal future city vision. Yet, the concept of digitalisation is articulated in many interpretations and presented in different applications in the built environment.
  • 1.3K
  • 26 May 2022
Topic Review
Colorectal Adenomas
Colorectal cancer (CRC) is a malignant disease with an incidence of over 1.8 million new cases per year worldwide. CRC outcome is closely related to the respective stage of CRC and is more favorable at less advanced stages. Detection of early colorectal adenomas is the key to survival. In spite of implemented screening programs showing efficiency in the detection of early precancerous lesions and CRC in asymptomatic patients, a significant number of patients are still diagnosed in advanced stages. Research on CRC accomplished during the last decade has improved our understanding of the etiology and development of colorectal adenomas and revealed weaknesses in the general approach to their detection and elimination. Recent studies seek to find a reliable non-invasive biomarker detectable even in the blood.
  • 1.3K
  • 30 Oct 2020
Topic Review
Inclusive Education
Inclusive educational practices demand social justice where all students with special educational needs have the same right to access education, irrespective of their special needs. Increasingly, across the world, teachers are supporting and defending the inclusion of students with disabilities in mainstream schools and classrooms. 
  • 1.3K
  • 25 Jun 2023
Topic Review
Small Activating RNAs
Small double-strand RNAs (dsRNA) might target promoter regions of genes thereby activating transcription of targets a process known as RNA activation (RNAa). Small activating RNAs (saRNAs) involved in RNAa have been successfully used to activate gene expression in cultured cells as well as in different in vivo models. Thus, this technique might allow to develop various biotechnological applications without the need to synthesize hazardous construct systems harboring exogenous DNA sequences. The recent success of Covid-19 vaccinations is an excellent example of the therapeutic use of RNAs.
  • 1.3K
  • 11 May 2021
Topic Review
Cartography of Jerusalem
The cartography of Jerusalem is the creation, editing, processing and printing of maps of Jerusalem from ancient times until the rise of modern surveying techniques. Almost all extant maps known to scholars from the pre-modern era were prepared by Christian mapmakers for a Christian European audience. Maps of Jerusalem can be categorized between original factual maps, copied maps and imaginary maps, the latter being based on religious books. The maps were produced in a variety of materials, including parchment, vellum, mosaic, wall paintings and paper. All maps marking milestones in the cartography of Jerusalem are listed here following the cartographic histories of the city, from Titus Tobler and Reinhold Röhricht's studies in the 19th century to those of Hebrew University of Jerusalem academics Rehav Rubin and Milka Levy-Rubin in recent decades. The article lists maps that progressed the cartography of Jerusalem before the rise of modern surveying techniques, showing how mapmaking and surveying improved and helped outsiders to better understand the geography of the city. Imaginary maps of the ancient city and copies of existing maps are excluded. The Madaba Map is the oldest known map of Jerusalem, in the form of a mosaic in a Greek Orthodox Church. At least 12 maps survive from the Catholic mapmakers of the Crusades; they were drawn on vellum and mostly show the city as a circle. The first printed map of the city was drawn by Erhard Reuwich and published in 1486 by Bernhard von Breydenbach in his Peregrinatio in Terram Sanctam, based on his pilgrimage of 1483. Approximately 500 maps are known between the late-1400s and the mid-1800s; the significant increase in number is due to the advent of the printing press. Few of the mapmakers had travelled to Jerusalem – most of the maps were either copies of others' maps or were imaginary (i.e. based on reading of religious texts) in nature. The first map based on actual field measurements was published in 1818 by the Czech mapmaker Franz Wilhelm Sieber. The first map based on modern surveying techniques was published by Charles Wilson of the Palestine Exploration Fund in 1864–65, who produced two maps for the British Ordnance Survey.
  • 1.3K
  • 07 Oct 2022
Topic Review
Platelet-Rich Fibrin
Tendons are hypocellular and hypovascular tissues, and thus, their natural healing capacity is low. In this study, we sought to evaluate the efficacy of platelet-rich fibrin (PRF) to serve as a bioactive scaffold in promoting the healing of rabbit Achilles tendon injury. For in vitro study, the essence portion of PRF was determined through bioluminescent assay. Furthermore, we analyzed the time-sequential cytokines-release kinetics of PRF and evaluated their effects on tenocytes proliferation and tenogenic gene expressions. In animal study, the rabbit Achilles tendon defect was left untreated or implanted with normal/heat-denatured PRF scaffolds. Six weeks postoperatively, the specimens were evaluated through sonographic imaging and histological analysis. The results revealed significantly more activated platelets on bottom half of the PRF scaffold. Cytokine concentrations released from PRF could be detected from the first hour to six days. For the in vitro study, PRF enhanced cell viability and collagen I, collagen III, tenomodulin, and tenascin gene expression compared to the standard culture medium. For in vivo study, sonographic images revealed significantly better tendon healing in the PRF group in terms of tissue echogenicity and homogeneity. The histological analysis showed that the healing tissues in the PRF group had more organized collagen fiber, less vascularity, and minimal cartilage formation. In conclusion, bioactive PRF promotes in vitro tenocytes viability and tenogenic phenotypic differentiation. Administration of a PRF scaffold at the tendon defect promotes tissue healing as evidenced by imaging and histological outcomes.
  • 1.3K
  • 28 Oct 2020
Topic Review
Chromosome 12
Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 12, one copy inherited from each parent, form one of the pairs.
  • 1.3K
  • 24 Dec 2020
Topic Review
Complete PAI-1 Deficiency
Complete plasminogen activator inhibitor 1 deficiency (complete PAI-1 deficiency) is a disorder that causes abnormal bleeding. In people with this disorder, bleeding associated with injury can be excessive and last longer than usual.
  • 1.3K
  • 04 Jan 2021
Topic Review
Blood–Brain Barrier Penetrating Nanoplatforms
The current knowledge and advancements on various nanoplatforms (NF) and the use of nanoparticles for successful cross of BBB to treat the brain-related disorders such as brain tumors, Alzheimer’s disease, Parkinson’s disease, and stroke. 
  • 1.3K
  • 12 Jan 2021
Topic Review
Cationic Antibacterial Dendrimers
The alarming increase in antimicrobial resistance, based on the built-in abilities of bacteria to nullify the activity of current antibiotics, leaves a growing number of bacterial infections untreatable. An appealing approach, advanced in recent decades, concerns the development of novel agents able to interact with the external layers of bacteria, causing irreparable damage. Regarding this, some natural cationic antimicrobial peptides (CAMPs) have been reconsidered, and synthetic cationic polymers, mimicking CAMPs and able to kill bacteria by non-specific detrimental interaction with the negative bacterial membranes, have been proposed as promising solutions. Lately, also dendrimers were considered suitable macromolecules for the preparation of more advanced cationic biomimetic nanoparticles, able to harmonize the typical properties of dendrimers, including nanosize, mono-dispersion, long-term stability, high functionality, and the non-specific mechanism of action of CAMPs. Although cationic dendrimers are extensively applied in nanomedicine for drug or gene delivery, their application as antimicrobial agents is still in its infancy. In this first part of our overview on the main types of cationic antibacterial dendrimers, the state of the art of the potential applications of PAMAM and PPI-based agents has therefore been reviewed here, with particular attention to the innovative case studies reported in the literature 
  • 1.3K
  • 14 Jan 2021
Topic Review
Vision-Based Fall Detection Systems
Vision-based fall detection systems have experienced fast development over the last years. To determine the course of its evolution and help new researchers, the main audience of this paper, a comprehensive revision of all published articles in the main scientific databases regarding this area during the last five years has been made. After a selection process, detailed in the Materials and Methods Section, eighty-one systems were thoroughly reviewed. Their characterization and classification techniques were analyzed and categorized. Their performance data were also studied, and comparisons were made to determine which classifying methods best work in this field. The evolution of artificial vision technology, very positively influenced by the incorporation of artificial neural networks, has allowed fall characterization to become more resistant to noise resultant from illumination phenomena or occlusion. The classification has also taken advantage of these networks, and the field starts using robots to make these systems mobile. However, datasets used to train them lack real-world data, raising doubts about their performances facing real elderly falls. In addition, there is no evidence of strong connections between the elderly and the communities of researchers.
  • 1.3K
  • 17 Feb 2021
Topic Review
Connected Vehicle
A connected vehicle is an electric vehicle connected with different communication systems that enable its connection to external devices, networks, applications, and services.
  • 1.3K
  • 28 Apr 2021
Topic Review
Tissue Engineering(TE)
Tissue engineering (TE) was initially designed to tackle clinical organ shortage problems. Although some engineered tissues have been successfully used for non-clinical applications, very few (e.g., reconstructed human skin) have been used for clinical purposes. As the current TE approach has not achieved much success regarding more broad and general clinical applications, organ shortage still remains a challenging issue. This very limited clinical application of TE can be attributed to the constraints in manufacturing fully functional tissues via the traditional top–down approach, where very limited cell types are seeded and cultured in scaffolds with equivalent sizes and morphologies as the target tissues. The newly proposed developmental engineering (DE) strategy towards the manufacture of fully functional tissues utilises a bottom–up approach to mimic developmental biology processes by implementing gradual tissue assembly alongside the growth of multiple cell types in modular scaffolds. This approach may overcome the constraints of the traditional top–down strategy as it can imitate in vivo-like tissue development processes. 
  • 1.3K
  • 11 Oct 2021
Topic Review
Salvigenin
Phytochemical analysis of the Iranian plant Achillea wilhelmsii led to the isolation of 17 pure secondary metabolites belonging to the classes of sesquiterpenoids and phenolics. Two of these compounds, named wilhemsin (7) and wilhelmsolide (9), are new sesquiterpenoids, and the first shows undescribed structural features. Their structures were elucidated through extensive spectroscopic analysis, mainly based on 1D and 2D NMR, and chemical derivatization. Starting from plant traditional use and previous reports on the activity of the plant extracts, all the pure compounds were evaluated on endpoints related to the treatment of metabolic syndrome. The sesquiterpene hanphyllin (8) showed a selective cholesterol-lowering activity (−12.7% at 30 µM), santoflavone (13) stimulated glucose uptake via the GLUT transporter (+16.2% at 30 µM), while the trimethoxylated flavone salvigenin (14) showed a dual activity in decreasing lipid levels (−22.5% palmitic acid biosynthesis at 30 µM) and stimulating mitochondrial functionality (+15.4% at 30 µM). 
  • 1.3K
  • 13 Aug 2021
Topic Review
Factors Affecting Carbonate Crystallization in EICP Treatment
Urea hydrolysis involves the breakdown of urea in water. The result of this reaction forms calcite in the presence of a calcium source. The reaction can be 10 to the power of 14 times faster than the chemical (un-catalysed) urea hydrolysis in the presence of a catalyst (urease enzyme). The improvement in EICP treatment is based on the precipitation of calcium carbonate within the treated soil matrix. It is thus important to shed light on the crystallographic patterns, such as size, shape, and distribution of precipitates since they play a significant role in defining the mechanical properties of EICP bio-cemented soils. The main factors that affect crystallization are the temperature, urease activity, pH level of the cementing solution, and concentration of cementation solution. These factors are discussed in some detail below.
  • 1.3K
  • 24 Jan 2022
Topic Review
First-Line and Second-Line Pharmacotherapies for Osteoarthritis
Osteoarthritis (OA) can be defined as the result of pathological processes of various etiologies leading to damage to the articular structures. Although the mechanism of degenerative changes has become better understood due to the plethora of biochemical and genetic studies, the drug that could stop the degenerative cascade is still unknown. All available forms of OA therapy are based on symptomatic treatment.
  • 1.3K
  • 23 Feb 2022
Topic Review
The Feeding Behaviour Habits of Growing-Finishing Pigs
Feed cost represents approximately 65% of the cost production of a pig kg deadweight. Therefore, the search for strategies to improve the utilisation rate of nutrients during the growing-finishing period is of permanent interest. One of the important factors influencing the performance and carcass quality of growing-finishing pigs is feeding behaviour habits (FBHs), which can be described not only by average daily feed intake (ADFI), but also by other criteria such as the daily number of feeder visits, the daily time spent eating, the feed consumed per feeder visit or the rhythm of ingesta, among others. These can be registered and calculated thanks to the availability in the market of automatic feeding systems.
  • 1.3K
  • 19 May 2022
Topic Review
Targeting Replication Stress Response Pathways to Treat Cancer
Proliferating cells regularly experience replication stress caused by spontaneous DNA damage that results from endogenous reactive oxygen species, DNA sequences that can assume secondary and tertiary structures, collisions between opposing transcription and replication machineries, and exogenous genotoxic agents. Replication stress often leads to DNA double-strand breaks (DSBs) that can cause genome instability and cell death. The importance of replication stress responses in cells exposed to genotoxic chemo- or radiotherapy has prompted considerable research focused on how tumor cells might be selectively killed by combined treatments with genotoxins and agents targeting DNA damage response (DDR) factors involved in the replication stress response.
  • 1.3K
  • 12 Aug 2022
Topic Review
Military Simulation
Military simulations, also known informally as war games, are simulations in which theories of warfare can be tested and refined without the need for actual hostilities. Military simulations are seen as a useful way to develop tactical, strategical and doctrinal solutions, but critics argue that the conclusions drawn from such models are inherently flawed, due to the approximate nature of the models used. Many professional analysts object to the term wargames as this is generally taken to be referring to the civilian hobby, thus the preference for the term simulation. Simulations exist in many different forms, with varying degrees of realism. In recent times, the scope of simulations has widened to include not only military but also political and social factors, which are seen as inextricably entwined in a realistic warfare model. Whilst many governments make use of simulation, both individually and collaboratively, little is known about it outside professional circles. Yet modelling is often the means by which governments test and refine their military and political policies.
  • 1.3K
  • 29 Sep 2022
Topic Review
Geographical Indication
A geographical indication (GI) is a name or sign used on products which corresponds to a specific geographical location or origin (e.g., a town, region, or country). The use of a geographical indication, as an indication of the product's source, acts as a certification that the product possesses certain qualities, is made according to traditional methods, or enjoys a good reputation due to its geographical origin. Appellation d'origine contrôlée ('Appellation of origin') is a sub-type of geographical indication where quality, method, and reputation of a product originate from a strictly defined area specified in its intellectual property right registration.
  • 1.3K
  • 14 Oct 2022
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